Alternate Title
Basic Trial Information
Objectives
Entry Criteria
Expected Enrollment
Outline
Trial Contact Information
Registry Information

Alternate Title

Calcitriol and Zoledronate in Treating Patients With Progressive Prostate Cancer

Basic Trial Information

Phase	Type	Status	Age	Sponsor	Protocol IDs
Phase I	Treatment	Closed	18 and over	NCI	MSKCC-99073 NCI-H00-0048, NCT00004928

Objectives

1. Determine the maximum tolerated dose of calcitriol administered with zoledronate in patients with progressive prostate cancer.
2. Assess the effects of this regimen on calcium homeostasis and bone turnover in this patient population.
3. Assess changes in PSA in patients treated with this regimen.
4. Determine other antitumor effects of this regimen in these patients.

Entry Criteria

Disease Characteristics:

• Histologically confirmed prior localized adenocarcinoma of the prostate that has undergone definitive radiation or surgery and demonstrates progression biochemically with all of the following:
  • Baseline PSA at least 4 ng/mL
  • At least a 50% increase in PSA over at least 3 determinations taken at more than 2 week intervals
  • No radiographically evident disease
  • Neoadjuvant hormonal therapy prior to radical prostatectomy or radiotherapy allowed
  • Treatment in an intermittent approach allowed if off therapy for at least 12 weeks

  OR




• Histologically confirmed androgen-independent adenocarcinoma of the prostate with all of the following:
  • Progression on primary hormonal treatment (e.g., orchiectomy, estrogen therapy, gonadotropin-releasing hormone analog with or without an antiandrogen) with either new osseous lesions in bone, a greater than 25% increase in bidimensionally measurable tumor mass, or rising PSA values (rising PSA on any 3 determinations taken at at least weekly intervals, to greater than 50% above baseline PSA) despite castrate levels of testosterone (no greater than 30 ng/mL)
  • If receiving antiandrogen as part of primary hormonal therapy, must meet criteria above for progression after discontinuation of antiandrogen
  • No change in hormonal therapy (including prednisone or dexamethasone) within the past 2 weeks
  • If no prior surgical orchiectomy, must continue on medical therapies to maintain castrate levels of testosterone
  • Prior chemotherapy, palliative radiotherapy, or radioisotope treatment allowed

Prior/Concurrent Therapy:

Biologic therapy:

• Not specified

Chemotherapy:

• See Disease Characteristics
• At least 4 weeks since prior chemotherapy and recovered
• No concurrent chemotherapy

Endocrine therapy:

• See Disease Characteristics
• Recovered from prior endocrine therapy

Radiotherapy:

• See Disease Characteristics
• At least 4 weeks since prior radiotherapy and recovered
• No concurrent radiotherapy to sole measurable lesion

Surgery:

• See Disease Characteristics
• Recovered from prior surgery
• No concurrent surgery to sole measurable lesion

Other:

• No other concurrent cholecalciferol

Patient Characteristics:

Age:

• 18 and over

Performance status:

• Karnofsky 70-100%

Life expectancy:

• At least 3 months

Hematopoietic:

• WBC at least 3,500/mm³
• Platelet count at least 100,000/mm³

Hepatic:

• Bilirubin less than 2.0 mg/dL

  OR

• SGOT less than 3 times upper limit of normal

Renal:

• Creatinine less than 1.5 mg/dL

  OR

• Creatinine clearance at least 60 mL/min
• No history of nephrolithiasis
• Must have 2 functioning kidneys

Cardiovascular:

• No New York Heart Association class III or IV heart disease

Pulmonary:

• No severe debilitating pulmonary disease

Metabolic:

• No pre-existing endocrine or metabolic disorders that impact calcium regulatory axis including hypercalcemia (ionized serum calcium greater than 5.3 mg/dL or total calcium greater than 10.5 mg/dL) or hypercalciuria (greater than 300 mg urinary calcium/24 hours)

Other:

• No active secondary malignancy except nonmelanoma skin cancer
• Must maintain low calcium diet (less than 800 mg calcium daily)
• No uncontrolled serious active infection
• No history of malabsorption disorders
• No history of inflammatory bowel disease

Expected Enrollment

A total of 30 patients will be accrued for this study within 1 year.

Outline

This is a dose-escalation study of calcitriol.

Patients receive oral calcitriol weekly for 3 consecutive days and zoledronate IV monthly. Treatment continues in the absence of unacceptable toxicity or disease progression.

Cohorts of 3-6 patients receive escalating doses of calcitriol until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 3 of 6 patients experience dose-limiting toxicity.

Trial Contact Information

Trial Lead Organizations

Memorial Sloan-Kettering Cancer Center

Michael Morris, MD, Protocol chair		Ph: 646-422-4469; 800-525-2225

Registry Information
Official Title		A Phase I Study of 1,25 Dihydroxy-Vitamin D3 (Calcitriol) in Patients with Prostate Cancer
Trial Start Date		1999-10-12
Registered in ClinicalTrials.gov		NCT00004928
Date Submitted to PDQ		2000-01-13
Information Last Verified		2002-10-16
NCI Grant/Contract Number		CA05826, CA08748

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