Because of the potential cancer and cardiovascular risks inherent in hormone pills containing estrogen and progesterone, scientists are working on the development of SERMs for postmenopausal women that can mimic the beneficial effects of estrogen without exerting any of its harmful effects.

The ideal drug, of course, would be a SERM exhibiting the positive effects of estrogen on bones, heart, and blood vessels, without exhibiting the potentially harmful effects of estrogen on the breast and uterus.