Alternate Title
Basic Trial Information
Objectives
Entry Criteria
Expected Enrollment
Outcomes
Outline
Related Publications
Trial Contact Information
Registry Information

Alternate Title

Single-Fraction Radiation Therapy Compared With Multiple-Fraction Reirradiation Therapy in Treating Patients With Painful Bone Metastases

Basic Trial Information

Phase	Type	Status	Age	Sponsor	Protocol IDs
Phase III	Treatment	Active	18 and over	NCI, Other	CAN-NCIC-SC20 NCT00080912, RTOG-0433, TROG-03.08, SC20

Objectives

Primary

1. Compare pain relief in patients undergoing single-fraction vs multiple-fraction re-irradiation of painful bone metastases.

Secondary

1. Compare overall pain relief in patients treated with these regimens.
2. Compare time to pain progression in patients treated with these regimens.
3. Correlate initial irradiation response with pain relief after re-irradiation in these patients.
4. Compare changes in functional interference after re-irradiation using the Brief Pain Inventory in patients treated with these regimens.
5. Compare quality of life of patients treated with these regimens (patients in Canada, the Netherlands, and patients registered through RTOG).
6. Determine characteristics of non-responders (to both initial and re-irradiation) among patients treated with these regimens.
7. Monitor the incidence of acute severe radiation-related side effects in patients treated with these regimens.
8. Monitor the incidence of in-field pathological fractures and spinal cord compression in patients treated with these regimens.

Entry Criteria

Disease Characteristics:

• Histologically or cytologically confirmed malignancy
  • Diagnosis by needle biopsy, bone marrow biopsy, cytology, or surgical biopsy or resection
• Bone metastases at clinically painful areas confirmed by any of the following:
  • Plain radiographs
  • Radionuclide bone scans
  • CT scans
  • Magnetic resonance imaging
• Worst pain score of ≥ 2/10 using the baseline Brief Pain Inventory
• Pain arising from previously irradiated metastases and not from progressive disease in adjoining or remote areas
• Initial radiotherapy field is reproducible for re-irradiation
  • Current treatment field for palliative radiotherapy must be the same size or smaller than the initial treatment field
• No radiological evidence of high-risk lesions for pathological fractures in the extremities (lytic lesions > 3cm or > 50% cortical erosion of bone diameter) AND patient is a candidate for surgical intervention.
• No clinical or radiological evidence of spinal cord compression

Prior/Concurrent Therapy:

Biologic therapy

• Not specified

Chemotherapy

• Not specified

Endocrine therapy

• Not specified

Radiotherapy

• See Disease Characteristics
• No more than 1 prior course of radiotherapy to the target site
• No prior radiotherapy dose ≥ 24 Gy in 6 fractions, 27 Gy in 8 fractions, or 30 Gy in 10 fractions to the spine or any part of the pelvis encompassing small or large bowel and/or the rectum, if these sites are being treated on study
  • Initial doses of 24 Gy in 6 fractions, 27 Gy in 8 fractions or 30 Gy in 10 fractions to the acetabulum or hip and proximal femur allowed as long as the medial field border of the initial treatment did not cross midline
• No prior radiotherapy dose > 30Gy in 10 fractions to the ribs or extremities if these sites are being treated on study
• More than 30 days since prior strontium chloride Sr 89
• More than 30 days since prior half-body radiotherapy, including the current re-irradiation field
• At least 4 weeks since prior initial radiotherapy

Surgery

• No prior palliative surgery in treatment area
• No concurrent surgical intervention on treatment area

Other

• No prior participation on this protocol
• No plan to make an immediate change in analgesic regimen

Patient Characteristics:

Age

• 18 and over

Performance status

• Karnofsky 50-100%

Life expectancy

• Not specified

Hematopoietic

• Not specified

Hepatic

• Not specified

Renal

• Not specified

Other

• Not pregnant or nursing
• Fertile patients must use effective barrier contraception
• Able and willing to complete quality of life questionnaire in English, French, Dutch, or Spanish
• Must be accessible for treatment follow-up

Expected Enrollment

A total of 850 patients will be accrued for this study.

Outcomes

Pain relief measured by the Brief Pain Inventory at 2 months after treatment

Quality of life assessed by the EORTC QLQ-C30

Outline

This is a randomized, multicenter study. Patients are stratified according to response to initial radiotherapy (yes vs no), initial fractionation (single fraction vs multiple fraction), and participating center. Patients are randomized to 1 of 2 treatment arms.

