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Last Modified: 11/20/2009     First Published: 9/23/2006  
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Phase III Randomized Study of Letrozole in Postmenopausal Women With Hormone Receptor-Positive Breast Cancer Who Have Completed Adjuvant Hormonal Therapy Comprising An Aromatase Inhibitor and/or Tamoxifen Citrate

Alternate Title
Basic Trial Information
Objectives
Entry Criteria
Expected Enrollment
Outcomes
Outline
Related Publications
Trial Contact Information
Registry Information

Alternate Title

Letrozole in Treating Postmenopausal Women Who Have Received Hormone Therapy for Hormone Receptor-Positive Breast Cancer

Basic Trial Information

PhaseTypeStatusAgeSponsorProtocol IDs
Phase IIITreatmentActiveAny age (postmenopausal)NCINSABP-B-42
NCT00382070

Special Category: CTSU trial

Objectives

Primary

  1. Determine whether or not prolonged adjuvant hormonal therapy comprising letrozole vs placebo will improve disease-free interval of postmenopausal women with estrogen receptor-positive and/or progesterone receptor-positive breast cancer who have completed 5 years of hormonal therapy with 5 years of an aromatase inhibitor (AI) or 5 years of a combination of up to 3 years of tamoxifen citrate followed by an AI.
  2. Compare the disease-free survival of patients treated with these regimens.

Secondary

  1. Compare overall survival of patients treated with these regimens.
  2. Compare breast cancer-free survival of patients treated with these regimens.
  3. Compare distant recurrence in patients treated with these regimens.
  4. Compare the incidence of osteoporotic-related fractures (e.g., Colles', hip, and spine) in these patients treated with these regimens.
  5. Compare the incidence of arterial thrombotic events in patients treated with these regimens.

Entry Criteria

Disease Characteristics:

  • Histologically confirmed invasive carcinoma of the breast by core needle or final pathological evaluation of the surgical specimen
    • Clinical stage I, II, or IIIA primary tumor for patients who received neoadjuvant chemotherapy
    • Primary tumor t1-3 on pathologic evaluation and ipsilateral nodes pN0, pN1 (pN1mi, pN1a, pN1b, pN1c), pN2a, pN3a, or pN3b for patients who received adjuvant chemotherapy

  • Received adjuvant hormonal therapy after breast cancer diagnosis for a duration of 57-63 months from the first dose (regardless of the number of missed doses) with 1 of the following:
    • Aromatase inhibitor* (AI)
    • Combination of up to 3 years of tamoxifen citrate followed by an AI for a total of 5 years
      • No tamoxifen citrate during years 4 and 5 of 5-year adjuvant hormonal therapy

     [Note: *Adjuvant AI therapy must be discontinued at the time of randomization]

  • Must have completed adjuvant hormonal therapy within the past 6 months

  • Must have undergone a bilateral mammogram within the past year (unilateral if patient had a mastectomy)
    • Mammogram not required if patient has a prophylactic contralateral mastectomy

  • Must have undergone a bone mineral density test within the past year

  • Must have undergone a lumpectomy with axillary nodal staging followed by breast radiotherapy OR a total mastectomy with axillary nodal staging
    • Nodal staging with sentinel node biopsy alone is allowed provided sentinel nodes were negative on H&E staining

  • No evidence of recurrent breast cancer by history and physical within the past 3 months

  • No diagnosis of bilateral breast cancer, including ductal carcinoma in situ (synchronous or metachronous)

  • Estrogen receptor (ER)-positive and/or progesterone receptor-positive tumor
    • Patients with a tumor considered to be borderline hormone receptor-positive that was treated with tamoxifen citrate and/or AI are allowed

Prior/Concurrent Therapy:

  • See Disease Characteristics
  • No other investigational agent within the past 30 days
  • No other concurrent anticancer therapy
  • No concurrent participation in any other hormonal therapy or placebo-controlled supportive therapy clinical trial
  • No other concurrent hormonal therapy, including any of the following:
    • Hormonal agent for management of osteoporosis (e.g., raloxifene)
    • Selective estrogen receptor modulators (e.g., raloxifene)
    • Sex hormonal therapy (e.g., estrogen- or progesterone-replacement therapy, including low-dose estrogen in the form of vaginal cream) or oral contraceptives
    • Luteinizing hormone-releasing hormone agonists/antagonists (e.g., goserelin)
    • Estradiol acetate
      • Conjugated estrogen ring or estradiol hemihydrate vaginal tab allowed
    • Other aromatase inhibitors
  • Concurrent bisphosphonates allowed provided dose is as recommended for bone protection, not anticancer therapy

Patient Characteristics:

  • Female
  • Postmenopausal as defined by any of the following criteria:
    • Age ≥ 56 years with no spontaneous menses for ≥ 12 months prior to study entry
    • Age ≤ 55 years with no spontaneous menses for ≥ 12 months prior to study entry (e.g., spontaneous or secondary to hysterectomy) AND a documented estradiol level in the postmenopausal range
    • Prior documented bilateral oophorectomy
  • ECOG performance status 0 or 1
  • Cholesterol ≤ grade 1 (with or without cholesterol-lowering therapy) meeting 1 of the following criteria:
    • Criteria must be met within the past year if patient has any of the following:
      • History of hypercholesterolemia controlled with cholesterol-lowering therapy and/or therapeutic lifestyle changes
      • History of ≥ 1 of the following risk factors for cardiovascular events:
        • Diabetes
        • Hypertension
        • Obesity
        • Tobacco use
        • Hypertriglyceridemia
        • Documented coronary artery disease
        • Family history of premature coronary heart disease
    • Criteria must be met within the past 2 years for all other patients
  • Not pregnant or nursing
  • No history of nontraumatic osteoporotic fracture of the wrist, hip, or spine
  • No other malignancies unless disease-free for ≥ 5 years and, in the opinion of the investigator, at low risk for recurrence
  • No other prior malignancy within the past 5 years except for the following:
    • Carcinoma in situ of the cervix
    • Colon carcinoma in situ
    • Melanoma in situ
    • Basal cell or squamous cell carcinoma of the skin

Expected Enrollment

3840

A total of 3,840 patients will be accrued for this study.

Outcomes

Primary Outcome(s)

Disease-free survival

Secondary Outcome(s)

Overall survival
Breast cancer-free interval (time to recurrence or contralateral second primary breast cancer)
Distant recurrence
Incidence of osteoporotic-related fractures (e.g., Colles', hip, and spine)
Incidence of arterial thrombotic events (CTCAE v. 3.0 grades 3, 4, or 5 cardiac ischemia/infarction, CNS cerebrovascular ischemia, peripheral arterial ischemia, and visceral arterial ischemia [nonmyocardial])

Outline

This is a double-blind, multicenter, placebo-controlled, randomized study. Patients are stratified according to pathologic nodal status (negative vs positive), adjuvant tamoxifen citrate therapy (yes vs no), and lowest bone mineral density T score for lumbosacral spine, total hip, or femoral neck (> -2.0 vs ≤ -2.0 standard deviation). Patients are randomized to 1 of 2 treatment arms.

  • Arm I: Patients receive oral letrozole once daily.

  • Arm II: Patients receive oral placebo once daily.

In both arms, treatment continues for up to 5 years in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed annually.

Related Publications

Mamounas EP, Lembersky B, Jeong JH, et al.: NSABP B-42: a clinical trial to determine the efficacy of five years of letrozole compared with placebo in patients completing five years of hormonal therapy consisting of an aromatase inhibitor (AI) or tamoxifen followed by an AI in prolonging disease-free survival in postmenopausal women with hormone receptor-positive breast cancer. Clin Breast Cancer 7 (5): 416-21, 2006.[PUBMED Abstract]

Trial Contact Information

Trial Lead Organizations

National Surgical Adjuvant Breast and Bowel Project

Terry Mamounas, MD, MPH, FACS, Protocol chair
Ph: 330-363-6281
Email: tmamounas@aultman.com

