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Understanding Cancer Series: Cancer Genomics
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    Posted: 01/28/2005    Reviewed: 09/01/2006
Slide 23  :  Example: Translocation of Bcr-Abl Genes

In chronic myelogenous leukemia, a translocation occurs between chromosomes 9 and 22. This rearrangement of genomic material creates a fusion gene call Bcr-Abl that produces a protein (tyrosine kinase) thought to promote the development of leukemia. The drug Gleevec blocks the activation of the Bcr-Abl protein.

Example: Translocation of <i>Bcr-Abl</i> Genes