• Arm I: Patients receive single-fraction radiotherapy on day 1.
• Arm II: Patients receive multiple-fraction radiotherapy once daily on days 1-5 or on days 1-8 if re-irradiation of the spine and/or whole pelvis is involved AND prior initial radiotherapy was given in multiple fractions.

At least 4 weeks after the first re-treatment, patients in both arms may receive a second re-treatment in the absence of unacceptable pain progression or unacceptable toxicity.

Patients complete a Brief Pain Inventory questionnaire at baseline, on days 7 and 14, monthly during months 1-6, and at months 9 and 12. Acute Toxicities are assessed on days 7 and 14. Quality of life is assessed at baseline and then monthly during months 1-6.

Patients are followed for up to 1 year.

Peer Reviewed and Funded or Endorsed by Cancer Research UK

Chow E, Hoskin PJ, Wu J, et al.: A phase III international randomised trial comparing single with multiple fractions for re-irradiation of painful bone metastases: National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) SC 20. Clin Oncol (R Coll Radiol) 18 (2): 125-8, 2006.[PUBMED Abstract]

Trial Contact Information

Trial Lead Organizations

NCIC-Clinical Trials Group

Edward Chow, MD, Protocol chair		Ph: 416-480-4998

Radiation Therapy Oncology Group

William Hartsell, MD, Protocol chair		Ph: 847-981-5760

Trans Tasman Radiation Oncology Group at Calvary Mater Newcastle

Daniel Roos, MD, Protocol chair		Ph: 61-88-222-4000 Email: Daniel.Roos@health.sa.gov.au