Trial Sites

U.S.A.
Alabama
  Anniston
 Regional Medical Center
 Pramod Vadlamani
Ph: 256-235-5877
  Mobile
 Providence Cancer Center at Providence Hospital
 Thaddeus Beeker
Ph: 251-633-1890
Alaska
  Anchorage
 Providence Cancer Center
 Clinical Trials Office - Providence Cancer Center
Ph: 907-261-3109
  Fairbanks
 Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital
 Jacqueline Vuky
Ph: 907-458-5380
800-678-5458
Arkansas
  Little Rock
 Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
 Clinical Trial Office - Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
Ph: 501-686-8274
California
  Berkeley
 Alta Bates Summit Comprehensive Cancer Center
 Clinical Trials Office - Alta Bates Summit Comprehensive Cancer Center
Ph: 510-204-3428
  Burbank
 Providence Saint Joseph Medical Center - Burbank
 Clinical Trials Office - Providence Saint Joseph Medical Center - Burbank
Ph: 818-847-3220
  Burlingame
 Peninsula Medical Center
 David Irwin, MD
Ph: 510-204-1591
  Castro Valley
 East Bay Radiation Oncology Center
 James Feusner, MD
Ph: 510-428-3689
 Eden Medical Center
 James Feusner, MD
Ph: 510-428-3689
 Valley Medical Oncology Consultants - Castro Valley
 James Feusner, MD
Ph: 510-428-3689
  Concord
 Cancer Care Center at John Muir Health - Concord Campus
 Clinical Trials Office - Cancer Care Center at John Muir Health - Concord Campus
Ph: 925-674-2580
  Duarte
 City of Hope Comprehensive Cancer Center
 Clinical Trials Office - City of Hope Comprehensive Cancer Center
Ph: 800-826-4673
 Email: becomingapatient@coh.org
  Fairfield
 North Bay Cancer Center
 Clinical Trials Office - North Bay Cancer Center
Ph: 707-429-6976
  Fremont
 Kaiser Permanente - Fremont
 Louis Fehrenbacher, MD
Ph: 707-651-2577
 Valley Medical Oncology
 James Feusner, MD
Ph: 510-428-3689
  Fresno
 Cancer Care Associates
 Charles Kuzma
Ph: 559-326-1222
877-490-4222
  Fullerton
 Virginia K. Crosson Cancer Center at St. Jude Medical Center
 Clinical Trials Office - Virginia K. Crosson Cancer Center
Ph: 714-446-5642
  Glendale
 Glendale Memorial Hospital Comprehensive Cancer Center
 Clinical Trials Office - Glendale Memorial Hospital Comprehensive Cancer Center
Ph: 818-409-7653
  Greenbrae
 Marin Cancer Institute at Marin General Hospital
 David Irwin, MD
Ph: 510-204-1591
 Sutter Health - Western Division Cancer Research Group
 David Irwin, MD
Ph: 510-204-1591
  Hayward
 Kaiser Permanente Medical Center - Hayward
 Louis Fehrenbacher, MD
Ph: 707-651-2577
  La Jolla
 Rebecca and John Moores UCSD Cancer Center
 Clinical Trials Office - Rebecca and John Moores UCSD Cancer Center
Ph: 858-822-5354
 Email: cancercto@ucsd.edu
 Scripps Cancer Center - San Diego
 Joan Kroener, MD
Ph: 858-554-8629
  Loma Linda
 Loma Linda University Cancer Institute at Loma Linda University Medical Center
 Clinical Trials Office - Loma Linda University Cancer Institute
Ph: 909-558-3375
  Long Beach
 Breastlink Medical Group, Incorporated at Long Beach Memorial Medical Center
 Clinical Trials Office - Breastlink Medical Group, Incorporated
Ph: 562-981-6101
 Pacific Shores Medical Group - Long Beach
 N. Simon Tchekmedyian, MD, FACP
Ph: 562-590-0345
  Los Angeles
 Jonsson Comprehensive Cancer Center at UCLA
 Clinical Trials Office - Jonsson Comprehensive Cancer Center at UCLA
Ph: 888-798-0719
 USC/Norris Comprehensive Cancer Center and Hospital
 Clinical Trials Office - USC/Norris Comprehensive Cancer Center and Hospital
Ph: 323-865-0451
  Martinez
 Contra Costa Regional Medical Center
 James Feusner, MD
Ph: 510-428-3689
  Mountain View
 El Camino Hospital Cancer Center
 Clinical Trials Office - El Camino Hospital Cancer Center
Ph: 650-988-7623
  Oakland
 Alta Bates Summit Medical Center - Summit Campus
 Clinical Trials Office - Alta Bates Summit Medical Center - Summit Campus
Ph: 510-204-1414
 Bay Area Breast Surgeons, Incorporated
 James Feusner, MD
Ph: 510-428-3689
 CCOP - Bay Area Tumor Institute
 James Feusner, MD
Ph: 510-428-3689
 Highland General Hospital
 James Feusner, MD
Ph: 510-428-3689
 Kaiser Permanente Medical Center - Oakland
 Louis Fehrenbacher, MD
Ph: 707-651-2577
 Larry G Strieff MD Medical Corporation
 James Feusner, MD
Ph: 510-428-3689
 Tom K Lee, Incorporated
 James Feusner, MD
Ph: 510-428-3689
  Orange
 Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center
 Clinical Trials Office - Chao Family Comprehensive Cancer Center
Ph: 877-UC-STUDY
 Email: ucstudy@uci.edu
 St. Joseph Hospital Regional Cancer Center - Orange
 David Margileth
Ph: 714-771-8999
  Palm Springs
 Desert Regional Medical Center Comprehensive Cancer Center
 Clinical Trials Office - Desert Regional Medical Center Comprehensive Cancer Center
Ph: 760-416-4730
  Pleasanton
 Valley Care Medical Center
 James Feusner, MD
Ph: 510-428-3689
 Valley Medical Oncology Consultants - Pleasanton
 James Feusner, MD
Ph: 510-428-3689
  Pomona
 Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical Center
 Clinical Trials Office - Robert and Beverly Lewis Family Cancer Care Center
Ph: 909-865-9555
  Rancho Mirage
 Lucy Curci Cancer Center at Eisenhower Memorial Hospital and Medical Center
 Murthy Andavolu
Ph: 760-674-3600
  Redwood City
 Kaiser Permanente Medical Center - Redwood City
 Louis Fehrenbacher, MD
Ph: 707-651-2577
  Richmond
 Kaiser Permanente Medical Center - Richmond
 Louis Fehrenbacher, MD
Ph: 707-651-2577
  Roseville
 Kaiser Permanente Medical Center - Roseville
 Louis Fehrenbacher, MD
Ph: 707-651-2577
 Sutter Cancer Center at Roseville Medical Center
 Clinical Trials Office - Sutter Cancer Center
Ph: 916-454-6595
  Sacramento
 Kaiser Permanente Medical Center - Sacramento
 Louis Fehrenbacher, MD
Ph: 707-651-2577
 South Sacramento Kaiser-Permanente Medical Center
 Louis Fehrenbacher, MD
Ph: 707-651-2577
 Sutter Cancer Center
 Clinical Trial Office - Sutter Cancer Center
Ph: 916-454-6595
  Salinas
 Salinas Valley Memorial Hospital
 Shehzad Aziz, MD
Ph: 831-755-1701
  San Diego
 Kaiser Permanente Medical Office -Vandever Medical Office
 Jonathan Polikoff, MD
Ph: 619-528-5888
  San Francisco
 California Pacific Medical Center - California Campus
 David Irwin, MD
Ph: 510-204-1591
 Kaiser Permanente Medical Center - San Francisco Geary Campus
 Louis Fehrenbacher, MD
Ph: 707-651-2577
 San Francisco General Hospital Medical Center
 Judith Luce, MD
Ph: 415-476-4082ext.414
  San Jose
 Kaiser Permanente Medical Center - Santa Teresa
 Louis Fehrenbacher, MD
Ph: 707-651-2577
  San Pablo
 Doctors Medical Center - San Pablo Campus
 James Feusner, MD
Ph: 510-428-3689
  San Rafael
 Kaiser Foundation Hospital - San Rafael
 Louis Fehrenbacher, MD
Ph: 707-651-2577
  Santa Clara
 Kaiser Permanente Medical Center - Santa Clara Kiely Campus
 Louis Fehrenbacher, MD
Ph: 707-651-2577
  Santa Rosa
 Kaiser Permanente Medical Center - Santa Rosa
 Louis Fehrenbacher, MD
Ph: 707-651-2577
  South San Francisco
 Kaiser Permanente Medical Center - South San Francisco
 Louis Fehrenbacher, MD
Ph: 707-651-2577
  Stanford
 Stanford Cancer Center
 Clinical Trials Office - Stanford Cancer Center
Ph: 650-498-7061
 Email: cctoffice@stanford.edu
  Stockton
 Kaiser Permanente Medical Facility - Stockton
 Louis Fehrenbacher, MD
Ph: 707-651-2577
  Vallejo
 Kaiser Permanente Medical Center - Vallejo
 Louis Fehrenbacher, MD
Ph: 707-651-2577
 Sutter Solano Medical Center
 David Irwin, MD
