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Last Modified: 2/9/2010     First Published: 9/24/2008  
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Phase III Randomized Study of Radiotherapy With Versus Without Trastuzumab (Herceptin®) in Women With HER2-Positive Ductal Carcinoma In Situ Who Underwent Lumpectomy

Alternate Title
Basic Trial Information
Objectives
Entry Criteria
Expected Enrollment
Outcomes
Outline
Trial Contact Information
Registry Information

Alternate Title

Radiation Therapy With or Without Trastuzumab in Treating Women With Ductal Carcinoma In Situ Who Have Undergone Lumpectomy

Basic Trial Information

PhaseTypeStatusAgeSponsorProtocol IDs
Phase IIIBiomarker/Laboratory analysis, TreatmentActive18 and overNCINSABP-B-43
NSABP-B-43, NCT00769379

Objectives

Primary

  1. To determine the value of radiotherapy with vs without trastuzumab (Herceptin®) in preventing subsequent occurrence of ipsilateral breast cancer recurrence, ipsilateral skin cancer recurrence, or ipsilateral ductal carcinoma in situ (DCIS) in women with HER2-positive DCIS resected by lumpectomy.

Secondary

  1. To determine the value of these regimens in prolonging invasive or DCIS disease-free survival.
  2. To determine the value of these regimens in increasing invasive or DCIS recurrence-free interval.
  3. To determine the value of these regimens in improving regional or distant recurrence.
  4. To determine the value of these regimens in improving the incidence of contralateral invasive or DCIS breast cancer.
  5. To determine the value of these regimens in improving overall survival.
  6. To explore the effect of trastuzumab on ovarian function.
  7. To determine if the benefit of trastuzumab added to radiotherapy will be significantly higher in cMYC-amplified tumors than in the cMYC nonamplified subset.
  8. To determine if the benefit of trastuzumab added to radiotherapy will be less in tumors with mutations in the PI3 kinase gene than in tumors without PI3 kinase gene mutations.

Entry Criteria

Disease Characteristics:

  • Histologically confirmed ductal carcinoma in situ (DCIS)
    • Mixed DCIS and lobular carcinoma in situ (LCIS) allowed

  • HER2 receptor-positive as determined by central testing

  • Must have undergone resection by lumpectomy and meets the following criteria:
    • Margins of the resected specimen must be histologically free of DCIS (re-excision to obtain clear margins allowed)
    • No more than 120 days since the last surgery for excision of DCIS (lumpectomy or re-excision of lumpectomy margins)

  • None of the following allowed:
    • Patients who require mastectomy
    • Invasive (including microinvasion staged as T1mic) breast cancer (DCIS “suspicious” for microinvasion, but not confirmed, allowed)
    • Nodal staging of pN1 (including pN1mi) (axillary staging not required)
    • DCIS present in more than one quadrant (multicentric)
    • Masses or clusters of calcification that are clinically or mammographically suspicious unless biopsied and proven to be benign
    • Contralateral breast cancer (including DCIS)
    • History of breast cancer, including DCIS (history of LCIS allowed)

  • Hormone receptor status:
    • Estrogen receptor and/or progesterone receptor-positive or -negative

  • Must submit tumor block for correlative studies

Prior/Concurrent Therapy:

  • See Disease Characteristics
  • No prior whole or partial breast irradiation
  • No prior anthracycline chemotherapy for any malignancy
  • No investigational agents within the past 30 days
  • No other cancer therapy until the time of first cancer recurrence or second primary cancer

Patient Characteristics:

  • Pre- or postmenopausal
  • ECOG performance status 0-1
  • Life expectancy ≥ 10 years (excluding diagnosis of DCIS)
  • Not pregnant or nursing
  • Negative pregnancy test
  • Fertile patients must use effective non-hormonal contraception during and for 6 months after completion of treatment with trastuzumab (Herceptin®)
  • No psychiatric or addictive disorders or other conditions that, in the opinion of the investigator, would preclude the patient from meeting the study requirements
  • No cardiac disease that would preclude the use of study treatment drugs, including, but not limited to, any of the following:
    • Active cardiac disease
      • Angina pectoris that requires the use of anti-anginal medication
      • Ventricular arrhythmias except for benign premature ventricular contractions controlled by medication
      • Conduction abnormality requiring a pacemaker
      • Supraventricular and nodal arrhythmias requiring a pacemaker or not controlled with medication
      • Clinically significant valvular disease
    • History of cardiac disease
      • Myocardial infarction documented by elevated cardiac enzymes or persistent regional wall abnormalities on assessment of left ventricular function
      • Documented congestive heart failure
      • Documented cardiomyopathy
  • No uncontrolled hypertension (i.e., systolic BP > 180 mm Hg and/or diastolic BP > 100 mm Hg) (hypertension that is well controlled on medication allowed)
  • No other nonmalignant systemic disease that would preclude a patient from receiving trastuzumab or radiotherapy or would prevent prolonged follow-up
  • No other malignancies unless patient has been disease-free ≥ 5 years and at low risk for recurrence, except for treated carcinoma in situ of the cervix, carcinoma in situ of the colon, melanoma in situ, or basal cell or squamous cell carcinoma of the skin

Expected Enrollment

2000

Outcomes

Primary Outcome(s)

Time from randomization to ipsilateral invasive breast cancer, ipsilateral skin cancer recurrence, or ipsilateral ductal carcinoma in situ (DCIS)

Secondary Outcome(s)

Invasive or DCIS disease-free survival as assessed by time to local recurrence in the ipsilateral breast following lumpectomy, regional recurrence, distant recurrence, contralateral breast cancer, second primary cancer (other than squamous cell and basal cell carcinoma of the skin, melanoma in situ, and carcinoma in situ of the colon and cervix), or death from any cause prior to recurrence or second primary cancer
Time from randomization to first diagnosis of a local, regional or distant recurrence regardless of any intervening contralateral or other second primary cancer
Time from randomization to first diagnosis of regional or distant recurrence
Time from randomization to first diagnosis of contralateral invasive or DCIS breast cancer
Time from randomization to death from any cause
Incidence of post-treatment amenorrhea (absence of menstrual period for at least 12 months) at 18 months in women who were premenopausal at the time of study entry
Correlation of cMYC-amplification status with trastuzumab (Herceptin®) in addition to radiotherapy
Correlation of PI3 kinase gene mutation status with trastuzumab in addition to radiotherapy

Outline

Patients are stratified according to menopausal status (pre- vs post-), plan for hormonal therapy (yes vs no), and nuclear grade (low or intermediate vs high). Patients are randomized to 1 of 2 treatment arms.

  • Arm I: Patients undergo standard whole breast irradiation (WBI) over 5-6 weeks.

  • Arm II: Patients receive trastuzumab (Herceptin®) IV over 30-90 minutes once in weeks 1 and 4. Patients also undergo WBI as in arm I.

