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Hodgkin Lymphoma

  • Posted: 07/31/2013

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Doctors Who Treat Hodgkin Lymphoma
Second Opinion
Treatment Clinical Trials
Targeted Therapy
Radiation Therapy
Stem Cell Transplant

People with Hodgkin lymphoma have many treatment options. Treatment options include:

  • Chemotherapy
  • Targeted Therapy
  • Radiation Therapy
  • Stem Cell Transplant

The treatment that’s right for you depends mainly on the type of Hodgkin lymphoma (most people have classical Hodgkin lymphoma), where the lymphoma was found in your body (its stage), and whether you’ve had weight loss, drenching night sweats, or fevers. It also may depend on whether you have a tumor that is bigger than 10 centimeters (4 inches). You may receive more than one type of treatment, such as chemotherapy and radiation therapy.

At any time, care is available to prevent infections, control pain, relieve the side effects of treatment, and ease emotional concerns. You can get information about coping on NCI’s website at

Also, you can get information about coping from NCI’s Cancer Information Service at 1-800-4-CANCER (1-800-422-6237). Or, chat using NCI’s instant messaging service, LiveHelp (

Doctors Who Treat Hodgkin Lymphoma

Whenever possible, people should be treated at a medical center that has doctors experienced in treating Hodgkin lymphoma. If this isn’t possible, your doctor may discuss the treatment plan with a specialist at such a center.

Resources are available to help you find doctors who treat Hodgkin lymphoma:

  • Your doctor may be able to refer you to specialists.
  • You can ask a hospital, medical school, or medical society for names of specialists near you.
  • NCI’s Cancer Information Service can give you information about treatment centers near you. Call 1-800-4-CANCER (1-800-422-6237). Or, chat using LiveHelp (, NCI’s instant messaging service.
  • Other sources can be found in the NCI fact sheet How To Find a Doctor or Treatment Facility If You Have Cancer.

Your health care team may include the following specialists:

Your health care team may also include an oncology nurse, a social worker, and a registered dietitian.

Ask your health care team about your treatment options, the expected results of each option, and possible side effects. Because cancer treatments often damage healthy cells and tissues, side effects are common. These side effects depend on many factors, including the type of treatment. The specific side effects may not be the same for everyone, and they may even change from one treatment session to the next.

You may want to talk with your doctor about taking part in a research study (clinical trial) of new treatment methods. Research studies are an important option for people with Hodgkin lymphoma. See the Treatment Clinical Trials section.

Questions you may want to ask your doctor about treatment options

  • What are my treatment options? Which do you recommend for me? Why?
  • What are the expected benefits of each kind of treatment?
  • What are the risks and possible side effects of each treatment? How can side effects be managed?
  • What can I do to prepare for treatment?
  • What is the treatment likely to cost? Will my insurance cover it?
  • How will treatment affect my normal activities?
  • Would a treatment research study be right for me?

Second Opinion

Before starting treatment, you might want a second opinion about your diagnosis and treatment options. Some people worry that the doctor will be offended if they ask for a second opinion. Usually the opposite is true. Most doctors welcome a second opinion. And many health insurance companies will pay for a second opinion if you or your doctor requests it. Some insurance companies actually require a second opinion.

If you get a second opinion, the second doctor may agree with your first doctor’s diagnosis and treatment recommendation. Or, the second doctor may suggest another approach. Either way, you have more information and perhaps a greater sense of control. You can feel more confident about the decisions you make, knowing that you’ve looked at all of your options.

It may take some time and effort to gather your medical records and see another doctor. In most cases, it’s not a problem to take several weeks to get a second opinion. The delay in starting treatment usually will not make treatment less effective. To make sure, you should discuss this delay with your doctor. Some people with Hodgkin lymphoma need treatment right away.

Treatment Clinical Trials

For anyone thinking about cancer treatment, clinical trials are an option. Clinical trials are research studies that involve people. They are an option for all stages of cancer.

Cancer research has led to real progress in the treatment of Hodgkin lymphoma. Because of research, most people diagnosed with Hodgkin lymphoma can now be cured, or their disease can be controlled for many years. Doctors continue to search for new and better ways to treat
Hodgkin lymphoma.

Like all other treatment options, clinical trials have possible benefits and risks. But, by looking closely at all options, including clinical trials, you are taking an active role in a decision that affects your life.

Even if you don’t benefit directly from the treatment under study, you may still make an important contribution by helping doctors learn more about Hodgkin lymphoma and how to control it. If you’re interested in being part of a clinical trial, talk with your doctor.

NCI’s website has a section called Learn About Clinical Trials at You can learn about:

  • What clinical trials are and why they are important
  • How your safety is protected
  • Who pays for clinical trials
  • What to think about if you’re deciding whether to take part in a clinical trial
  • What to ask your doctor

In addition, NCI’s Cancer Information Service can answer your questions and provide information about clinical trials. Contact CIS at 1-800-4-CANCER (1-800-422-6237) or at LiveHelp (

You can search for clinical trials of Hodgkin lymphoma at on NCI’s website.


Most people with Hodgkin lymphoma are treated with chemotherapy. Chemotherapy uses drugs to kill lymphoma cells.

Many drugs are used for Hodgkin lymphoma. Usually, the drugs are given through a thin needle directly into a vein (intravenously). Some are given by mouth.

You’ll probably receive a combination of drugs in a clinic, at the doctor’s office, or at home. Some people need to stay in the hospital during treatment.