U.S.A.
California
	Antioch
	Kaiser Permanente - Deer Valley
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Burbank
	Providence Saint Joseph Medical Center - Burbank
		Clinical Trials Office - Providence Saint Joseph Medical Center - Burbank	Ph:  818-847-3220
	Castro Valley
	East Bay Radiation Oncology Center
		James Feusner, MD	Ph:  510-428-3689
	Eden Medical Center
		James Feusner, MD	Ph:  510-428-3689
	Valley Medical Oncology Consultants - Castro Valley
		James Feusner, MD	Ph:  510-428-3689
	Chico
	Enloe Cancer Center at Enloe Medical Center
		Clinical Trials Office - Enloe Cancer Center at Enloe Medical Center	Ph:  530-332-3808
	Fremont
	Kaiser Permanente - Fremont
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Valley Medical Oncology
		James Feusner, MD	Ph:  510-428-3689
	Hayward
	Kaiser Permanente Medical Center - Hayward
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Los Angeles
	Kaiser Permanente Medical Center - Los Angeles
		Michael Girvigian	Ph:  323-667-4011 800-954-8000
	Martinez
	Contra Costa Regional Medical Center
		James Feusner, MD	Ph:  510-428-3689
	Mountain View
	El Camino Hospital Cancer Center
		Clinical Trials Office - El Camino Hospital Cancer Center	Ph:  650-988-7623
	Oakland
	Alta Bates Summit Medical Center - Summit Campus
		Clinical Trials Office - Alta Bates Summit Medical Center - Summit Campus	Ph:  510-204-1414
	Bay Area Breast Surgeons, Incorporated
		James Feusner, MD	Ph:  510-428-3689
	CCOP - Bay Area Tumor Institute
		James Feusner, MD	Ph:  510-428-3689
	Highland General Hospital
		James Feusner, MD	Ph:  510-428-3689
	Kaiser Permanente - Division of Research - Oakland
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Kaiser Permanente Medical Center - Oakland
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Larry G Strieff MD Medical Corporation
		James Feusner, MD	Ph:  510-428-3689
	Tom K Lee, Incorporated
		James Feusner, MD	Ph:  510-428-3689
	Pleasanton
	Valley Care Medical Center
		James Feusner, MD	Ph:  510-428-3689
	Valley Medical Oncology Consultants - Pleasanton
		James Feusner, MD	Ph:  510-428-3689
	Pomona
	Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical Center
		Clinical Trials Office - Robert and Beverly Lewis Family Cancer Care Center	Ph:  909-865-9555
	Rancho Cardova
	Kaiser Permanente Medical Center - Rancho Cordova
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Redwood City
	Kaiser Permanente Medical Center - Redwood City
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Richmond
	Kaiser Permanente Medical Center - Richmond
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Rohnert Park
	Rohnert Park Cancer Center
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Roseville
	Kaiser Permanente Medical Center - Roseville
		Louis Fehrenbacher, MD	Ph:  707-651-2577
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Sacramento
	Kaiser Permanente Medical Center - Sacramento
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	South Sacramento Cancer Center
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	South Sacramento Kaiser-Permanente Medical Center
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	San Francisco
	Kaiser Permanente Medical Center - San Francisco Geary Campus
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	San Jose
	Kaiser Permanente Medical Center - Santa Teresa
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	San Pablo
	Doctors Medical Center - San Pablo Campus
		James Feusner, MD	Ph:  510-428-3689
	San Rafael
	Kaiser Foundation Hospital - San Rafael
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Santa Clara
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Kaiser Permanente Medical Center - Santa Clara Kiely Campus
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Santa Rosa
	Kaiser Permanente Medical Center - Santa Rosa
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	South San Francisco
	Kaiser Permanente Medical Center - South San Francisco
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Stockton
	Kaiser Permanente Medical Facility - Stockton
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Vacaville
	Kaiser Permanente Medical Center - Vacaville
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Vallejo
