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Researchers are now asking if inhibiting angiogenesis can slow down or prevent
the growth and spread of cancer cells in humans.
To answer this question, almost two dozen angiogenesis inhibitors are currently
being tested in cancer patients. The inhibitors being tested fall into several
different categories, depending on their mechanism of action. Some inhibit
endothelial cells directly, while others inhibit the angiogenesis signaling
cascade or block the ability of endothelial cells to break down the
extracellular matrix.
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