Tumor tissue samples are analyzed for mRNA and DNA copy numbers of HER2, cMYC, and other candidate predictive genes; PI3K gene mutation status; other candidate predictors of trastuzumab response; and candidate prognostic markers of ductal carcinoma in situ.

After completion of study therapy, patients are followed every 6 months for 5 years and then every 12 months for 5 years.

Trial Contact Information

Trial Lead Organizations

National Surgical Adjuvant Breast and Bowel Project

Melody Cobleigh, MD, Protocol chair
Ph: 312-942-2242
Douglas Arthur, MD, Protocol co-chair
Ph: 804-828-7232
Email: darthur@mcvh-vcu.edu

Trial Sites

U.S.A.
Alabama
  Mobile
 Providence Cancer Center at Providence Hospital
 Thaddeus Beeker
Ph: 251-633-1890
Alaska
  Anchorage
 Providence Cancer Center
 Clinical Trials Office - Providence Cancer Center
Ph: 907-261-3109
  Fairbanks
 Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital
 Jacqueline Vuky
Ph: 907-458-5380
800-678-5458
Arizona
  Phoenix
 Arizona Oncology Services Foundation
 David Brachman, MD, FACRO
Ph: 602-274-4484
  Scottsdale
 Arizona Breast Cancer Specialists
 Robert Kuske
Ph: 480-922-4600
 Premiere Oncology of Arizona
 Giraldo (Gerry) Kato
Ph: 480-860-5000
  Tucson
 Arizona Oncology - Tucson
 Vivek Kavadi
Ph: 520-797-4468
California
  Antioch
 Kaiser Permanente - Deer Valley
 Louis Fehrenbacher, MD
Ph: 707-651-2577
  Auburn
 Auburn Radiation Oncology
 Christopher Jones, MD
Ph: 916-646-6600
  Burbank
 Providence Saint Joseph Medical Center - Burbank
 Clinical Trials Office - Providence Saint Joseph Medical Center - Burbank
Ph: 818-847-3220
  Cameron Park
 Radiation Oncology Centers - Cameron Park
 Christopher Jones, MD
Ph: 916-646-6600
  Carmichael
 Mercy Cancer Center at Mercy San Juan Medical Center
 Christopher Jones, MD
Ph: 916-646-6600
  Castro Valley
 East Bay Radiation Oncology Center
 James Feusner, MD
Ph: 510-428-3689
 Eden Medical Center
 James Feusner, MD
Ph: 510-428-3689
 Valley Medical Oncology Consultants - Castro Valley
 James Feusner, MD
Ph: 510-428-3689
  Duarte
 City of Hope Comprehensive Cancer Center
 Clinical Trials Office - City of Hope Comprehensive Cancer Center
Ph: 800-826-4673
 Email: becomingapatient@coh.org
  Fairfield
 North Bay Cancer Center
 Clinical Trials Office - North Bay Cancer Center
Ph: 707-429-6976
  Fremont
 Kaiser Permanente - Fremont
 Louis Fehrenbacher, MD
Ph: 707-651-2577
 Valley Medical Oncology
 James Feusner, MD
Ph: 510-428-3689
  Fresno
 California Cancer Center - Woodward Park Office
 Brent Kane
Ph: 559-447-4050
 Cancer Care Associates
 Steven Hager, DO
Ph: 559-326-1222
  Glendale
 Glendale Memorial Hospital Comprehensive Cancer Center
 Clinical Trials Office - Glendale Memorial Hospital Comprehensive Cancer Center
Ph: 818-409-7653
  Hayward
 Kaiser Permanente Medical Center - Hayward
 Louis Fehrenbacher, MD
Ph: 707-651-2577
  La Jolla
 Rebecca and John Moores UCSD Cancer Center
 Clinical Trials Office - Rebecca and John Moores UCSD Cancer Center
Ph: 858-822-5354
 Email: cancercto@ucsd.edu
  Long Beach
 Breastlink Medical Group, Incorporated at Long Beach Memorial Medical Center
 Clinical Trials Office - Breastlink Medical Group, Incorporated
Ph: 562-981-6101
  Los Angeles
 Jonsson Comprehensive Cancer Center at UCLA
 Clinical Trials Office - Jonsson Comprehensive Cancer Center at UCLA
Ph: 888-798-0719
  Martinez
 Contra Costa Regional Medical Center
 James Feusner, MD
Ph: 510-428-3689
  Mountain View
 Camino Medical Group - Treatment Center
 Peter Yu, MD
Ph: 408-524-5814
 El Camino Hospital Cancer Center
 Clinical Trials Office - El Camino Hospital Cancer Center
Ph: 650-988-7623
  Oakland
 Alta Bates Summit Medical Center - Summit Campus
 Clinical Trials Office - Alta Bates Summit Medical Center - Summit Campus
Ph: 510-204-1414
 Bay Area Breast Surgeons, Incorporated
 James Feusner, MD
Ph: 510-428-3689
 CCOP - Bay Area Tumor Institute
 James Feusner, MD
Ph: 510-428-3689
 Highland General Hospital
 James Feusner, MD
Ph: 510-428-3689
 Kaiser Permanente Medical Center - Oakland
 Louis Fehrenbacher, MD
Ph: 707-651-2577
 Larry G Strieff MD Medical Corporation
 James Feusner, MD
Ph: 510-428-3689
 Tom K Lee, Incorporated
 James Feusner, MD
Ph: 510-428-3689
  Orange
 St. Joseph Hospital Regional Cancer Center - Orange
 Venita Williams
Ph: 714-771-8999
  Palo Alto
 Palo Alto Medical Foundation
 David Leibowitz
Ph: 650-321-4121
  Pleasanton
 Valley Care Medical Center
 James Feusner, MD
Ph: 510-428-3689
 Valley Medical Oncology Consultants - Pleasanton
 James Feusner, MD
Ph: 510-428-3689
  Redwood City
 Kaiser Permanente Medical Center - Redwood City
 Louis Fehrenbacher, MD
Ph: 707-651-2577
  Richmond
 Kaiser Permanente Medical Center - Richmond
 Louis Fehrenbacher, MD
Ph: 707-651-2577
  Roseville
 Kaiser Permanente Medical Center - Roseville
 Louis Fehrenbacher, MD
Ph: 707-651-2577
 Radiation Oncology Center - Roseville
 Christopher Jones, MD
Ph: 916-646-6600
  Sacramento
 Kaiser Permanente Medical Center - Sacramento
 Louis Fehrenbacher, MD
Ph: 707-651-2577
 Mercy General Hospital
 Christopher Jones, MD
Ph: 916-646-6600
 Radiological Associates of Sacramento Medical Group, Incorporated
 Christopher Jones, MD
Ph: 916-646-6600
 South Sacramento Kaiser-Permanente Medical Center
 Louis Fehrenbacher, MD
