ASC-US

• Some cells from the lining of the outer cervix (also called squamous cells) do not appear normal.
• Your health care provider will need to do additional tests to clarify the results.

• Follow-up with repeat Pap tests every 6 months
• Testing for high-risk HPV
• Immediate colposcopy (a test that can be done in the doctor's office to get a magnified view of your cervix)
• Biopsy
• Estrogen cream

Abnormal Pap Test Result
If a repeat Pap test is abnormal, your health care provider will probably recommend a colposcopy.

Positive HPV Test Result
If your HPV test is positive, your health care provider will probably recommend a colposcopy.

Negative HPV Test Result
If your HPV test is negative, your health care provider may recommend a repeat screening in 1 year. Because ASC-US can also be caused by an estrogen deficiency, your health care provider may prescribe an estrogen cream if you are near or past menopause.

Abnormal Colposcopy Result
If your colposcopy is abnormal, your health care provider may do a biopsy, endocervical curettage, or both.

ASC-H

AGC

ASC-H (atypical squamous cells, cannot exclude HSIL)

• Cervical cells do not appear normal.
• A high-grade lesion may be present, but the cell changes are too minor to be sure.

AGC (atypical glandular cells)

• Some glandular cells in the lining of the cervix appear abnormal.

• Colposcopy
• Biopsy

Normal Colposcopy Result
If cervical tissue looks healthy, your health care provider may not need to do any further testing or treatment right away, but may recommend an HPV test in 1 year or repeat Pap tests after 6 and 12 months.

Abnormal Colposcopy Result
If your colposcopy is abnormal, your health care provider may do a biopsy, endocervical curettage, or both.

LSIL (low-grade squamous intraepithelial lesion)

• Squamous cells are abnormal, but are usually not precancerous.

• Colposcopy
• Biopsy

Normal Colposcopy Result
If cervical tissue looks healthy, your health care provider may not need to do any further testing or treatment right away but may recommend an HPV test in 1 year or repeat Pap tests after 6 and 12 months.

Abnormal Colposcopy Result
If your colposcopy is abnormal, your health care provider may do a biopsy, endocervical curettage, or both.

HSIL

AIS

If you have one of the results below, it is very important that you get the necessary tests and treatments.

HSIL (high-grade squamous intraepithelial lesion)

• The lesion is precancerous; without treatment, it may turn into invasive cancer.

AIS (adenocarcinoma in situ)

• A precancerous lesion is found in the glandular tissue of the cervix.

• Colposcopy
• Biopsy

Normal Colposcopy Result
Even if cervical tissue looks healthy, your health care provider may need to do further testing or treatment, including loop electrosurgical excision procedure (LEEP) or repeat colposcopy and Pap tests after 6 and 12 months.

Abnormal Colposcopy Result
If your colposcopy is abnormal, your health care provider will probably do a biopsy, endocervical curettage, or both.

• Colposcopy
• Biopsy

Your health care provider will probably refer you to a gynecologic oncologist.

Abnormal Colposcopy Result
If your colposcopy is abnormal, your health care provider will probably initially do a biopsy, endocervical curettage, or both, and then refer you to a gynecologic oncologist for further evaluation and treatment.