Drugs That Block the Angiogenesis Signaling Cascade
A second group of angiogenesis inhibitors being tested in human clinical trials are molecules that interfere with steps in the angiogenesis signaling cascade. Included in this category are anti-VEGF antibodies that block the VEGF receptor from binding growth factor. Bevacizumab (Avastin), a monoclonal antibody, is the first of these anti-VEGF antibodies to be FDA-approved. This new drug has been proven to delay tumor growth and more importantly, to extend the lives of patients. Another agent, interferon-alpha, is a naturally occurring protein that inhibits the production of bFGF and VEGF, preventing these growth factors from starting the signaling cascade.
Also, several synthetic drugs capable of interfering with endothelial cell receptors are being tested in cancer patients.