Ph: 510-204-1591
  Walnut Creek
 John Muir/Mt. Diablo Comprehensive Cancer Center
 Clinical Trials Office - John Muir/Mt. Diablo Comprehensive Cancer Center
Ph: 925-941-4246
 Kaiser Permanente Medical Center - Walnut Creek
 Louis Fehrenbacher, MD
Ph: 707-651-2577
Colorado
  Aurora
 Aurora Presbyterian Hospital
 Eduardo Pajon, MD
Ph: 303-399-8020ext2261
 University of Colorado Cancer Center at UC Health Sciences Center
 Clinical Trials Office - University of Colorado Cancer Center
Ph: 720-848-0650
  Boulder
 Boulder Community Hospital
 Clinical Trials Office - Boulder Community Hospital
Ph: 303-938-5253
  Colorado Springs
 Memorial Hospital Cancer Center - Colorado Springs
 Clinical Trials Office - Memorial Hospital
Ph: 719-365-2406
 Penrose Cancer Center at Penrose Hospital
 Clinical Trials Office - Penrose Cancer Center
Ph: 719-776-5275
  Denver
 CCOP - Colorado Cancer Research Program
 Eduardo Pajon, MD
Ph: 303-399-8020ext2261
 Denver Health Medical Center
 Michael McCrohan
Ph: 303-436-6000
 Porter Adventist Hospital
 Eduardo Pajon, MD
Ph: 303-399-8020ext2261
 Presbyterian - St. Luke's Medical Center
 Clinical Trials Office - Presbyterian - St. Luke's Medical Center
Ph: 303-839-6000
 Rose Medical Center
 Eduardo Pajon, MD
Ph: 303-399-8020ext2261
 St. Anthony Central Hospital
 Eduardo Pajon, MD
Ph: 303-399-8020ext2261
 St. Joseph Hospital
 Eduardo Pajon, MD
Ph: 303-399-8020ext2261
 Veterans Affairs Medical Center - Denver
 Michael McCrohan
Ph: 303-399-8020
888-336-8262
  Edwards
 Shaw Regional Cancer Center
 Michael McCrohan
Ph: 970-569-7429
  Englewood
 Swedish Medical Center
 Eduardo Pajon, MD
Ph: 303-399-8020ext2261
  Fort Collins
 Front Range Cancer Specialists
 Robert Marschke, Jr.
Ph: 970-212-7600
 Poudre Valley Hospital
 Clinical Trials Office - Poudre Valley Hospital
Ph: 970-495-8226
  Grand Junction
 St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
 Eduardo Pajon, MD
Ph: 303-399-8020ext2261
  Greeley
 North Colorado Medical Center
 Eduardo Pajon, MD
Ph: 303-399-8020ext2261
  Lone Tree
 Sky Ridge Medical Center
 Eduardo Pajon, MD
Ph: 303-399-8020ext2261
  Longmont
 Hope Cancer Care Center at Longmont United Hospital
 Eduardo Pajon, MD
Ph: 303-399-8020ext2261
  Loveland
 McKee Medical Center
 Eduardo Pajon, MD
Ph: 303-399-8020ext2261
  Pueblo
 St. Mary - Corwin Regional Medical Center
 Eduardo Pajon, MD
Ph: 303-399-8020ext2261
  Thornton
 North Suburban Medical Center
 Eduardo Pajon, MD
Ph: 303-399-8020ext2261
  Wheat Ridge
 Exempla Lutheran Medical Center
 Clinical Trials Office - Exempla Lutheran Medical Center
Ph: 303-403-3605
Connecticut
  Bristol
 Bristol Hospital
 Clinical Trials Office - Bristol Hospital
Ph: 860-585-3400
  Farmington
 Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center
 Clinical Trials Office - Carole and Ray Neag Comprehensive Cancer Center
Ph: 800-579-7822
  Hartford
 Helen and Harry Gray Cancer Center at Hartford Hospital
 Clinical Trials Office - Helen and Harry Gray Cancer Center
Ph: 860-545-5363
  Middletown
 Middlesex Hospital Cancer Center
 Susanna Hong
Ph: 860-358-2050
  Norwalk
 Norwalk Hospital
 Richard Frank, MD
Ph: 203-845-2132
  Norwich
 Eastern Connecticut Hematology and Oncology Associates
 Dennis Slater, MD
Ph: 860-886-8362
  Stamford
 Carl and Dorothy Bennett Cancer Center at Stamford Hospital
 Clinical Trials Office - Carl and Dorothy Bennett Cancer Center
Ph: 203-323-8944
  Torrington
 Connecticut Oncology & Hematology - Torrington
 Michael Magnifico, MD
Ph: 860-482-5384
  Waterbury
 Harold Leever Regional Cancer Center
 Joseph Sinning
Ph: 203-575-5555
Delaware
  Lewes
 Tunnell Cancer Center at Beebe Medical Center
 Clinical Trials Office - Tunnell Cancer Center
Ph: 302-645-3171
  Newark
 CCOP - Christiana Care Health Services
 Clinical Trial Office - CCOP - Christiana Care Health Services
Ph: 302-733-6227
District of Columbia
  Washington
 Lombardi Comprehensive Cancer Center at Georgetown University Medical Center
 Clinical Trials Office - Lombardi Comprehensive Cancer Center
Ph: 202-444-0381
 Sibley Memorial Hospital
 Kenneth Goldstein, MD, FACP
Ph: 202-293-5382
 Walter Reed Army Medical Center
 Clinical Trials Office - Walter Reed Army Medical Center
Ph: 202-782-7840
 Washington Cancer Institute at Washington Hospital Center
 Clinical Trials Office - Washington Cancer Institute
Ph: 202-877-8839
Florida
  Boca Raton
 Eugene M. and Christine E. Lynn Cancer Institute at Boca Raton Community Hospital - West
 Charles Vogel, MD
Ph: 561-477-2759
 Eugene M. and Christine E. Lynn Cancer Institute at Boca Raton Community Hospital - Main Campus
 Clinical Trials Office - Eugene M. and Christine E. Lynn Cancer Institute
Ph: 561-955-4800
  Clearwater
 Morton Plant Hospital
 Marcos Joppert
Ph: 727-462-7000
  Daytona Beach
 Herbert D. Kerman Regional Oncology Center - Daytona Beach
 Ruby Anne Deveras
Ph: 386-254-4211
  Dearfield Beach
 North Broward Medical Center
 Clinical Trials Office - North Broward Medical Center
Ph: 954-941-8300
  Fort Lauderdale
 Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
 Clinical Trials Office - Michael and Dianne Bienes Comprehensive Cancer Center
Ph: 954-776-3239
  Gainesville
 University of Florida Shands Cancer Center
 Clinical Trials Office - University of Florida Shands Cancer Center
Ph: 888-254-7581
  Hollywood
 Memorial Cancer Institute at Memorial Regional Hospital
 Clinical Trials Office - Memorial Cancer Institute
Ph: 954-985-3443
  Jacksonville
 Baptist Cancer Institute - Jacksonville
 Clinical Trials Office - Baptist Cancer Institute - Jacksonville
Ph: 904-202-7051
  Miami
 University of Miami Sylvester Comprehensive Cancer Center - Miami
 University of Miami Sylvester Comprehensive Cancer Center Clinical Trial Matching Service
Ph: 866-574-5124
 Email: Sylvester@emergingmed.com
  Miami Beach
 CCOP - Mount Sinai Medical Center
 Elisa Krill-Jackson, MD
Ph: 305-535-3300
  Orange Park
 Integrated Community Oncology Network - Orange Park
 Linda Struhar-Sylvester, MD, FACP
Ph: 904-272-3139
  Orlando
 M.D. Anderson Cancer Center at Orlando
 Nikita Shah
Ph: 321-841-1075
  Sarasota
 Florida Cancer Specialists - Sarasota Downtown
 Clinical Trials Office - Florida Cancer Specialists - Sarasota Downtown
Ph: 941-957-1000 ext. 213
  Weston
 Cleveland Clinic Florida - Weston
 Clinical Trials Office - Cleveland Clinic Florida - Weston
Ph: 954-659-5705
Georgia
  Albany
 Phoebe Cancer Center at Phoebe Putney Memorial Hospital
 Clinical Trials Office - Phoebe Cancer Center
Ph: 229-312-2251
  Altanta
 Winship Cancer Institute of Emory University
 Toncred Styblo, MD
Ph: 404-778-5372
  Athens
 Northeast Georgia Cancer Care, LLC - Medical Oncology
 Clinical Trials Office - Northeast Georgia Cancer Care, LLC
Ph: 706-353-5006
  Atlanta
 CCOP - Atlanta Regional
 Thomas Seay, MD, PhD
Ph: 404-851-2340
 Emory Crawford Long Hospital
 Toncred Styblo, MD
Ph: 404-778-5372
 Georgia Cancer Center for Excellence at Grady Memorial Hospital
 Toncred Styblo, MD
Ph: 404-778-5372
 Northside Hospital Cancer Center
 Clinical Trials Office - Northside Hospital Cancer Center
Ph: 404-303-3355
 Piedmont Hospital
 Thomas Seay, MD, PhD
Ph: 404-851-2340
 Saint Joseph's Hospital of Atlanta
 Clinical Trials Office - Saint Joseph's Hospital of Atlanta
Ph: 404-851-7115
  Augusta
 Augusta Oncology Associates - Walton Way
