Alternate Title
Basic Trial Information
Objectives
Entry Criteria
Expected Enrollment
Outcomes
Outline
Trial Contact Information
Registry Information

Alternate Title

Induction Chemotherapy Using Doxorubicin and Cisplatin Followed by Combretastatin A4 Phosphate and Radiation Therapy in Treating Patients With Newly Diagnosed Regionally Advanced Anaplastic Thyroid Cancer

Basic Trial Information

Phase	Type	Status	Age	Sponsor	Protocol IDs
Phase II, Phase I	Treatment	Completed	18 and over	NCI, Pharmaceutical / Industry	CASE-CWRU-3302 CWRU-040337, OXIGENE-CWRU-3302, NCT00077103, CASE-3302

Objectives

Primary

1. Determine the objective response rate in patients with newly diagnosed regionally advanced anaplastic thyroid cancer treated with induction chemotherapy comprising doxorubicin and cisplatin followed by combretastatin A4 phosphate (CA4P) and radiotherapy.
2. Determine whether this regimen alters the natural history of anaplastic thyroid cancer by virtue of doubling the median survival of these patients from 10 to 20 months.

Secondary

1. Determine a tolerable dose of CA4P when administered with radiotherapy in these patients. (Phase I portion of the study closed as of 5/6/04; patients now receive a fixed dose of CA4P)
2. Determine the safety profile of this regimen in these patients.
3. Determine clinical predictors of response (e.g., pretreatment tumor microvessel density and immature vessel staining, changes in sICAM-1 levels and tumor blood flow, and pharmacokinetic parameters) in patients treated with this regimen.
4. Correlate the diminution in blood flow with tumor pain and response in patients treated with this regimen.

Entry Criteria

Disease Characteristics:

• Histologically confirmed anaplastic or poorly differentiated variant thyroid carcinoma of either of the following:
  • Regionally advanced disease
    • Confined to the neck and/or superior mediastinum (i.e., above the level of the carina)
    • Measurable or evaluable* disease
  
  
  
  • Completely resected disease without measurable or evaluable disease
  
  
  

   [Note: *At a minimum, abnormalities on physical exam or radiographic studies that may not be precisely measured but readily followed]




• Must have original/diagnostic tumor blocks available to confirm histopathology and for tumor microvessel density immunohistochemistry
  • Patients with no available original/diagnostic tumor blocks must have tumor accessible for pretreatment needle core biopsy



• Must undergo indirect and direct laryngoscopy to ensure patency of the trachea/airway if deemed inoperable, with bulky thyroid/neck masses and/or suspicion of airway obstruction



• No distant metastases, including but not limited to, brain metastases, disease below the level of the carina, pulmonary parenchyma, and hepatic or bony metastases
  • Superior mediastinal disease (i.e., above the level of the carina) in addition to regional neck disease is allowed provided the disease can be contained in a single radiotherapy port

Prior/Concurrent Therapy:

Biologic therapy

• No concurrent biologic therapy
• No concurrent immunotherapy

Chemotherapy

• No prior chemotherapy
• No other concurrent chemotherapy

Endocrine therapy

• No concurrent hormonal therapy, except for the following:
  • Gonadotropin-releasing hormone agonists for patients with hormone-refractory prostate cancer
  • Hormone replacement therapy
  • Oral contraceptives
  • Megestrol for anorexia/cachexia

Radiotherapy

• No prior radiotherapy
• No concurrent radiotherapy

Surgery

• See Disease Characteristics
• Prior attempt at resection or cytoreduction (e.g., debulking) surgery irrespective of surgical margins allowed provided there are no distant metastases
• At least 1 week but no more than 8 weeks since prior surgery and recovered

Other

• No other concurrent cytotoxic therapy
• No other concurrent antineoplastic therapy
• No other concurrent investigational therapy
• No concurrent medications known to prolong the QTc interval unless the medication can be held for at least 4 days during each treatment course

Patient Characteristics:

Age

• 18 and over

Performance status

• ECOG 0-2

Life expectancy

• At least 12 weeks

Hematopoietic

• Absolute granulocyte count ≥ 1,500/mm³
• Platelet count ≥ 75,000/mm³
• Hemoglobin ≥ 8.5 g/dL

