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  • Posted: 12/29/2009

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Slide 13

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Example: Drug Metabolism and SNPs in CYP2C9

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CYP2C9 genetic variants are a good example of how SNPs can be linked to abnormal drug metabolism. CYP2C9 is an important cytochrome P450 protein that works in the liver to metabolize drugs. Genetic variation in the gene for this protein can alter this metabolism. As many as 40 percent of persons carry a SNP that produces a deficient CYP2C9 protein. Deficiencies in this protein can impair the metabolism of as many as 1 in 5 medications currently on the market. Fortunately, technology makes it possible for a person to discover the drug metabolism variants that he or she carries. This information can then inform drug selection.

Graphic shows how a gene chip can test for variants in CYP2C9, an important cytochrome P450 protein that works in the liver to metabolize drugs.