 Mark Keaton, MD
Ph: 706-821-2944
 MBCCOP - Medical College of Georgia Cancer Center
 Anand Jillella, MD
Ph: 706-721-2505
  Austell
 WellStar Cobb Hospital
 Clinical Trials Office - WellStar Cobb Hospital
Ph: 770-793-5980
  Columbus
 John B. Amos Cancer Center
 Clinical Trials Office - John B. Amos Cancer Center
Ph: 706-660-6404
  Decatur
 Charles B. Eberhart Cancer Center at DeKalb Medical Center
 Thomas Seay, MD, PhD
Ph: 404-851-2340
  Gainesville
 Northeast Georgia Medical Center
 Richard LoCicero, MD
Ph: 770-297-5700
  Lawrenceville
 Gwinnett Medical Center
 Thomas Seay, MD, PhD
Ph: 404-851-2340
  Marietta
 Kennestone Cancer Center at Wellstar Kennestone Hospital
 Clinical Trials Office - Kennestone Cancer Center
Ph: 770-793-5980
  Riverdale
 Southern Regional Medical Center
 Clinical Trials Office - Southern Regional Medical Center
Ph: 770-991-8611
  Rome
 Harbin Clinic Cancer Center - Medical Oncology
 Thomas Seay, MD, PhD
Ph: 404-851-2340
  Savannah
 Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center
 Clinical Trials Office - Curtis and Elizabeth Anderson Cancer Institute
Ph: 912-350-8568
 Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler
 Mark Taylor, MD
Ph: 912-354-6187
Hawaii
  Aiea
 Kapiolani Medical Center at Pali Momi
 Robert Oishi, MD
Ph: 808-536-5811
  Honolulu
 Cancer Research Center of Hawaii
 Clinical Trials Office - Cancer Research Center of Hawaii
Ph: 808-586-2979
 Hawaii Medical Center - East
 Robert Oishi, MD
Ph: 808-536-5811
 Kapiolani Medical Center for Women and Children
 Robert Oishi, MD
Ph: 808-536-5811
 OnCare Hawaii, Incorporated - Kuakini
 Robert Oishi, MD
Ph: 808-536-5811
 OnCare Hawaii, Incorporated - Lusitana
 Robert Oishi, MD
Ph: 808-536-5811
 Queen's Cancer Institute at Queen's Medical Center
 Robert Oishi, MD
Ph: 808-536-5811
 Straub Clinic and Hospital, Incorporated
 Robert Oishi, MD
Ph: 808-536-5811
  Wailuku
 Maui Memorial Medical Center
 Robert Oishi, MD
Ph: 808-536-5811
 Pacific Cancer Institute - Maui
 Robert Oishi, MD
Ph: 808-536-5811
Idaho
  Boise
 Mountain States Tumor Institute at St. Luke's Regional Medical Center
 Theodore Walters, MD
Ph: 208-381-2711
 Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
 Clinical Trials Office - Saint Alphonsus Cancer Care Center
Ph: 208-367-7954
  Coeur d'Alene
 Kootenai Cancer Center - Coeur d'Alene
 Clinical Trials Office - North Idaho Cancer Center
Ph: 208-666-3764
Illinois
  Alton
 Saint Anthony's Hospital at Saint Anthony's Health Center
 Bethany Sleckman, MD
Ph: 314-251-7057
  Bloomington
 St. Joseph Medical Center
 John Kugler, MD
Ph: 309-243-3605
  Canton
 Graham Hospital
 John Kugler, MD
Ph: 309-243-3605
  Carthage
 Memorial Hospital
 John Kugler, MD
Ph: 309-243-3605
  Chicago
 Creticos Cancer Center at Advocate Illinois Masonic Medical Center
 Clinical Trials Office - Creticos Cancer Center at Advocate Illinois Masonic Medical Center
Ph: 773-296-5360
 Louis A. Weiss Memorial Hospital
 Clinical Trials Office - Louis A. Weiss Memorial Hospital
Ph: 773- 564-5044
 Resurrection Medical Center
 Christopher Rose, MD
Ph: 847-965-3200
 Rush University Medical Center
 Clinical Trials Office - Rush University Medical Center
Ph: 312-942-5498
 Email: clinical_trials@rush.edu
 University of Chicago Cancer Research Center
 Clinical Trials Office - University of Chicago Cancer Research Center
Ph: 773-834-7424
  Decatur
 Decatur Memorial Hospital Cancer Care Institute
 Clinical Trials Office - Decatur Memorial Hospital Cancer Care Institute
Ph: 217-876-6601
  Elgin
 Sherman Hospital
 James Wade, MD
Ph: 217-876-6617
  Elk Grove Village
 Alexian Brothers Radiation Oncology
 Paul Sowray, MD
Ph: 847-437-3312
  Elmhurst
 Elmhurst Memorial Hospital
 Gerald Kozuh, MD
Ph: 630-614-4060
  Eureka
 Eureka Community Hospital
 John Kugler, MD
Ph: 309-243-3605
  Evanston
 Evanston Hospital
 Clinical Trials Office - Evanston Hospital
Ph: 847-570-1381
  Galesburg
 Galesburg Clinic, PC
 John Kugler, MD
Ph: 309-243-3605
 Galesburg Cottage Hospital
 John Kugler, MD
Ph: 309-243-3605
  Havana
 Mason District Hospital
 John Kugler, MD
Ph: 309-243-3605
  Hinsdale
 Hinsdale Hematology Oncology Associates
 Elyse Schneiderman, MD
Ph: 630-654-1790
  Kankakee
 Provena St. Mary's Regional Cancer Center - Kankakee
 Riaz Elahi, MD
Ph: 708-873-4500
  La Grange
 La Grange Memorial Hospital
 Clinical Trials Office - La Grange Memorial Hospital
Ph: 630-856-7526
  Macomb
 McDonough District Hospital
 John Kugler, MD
Ph: 309-243-3605
  Maywood
 Cardinal Bernardin Cancer Center at Loyola University Medical Center
 Clinical Trials Office - Cardinal Bernardin Cancer Center
Ph: 708-226-4357
  Moline
 Costas Constantinou, MD
Ph: 563-359-9876
 Trinity Cancer Center at Trinity Medical Center - 7th Street Campus
 Costas Constantinou, MD
Ph: 563-359-9876
  Monmouth
 OSF Holy Family Medical Center
 John Kugler, MD
Ph: 309-243-3605
  Mt. Vernon
 Good Samaritan Regional Health Center
 Bethany Sleckman, MD
Ph: 314-251-7057
  Naperville
 Edward Hospital Cancer Center
 Clinical Trials Office - Edward Hospital Cancer Center
Ph: 630-646-6075
 Hematology Oncology Consultants - Naperville
 Fariborze Barhamand, MD
Ph: 630-369-1501
  Normal
 BroMenn Regional Medical Center
 John Kugler, MD
Ph: 309-243-3605
 Community Cancer Center
 John Kugler, MD
Ph: 309-243-3605
  Oak Lawn
 Advocate Christ Medical Center
 James Weese
Ph: 708-684-8000
  Ottawa
 Community Hospital of Ottawa
 John Kugler, MD
Ph: 309-243-3605
 Oncology Hematology Associates of Central Illinois, PC - Ottawa
 John Kugler, MD
Ph: 309-243-3605
  Park Ridge
 Advocate Lutheran General Cancer Care Center
 Clinical Trials Office - Advocate Lutheran General Cancer Care Center
Ph: 847-384-3621
  Pekin
 Cancer Treatment Center at Pekin Hospital
 John Kugler, MD
Ph: 309-243-3605
  Peoria
 CCOP - Illinois Oncology Research Association
 John Kugler, MD
Ph: 309-243-3605
 Methodist Medical Center of Illinois
 Clinical Trials Office - Methodist Medical Center of Illinois
Ph: 309-243-3000
 Oncology Hematology Associates of Central Illinois, PC - Peoria
 John Kugler, MD
Ph: 309-243-3605
 OSF St. Francis Medical Center
 John Kugler, MD
Ph: 309-243-3605
 Proctor Hospital
 John Kugler, MD
Ph: 309-243-3605
  Peru
 Illinois Valley Community Hospital
 John Kugler, MD
Ph: 309-243-3605
  Rockford
 Center for Cancer Care at OSF Saint Anthony Medical Center
 Clinical Trials Office - Center for Cancer Care at OSF Saint Anthony Medical Center
Ph: 815-227-2633
 Swedish-American Regional Cancer Center
 Clinical Trials Office - Swedish-American Regional Cancer Center
Ph: 815-489-4413
  Spring Valley
 St. Margaret's Hospital
 John Kugler, MD
Ph: 309-243-3605
  Springfield
 Regional Cancer Center at Memorial Medical Center
 Clinical Trials Office - Regional Cancer Center at Memorial Medical Center
Ph: 217-788-4233
  Winfield
 Central Dupage Cancer Center
 Lucio Di Nunno, MD
Ph: 806-725-8000
Indiana
  Beech Grove
 St. Francis Hospital and Health Centers - Beech Grove Campus
 Howard Gross, MD
Ph: 937-832-1093
  Elkhart
 Elkhart General Hospital
 Naftali Bechar
Ph: 574-294-2621
  Fort Wayne
 Fort Wayne Medical Oncology and Hematology
 Sreenivasa Nattam, MD
Ph: 260-484-8830
  Goshen
 Center for Cancer Care at Goshen General Hospital
 Clinical Trials Office - Center for Cancer Care at Goshen General Hospital
