Basic Trial Information
Trial Description
     Summary
     Further Trial Information
     Eligibility Criteria
Trial Contact Information

Basic Trial Information

Phase	Type	Status	Age	Sponsor	Protocol IDs
Phase III	Treatment	Completed	18 and over	Pharmaceutical / Industry	C-100-12 Part I NCT00033904

Trial Description

Summary

Determine whether patients receiving adjuvant HSPPC-96 treatment after surgically resected, locally advanced renal cell carcinoma have improved recurrence-free survival as compared to subjects with no adjuvant treatment.

Further Study Information

Primary Objective:

• The primary objective of this study is to determine whether subjects randomized to receive adjuvant HSPPC-96 after surgical resection of locally advanced renal cell carcinoma at high risk of recurrence, have improved recurrence-free survival as compared to subjects with no adjuvant treatment.

Secondary Objective:

• Determine whether subjects randomized to receive HSPPC-96 have improved survival as compared to subjects with no adjuvant treatment.

• Further characterize the safety profile of HSPPC-96.

Eligibility Criteria

Pre-Surgery Inclusion Criteria:

• Primary-intact resectable renal cell cancer, without known distant metastasis and be scheduled to have surgery with curative intent;

• Tumor size greater than or equal to 5 cm OR macroscopic nodes OR renal vein thrombus OR vena cava thrombus by radiologic evaluation

• Performance status (Zubrod / ECOG-WHO scale)less than or equal to 1 and life expectancy of greater than three months, within 2 weeks of surgery.

• Women of child-bearing potential must have a negative urine or serum pregnancy test within 2 weeks of surgery.

• Signed written informed consent.

Pre-Surgery Exclusion Criteria:

• Prior chemo-, hormonal, immuno- or radiotherapy for renal cell cancer;

• History of primary or secondary immunodeficiency, or patients using immunosuppressive drugs, e.g. systemic corticosteroids, cyclosporin A;

• Current malignancies at other sites or previous other cancer within the last 5 years, with the exception of adequately treated cone-biopsied in situ carcinoma of the cervix uteri or basal or squamous cell carcinoma of the skin;

• Embolization of the renal artery prior to nephrectomy;

• Known distant metastases;

• Active, uncontrolled infection or other serious medical illnesses.

Eligibility Assessment:

(between 2 weeks pre- and 4 weeks post-surgery)

Prior to randomization and entry into the tumor evaluation phase, all subjects must undergo testing to confirm that they are free of distant metastatic disease, and that they meet all other criteria.

Eligibility Criteria which must be assessed and confirmed prior to randomization:

• No evidence of metastatic or residual renal carcinoma as documented by all of the following: abdominal/pelvis CT scan; chest CT scan; and brain CT or MRI scan.

• Provide Antigenics with greater than or equal to 7 grams of viable tumor tissue

• Adequate bone marrow function.

• Adequate renal and hepatic function.

• Adequate cardiac function.

• Signed written informed consent.

• Patients must be willing to be followed during the course of tumor evaluation and follow-up phases.

• Male or female patients of child producing potential must agree to use adequate contraception during the treatment/observation phase of the study.

• Patients must not use any other investigational drug for four weeks prior to the start of the tumor evaluation phase and throughout the tumor evaluation phase of the study.

Trial Contact Information

Trial Lead Organizations/Sponsors

Antigenics, Incorporated

Link to the current ClinicalTrials.gov record.
NLM Identifer NCT00033904
Information obtained from ClinicalTrials.gov on October 06, 2009

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