Ph: 707-651-2577
  Salinas
 Salinas Valley Memorial Hospital
 Shehzad Aziz, MD
Ph: 831-755-1701
  San Diego
 Kaiser Permanente Medical Office -Vandever Medical Office
 Jonathan Polikoff, MD
Ph: 619-528-5888
  San Francisco
 Kaiser Permanente Medical Center - San Francisco Geary Campus
 Louis Fehrenbacher, MD
Ph: 707-651-2577
  San Jose
 Kaiser Permanente Medical Center - Santa Teresa
 Louis Fehrenbacher, MD
Ph: 707-651-2577
  San Pablo
 Doctors Medical Center - San Pablo Campus
 James Feusner, MD
Ph: 510-428-3689
  San Rafael
 Kaiser Foundation Hospital - San Rafael
 Louis Fehrenbacher, MD
Ph: 707-651-2577
  Santa Clara
 Kaiser Permanente Medical Center - Santa Clara Kiely Campus
 Louis Fehrenbacher, MD
Ph: 707-651-2577
  Santa Rosa
 Kaiser Permanente Medical Center - Santa Rosa
 Louis Fehrenbacher, MD
Ph: 707-651-2577
  South San Francisco
 Kaiser Permanente Medical Center - South San Francisco
 Louis Fehrenbacher, MD
Ph: 707-651-2577
  Stanford
 Stanford Cancer Center
 Clinical Trials Office - Stanford Cancer Center
Ph: 650-498-7061
 Email: cctoffice@stanford.edu
  Stockton
 Kaiser Permanente Medical Facility - Stockton
 Louis Fehrenbacher, MD
Ph: 707-651-2577
  Vacaville
 Solano Radiation Oncology Center
 Christopher Jones, MD
Ph: 916-646-6600
  Vallejo
 Kaiser Permanente Medical Center - Vallejo
 Louis Fehrenbacher, MD
Ph: 707-651-2577
  Walnut Creek
 Kaiser Permanente Medical Center - Walnut Creek
 Louis Fehrenbacher, MD
Ph: 707-651-2577
Colorado
  Aurora
 Aurora Presbyterian Hospital
 Eduardo Pajon, MD
Ph: 303-399-8020ext2261
 Rocky Mountain Cancer Centers - Aurora
 Vivek Kavadi
Ph: 303-418-7600
 University of Colorado Cancer Center at UC Health Sciences Center
 Clinical Trials Office - University of Colorado Cancer Center
Ph: 720-848-0650
  Boulder
 Boulder Community Hospital
 Clinical Trials Office - Boulder Community Hospital
Ph: 303-938-5253
  Colorado Springs
 Memorial Hospital Cancer Center - Colorado Springs
 Clinical Trials Office - Memorial Hospital
Ph: 719-365-2406
 Penrose Cancer Center at Penrose Hospital
 Clinical Trials Office - Penrose Cancer Center
Ph: 719-776-5275
  Denver
 CCOP - Colorado Cancer Research Program
 Eduardo Pajon, MD
Ph: 303-399-8020ext2261
 Porter Adventist Hospital
 Eduardo Pajon, MD
Ph: 303-399-8020ext2261
 Presbyterian - St. Luke's Medical Center
 Clinical Trials Office - Presbyterian - St. Luke's Medical Center
Ph: 303-839-6000
 Rose Medical Center
 Eduardo Pajon, MD
Ph: 303-399-8020ext2261
 St. Anthony Central Hospital
 Eduardo Pajon, MD
Ph: 303-399-8020ext2261
 St. Joseph Hospital
 Eduardo Pajon, MD
Ph: 303-399-8020ext2261
  Englewood
 Swedish Medical Center
 Eduardo Pajon, MD
Ph: 303-399-8020ext2261
  Fort Collins
 Poudre Valley Radiation Oncology
 C. Kelley Simpson, MD
Ph: 970-482-3328
  Grand Junction
 St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
 Eduardo Pajon, MD
Ph: 303-399-8020ext2261
  Greeley
 North Colorado Medical Center
 Eduardo Pajon, MD
Ph: 303-399-8020ext2261
  Lone Tree
 Sky Ridge Medical Center
 Eduardo Pajon, MD
Ph: 303-399-8020ext2261
  Longmont
 Hope Cancer Care Center at Longmont United Hospital
 Eduardo Pajon, MD
Ph: 303-399-8020ext2261
  Loveland
 McKee Medical Center
 Eduardo Pajon, MD
Ph: 303-399-8020ext2261
  Pueblo
 St. Mary - Corwin Regional Medical Center
 Eduardo Pajon, MD
Ph: 303-399-8020ext2261
  Thornton
 North Suburban Medical Center
 Eduardo Pajon, MD
Ph: 303-399-8020ext2261
  Wheat Ridge
 Exempla Lutheran Medical Center
 Clinical Trials Office - Exempla Lutheran Medical Center
Ph: 303-403-3605
Connecticut
  Danbury
 Praxair Cancer Center at Danbury Hospital
 Robert Kloss, MD
Ph: 203-797-7029
  Hartford
 Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center
 Philip Stella, MD
Ph: 734-712-1000
  Norwich
 Eastern Connecticut Hematology and Oncology Associates
 Dennis Slater, MD
Ph: 860-886-8362
  Stamford
 Carl and Dorothy Bennett Cancer Center at Stamford Hospital
 Clinical Trials Office - Carl and Dorothy Bennett Cancer Center
Ph: 203-323-8944
Delaware
  Lewes
 Tunnell Cancer Center at Beebe Medical Center
 Clinical Trials Office - Tunnell Cancer Center
Ph: 302-645-3171
  Newark
 CCOP - Christiana Care Health Services
 Clinical Trial Office - CCOP - Christiana Care Health Services
Ph: 302-733-6227
District of Columbia
  Washington
 Washington Cancer Institute at Washington Hospital Center
 Clinical Trials Office - Washington Cancer Institute
Ph: 202-877-8839
Florida
  Jacksonville
 Baptist Cancer Institute - Jacksonville
 Clinical Trials Office - Baptist Cancer Institute - Jacksonville
Ph: 904-202-7051
  Lakeland
 Center for Cancer Care and Research at Watson Clinic, LLP
 Clinical Trials Office - Center for Cancer Care and Research
Ph: 863-680-7780
  Orlando
 Florida Hospital Cancer Institute at Florida Hospital Orlando
 Clinical Trials Office - Florida Hospital Cancer Institute
Ph: 407-303-5623
 Florida Institute of Research, Medicine and Surgery Cancer Center
 Vivek Kavadi
Ph: 407-426-8484
 M.D. Anderson Cancer Center at Orlando
 Nikita Shah
Ph: 321-841-1075
  Sarasota
 Florida Cancer Specialists - Sarasota Downtown
 Clinical Trials Office - Florida Cancer Specialists - Sarasota Downtown
Ph: 941-957-1000 ext. 213
  Stuart
 Robert and Carol Weissman Cancer Center at Martin Memorial
 James Vopal, MD