Ph: 574-535-2858
  Indianapolis
 Community Regional Cancer Care at Community Hospital East
 Radhika Walling
Ph: 317-355-5347
 Community Regional Cancer Care at Community Hospital North
 Radhika Walling
Ph: 317-621-4300
 St. Vincent Indianapolis Hospital
 Clinical Trials Office - St. Vincent Indianapolis Hospital
Ph: 317-338-2194
  Kokomo
 Howard Community Hospital
 Naftali Bechar
Ph: 765-453-8571
  La Porte
 Center for Cancer Therapy at LaPorte Hospital and Health Services
 Naftali Bechar
Ph: 219-326-2683
  Lafayette
 Horizon Oncology Center
 Wael Harb
Ph: 765-446-5111
866-877-1077
  Munster
 Community Hospital
 Erwin Robin, MD
Ph: 219-836-2860
  Richmond
 Reid Hospital & Health Care Services
 Howard Gross, MD
Ph: 937-832-1093
  South Bend
 CCOP - Northern Indiana CR Consortium
 Naftali Bechar
Ph: 574-647-7370
800-284-7370
 Memorial Hospital of South Bend
 Clinical Trials Office - Memorial Hospital of South Bend
Ph: 800-284-7370
 Saint Joseph Regional Medical Center
 Naftali Bechar
Ph: 574-237-7111
 South Bend Clinic
 Naftali Bechar
Ph: 219-234-8161
Iowa
  Ames
 McFarland Clinic, PC
 Clinical Trials Office - McFarland Clinic, PC
Ph: 515-239-2621
  Bettendorf
 Costas Constantinou, MD
Ph: 563-359-9876
 Hematology Oncology Associates of the Quad Cities
 Shobha Chitneni, MD, MBBS
Ph: 563-355-7733
  Cedar Rapids
 Cedar Rapids Oncology Associates
 Clinical Trials Office - Cedar Rapids Oncology Associates
Ph: 319-363-2690
 Iowa Blood and Cancer Care
 David Zenk, MD
Ph: 319-369-7091
 Mercy Regional Cancer Center at Mercy Medical Center
 Martin Wiesenfeld, MD
Ph: 319-363-8303
 St. Luke's Hospital
 David Zenk, MD
Ph: 319-369-7091
  Clive
 Medical Oncology and Hematology Associates - West Des Moines
 Robert Behrens
Ph: 515-875-9713
  Council Bluffs
 Heartland Oncology and Hematology
 John Okerbloom, MD
Ph: 712-322-4136
  Davenport
 Genesis Medical Center - West Campus
 George Kovach, MD
Ph: 563-421-1960
 Genesis Regional Cancer Center at Genesis Medical Center
 George Kovach, MD
Ph: 563-421-1960
  Des Moines
 CCOP - Iowa Oncology Research Association
 Robert Behrens
Ph: 515-244-7586
888-244-6061
 John Stoddard Cancer Center at Iowa Lutheran Hospital
 Clinical Trials Office - John Stoddard Cancer Center at Iowa Lutheran Hospital
Ph: 515-241-8704
 John Stoddard Cancer Center at Iowa Methodist Medical Center
 Clinical Trials Office - John Stoddard Cancer Center at Iowa Methodist Medical Center
Ph: 515-241-6727
 Medical Oncology and Hematology Associates at John Stoddard Cancer Center
 Robert Behrens
Ph: 515-282-2921
 Medical Oncology and Hematology Associates at Mercy Cancer Center
 Robert Behrens
Ph: 515-643-8740
 Mercy Cancer Center at Mercy Medical Center - Des Moines
 Robert Behrens
Ph: 515-643-8206
888-221-4849
  Iowa City
 Holden Comprehensive Cancer Center at University of Iowa
 Cancer Information Service
Ph: 800-237-1225
  Mason City
 Mercy Cancer Center at Mercy Medical Center - North Iowa
 Clinical Trials Office - Mercy Cancer Center at Mercy Medical Center - North Iowa
Ph: 641-422-6304
  Ottumwa
 McCreery Cancer Center at Ottumwa Regional
 Robert Behrens
Ph: 641-684-2946
  Sioux City
 Mercy Medical Center - Sioux City
 Donald Wender, MD, PhD
Ph: 712-252-0088
 Siouxland Hematology-Oncology Associates, LLP
 Donald Wender, MD, PhD
Ph: 712-252-0088
 St. Luke's Regional Medical Center
 Donald Wender, MD, PhD
Ph: 712-252-0088
  Waterloo
 Covenant Cancer Treatment Center
 Clinical Trials Office - Covenant Cancer Treatment Center
Ph: 319-272-2070
Kansas
  Anthony
 Hospital District Sixth of Harper County
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
  Chanute
 Cancer Center of Kansas, PA - Chanute
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
  Dodge City
 Cancer Center of Kansas, PA - Dodge City
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
  El Dorado
 Cancer Center of Kansas, PA - El Dorado
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
  Fort Scott
 Cancer Center of Kansas - Fort Scott
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
  Independence
 Cancer Center of Kansas-Independence
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
  Kingman
 Cancer Center of Kansas, PA - Kingman
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
  Lawrence
 Lawrence Memorial Hospital
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
  Liberal
 Southwest Medical Center
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
  Newton
 Cancer Center of Kansas, PA - Newton
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
  Parsons
 Cancer Center of Kansas, PA - Parsons
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
  Pittsburg
 Mount Carmel Regional Cancer Center
 Boban Mathew, MD
Ph: 620-235-7900
  Pratt
 Cancer Center of Kansas, PA - Pratt
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
  Salina
 Cancer Center of Kansas, PA - Salina
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
  Topeka
 Cotton-O'Neil Cancer Center
 Clinical Trials Office - Cotton-O'Neil Cancer Center
Ph: 785-270-4963
  Wellington
 Cancer Center of Kansas, PA - Wellington
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
  Wichita
 Associates in Womens Health, PA - North Review
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
 Cancer Center of Kansas, PA - Wichita
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
 Cancer Center of Kansas, PA - Medical Arts Tower
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
 CCOP - Wichita
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
 Via Christi Cancer Center at Via Christi Regional Medical Center
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
  Winfield
 Cancer Center of Kansas, PA - Winfield
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
Kentucky
  Ashland
 Cancer Care at Our Lady of Bellefonte Hospital
 Clinical Trials Office - Cancer Care at Our Lady of Bellefonte Hospital
Ph: 606-833-3253
 Cancer Resource Center at King's Daughters Medical Center
 Clinical Trial Office - Cancer Resource Center at Kings Daughter's Medical Center
Ph: 606-327-6499
  Lexington
 Central Baptist Hospital
 Clinical Trials Office - Central Baptist Hospital
Ph: 859-260-6425
 Lucille P. Markey Cancer Center at University of Kentucky
 Clinical Trials Office - Markey Cancer Center at University of Kentucky Chandler Medical Center
Ph: 859-257-3379
  Louisville
 Consultants in Blood Disorders and Cancer
 Udaya Joseph, MD
Ph: 502-897-1166
 Drs. Carrol, Sheth, Raghavan
 J. Philip Kuebler, MD, PhD
Ph: 614-442-3130
 James Graham Brown Cancer Center at University of Louisville
 Anees Chagpar
Ph: 502-629-6950
 Louisville Oncology at Norton Cancer Institute - Louisville
 Clinical Trials Office - Louisville Oncology
Ph: 502-629-2500
Louisiana
  Baton Rouge
 Mary Bird Perkins Cancer Center - Baton Rouge
 Robert Veith
Ph: 225-767-0847
 Ochsner Health Center - Bluebonnet
 Jyotsna Fuloria
Ph: 225-761-5200
 Pennington Cancer Center at Baton Rouge General
 Clinical Trials Office - Pennington Cancer Center at Baton Rouge General
Ph: 225-381-6451
  Houma
 Terrebonne General Medical Center
 Jyotsna Fuloria
Ph: 985-850-6300
  Metairie
 Drs Gurtler Brinz and Russo APMC-Metairie Oncologists
 Jayne Gurtler
Ph: 504-885-0577
  New Orleans
 CCOP - Ochsner
 Jyotsna Fuloria
Ph: 504-842-3910
 MBCCOP - LSU Health Sciences Center