	Kaiser Permanente Medical Center - Vallejo
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Walnut Creek
	Kaiser Permanente Medical Center - Walnut Creek
		Louis Fehrenbacher, MD	Ph:  707-651-2577
Colorado
	Aurora
	University of Colorado Cancer Center at UC Health Sciences Center
		Clinical Trials Office - University of Colorado Cancer Center	Ph:  720-848-0650
	Colorado Springs
	Penrose Cancer Center at Penrose Hospital
		Clinical Trials Office - Penrose Cancer Center	Ph:  719-776-5275
	Fort Collins
	Poudre Valley Radiation Oncology
		C. Kelley Simpson, MD	Ph:  970-482-3328
	Pueblo
	St. Mary - Corwin Regional Medical Center
		John Stageberg	Ph:  719-557-4000
Florida
	Miami
	University of Miami Sylvester Comprehensive Cancer Center - Miami
		University of Miami Sylvester Comprehensive Cancer Center Clinical Trial Matching Service	Ph:  866-574-5124
			Email: Sylvester@emergingmed.com
Georgia
	Altanta
	Winship Cancer Institute of Emory University
		Scott Edelman	Ph:  404-778-5180 888-946-7447
	Atlanta
	Emory Crawford Long Hospital
		Scott Edelman	Ph:  404-686-4411
	Georgia Cancer Center for Excellence at Grady Memorial Hospital
		Scott Edelman	Ph:  404-489-9000
	Decatur
	Veterans Affairs Medical Center - Atlanta (Decatur)
		Scott Edelman	Ph:  404-728-7680
	Gainesville
	Northeast Georgia Medical Center
		Frank Lake, MD	Ph:  770-535-3393
Illinois
	Barrington
	Good Shepherd Hospital
		John Chang, MD	Ph:  847-723-8030
	Chicago
	Creticos Cancer Center at Advocate Illinois Masonic Medical Center
		Clinical Trials Office - Creticos Cancer Center at Advocate Illinois Masonic Medical Center	Ph:  773-296-5360
	John H. Stroger, Jr. Hospital of Cook County
		Nathanial Holloway	Ph:  312-864-3200
	Downers Grove
	Good Samaritan Cancer Care Center at Advocate Good Samaritan Hospital
		Clinical Trials Office - Good Samaritan Cancer Care Center at Advocate Good Samaritan Hospital	Ph:  630-275-1270
	Elk Grove Village
	Alexian Brothers Radiation Oncology
		Martin Boyer, MD	Ph:  847-981-5760
	Park Ridge
	Advocate Lutheran General Cancer Care Center
		Clinical Trials Office - Advocate Lutheran General Cancer Care Center	Ph:  847-384-3621
	Peoria
	Methodist Medical Center of Illinois
		Clinical Trials Office - Methodist Medical Center of Illinois	Ph:  309-243-3000
Indiana
	Anderson
	Saint John's Cancer Center at Saint John's Medical Center
		Darrel Ross	Ph:  765-646-8459
	Elkhart
	Elkhart General Hospital
		David Hornback, MD	Ph:  574-647-7461
	Fort Wayne
	Parkview Regional Cancer Center at Parkview Health
		Brian Chang	Ph:  260-373-7850
	Radiation Oncology Associates Southwest
		Tony Lee	Ph:  260-373-7850
	Indianapolis
	Indiana University Melvin and Bren Simon Cancer Center
		Clinical Trials Office - Indiana University Cancer Center	Ph:  317-274-2552
	Veterans Affairs Medical Center - Indianapolis
		Achilles Fakiris	Ph:  317-554-0000 888-878-6889
	Kokomo
	Howard Community Hospital
		David Hornback, MD	Ph:  574-647-7461
	La Porte
	Center for Cancer Therapy at LaPorte Hospital and Health Services
		David Hornback, MD	Ph:  574-647-7461
	South Bend
	CCOP - Northern Indiana CR Consortium
		David Hornback, MD	Ph:  574-647-7461
	Memorial Hospital of South Bend
		Clinical Trials Office - Memorial Hospital of South Bend	Ph:  800-284-7370
	Saint Joseph Regional Medical Center
		David Hornback, MD	Ph:  574-647-7461
	South Bend Clinic
		David Hornback, MD	Ph:  574-647-7461
Kansas
	Overland Park
	Menorah Medical Center
		Rakesh Gaur, MD	Ph:  816-823-0555
	Saint Luke's Hospital - South
		Rakesh Gaur, MD	Ph:  816-823-0555
	Shawnee Mission
	Shawnee Mission Medical Center
		Rakesh Gaur, MD	Ph:  816-823-0555
Kentucky
	Lexington
	Lucille P. Markey Cancer Center at University of Kentucky
		Clinical Trials Office - Markey Cancer Center at University of Kentucky Chandler Medical Center	Ph:  859-257-3379
Massachusetts
	Boston
	Boston University Cancer Research Center
		Clinical Trials Office - Boston University Cancer Research Center	Ph:  617-353-7571
Michigan
	Adrian
	Hickman Cancer Center at Bixby Medical Center
		Clinical Trials Office - Hickman Cancer Center at Bixby Medical Center	Ph:  517-265-0116
	Ann Arbor
	University of Michigan Comprehensive Cancer Center
		Clinical Trials Office - University of Michigan Comprehensive Cancer Center	Ph:  800-865-1125