Ph: 772-220-4050
 James Vopal, MD
Ph: 772-220-4050
Georgia
  Albany
 Phoebe Cancer Center at Phoebe Putney Memorial Hospital
 Clinical Trials Office - Phoebe Cancer Center
Ph: 229-312-2251
  Atlanta
 CCOP - Atlanta Regional
 Thomas Seay, MD, PhD
Ph: 404-851-2340
 Northside Hospital Cancer Center
 Clinical Trials Office - Northside Hospital Cancer Center
Ph: 404-303-3355
 Piedmont Hospital
 Thomas Seay, MD, PhD
Ph: 404-851-2340
 Saint Joseph's Hospital of Atlanta
 Clinical Trials Office - Saint Joseph's Hospital of Atlanta
Ph: 404-851-7115
  Austell
 WellStar Cobb Hospital
 Clinical Trials Office - WellStar Cobb Hospital
Ph: 770-793-5980
  Columbus
 John B. Amos Cancer Center
 Clinical Trials Office - John B. Amos Cancer Center
Ph: 706-660-6404
  Decatur
 Charles B. Eberhart Cancer Center at DeKalb Medical Center
 Thomas Seay, MD, PhD
Ph: 404-851-2340
  Gainesville
 Northeast Georgia Medical Center
 Richard LoCicero, MD
Ph: 770-297-5700
  Lawrenceville
 Gwinnett Medical Center
 Thomas Seay, MD, PhD
Ph: 404-851-2340
  Macon
 Medical Center of Central Georgia
 Frederick Schnell, MD, FACP
Ph: 478-743-7068
  Marietta
 Kennestone Cancer Center at Wellstar Kennestone Hospital
 Clinical Trials Office - Kennestone Cancer Center
Ph: 770-793-5980
  Riverdale
 Southern Regional Medical Center
 Clinical Trials Office - Southern Regional Medical Center
Ph: 770-991-8611
  Rome
 Harbin Clinic Cancer Center - Medical Oncology
 Thomas Seay, MD, PhD
Ph: 404-851-2340
  Savannah
 Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center
 Clinical Trials Office - Curtis and Elizabeth Anderson Cancer Institute
Ph: 912-350-8568
 Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler
 Mark Taylor, MD
Ph: 912-354-6187
Hawaii
  Aiea
 Kapiolani Medical Center at Pali Momi
 Robert Oishi, MD
Ph: 808-536-5811
  Honolulu
 Cancer Research Center of Hawaii
 Clinical Trials Office - Cancer Research Center of Hawaii
Ph: 808-586-2979
 Queen's Cancer Institute at Queen's Medical Center
 Robert Oishi, MD
Ph: 808-536-5811
 Straub Clinic and Hospital, Incorporated
 Robert Oishi, MD
Ph: 808-536-5811
  Wailuku
 Maui Memorial Medical Center
 Robert Oishi, MD
Ph: 808-536-5811
Idaho
  Boise
 Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
 Clinical Trials Office - Saint Alphonsus Cancer Care Center
Ph: 208-367-7954
  Coeur d'Alene
 Kootenai Cancer Center - Coeur d'Alene
 Clinical Trials Office - North Idaho Cancer Center
Ph: 208-666-3764
Illinois
  Alton
 Saint Anthony's Hospital at Saint Anthony's Health Center
 Bethany Sleckman, MD
Ph: 314-251-7057
  Bloomington
 St. Joseph Medical Center
 John Kugler, MD
Ph: 309-243-3605
  Canton
 Graham Hospital
 John Kugler, MD
Ph: 309-243-3605
  Carthage
 Memorial Hospital
 John Kugler, MD
Ph: 309-243-3605
  Chicago
 Creticos Cancer Center at Advocate Illinois Masonic Medical Center
 Clinical Trials Office - Creticos Cancer Center at Advocate Illinois Masonic Medical Center
Ph: 773-296-5360
 John H. Stroger, Jr. Hospital of Cook County
 Thomas Lad, MD
Ph: 312-864-3200
 Resurrection Medical Center
 Christopher Rose, MD
Ph: 847-965-3200
 Rush University Medical Center
 Clinical Trials Office - Rush University Medical Center
Ph: 312-942-5498
 Email: clinical_trials@rush.edu
  Decatur
 Decatur Memorial Hospital Cancer Care Institute
 Clinical Trials Office - Decatur Memorial Hospital Cancer Care Institute
Ph: 217-876-6601
  Elk Grove Village
 Alexian Brothers Radiation Oncology
 Paul Sowray, MD
Ph: 847-437-3312
  Elmhurst
 Elmhurst Memorial Hospital
 Robert Eisner
Ph: 630-833-1400
  Eureka
 Eureka Community Hospital
 John Kugler, MD
Ph: 309-243-3605
  Galesburg
 Galesburg Clinic, PC
 John Kugler, MD
Ph: 309-243-3605
 Galesburg Cottage Hospital
 John Kugler, MD
Ph: 309-243-3605
 InterCommunity Cancer Center of Western Illinois
 John Kugler, MD
Ph: 309-243-3605
  Geneva
 Delnor Community Hospital - Geneva
 Robert Bayer, MD
Ph: 630-232-0610
 La Grange Oncology Associates - Geneva
 Robert Bayer, MD
Ph: 630-232-0610
  Harvey
 Ingalls Cancer Care Center at Ingalls Memorial Hospital
 Clinical Trials Office - Ingalls Cancer Care Center at Ingalls Memorial Hospital
Ph: 708-915-6747
  Havana
 Mason District Hospital
 John Kugler, MD
Ph: 309-243-3605
  Macomb
 McDonough District Hospital
 John Kugler, MD
Ph: 309-243-3605
  Moline
 Trinity Cancer Center at Trinity Medical Center - 7th Street Campus
 Costas Constantinou, MD
Ph: 563-359-9876
  Mt. Vernon
 Good Samaritan Regional Health Center
 Bethany Sleckman, MD
Ph: 314-251-7057
  Naperville
 Edward Hospital Cancer Center
 Clinical Trials Office - Edward Hospital Cancer Center
Ph: 630-646-6075
  Normal
 BroMenn Regional Medical Center
 John Kugler, MD
Ph: 309-243-3605
 Community Cancer Center
 John Kugler, MD
Ph: 309-243-3605
  Oak Lawn
 Advocate Christ Medical Center
 James Weese
Ph: 708-684-8000
  Ottawa
 Community Hospital of Ottawa
 John Kugler, MD
Ph: 309-243-3605
  Pekin
 Cancer Treatment Center at Pekin Hospital
 John Kugler, MD
Ph: 309-243-3605
  Peoria
 CCOP - Illinois Oncology Research Association
 John Kugler, MD
Ph: 309-243-3605
 Methodist Medical Center of Illinois
 Clinical Trials Office - Methodist Medical Center of Illinois
Ph: 309-243-3000
 Oncology Hematology Associates of Central Illinois, PC - Peoria
 John Kugler, MD
Ph: 309-243-3605