 Robert Veith
Ph: 504-568-5151
 Medical Center of Louisiana - New Orleans
 Robert Veith
Ph: 504-903-2311
 Ochsner Cancer Institute at Ochsner Clinic Foundation
 Jyotsna Fuloria
Ph: 504-842-4360
888-624-7637
  Shreveport
 Christus Schumpert Cancer Treatment Center
 Clinical Trials Office - Christus Schumpert Cancer Treatment Center
Ph: 318-681-4763
Maine
  Bangor
 CancerCare of Maine at Eastern Maine Medical Center
 Clinical Trials Office - CancerCare of Maine
Ph: 207-973-4274
  Lewiston
 Central Maine Comprehensive Cancer Center at Central Maine Medical Center
 Anne Traynor, MD
Ph: 608-262-5092
  Portland
 Mercy Hospital
 Roger Inhorn, MD, PhD
Ph: 207-879-3030
  York
 York Hospital's Oncology Treatment Center
 Jonathan Eneman
Ph: 207-351-3777
Maryland
  Baltimore
 Greater Baltimore Medical Center Cancer Center
 Clinical Trials Office - Greater Baltimore Medical Center Cancer Center
Ph: 443-849-3706
 Harry & Jeanette Weinberg Cancer Institute at Franklin Square Hospital Center
 Clinical Trials Office - Harry & Jeanette Weinberg Cancer Institute at Franklin Square Hospital Center
Ph: 443-777-7364
 Mercy Medical Center
 David Riseberg, MD
Ph: 410-783-5858
 St. Agnes Hospital Cancer Center
 Diana Griffiths
Ph: 410-368-2910
  Bethesda
 Suburban Hospital
 Carolyn Hendricks, MD
Ph: 301-897-1503
  Easton
 Shore Regional Cancer Center at Memorial Hospital - Easton
 Susan Forlifer
Ph: 410-820-6800
  Elkton MD
 Union Hospital Cancer Program at Union Hospital
 David Biggs, MD
Ph: 302-366-1200
  Frederick
 Frederick Memorial Hospital Regional Cancer Therapy Center
 Brian O'Connor, MD
Ph: 301-662-8477
  Leonardtown
 St. Mary's Hospital
 John Zapas, MD
Ph: 443-777-7911
  Salisbury
 Peninsula Regional Medical Center
 Clinical Trials Office - Peninsula Regional Medical Center
Ph: 410-543-7000
Massachusetts
  Attleboro
 Sturdy Memorial Hospital
 Michael Vasconcelles, MD
Ph: 617-632-5301
  Boston
 Boston University Cancer Research Center
 Clinical Trials Office - Boston University Cancer Research Center
Ph: 617-353-7571
 Tufts-NEMC Cancer Center
 Kathy Theall, MD
Ph: 617-636-2520
  Burlington
 Lahey Clinic Medical Center - Burlington
 Clinical Trials Office - Lahey Clinic Medical Center - Burlington
Ph: 781-744-8027
  Concord
 Commonwealth Hematology-Oncology, PC - Concord
 Susan Sajer, MD
Ph: 978-287-3436
  Dorchester
 Commonwealth Hematology Oncology PC - Dorchester
 Susan Sajer, MD
Ph: 978-287-3436
  Fall River
 Hudner Oncology Center at Saint Anne's Hospital - Fall River
 Clinical Trials Office - Hudner Oncology Center at Saint Anne's Hospital - Fall River
Ph: 508-674-5600 ext. 2019
  Fitchburg
 Simonds-Sinon Regional Cancer Center at HealthAlliance Hospital - Burbank Campus
 Kathryn Edmiston, MD
Ph: 508-334-5141
  Gloucester
 Addison Gilbert Hospital
 Angus McIntyre, MD
Ph: 978-927-6850
  Lawrence
 Commonwealth Hematology-Oncology, PC - Lawrence
 Susan Sajer, MD
Ph: 978-287-3436
  Leominster
 Commonwealth Hematology Oncology PC - Leominster
 Susan Sajer, MD
Ph: 978-287-3436
  Methuen
 Caritas Holy Family Hospital
 Pedro Sanz-Altamira, MD
Ph: 978-685-7811
  Peabody
 NSMC Cancer Center - Peabody
 Karen Krag, MD
Ph: 978-977-3434
  Pittsfield
 Berkshire Hematology Oncology, PC
 Harvey Zimbler, MD
Ph: 413-496-8205
  Plymouth
 Jordan Hospital Club Cancer Center
 Maureen Kavanah, MD
Ph: 617-638-8473
  Quincy
 Commonwealth Hematology-Oncology, PC - Quincy
 Susan Sajer, MD
Ph: 978-287-3436
  Springfield
 Baystate Regional Cancer Program at D'Amour Center for Cancer Care
 Velusami Arumugam
Ph: 413-794-9338
  Stoneham
 Commonwealth Hematology-Oncology, PC - Stoneham
 Susan Sajer, MD
Ph: 978-287-3436
  Weymouth
 Commonwealth Hematology-Oncology, PC - Weymouth
 Susan Sajer, MD
Ph: 978-287-3436
  Worcester
 Commonwealth Hematology-Oncology, PC - Worcester
 Susan Sajer, MD
Ph: 978-287-3436
 UMASS Memorial Cancer Center - University Campus
 Kathryn Edmiston, MD
Ph: 508-334-5141
Michigan
  Adrian
 Hickman Cancer Center at Bixby Medical Center
 Clinical Trials Office - Hickman Cancer Center at Bixby Medical Center
Ph: 517-265-0116
  Ann Arbor
 CCOP - Michigan Cancer Research Consortium
 Philip Stella, MD
Ph: 734-712-1000
 Saint Joseph Mercy Cancer Center
 Philip Stella, MD
Ph: 734-712-1000
  Battle Creek
 Battle Creek Health System Cancer Care Center
 Martin Bury
Ph: 616-966-8000
  Bay City
 Bay Regional Medical Center
 Clinical Trials Office - Bay Regional Medical Center
Ph: 989-667-6257
  Big Rapids
 Mecosta County Medical Center
 Martin Bury
Ph: 231-796-8691
  Dearborn
 Oakwood Cancer Center at Oakwood Hospital and Medical Center
 Clinical Trials Office - Oakwood Cancer Center at Oakwood Hospital and Medical Center
Ph: 313-593-8090
  Detroit
 Barbara Ann Karmanos Cancer Institute
 Clinical Trials Office - Barbara Ann Karmanos Cancer Institute
Ph: 313-576-9363
 Josephine Ford Cancer Center at Henry Ford Hospital
 Thomas Doyle, MD
Ph: 313-916-1502
  Escanaba
 Green Bay Oncology, Limited - Escanaba
 Pamela Vanderwall, MD
Ph: 414-433-8184
  Flint
 Genesys Hurley Cancer Institute
 Clinical Trials Office - Genesys Hurley Cancer Institute
Ph: 810-762-8057
 Great Lakes Cancer Institute at McLaren Regional Medical Center
 Clinical Trials Office - Great Lakes Cancer Institute at McLaren Regional Medical Center
Ph: 810-342-4071
 Hurley Medical Center
 Clinical Trials Office - Hurley Medical Center
Ph: 810-762-8057
  Grand Rapids
 Butterworth Hospital at Spectrum Health
 Martin Bury
Ph: 616-391-2799
 CCOP - Grand Rapids
 Martin Bury
Ph: 616-391-1230
 Lacks Cancer Center at Saint Mary's Health Care
 Martin Bury
Ph: 616-752-5222
  Grosse Pointe Woods
 Van Elslander Cancer Center at St. John Hospital and Medical Center
 Clincial Trials Office - Van Elslander Cancer Center at St. John Hospital and Medical Center
Ph: 313-343-3166
  Iron Mountain
 Dickinson County Healthcare System
 Pamela Vanderwall, MD
Ph: 414-433-8184
  Jackson
 Foote Memorial Hospital
 Philip Stella, MD
Ph: 734-712-1000
  Kalamazoo
 Borgess Medical Center
 Raymond Lord, MD
Ph: 269-373-7458
 Bronson Methodist Hospital
 Raymond Lord, MD
Ph: 269-373-7458
 West Michigan Cancer Center
 Clinical Trials Office - West Michigan Cancer Center
Ph: 269-373-7458
  Lambertville
 Haematology-Oncology Associates of Ohio and Michigan, PC
 Paul Schaefer, MD
Ph: 419-479-5605
  Lansing
 Breslin Cancer Center at Ingham Regional Medical Center
 Clinical Trials Office - Breslin Cancer Center at Ingham Regional Medical Center
Ph: 517-334-2765
 Sparrow Regional Cancer Center
 Clinical Trials Office - Sparrow Regional Cancer Center
Ph: 517-364-2890
  Lapeer
 Lapeer Regional Hospital
 Barbara Conley, MD
Ph: 517-334-2765
  Livonia
 St. Mary Mercy Hospital
 Philip Stella, MD
Ph: 734-712-1000
  Marquette
 Upper Michigan Cancer Center at Marquette General Hospital
 Clinical Trials Office - Upper Michigan Cancer Center at Marquette General Hospital
Ph: 906-225-3467
  Midland
 MidMichigan Medical Center - Midland
 Clinical Trials Office - MidMichigan Medical Center - Midland
Ph: 989-839-3377
  Monroe
 Community Cancer Center of Monroe
 Paul Schaefer, MD
Ph: 419-479-5605
 Mercy Memorial Hospital - Monroe
 Paul Schaefer, MD
Ph: 419-479-5605
  Mount Clemens
 Clemens Regional Medical Center
 Clinical Trials Office - Ted B. Wahby Cancer Center at Mount Clemens General Hospital
Ph: 586-493-3426
