In English | En español
Questions About Cancer? 1-800-4-CANCER

Understanding Cancer Series

< Back to Main
  • Posted: 01/28/2005
  • Reviewed: 09/01/2006

Page Options

  • Print This Page
  • Print This Document
  • View Entire Document
  • Email This Document
  • View/Print PDF
  • View/Print PowerPoint

Slide 22

:

Large Deletions or Insertions

< Previous SectionNext Section >

Large deletions or insertions in a chromosome also may lead to cancer. These may occur during mitosis or during recombination in meiosis. Translocations occur when segments of one chromosome break off and fuse to a different chromosome, without any loss of genetic material. Many of these have been found to enable tumor development. Inversions are mutations that arise when two breaks occur in a chromosome and the piece is reinserted in reversed order. Other chromosomal abnormalities include nondisjunction, the failure of the homologs (chromosome pairs) to separate as new cells divide. Source: Ried Lab, NCI

Large Deletions or Insertions