 OSF St. Francis Medical Center
 John Kugler, MD
Ph: 309-243-3605
 John Kugler, MD
Ph: 309-243-3605
 Proctor Hospital
 John Kugler, MD
Ph: 309-243-3605
  Peru
 Illinois Valley Community Hospital
 John Kugler, MD
Ph: 309-243-3605
  Princeton
 Perry Memorial Hospital
 John Kugler, MD
Ph: 309-243-3605
  Spring Valley
 St. Margaret's Hospital
 John Kugler, MD
Ph: 309-243-3605
 Valley Cancer Center
 John Kugler, MD
Ph: 309-243-3605
  Springfield
 Regional Cancer Center at Memorial Medical Center
 Clinical Trials Office - Regional Cancer Center at Memorial Medical Center
Ph: 217-788-4233
Indiana
  Beech Grove
 St. Francis Hospital and Health Centers - Beech Grove Campus
 Howard Gross, MD
Ph: 937-832-1093
  Bloomington
 Bloomington Hospital Regional Cancer Institute
 David Lee, MD
Ph: 812-353-2800
  Elkhart
 Elkhart General Hospital
 Naftali Bechar
Ph: 574-294-2621
  Fort Wayne
 Parkview Regional Cancer Center at Parkview Health
 Tony Lee
Ph: 260-373-7850
 Radiation Oncology Associates Southwest
 Tony Lee
Ph: 260-373-7850
  Indianapolis
 Central Indiana Cancer Centers - East
 Vivek Kavadi
Ph: 317-964-5200
 Methodist Cancer Center at Methodist Hospital
 Alexander Yeh, MD
Ph: 317-962-3172
 St. Vincent Indianapolis Hospital
 Clinical Trials Office - St. Vincent Indianapolis Hospital
Ph: 317-338-2194
  Kokomo
 Howard Community Hospital
 Naftali Bechar
Ph: 765-453-8571
  La Porte
 Center for Cancer Therapy at LaPorte Hospital and Health Services
 Naftali Bechar
Ph: 219-326-2683
  Munster
 Community Hospital
 Erwin Robin, MD
Ph: 219-836-2860
  Richmond
 Reid Hospital & Health Care Services
 Howard Gross, MD
Ph: 937-832-1093
  South Bend
 CCOP - Northern Indiana CR Consortium
 Naftali Bechar
Ph: 574-647-7370
800-284-7370
 Memorial Hospital of South Bend
 Clinical Trials Office - Memorial Hospital of South Bend
Ph: 800-284-7370
Iowa
  Ames
 McFarland Clinic, PC
 Clinical Trials Office - McFarland Clinic, PC
Ph: 515-239-2621
  Bettendorf
 Hematology Oncology Associates of the Quad Cities
 Shobha Chitneni, MD, MBBS
Ph: 563-355-7733
  Cedar Rapids
 Cedar Rapids Oncology Associates
 Clinical Trials Office - Cedar Rapids Oncology Associates
Ph: 319-363-2690
 Iowa Blood and Cancer Care
 David Zenk, MD
Ph: 319-369-7091
 Mercy Regional Cancer Center at Mercy Medical Center
 David Zenk, MD
Ph: 319-369-7091
 St. Luke's Hospital
 David Zenk, MD
Ph: 319-369-7091
  Clive
 Medical Oncology and Hematology Associates - West Des Moines
 Robert Behrens
Ph: 515-875-9713
  Davenport
 Genesis Regional Cancer Center at Genesis Medical Center
 George Kovach, MD
Ph: 563-421-1960
  Des Moines
 CCOP - Iowa Oncology Research Association
 Robert Behrens
Ph: 515-244-7586
888-244-6061
 John Stoddard Cancer Center at Iowa Lutheran Hospital
 Clinical Trials Office - John Stoddard Cancer Center at Iowa Lutheran Hospital
Ph: 515-241-8704
 John Stoddard Cancer Center at Iowa Methodist Medical Center
 Clinical Trials Office - John Stoddard Cancer Center at Iowa Methodist Medical Center
Ph: 515-241-6727
 Medical Oncology and Hematology Associates at John Stoddard Cancer Center
 Robert Behrens
Ph: 515-282-2921
 Medical Oncology and Hematology Associates at Mercy Cancer Center
 Robert Behrens
Ph: 515-643-8740
 Mercy Cancer Center at Mercy Medical Center - Des Moines
 Robert Behrens
Ph: 515-643-8206
888-221-4849
 Mercy Capitol Hospital
 Robert Behrens
Ph: 515-643-1000
  Iowa City
 Holden Comprehensive Cancer Center at University of Iowa
 Cancer Information Service
Ph: 800-237-1225
  Mason City
 Mercy Cancer Center at Mercy Medical Center - North Iowa
 Clinical Trials Office - Mercy Cancer Center at Mercy Medical Center - North Iowa
Ph: 641-422-6304
  Ottumwa
 McCreery Cancer Center at Ottumwa Regional
 Robert Behrens
Ph: 641-684-2946
  Sioux City
 Mercy Medical Center - Sioux City
 Donald Wender, MD, PhD
Ph: 712-252-0088
 Siouxland Hematology-Oncology Associates, LLP
 Donald Wender, MD, PhD
Ph: 712-252-0088
 St. Luke's Regional Medical Center
 Donald Wender, MD, PhD
Ph: 712-252-0088
  Waterloo
 Covenant Cancer Treatment Center
 Clinical Trials Office - Covenant Cancer Treatment Center
Ph: 319-272-2070
Kansas
  Dodge City
 Cancer Center of Kansas, PA - Dodge City
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
  El Dorado
 Cancer Center of Kansas, PA - El Dorado
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
  Lawrence
 Lawrence Memorial Hospital
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
  Liberal
 Southwest Medical Center
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
  Overland Park
 Kansas City Cancer Centers - Southwest
 Vivek Kavadi
Ph: 913-234-0400
  Topeka
 Cotton-O'Neil Cancer Center
 Clinical Trials Office - Cotton-O'Neil Cancer Center
Ph: 785-270-4963
  Wellington
 Cancer Center of Kansas, PA - Wellington
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
  Wichita
 Associates in Womens Health, PA - North Review
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
 CCOP - Wichita
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
 Via Christi Cancer Center at Via Christi Regional Medical Center
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
 Wesley Medical Center
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
  Winfield
 Cancer Center of Kansas, PA - Winfield
 Shaker Dakhil, MD, FACP