  Muskegon
 Mercy General Health Partners
 Martin Bury
Ph: 231-672-2000
  Pontiac
 St. Joseph Mercy Oakland
 Philip Stella, MD
Ph: 734-712-1000
  Port Huron
 Mercy Regional Cancer Center at Mercy Hospital
 Philip Stella, MD
Ph: 734-712-1000
  Royal Oak
 William Beaumont Hospital - Royal Oak Campus
 Clinical Trials Office - William Beaumont Hospital - Royal Oak Campus
Ph: 248-551-7695
  Saginaw
 Seton Cancer Institute at Saint Mary's - Saginaw
 Clinical Trials Office - Seton Cancer Institute - Saginaw
Ph: 989-776-8411
  Southfield
 Providence Cancer Institute at Providence Hospital - Southfield Campus
 Anibal Drelichman, MD, MPH, FACP
Ph: 313-552-0620
  St. Joseph
 Lakeland Regional Cancer Care Center - St. Joseph
 Naftali Bechar
Ph: 269-983-8698
800-303-8399
  Traverse City
 Munson Medical Center
 Martin Bury
Ph: 231-935-6202
  Warren
 St. John Macomb Hospital
 Philip Stella, MD
Ph: 734-712-1000
  Wyoming
 Metro Health Hospital
 Martin Bury
Ph: 616-252-7200
Minnesota
  Bemidji
 MeritCare Bemidji
 Preston Steen, MD
Ph: 701-234-2397
  Burnsville
 Fairview Ridges Hospital
 Patrick Flynn, MD
Ph: 612-863-8585
  Coon Rapids
 Mercy and Unity Cancer Center at Mercy Hospital
 Patrick Flynn, MD
Ph: 612-863-8585
  Duluth
 CCOP - Duluth
 Daniel Nikcevich, MD, PhD
Ph: 218-786-3625
 Duluth Clinic Cancer Center - Duluth
 Clinical Trials Office - Duluth Clinic Cancer Center - Duluth
Ph: 218-786-3308
 Miller - Dwan Medical Center
 Daniel Nikcevich, MD, PhD
Ph: 218-786-3625
 St. Luke's Hospital Cancer Care Center
 Tanya Repka, MD, FACP
Ph: 218-726-3081
  Edina
 Fairview Southdale Hospital
 Clinical Trials Office - Fairview Southdale Hospital
Ph: 612-625-3650
  Fridley
 Mercy and Unity Cancer Center at Unity Hospital
 Patrick Flynn, MD
Ph: 612-863-8585
  Hutchinson
 Hutchinson Area Health Care
 Daniel Anderson
Ph: 320-234-5000
800-454-3903
  Lichfield
 Meeker County Memorial Hospital
 Clinical Trials Office - Meeker County Memorial Hospital
Ph: 320-693-4520
  Mankato
 Immanuel St. Joseph's
 Glenn Harman, MD
Ph: 815-777-1536
  Maplewood
 HealthEast Cancer Care at St. John's Hospital
 Daniel Anderson
Ph: 651-232-7970
 Minnesota Oncology Hematology, PA - Maplewood
 Patrick Flynn, MD
Ph: 612-863-8585
  Minneapolis
 Hennepin County Medical Center - Minneapolis
 Clinical Trials Office - Hennepin County Medical Center - Minneapolis
Ph: 612-873-5911
 Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
 Clinical Trials Office - Virginia Piper Cancer Institute
Ph: 612-863-5654
  Robbinsdale
 Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center
 Clinical Trials Office - Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center
Ph: 763-520-1893
  Saint Louis Park
 CCOP - Metro-Minnesota
 Patrick Flynn, MD
Ph: 612-863-8585
 Park Nicollet Cancer Center
 Patrick Flynn, MD
Ph: 612-863-8585
  Saint Paul
 United Hospital
 Patrick Flynn, MD
Ph: 612-863-8585
  Shakopee
 St. Francis Cancer Center at St. Francis Medical Center
 Patrick Flynn, MD
Ph: 612-863-8585
  St. Paul
 Regions Hospital Cancer Care Center
 Clinical Trials Office - Regions Hospital Cancer Care Center
Ph: 651-254-1517
  Waconia
 Ridgeview Medical Center
 Patrick Flynn, MD
Ph: 612-863-8585
  Woodbury
 Minnesota Oncology Hematology, PA - Woodbury
 Patrick Flynn, MD
Ph: 612-863-8585
Mississippi
  Hattiesburg
 Hattiesburg Clinic, PA at Forrest General
 Jyotsna Fuloria
Ph: 601-288-8282
  Kessler AFB
 Keesler Air Force Base Medical Center
 Louis Varner
Ph: 228-377-2086
  Pascagoula
 Regional Cancer Center at Singing River Hospital
 James Clarkson, MD
Ph: 228-374-6296
Missouri
  Cape Girardeau
 Saint Francis Medical Center
 Bethany Sleckman, MD
Ph: 314-251-7057
  Chesterfield
 Saint Luke's Hospital
 Donald Busiek, MD
Ph: 314-205-6737
  Columbia
 Ellis Fischel Cancer Center at University of Missouri - Columbia
 Clinical Trial Office - Ellis Fischel Cancer Center
Ph: 573-882-7440
  Joplin
 Freeman Cancer Institute at Freeman Health System
 Anisa Hassan
Ph: 417-347-3066
 St. John's Regional Medical Center
 Clinical Trials Office - St. John's Regional Medical Center
Ph: 417-625-2488 ext. 2949
  Saint Louis
 Arch Medical Services, Incorporated at Center for Cancer Care and Research
 Alan Lyss, MD
Ph: 314-996-5514
 CCOP - St. Louis-Cape Girardeau
 Bethany Sleckman, MD
Ph: 314-251-7057
 David C. Pratt Cancer Center at St. John's Mercy
 Clinical Trials Office - David C. Pratt Cancer Center at St. John's Mercy
Ph: 314-251-6770
 Midwest Hematology Oncology Group, Incorporated
 Bethany Sleckman, MD
Ph: 314-251-7057
 Missouri Baptist Cancer Center
 Alan Lyss, MD
Ph: 314-996-5514
 Saint Louis University Cancer Center
 Clinical Trials Office - Saint Louis University Cancer Center
Ph: 314-977-4440
 Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
 Michael Naughton, MD
Ph: 314-996-8872
 St. Anthony's Cancer Center
 R. William Morris, MD
Ph: 314-849-6066
  Springfield
 CCOP - Cancer Research for the Ozarks
 Robert Carolla
Ph: 417-269-4520
 Hulston Cancer Center at Cox Medical Center South
 Robert Carolla
Ph: 417-269-5257
 St. John's Regional Health Center
 Robert Carolla
Ph: 417-820-2000
Montana
  Billings
 Billings Clinic - Downtown
 Clinical Trials Office - Billings Clinic - Downtown
Ph: 800-996-2663
 Email: research@billingsclinic.org
 CCOP - Montana Cancer Consortium
 Benjamin Marchello, MD
Ph: 406-238-6290
 Hematology-Oncology Centers of the Northern Rockies - Billings
 Benjamin Marchello, MD
Ph: 406-238-6290
 Northern Rockies Radiation Oncology Center
 Benjamin Marchello, MD
Ph: 406-238-6290
 St. Vincent Healthcare Cancer Care Services
 Benjamin Marchello, MD
Ph: 406-238-6290
  Bozeman
 Bozeman Deaconess Cancer Center
 Benjamin Marchello, MD
Ph: 406-238-6290
  Butte
 St. James Healthcare Cancer Care
 Benjamin Marchello, MD
Ph: 406-238-6290
  Great Falls
 Benjamin Marchello, MD
Ph: 406-238-6290
 Big Sky Oncology
 Clinical Trail Office - Big Sky Oncology
Ph: 406-731-8217
 Great Falls Clinic - Main Facility
 Benjamin Marchello, MD
Ph: 406-238-6290
 Sletten Cancer Institute at Benefis Healthcare
 Grant Harrer, MD, FACP, CCTI
Ph: 406-731-8100
  Havre
 Northern Montana Hospital
 Benjamin Marchello, MD
Ph: 406-238-6290
  Helena
 St. Peter's Hospital
 Benjamin Marchello, MD
Ph: 406-238-6290
  Kalispell
 Glacier Oncology, PLLC
 Benjamin Marchello, MD
Ph: 406-238-6290
 Kalispell Medical Oncology at KRMC
 Benjamin Marchello, MD
Ph: 406-238-6290
 Kalispell Regional Medical Center
 Benjamin Marchello, MD
Ph: 406-238-6290
  Missoula
 Community Medical Center
 Benjamin Marchello, MD
Ph: 406-238-6290
 Guardian Oncology and Center for Wellness
 Benjamin Marchello, MD
Ph: 406-238-6290
 Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
 Clinical Trials Office - Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
Ph: 406-329-7029
 Montana Cancer Specialists at Montana Cancer Center
 Clinical Trials Office - Montana Cancer Specialists at Montana Cancer Center
Ph: 406-238-6962
Nebraska
  Grand Island
 Saint Francis Cancer Treatment Center at Saint Francis Memorial Health Center
 Elizabeth Reed, MD
Ph: 402-559-5388
  Kearney
 Good Samaritan Cancer Center at Good Samaritan Hospital
 Clinical Trials Office - Good Samaritan Cancer Center at Good Samaritan Hospital
Ph: 308-865-7963
  Lincoln
 Cancer Resource Center - Lincoln
 Alan Berg, MD
Ph: 402-420-7000
