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Understanding Cancer Series

  • Posted: 01/28/2005
  • Reviewed: 09/01/2006

Slide 3

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Markers of Non-Self

Any non-self substance capable of triggering an immune response is known as an antigen. An antigen can be a whole non-self cell, a bacterium, a virus, an MHC marker protein or even a portion of a protein from a foreign organism.

The distinctive markers on antigens that trigger an immune response are called epitopes. When tissues or cells from another individual enter your body carrying such antigenic non-self epitopes, your immune cells react. This explains why transplanted tissues may be rejected as foreign and why antibodies will bind to them.

Markers of Non-Self