The side effects depend mainly on which drugs are given and how much. Chemotherapy kills fast-growing Hodgkin lymphoma cells, but the drugs can also harm normal cells that divide rapidly:

  • Blood cells: When drugs lower the levels of healthy blood cells, you’re more likely to get infections, bruise or bleed easily, and feel very weak and tired. Your health care team will check for low levels of blood cells. If your levels are low, your health care team may stop the chemotherapy for a while or reduce the dose of the drug.
  • Cells in hair roots: Chemotherapy may cause hair loss. If you lose your hair, it will grow back after treatment, but the color and texture may be changed.
  • Cells that line the digestive tract: Chemotherapy can cause a poor appetite, nausea and vomiting, diarrhea, or mouth blisters. Your health care team can give you medicines and suggest other ways to help with these problems.

Ask your health care team whether the chemotherapy used for Hodgkin lymphoma could make you unable to have children. The fertility of adults may be harmed by the drugs, but most children treated for Hodgkin lymphoma seem to have normal fertility when they grow up. If you want to have a child someday after treatment, you may choose to store sperm or eggs before treatment starts.

Some of the drugs used for Hodgkin lymphoma can cause heart disease or cancer later on. See the Follow-up Care section for information about checkups after treatment.

The NCI booklet Chemotherapy and You has helpful ideas for coping with chemotherapy side effects.

Targeted Therapy

People with lymphocyte-predominant Hodgkin lymphoma may be treated with a targeted therapy. The drug binds to lymphoma cells, and the body destroys them.

People receive targeted therapy directly into a vein through a thin needle. The drug may cause nausea, vomiting, diarrhea, night sweats, or tingling hands or feet. Side effects usually go away after treatment ends.

You may want to read the NCI fact sheet Targeted Cancer Therapies to learn more about this type of treatment.

Questions you may want to ask your doctor about chemotherapy or targeted therapy

  • Which drug or drugs do you suggest for me? What will they do?
  • What are the possible side effects? What can we do about them?
  • When will treatment start? When will it end? How often will I have treatments?
  • How will we know the treatment is working?
  • Will there be lasting side effects?

Radiation Therapy

Many people with classical or lymphocyte-predominant Hodgkin lymphoma receive radiation therapy after chemotherapy. Some people with lymphocyte-predominant Hodgkin lymphoma receive radiation therapy without chemotherapy. Radiation therapy can destroy lymphoma cells, shrink tumors, and help control pain.

Radiation therapy for Hodgkin lymphoma is usually given by a large machine outside the body. This kind of radiation therapy won’t make you radioactive. While you’re lying on a treatment table, the machine will aim high-energy rays that you can’t see or feel at the areas affected by the Hodgkin lymphoma. Each treatment session usually lasts less than 30 minutes. You’ll probably go to a hospital or clinic for radiation therapy 5 days a week for several weeks.

Side effects may develop during radiation therapy or years later. Side effects depend mainly on how much radiation is given and on what part of your body receives treatment. For example, radiation to your chest and neck may cause a cough or shortness of breath.

It’s common for skin in the treated area to become red, dry, and itchy. Check with your doctor before using lotion or cream in that area. After treatment is over, your skin will slowly return to normal.

You’re likely to become tired during radiation therapy, especially in the later weeks of treatment. Although getting enough rest is important, most people say they feel better when they exercise every day. Try to go for a short walk, do gentle stretching exercises, or do yoga.

It may help to know that, in most cases, the side effects of radiation therapy are not permanent. However, you may want to ask your doctor about the chance of possible long-term effects. After treatment is over, some people have an increased chance of developing a second cancer, such as breast or lung cancer. Also, radiation therapy aimed at the chest may cause heart or thyroid disease.

Women who have radiation therapy aimed at the pelvis may have hot flashes and vaginal dryness, and their menstrual periods may stop. Menstrual periods are more likely to return for younger women.

Radiation therapy aimed at the pelvis can make both women and men unable to have children. This side effect may be temporary or permanent. People with Hodgkin lymphoma who may want to have a child after treatment should ask their health care team about ways to preserve their eggs or sperm before radiation therapy starts.

The NCI booklet Radiation Therapy and You has helpful ideas for coping with radiation therapy side effects.

Questions you may want to ask your doctor about radiation therapy

  • Why do I need this treatment?
  • When will treatment start? When will it end? How often will I have treatments?
  • How will we know the treatment is working?
  • What side effects should I expect? What should I tell you about?
  • Are there any lasting effects?

Stem Cell Transplant

Some people with Hodgkin lymphoma receive a stem cell transplant. A transplant of blood-forming stem cells allows you to be treated with high doses of chemotherapy. The high doses destroy both lymphoma cells and healthy blood cells in the bone marrow.

Stem cell transplants take place in the hospital. You may need to stay in the hospital for several weeks. After you receive high-dose chemotherapy to kill lymphoma cells, you’ll receive healthy stem cells through a flexible tube placed in a large vein in your neck or chest area. New, healthy blood cells will develop from the transplanted stem cells. The healthy blood cells will replace the abnormal ones that were destroyed by treatment.

Healthy stem cells may come from you, or they may come from a family member or another donor. If the healthy stem cells will come from you, then stem cells will be removed from your body before you receive high-dose chemotherapy. The stem cells may be treated to kill any lymphoma cells that may be present, and the healthy stem cells are then frozen and stored until the stem cell transplant takes place.

You may want to read the NCI fact sheet Bone Marrow Transplantation and Peripheral Blood Stem Cell Transplantation. It tells about the types of transplants and their side effects.

Questions you may want to ask your doctor about stem cell transplants

  • How long will I be in the hospital? Will I need special care? How will I be protected from germs?
  • What care will I need when I leave the hospital?
  • What are the risks and side effects? What can we do about them?
  • How will we know if the treatment is working?
  • What is my chance of a full recovery? How long will that take?

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