- Introduction
- Getting Cancer-Different Fates
- The Challenge: Cancer Genome Meets Patient's Genetic Background
- Human Genome and Coding Regions
- Variation in a Person's Genome
- What Is Variation in the Genome?
- Genetic Variations Called SNPs
- Genetic Variation in Noncoding Regions
- Genetic Variation in Coding Regions
- Harmful Genetic Variations: Mutations
- Genetic Variations: Latent Effects
- Genetic Variations: Drug Metabolism SNPs
- Example: Drug Metabolism and SNPs in CYP2C9
| | - Genotypes and Phenotypes
- Genotypes, Phenotypes and Alleles
- Mutations in Cancer Susceptibility Genes
- Different Locus, Different Allele, Same Phenotype
- Incomplete Penetrance
- Incomplete Penetrance and Phenocopies
- Modifier Genes
- Epigenetic Variation
- The Role of MicroRNAs
- Other Internal Factors
- External Factors
- Still Don't Completely Understand
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