Ph: 316-262-4467
Kentucky
  Lexington
 Central Baptist Hospital
 Clinical Trials Office - Central Baptist Hospital
Ph: 859-260-6425
 Lucille P. Markey Cancer Center at University of Kentucky
 Clinical Trials Office - Markey Cancer Center at University of Kentucky Chandler Medical Center
Ph: 859-257-3379
Louisiana
  Baton Rouge
 Mary Bird Perkins Cancer Center - Baton Rouge
 Robert Veith
Ph: 225-767-0847
 Pennington Cancer Center at Baton Rouge General
 Clinical Trials Office - Pennington Cancer Center at Baton Rouge General
Ph: 225-381-6451
  New Orleans
 MBCCOP - LSU Health Sciences Center
 Robert Veith
Ph: 504-568-5151
 Medical Center of Louisiana - New Orleans
 Robert Veith
Ph: 504-903-2311
Maine
  Bangor
 CancerCare of Maine at Eastern Maine Medical Center
 Clinical Trials Office - CancerCare of Maine
Ph: 207-973-4274
  York
 York Hospital's Oncology Treatment Center
 Jonathan Eneman
Ph: 207-351-3777
Maryland
  Baltimore
 Greater Baltimore Medical Center Cancer Center
 Clinical Trials Office - Greater Baltimore Medical Center Cancer Center
Ph: 443-849-3706
 Harry & Jeanette Weinberg Cancer Institute at Franklin Square Hospital Center
 Clinical Trials Office - Harry & Jeanette Weinberg Cancer Institute at Franklin Square Hospital Center
Ph: 443-777-7364
 Mercy Medical Center
 David Riseberg, MD
Ph: 410-783-5858
 St. Agnes Hospital Cancer Center
 Diana Griffiths
Ph: 410-368-2910
  Elkton MD
 Union Hospital Cancer Program at Union Hospital
 David Biggs, MD
Ph: 302-366-1200
  Salisbury
 Peninsula Regional Medical Center
 Clinical Trials Office - Peninsula Regional Medical Center
Ph: 410-543-7000
Massachusetts
  Boston
 Boston University Cancer Research Center
 Clinical Trials Office - Boston University Cancer Research Center
Ph: 617-638-8265
  Burlington
 Lahey Clinic Medical Center - Burlington
 Clinical Trials Office - Lahey Clinic Medical Center - Burlington
Ph: 781-744-8027
  Concord
 Commonwealth Hematology-Oncology, PC - Concord
 Susan Sajer, MD
Ph: 978-287-3436
  Fall River
 Hudner Oncology Center at Saint Anne's Hospital - Fall River
 Clinical Trials Office - Hudner Oncology Center at Saint Anne's Hospital - Fall River
Ph: 508-674-5600 ext. 2019
  Gloucester
 Addison Gilbert Hospital
 Angus McIntyre, MD
Ph: 978-927-6850
  Pittsfield
 Berkshire Hematology Oncology, PC
 Harvey Zimbler, MD
Ph: 413-496-8205
  Quincy
 Commonwealth Hematology-Oncology, PC - Quincy
 Susan Sajer, MD
Ph: 978-287-3436
  Weymouth
 Commonwealth Hematology-Oncology, PC - Weymouth
 Susan Sajer, MD
Ph: 978-287-3436
Michigan
  Adrian
 Hickman Cancer Center at Bixby Medical Center
 Clinical Trials Office - Hickman Cancer Center at Bixby Medical Center
Ph: 517-265-0116
  Ann Arbor
 CCOP - Michigan Cancer Research Consortium
 Philip Stella, MD
Ph: 734-712-1000
 Saint Joseph Mercy Cancer Center
 Philip Stella, MD
Ph: 734-712-1000
  Battle Creek
 Battle Creek Health System Cancer Care Center
 Martin Bury
Ph: 616-966-8000
  Big Rapids
 Mecosta County Medical Center
 Martin Bury
Ph: 231-796-8691
  Dearborn
 Oakwood Cancer Center at Oakwood Hospital and Medical Center
 Clinical Trials Office - Oakwood Cancer Center at Oakwood Hospital and Medical Center
Ph: 313-593-8090
  Detroit
 Barbara Ann Karmanos Cancer Institute
 Clinical Trials Office - Barbara Ann Karmanos Cancer Institute
Ph: 313-576-9363
 Josephine Ford Cancer Center at Henry Ford Hospital
 Thomas Doyle, MD
Ph: 313-916-1502
  Escanaba
 Green Bay Oncology, Limited - Escanaba
 Pamela Vanderwall, MD
Ph: 414-433-8184
  Flint
 Genesys Hurley Cancer Institute
 Clinical Trials Office - Genesys Hurley Cancer Institute
Ph: 810-762-8057
 Hurley Medical Center
 Clinical Trials Office - Hurley Medical Center
Ph: 810-762-8057
  Grand Rapids
 Butterworth Hospital at Spectrum Health
 Martin Bury
Ph: 616-391-2799
 CCOP - Grand Rapids
 Martin Bury
Ph: 616-391-1230
 Lacks Cancer Center at Saint Mary's Health Care
 Martin Bury
Ph: 616-752-5222
  Grosse Pointe Woods
 Van Elslander Cancer Center at St. John Hospital and Medical Center
 Clincial Trials Office - Van Elslander Cancer Center at St. John Hospital and Medical Center
Ph: 313-343-3166
  Iron Mountain
 Dickinson County Healthcare System
 Pamela Vanderwall, MD
Ph: 414-433-8184
  Jackson
 Foote Memorial Hospital
 Philip Stella, MD
Ph: 734-712-1000
  Kalamazoo
 Borgess Medical Center
 Raymond Lord, MD
Ph: 269-373-7458
 Bronson Methodist Hospital
 Raymond Lord, MD
Ph: 269-373-7458
 West Michigan Cancer Center
 Clinical Trials Office - West Michigan Cancer Center
Ph: 269-373-7458
  Lambertville
 Haematology-Oncology Associates of Ohio and Michigan, PC
 Paul Schaefer, MD
Ph: 419-479-5605
  Lansing
 Sparrow Regional Cancer Center
 Clinical Trials Office - Sparrow Regional Cancer Center
Ph: 517-364-2890
  Livonia
 St. Mary Mercy Hospital
 Philip Stella, MD
Ph: 734-712-1000
  Marquette
 Upper Michigan Cancer Center at Marquette General Hospital
 Clinical Trials Office - Upper Michigan Cancer Center at Marquette General Hospital
Ph: 906-225-3467
  Monroe
 Mercy Memorial Hospital - Monroe
 Paul Schaefer, MD
Ph: 419-479-5605
  Mount Clemens
 Clemens Regional Medical Center
 Clinical Trials Office - Ted B. Wahby Cancer Center at Mount Clemens General Hospital
Ph: 586-493-3426
  Muskegon
 Mercy General Health Partners
 Martin Bury
Ph: 231-672-2000