	Kalamazoo
	Borgess Medical Center
		Raymond Lord, MD	Ph:  269-373-7458
	Bronson Methodist Hospital
		Raymond Lord, MD	Ph:  269-373-7458
	West Michigan Cancer Center
		Clinical Trials Office - West Michigan Cancer Center	Ph:  269-373-7458
	Lambertville
	Haematology-Oncology Associates of Ohio and Michigan, PC
		Paul Schaefer, MD	Ph:  419-479-5605
	Monroe
	Community Cancer Center of Monroe
		Paul Schaefer, MD	Ph:  419-479-5605
	Mercy Memorial Hospital - Monroe
		Paul Schaefer, MD	Ph:  419-479-5605
	St. Joseph
	Lakeland Regional Cancer Care Center - St. Joseph
		David Hornback, MD	Ph:  574-647-7461
Minnesota
	Saint Cloud
	CentraCare Clinic - River Campus
		Barbi Kaplan-Frenkel, DO	Ph:  320-229-4901
	Coborn Cancer Center
		Barbi Kaplan-Frenkel, DO	Ph:  320-229-4901
Missouri
	Kansas City
	CCOP - Kansas City
		Rakesh Gaur, MD	Ph:  816-823-0555
	North Kansas City Hospital
		Rakesh Gaur, MD	Ph:  816-823-0555
	Parvin Radiation Oncology
		Rakesh Gaur, MD	Ph:  816-823-0555
	Research Medical Center
		Rakesh Gaur, MD	Ph:  816-823-0555
	Saint Luke's Cancer Institute at Saint Luke's Hospital
		Rakesh Gaur, MD	Ph:  816-823-0555
	St. Joseph Medical Center
		Rakesh Gaur, MD	Ph:  816-823-0555
	Truman Medical Center - Hospital Hill
		Rakesh Gaur, MD	Ph:  816-823-0555
	Lee's Summit
	Saint Luke's East - Lee's Summit
		Rakesh Gaur, MD	Ph:  816-823-0555
	Liberty
	Liberty Hospital
		Rakesh Gaur, MD	Ph:  816-823-0555
	Saint Joseph
	Heartland Regional Medical Center
		Rakesh Gaur, MD	Ph:  816-823-0555
Nebraska
	Kearney
	Good Samaritan Cancer Center at Good Samaritan Hospital
		Clinical Trials Office - Good Samaritan Cancer Center at Good Samaritan Hospital	Ph:  308-865-7963
	Omaha
	Methodist Estabrook Cancer Center
		Tien-Shew Huang	Ph:  402-354-5890 877-850-3212
New Hampshire
	Keene
	Kingsbury Center for Cancer Care at Cheshire Medical Center
		Alan Hartford, MD, PhD	Ph:  603-650-6600
	Lebanon
	Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
		Clinical Trials Office - Norris Cotton Cancer Center	Ph:  603-650-7609
			Email: cancerhelp@dartmouth.edu
New Jersey
	Camden
	Cancer Institute of New Jersey at Cooper University Hospital - Camden
		Clinical Trial Office - Cancer Institute of New Jersey at Cooper Uniersity Hospital	Ph:  856-325-6757
	Voorhees
	Cancer Institute of New Jersey at Cooper - Voorhees
		Clinical Trials Office - Cancer Institute of New Jersey at Cooper University Hospital - Voorhees	Ph:  856-325-6757
New York
	Brooklyn
	Veterans Affairs Medical Center - Brooklyn
		Contact Person	Ph:  718-630-3574
	East Syracuse
	CCOP - Hematology-Oncology Associates of Central New York
		Jeffrey Kirshner, MD	Ph:  315-472-7504
North Carolina
	Goldsboro
	Wayne Memorial Hospital, Incorporated
		James Atkins, MD	Ph:  919-580-0000
	Wayne Radiation Oncology
		James Atkins, MD	Ph:  919-580-0000
	Rutherfordton
	Rutherford Hospital
		James Bearden, MD	Ph:  864-560-6812
Ohio
	Akron
	Summa Center for Cancer Care at Akron City Hospital
		Clinical Trials Office - Akron City Hospital	Ph:  330-375-6101
	Barberton
	Barberton Citizens Hospital
		William Demas, MD	Ph:  330-375-3557
	Bowling Green
	Wood County Oncology Center
		Paul Schaefer, MD	Ph:  419-479-5605
	Cleveland
	Cleveland Clinic Cancer Center at Fairview Hospital
		Clinical Trials Office - Cleveland Clinic Cancer Center at Fairview Hospital	Ph:  216-476-9362
	Cleveland Clinic Taussig Cancer Center
		Clinical Trials Office - Cleveland Clinic Taussig Cancer Center	Ph:  866-223-8100
	Clyde
	North Coast Cancer Care - Clyde
		Paul Schaefer, MD	Ph:  419-479-5605
	Dayton
	David L. Rike Cancer Center at Miami Valley Hospital
		Clinical Trials Office - David L. Rike Cancer Center at Miami Valley Hospital	Ph:  937-208-2079
	Elyria
	Hematology Oncology Center
		Paul Schaefer, MD	Ph:  419-479-5605
	Independence
	Cleveland Clinic Cancer Center
		John Suh, MD	Ph:  216-444-5574
	Lima
	Lima Memorial Hospital
		Paul Schaefer, MD	Ph:  419-479-5605
	Maumee
	Northwest Ohio Oncology Center
		Paul Schaefer, MD	Ph:  419-479-5605
		Paul Schaefer, MD	Ph:  419-479-5605
	St. Luke's Hospital
		Paul Schaefer, MD	Ph:  419-479-5605
	Mayfield Heights
	Hillcrest Cancer Center at Hillcrest Hospital
		John Suh, MD	Ph:  216-444-5574
	Oregon
	St. Charles Mercy Hospital
		Paul Schaefer, MD	Ph:  419-479-5605