Hepatic

• Bilirubin ≤ 1.5 mg/dL
• ALT and AST ≤ 3.5 times upper limit of normal

Renal

• Creatinine ≤ 1.5 mg/dL

Cardiovascular

• LVEF ≥ 50% by echocardiogram
• EKG normal
• No prior angina
• No prior myocardial infarction (e.g., significant Q waves), QTc > 450 msec, or other clinically significant abnormalities on ECG
• No congestive heart failure
• No uncontrolled atrial arrhythmias or clinically significant arrhythmias, including any of the following:
  • Conduction abnormality
  • Nodal junctional arrhythmias and dysrhythmias
  • Sinus bradycardia or tachycardia
  • Supraventricular arrhythmias
  • Atrial fibrillation or flutter
  • Syncope or vasovagal episodes
• No significant heart wall abnormality or heart muscle damage by echocardiogram
• No uncontrolled hypertension (i.e., blood pressure consistently greater than 150/100 mm Hg irrespective of medication)
  • Hypertension is allowed provided there is clinical documentation of controlled blood pressure for 2 months before study entry
• No symptomatic peripheral vascular disease or cerebrovascular disease

Other

• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception
• No uncontrolled hypokalemia or hypomagnesemia
• No concurrent serious infection
• No other nonmalignant uncontrolled medical illness or one whose control may be jeopardized by the complications of study therapy
• No grade 2 or greater pre-existing motor or sensory peripheral neuropathy
• No psychiatric disorder or other condition that would preclude study compliance
• No conditions associated with QTc prolongation

Expected Enrollment

A total of 33 patients will be accrued for this study within 18 months.

Outcomes

Median survival at months 2, 4, 6, 8, 10, 12, 15, 18, 21, 24, 27, 30, 33, and 36

Objective disease response at the end of induction, combined modality therapy, and consolidation therapy, at 2 months after completion of consolidation therapy, at 2 month intervals during year 1, and then 3 month intervals during years 2 and 3

Outline

This is a multicenter study of combretastatin A4 phosphate (CA4P). (Phase I portion of the study closed as of 5/6/04; patients now receive a fixed dose of CA4P)

• Induction phase: Patients receive doxorubicin IV over 5-10 minutes and cisplatin IV over 30-60 minutes on day 1. Patients also receive filgrastim (G-CSF) subcutaneously (SC) on days 3-21 or pegfilgrastim SC on day 2.



• Combined modality phase: Beginning on day 22, patients undergo radiotherapy twice daily, 5 days a week, for 3-4 weeks. Patients also receive CA4P IV over 10 minutes weekly on the fifth day of radiotherapy.

  Cohorts of 6 patients receive 1 of 2 escalating doses of CA4P to determine a tolerable dose. The tolerable dose is defined as the dose at which less than 2 of 6 patients experience dose-limiting toxicity. (Phase I portion of the study closed as of 5/6/04; patients now receive a fixed dose of CA4P)




• Consolidation phase: Beginning 4-6 weeks after the completion of the combined modality phase, patients receive CA4P IV over 10 minutes on days 1, 8, and 15. Treatment repeats every 28 days for 2 courses.

Treatment in all phases continues in the absence of disease progression or unacceptable toxicity.

Patients are followed every 2 months for 1 year and then every 3 months for 2 years from study entry.

Trial Contact Information

Trial Lead Organizations

Case Comprehensive Cancer Center

Scot Remick, MD, Protocol chair		Ph: 216-844-5412

Registry Information
Official Title		Phase II Trial of Combined Modality Combretastatin A-4 Phosphate (CA4P)-Based Therapy for Patients With Newly Diagnosed Anaplastic Thyroid Cancer [Induction Chemotherapy with Doxorubicin/Cisplatin; Combined Modality Therapy with CA4P and Radiation; Followed by 2 Cycles of CA4P Consolidation]
Trial Start Date		2003-11-20
Registered in ClinicalTrials.gov		NCT00077103
Date Submitted to PDQ		2003-12-11
Information Last Verified		2008-12-13
NCI Grant/Contract Number		CA43703

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