  Pontiac
 St. Joseph Mercy Oakland
 Philip Stella, MD
Ph: 734-712-1000
  Port Huron
 Mercy Regional Cancer Center at Mercy Hospital
 Philip Stella, MD
Ph: 734-712-1000
  Royal Oak
 William Beaumont Hospital - Royal Oak Campus
 Clinical Trials Office - William Beaumont Hospital - Royal Oak Campus
Ph: 248-551-7695
  Saginaw
 Seton Cancer Institute at Saint Mary's - Saginaw
 Clinical Trials Office - Seton Cancer Institute - Saginaw
Ph: 989-776-8411
  Southfield
 Providence Cancer Institute at Providence Hospital - Southfield Campus
 Anibal Drelichman, MD, MPH, FACP
Ph: 313-552-0620
  St. Joseph
 Lakeland Regional Cancer Care Center - St. Joseph
 Naftali Bechar
Ph: 269-983-8698
800-303-8399
  Traverse City
 Munson Medical Center
 Martin Bury
Ph: 231-935-6202
  Warren
 St. John Macomb Hospital
 Philip Stella, MD
Ph: 734-712-1000
  Wyoming
 Metro Health Hospital
 Martin Bury
Ph: 616-252-7200
Minnesota
  Bemidji
 MeritCare Bemidji
 Preston Steen, MD
Ph: 701-234-2397
  Burnsville
 Fairview Ridges Hospital
 Patrick Flynn, MD
Ph: 612-863-8585
  Coon Rapids
 Mercy and Unity Cancer Center at Mercy Hospital
 Patrick Flynn, MD
Ph: 612-863-8585
  Duluth
 CCOP - Duluth
 Daniel Nikcevich, MD, PhD
Ph: 218-786-3625
 Duluth Clinic Cancer Center - Duluth
 Clinical Trials Office - Duluth Clinic Cancer Center - Duluth
Ph: 218-786-3308
 Miller - Dwan Medical Center
 Daniel Nikcevich, MD, PhD
Ph: 218-786-3625
 St. Luke's Hospital Cancer Care Center
 Tanya Repka, MD, FACP
Ph: 218-726-3081
  Edina
 Fairview Southdale Hospital
 Clinical Trials Office - Fairview Southdale Hospital
Ph: 612-625-3650
  Fridley
 Mercy and Unity Cancer Center at Unity Hospital
 Patrick Flynn, MD
Ph: 612-863-8585
  Hutchinson
 Hutchinson Area Health Care
 Daniel Anderson
Ph: 320-234-5000
800-454-3903
  Maplewood
 HealthEast Cancer Care at St. John's Hospital
 Daniel Anderson
Ph: 651-232-7970
 Minnesota Oncology Hematology, PA - Maplewood
 Patrick Flynn, MD
Ph: 612-863-8585
  Minneapolis
 Hennepin County Medical Center - Minneapolis
 Clinical Trials Office - Hennepin County Medical Center - Minneapolis
Ph: 612-873-5911
 Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
 Clinical Trials Office - Virginia Piper Cancer Institute
Ph: 612-863-5654
  Robbinsdale
 Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center
 Clinical Trials Office - Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center
Ph: 763-520-1893
  Saint Louis Park
 CCOP - Metro-Minnesota
 Patrick Flynn, MD
Ph: 612-863-8585
 Park Nicollet Cancer Center
 Patrick Flynn, MD
Ph: 612-863-8585
  Saint Paul
 United Hospital
 Patrick Flynn, MD
Ph: 612-863-8585
  Shakopee
 St. Francis Cancer Center at St. Francis Medical Center
 Patrick Flynn, MD
Ph: 612-863-8585
  St. Paul
 Regions Hospital Cancer Care Center
 Clinical Trials Office - Regions Hospital Cancer Care Center
Ph: 651-254-1517
  Waconia
 Ridgeview Medical Center
 Patrick Flynn, MD
Ph: 612-863-8585
  Woodbury
 Minnesota Oncology Hematology, PA - Woodbury
 Patrick Flynn, MD
Ph: 612-863-8585
Mississippi
  Pascagoula
 Regional Cancer Center at Singing River Hospital
 James Clarkson, MD
Ph: 228-374-6296
Missouri
  Cape Girardeau
 Saint Francis Medical Center
 Bethany Sleckman, MD
Ph: 314-251-7057
  Columbia
 Ellis Fischel Cancer Center at University of Missouri - Columbia
 Clinical Trial Office - Ellis Fischel Cancer Center
Ph: 573-882-7440
  Joplin
 St. John's Regional Medical Center
 Clinical Trials Office - St. John's Regional Medical Center
Ph: 417-625-2488 ext. 2949
  Kansas City
 Kansas City Cancer Centers - North
 Vivek Kavadi
Ph: 816-746-4570
 Kansas City Cancer Centers - South
 Vivek Kavadi
Ph: 816-333-1326
  Saint Louis
 Arch Medical Services, Incorporated at Center for Cancer Care and Research
 Alan Lyss, MD
Ph: 314-996-5514
 CCOP - St. Louis-Cape Girardeau
 Bethany Sleckman, MD
Ph: 314-251-7057
 David C. Pratt Cancer Center at St. John's Mercy
 Clinical Trials Office - David C. Pratt Cancer Center at St. John's Mercy
Ph: 314-251-6770
 Midwest Hematology Oncology Group, Incorporated
 Bethany Sleckman, MD
Ph: 314-251-7057
 Missouri Baptist Cancer Center
 Alan Lyss, MD
Ph: 314-996-5514
 Saint Louis University Cancer Center
 Clinical Trials Office - Saint Louis University Cancer Center
Ph: 314-977-4440
  Springfield
 CCOP - Cancer Research for the Ozarks
 Robert Carolla
Ph: 417-269-4520
 Hulston Cancer Center at Cox Medical Center South
 Robert Carolla
Ph: 417-269-5257
 St. John's Regional Health Center
 Robert Carolla
Ph: 417-820-2000
Montana
  Billings
 Billings Clinic - Downtown
 Clinical Trials Office - Billings Clinic - Downtown
Ph: 800-996-2663
 Email: research@billingsclinic.org
 CCOP - Montana Cancer Consortium
 Benjamin Marchello, MD
Ph: 406-238-6290
 Hematology-Oncology Centers of the Northern Rockies - Billings
 Benjamin Marchello, MD
Ph: 406-238-6290
 Northern Rockies Radiation Oncology Center
 Benjamin Marchello, MD
Ph: 406-238-6290
 St. Vincent Healthcare Cancer Care Services
 Benjamin Marchello, MD
Ph: 406-238-6290
  Bozeman
 Bozeman Deaconess Cancer Center
 Benjamin Marchello, MD
Ph: 406-238-6290
  Butte
 St. James Healthcare Cancer Care
 Benjamin Marchello, MD
Ph: 406-238-6290
  Great Falls
 Benjamin Marchello, MD
Ph: 406-238-6290
 Big Sky Oncology
 Clinical Trail Office - Big Sky Oncology