	Toledo Clinic - Oregon
		Paul Schaefer, MD	Ph:  419-479-5605
	Salem
	Cancer Care Center, Incorporated
		William Demas, MD	Ph:  330-375-3557
	Sandusky
	North Coast Cancer Care, Incorporated
		Paul Schaefer, MD	Ph:  419-479-5605
	Sylvania
	Flower Hospital Cancer Center
		Clinical Trials Office - Flower Hospital Cancer Center	Ph:  419-824-1842
	Tiffin
	Mercy Hospital of Tiffin
		Paul Schaefer, MD	Ph:  419-479-5605
	Toledo
	CCOP - Toledo Community Hospital
		Paul Schaefer, MD	Ph:  419-479-5605
	Medical University of Ohio Cancer Center
		Clinical Trials Office - Medical University of Ohio Cancer Center	Ph:  419-383-6583
	St. Anne Mercy Hospital
		Paul Schaefer, MD	Ph:  419-479-5605
	St. Vincent Mercy Medical Center
		Paul Schaefer, MD	Ph:  419-479-5605
	Toledo Clinic, Incorporated - Main Clinic
		Paul Schaefer, MD	Ph:  419-479-5605
	Toledo Hospital
		Clinical Trials Office - Toledo Hospital	Ph:  419-824-1842
	Wauseon
	Fulton County Health Center
		Clinical Trials Office - Fulton County Health Center	Ph:  419-330-2708
	Wooster
	Cancer Treatment Center
		Clinical Trials Office - Cancer Treatment Center	Ph:  330-375-4221
	Cleveland Clinic - Wooster
		Clinical Trials Office - Cleveland Clinic - Wooster	Ph:  800-862-7798
Pennsylvania
	Abington
	Rosenfeld Cancer Center at Abington Memorial Hospital
		Clinical Trials Office - Rosenfeld Cancer Center at Abington Memorial Hospital	Ph:  215-481-2402
South Carolina
	Anderson
	AnMed Cancer Center
		Clinical Trials Office - AnMed Cancer Center	Ph:  864-512-1000
	Spartanburg
	CCOP - Upstate Carolina
		Clinical Trials Office - CCOP - Upstate Carolina	Ph:  800-486-5941
	Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
		Clinical Trials Office - Gibbs Regional Cancer Center	Ph:  800-486-5941
Vermont
	Rutland
	Community Cancer Center at Rutland Regional Medical Center
		Richard Lovett, MD	Ph:  802-747-1831
	Saint Johnsbury
	Norris Cotton Cancer Center - North
		Alan Hartford, MD, PhD	Ph:  603-650-6600
Virginia
	Fredericksburg
	Fredericksburg Oncology, Incorporated
		Paul Schaefer, MD	Ph:  419-479-5605
Wisconsin
	La Crosse
	Gundersen Lutheran Center for Cancer and Blood
		Clinical Trials Office - Gundersen Lutheran Cancer Center	Ph:  608-775-2385
			Email: cancerctr@gundluth.org
	Milwaukee
	Vince Lombardi Cancer Clinic at Aurora St. Luke's Medical Center
		Clinical Trials Office - Vince Lombardi Cancer Clinic	Ph:  414-649-5717
	West Allis
	West Allis Memorial Hospital
		Clinical Trials Office - West Allis Memorial Hospital	Ph:  414-649-5717
Canada
Alberta
	Calgary
	Tom Baker Cancer Centre - Calgary
		Marc Kerba	Ph:  403-521-3164
New Brunswick
	Moncton
	Doctor Leon Richard Oncology Centre
		Fernando Rojas	Ph:  506-862-4030
Newfoundland and Labrador
	St. John's
	Doctor H. Bliss Murphy Cancer Centre
		Jonathan Greenland	Ph:  709-777-7802
Ontario
	Hamilton
	Margaret and Charles Juravinski Cancer Centre
		William G. McMillan	Ph:  905-387-9495
	Kingston
	Cancer Centre of Southeastern Ontario at Kingston General Hospital
		Catherine de Metz	Ph:  613-549-6666
	Kitchener
	Grand River Regional Cancer Centre at Grand River Hospital
		Dilip Panjwani	Ph:  519-749-4300
	Ottawa
	Ottawa Hospital Regional Cancer Centre - General Campus
		Peter Cross	Ph:  613-737-7700
	Thunder Bay
	Cancer Care Program at Thunder Bay Regional Health Sciences
		Margaret L. Anthes	Ph:  807-684-7211
	Toronto
	Edmond Odette Cancer Centre at Sunnybrook
		Edward L.W. Chow	Ph:  416-480-4998
	Princess Margaret Hospital
		Andrea Bezjak	Ph:  416-946-2132
	Windsor
	Windsor Regional Cancer Centre at Windsor Regional Hospital
		Khalid J. Hirmiz	Ph:  519-253-5253
Quebec
	Montreal
	Hopital Notre-Dame du CHUM
		Isabelle Roy	Ph:  514-890-5420
	McGill Cancer Centre at McGill University
		Marc David	Ph:  514-934-8040
	Sherbrooke
	CHUS-Hopital Fleurimont
		Abdenour Nabid	Ph:  819-346-1110

Registry Information
Official Title		A Phase III International Randomized Trial Of Single Versus Multiple Fractions For Re-Irradiation Of Painful Bone Metastases
Trial Start Date		2004-01-07
Trial Completion Date		2010-12-31 (estimated)
Registered in ClinicalTrials.gov		NCT00080912
Date Submitted to PDQ		2004-02-17
Information Last Verified		2009-11-21

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