  North Platte
 Callahan Cancer Center at Great Plains Regional Medical Center
 Clinical Trials Office - Callahan Cancer Center at Great Plains Regional Medical Center
Ph: 308-696-7864
  Omaha
 Alegant Health Cancer Center at Bergan Mercy Medical Center
 Clinical Trials Office - Alegant Health Cancer Center at Bergen Mercy Medical Center
Ph: 402-398-6060
 CCOP - Missouri Valley Cancer Consortium
 Gamini Soori, MD, FACP, FRCP, MBA
Ph: 402-393-3110
 Creighton University Medical Center
 Clinical Trials Office - Creighton University Medical Center
Ph: 402-280-4100
 Immanuel Medical Center
 Gamini Soori, MD, FACP, FRCP, MBA
Ph: 402-393-3110
 Methodist Estabrook Cancer Center
 James Reilly, MD
Ph: 402-354-8163
 UNMC Eppley Cancer Center at the University of Nebraska Medical Center
 Clinical Trials Office - UNMC Eppley Cancer Center at the University of Nebraska Medical Center
Ph: 800-999-5465
Nevada
  Las Vegas
 CCOP - Nevada Cancer Research Foundation
 John Ellerton, MD, CM
Ph: 702-384-0013
 University Medical Center of Southern Nevada
 John Ellerton, MD, CM
Ph: 702-384-0013
New Hampshire
  Concord
 New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care
 Frederick Briccetti, MD
Ph: 603-224-2556
  Dover
 Seacoast Cancer Center at Wentworth - Douglass Hospital
 Barbara Shea, MD
Ph: 603-740-2390
  Exeter
 Center for Cancer Care at Exeter Hospital
 Danny Sims
Ph: 603-580-6636
  Hooksett
 New Hampshire Oncology - Hematology, PA - Hooksett
 Frederick Briccetti, MD
Ph: 603-224-2556
  Laconia
 Lakes Region General Hospital
 Charles Catcher, MD
Ph: 603-224-2556
  Portsmouth
 Portsmouth Regional Hospital
 Paul Poulin
Ph: 603-436-5110
800-685-8282
New Jersey
  Brick
 Ocean Medical Center at Meridian Health
 Clinical Trials Office - Ocean Medical Center at Meridian Health
Ph: 732-206-8384
  Englewood
 Dizzy Gillespie Cancer Institute at Englewood Hospital and Medical Center
 Clinical Trials Office - Dizzy Gillespie Cancer Institute at Englewood Hospital and Medical Center
Ph: 201-894-3456
  Flemington
 Hunterdon Regional Cancer Center at Hunterdon Medical Center
 Kenneth Blankstein, MD
Ph: 908-788-6100
  Freehold
 CentraState Medical Center
 Jeffrey Silberberg, MD
Ph: 732-431-8400
  Livingston
 St. Barnabas Medical Center Cancer Center
 Clinical Trials Office - St. Barnabas Medical Center Cancer Center
Ph: 973-322-2470
  Marlton
 Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton
 Clinical Trials Office - Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton
Ph: 888-847-8823
  New Brunswick
 Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School
 Clinical Trials Office - Cancer Institute of New Jersey
Ph: 732-235-8675
 Saint Peter's University Hospital
 Kathleen Toomey
Ph: 732-745-8600
  Newark
 Newark Beth Israel Medical Center
 Clinical Trials Office - Newark Beth Israel Medical Center
Ph: 973-926-3136
  Pomona
 AtlantiCare Cancer Care Institute at AtlantiCare Regional Medical Center - Mainland Campus
 Nasser Borai
Ph: 609-652-1000
  Princeton
 University Medical Center at Princeton
 Doreen Babott
Ph: 609-497-4000
  Ridgewood
 Valley Hospital - Ridgewood
 Thomas Rakowski, MD
Ph: 201-444-4526
  Somerville
 Somerset Medical Center
 Clinical Trials Office - Somerset Medical Center
Ph: 908-685-2481
  Sparta
 Frederick R. and Betty M. Smith Cancer Treatment Center
 Ronald Cantor
Ph: 973-726-4180
  Trenton
 Capital Health Regional Cancer Center
 Scott Kindsfather
Ph: 609-396-5800
 St. Francis Regional Cancer Center
 Clinical Trials Office - St. Francis Regional Cancer Center
Ph: 609-599-5060
  Vineland
 Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare
 Clinical Trials Office - Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare
Ph: 856-641-7933
  Voorhees
 Cancer Institute of New Jersey at Cooper - Voorhees
 Clinical Trials Office - Cancer Institute of New Jersey at Cooper University Hospital - Voorhees
Ph: 856-325-6757
 Fox Chase Virtua Health Cancer Program at Virtua West Jersey
 Michael Entmacher, MD
Ph: 609-702-1900
New Mexico
  Albuquerque
 Hematology Oncology Associates, PC
 Aroop Mangalik, MD
Ph: 505-272-4551
 Lovelace Medical Center - Downtown
 Aroop Mangalik, MD
Ph: 505-272-4551
 New Mexico Cancer Center
 Aroop Mangalik, MD
Ph: 505-272-4551
 University of New Mexico Cancer Center
 Clinical Trials Office - University of New Mexico Cancer Center
Ph: 505-272-6972
New York
  Albany
 New York Oncology Hematology, PC at Albany Medical Center
 Regina Resta
Ph: 518-262-6696
 New York Oncology Hematology, PC at Albany Regional Cancer Care
 Regina Resta
Ph: 518-489-2607
  Amsterdam
 Amsterdam Community Cancer Program
 Regina Resta
Ph: 518-843-0020
  Brooklyn
 Coney Island Hospital
 Jack Burton
Ph: 718-616-3000
  Buffalo
 Roswell Park Cancer Institute
 Clinical Trials Office - Roswell Park Cancer Institute
Ph: 877-275-7724
  East Syracuse
 CCOP - Hematology-Oncology Associates of Central New York
 Jeffrey Kirshner, MD
Ph: 315-472-7504
  Glens Falls
 Adirondack Cancer Care - Glens Falls
 Mark Hoffman, MD
Ph: 518-761-0000
 Charles R. Wood Cancer Center at Glens Falls Hospital
 Clinical Trials Office - Charles R. Wood Cancer Center at Glens Falls Hospital
Ph: 518-926-6700
  Hudson
 New York Oncology Hematology, PC - Hudson
 Regina Resta
Ph: 518-822-8484
  Lake Success
 Monter Cancer Center of the North Shore-LIJ Health System
 Lora Weiselberg, MD
Ph: 516-562-8963
  Latham
 New York Oncology Hematology, PC - Latham
 Regina Resta
Ph: 518-786-3122
  Manhasset
 CCOP - North Shore University Hospital
 Lora Weiselberg, MD
Ph: 516-562-8963
 Don Monti Comprehensive Cancer Center at North Shore University Hospital
 Clinical Trials Office - Don Monti Comprehensive Cancer Center at North Shore University Hospital
Ph: 516-734-8900
  Mount Kisco
 Northern Westchester Hospital
 Jonathan Goldberg
Ph: 914-666-1200
  New Hyde Park
 Long Island Jewish Medical Center
 Lora Weiselberg, MD
Ph: 516-562-8963
  New York
 Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center
 Clinical Trials Office - Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center
Ph: 212-305-8615
  Poughkeepsie
 Cancer Center of Poughkeepsie
 Radhika Rachamalla
Ph: 845-454-1942
 Dyson Center for Cancer Care at Vassar Brothers Medical Center
 Clinical Trials Office - Dyson Center for Cancer Care at Vassar Brothers Medical Center
Ph: 845-483-6483
 Hudson Valley Oncology Associates
 Radhika Rachamalla
Ph: 845-485-7767
 Saint Francis Hospital Cancer Center
 Theodora Budnik, MD, FACS
Ph: 845-473-1112
  Rexford
 Riverview Cancer Care Medical Associates, PC
 Regina Resta
Ph: 518-399-4600
  Rochester
 Interlakes Oncology/Hematology PC
 Richard Fisher, MD
Ph: 585-275-0842
 James P. Wilmot Cancer Center at University of Rochester Medical Center
 Richard Fisher, MD
Ph: 585-275-0842
 Lipson Cancer and Blood Center at Rochester General Hospital
 Peter Bushunow, MD
Ph: 585-922-4020
  Staten Island
 Nalitt Cancer Institute at Staten Island University Hospital
 Terenig Terjanian, MD
Ph: 718-226-6400
  Stony Brook
 Stony Brook University Cancer Center
 Clinical Trials Office - Stony Brook University Cancer Center
Ph: 800-862-2215
  Syracuse
 SUNY Upstate Medical University Hospital
 Clinical Trials Office - SUNY Upstate Medical University Hospital
Ph: 315-464-5476
  Troy
 Samaritan Hospital at Northeast Health
 Regina Resta