Ph: 406-731-8217
 Great Falls Clinic - Main Facility
 Benjamin Marchello, MD
Ph: 406-238-6290
 Sletten Cancer Institute at Benefis Healthcare
 Grant Harrer, MD, FACP, CCTI
Ph: 406-731-8100
  Helena
 St. Peter's Hospital
 Benjamin Marchello, MD
Ph: 406-238-6290
  Kalispell
 Glacier Oncology, PLLC
 Benjamin Marchello, MD
Ph: 406-238-6290
 Kalispell Medical Oncology at KRMC
 Benjamin Marchello, MD
Ph: 406-238-6290
  Missoula
 Guardian Oncology and Center for Wellness
 Benjamin Marchello, MD
Ph: 406-238-6290
 Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
 Clinical Trials Office - Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
Ph: 406-329-7029
 Montana Cancer Specialists at Montana Cancer Center
 Clinical Trials Office - Montana Cancer Specialists at Montana Cancer Center
Ph: 406-238-6962
Nebraska
  Kearney
 Good Samaritan Cancer Center at Good Samaritan Hospital
 Clinical Trials Office - Good Samaritan Cancer Center at Good Samaritan Hospital
Ph: 308-865-7963
  Lincoln
 Cancer Resource Center - Lincoln
 Alan Berg, MD
Ph: 402-420-7000
  Omaha
 Alegant Health Cancer Center at Bergan Mercy Medical Center
 Clinical Trials Office - Alegant Health Cancer Center at Bergen Mercy Medical Center
Ph: 402-398-6060
 CCOP - Missouri Valley Cancer Consortium
 Gamini Soori, MD, FACP, FRCP, MBA
Ph: 402-393-3110
 Creighton University Medical Center
 Clinical Trials Office - Creighton University Medical Center
Ph: 402-280-4100
 Immanuel Medical Center
 Gamini Soori, MD, FACP, FRCP, MBA
Ph: 402-393-3110
 Methodist Estabrook Cancer Center
 James Reilly, MD
Ph: 402-354-8163
Nevada
  Reno
 Renown Institute for Cancer at Renown Regional Medical Center
 Steven Schiff, MD
Ph: 775-329-0873
New Hampshire
  Dover
 Seacoast Cancer Center at Wentworth - Douglass Hospital
 Barbara Shea, MD
Ph: 603-740-2390
  Keene
 Kingsbury Center for Cancer Care at Cheshire Medical Center
 Steven Larmon
Ph: 603-354-5400
New Jersey
  Freehold
 CentraState Medical Center
 Henry Tsai
Ph: 732-431-2000
  Hamilton
 Cancer Institute of New Jersey at Hamilton
 Clinical Trials Office - Cancer Institute of New Jersey at Hamilton
Ph: 609-631-6946
  Marlton
 Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton
 Clinical Trials Office - Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton
Ph: 888-847-8823
  Morristown
 Carol G. Simon Cancer Center at Morristown Memorial Hospital
 Bonni Guerin
Ph: 973-971-6100
800-247-9580
  New Brunswick
 Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School
 Clinical Trials Office - Cancer Institute of New Jersey
Ph: 732-235-8675
 Saint Peter's University Hospital
 George Karp
Ph: 732-745-8600
  Newark
 Newark Beth Israel Medical Center
 Clinical Trials Office - Newark Beth Israel Medical Center
Ph: 973-926-3136
  Sparta
 Frederick R. and Betty M. Smith Cancer Treatment Center
 Rebecca Jaslow
Ph: 973-726-4180
  Summit
 Overlook Hospital
 Bonni Guerin
Ph: 908-522-2000
  Vineland
 Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare
 Clinical Trials Office - Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare
Ph: 856-641-7933
  Voorhees
 Cancer Institute of New Jersey at Cooper - Voorhees
 Clinical Trials Office - Cancer Institute of New Jersey at Cooper University Hospital - Voorhees
Ph: 856-325-6757
New Mexico
  Albuquerque
 Hematology Oncology Associates, PC
 Melanie Royce, MD, PhD
Ph: 505-272-6057
 University of New Mexico Cancer Center
 Clinical Trials Office - University of New Mexico Cancer Center
Ph: 505-272-6972
  Las Cruces
 University of New Mexico Cancer Center - South
 Melanie Royce, MD, PhD
Ph: 505-272-6057
New York
  Albany
 New York Oncology Hematology, PC at Albany Medical Center
 Regina Resta
Ph: 518-262-6696
 New York Oncology Hematology, PC at Albany Regional Cancer Care
 Regina Resta
Ph: 518-489-2607
  Amsterdam
 Amsterdam Community Cancer Program
 Regina Resta
Ph: 518-843-0020
  Buffalo
 Roswell Park Cancer Institute
 Clinical Trials Office - Roswell Park Cancer Institute
Ph: 877-275-7724
  East Syracuse
 CCOP - Hematology-Oncology Associates of Central New York
 Jeffrey Kirshner, MD
Ph: 315-472-7504
  Hudson
 New York Oncology Hematology, PC - Hudson
 Regina Resta
Ph: 518-822-8484
  Latham
 New York Oncology Hematology, PC - Latham
 Regina Resta
Ph: 518-786-3122
  Manhasset
 CCOP - North Shore University Hospital
 Lora Weiselberg, MD
Ph: 516-562-8963
 Don Monti Comprehensive Cancer Center at North Shore University Hospital
 Clinical Trials Office - Don Monti Comprehensive Cancer Center at North Shore University Hospital
Ph: 516-734-8900
  Middletown
 Tucker Center for Cancer Care at Orange Regional Medical Center
 Clinical Trials Office - Tucker Center for Cancer Care at Orange Regional Medical Center
Ph: 845-342-7609
  Mineola
 Winthrop University Hospital
 Harry Staszewski, MD
Ph: 516-663-9500
  New Hyde Park
 Long Island Jewish Medical Center
 Lora Weiselberg, MD
Ph: 516-562-8963
  Poughkeepsie
 Dyson Center for Cancer Care at Vassar Brothers Medical Center
 Clinical Trials Office - Dyson Center for Cancer Care at Vassar Brothers Medical Center
Ph: 845-483-6483
 Saint Francis Hospital Cancer Center
 Theodora Budnik, MD, FACS
Ph: 845-473-1112
  Rexford
 Riverview Cancer Care Medical Associates, PC
 Regina Resta
Ph: 518-399-4600
  Staten Island
 Nalitt Cancer Institute at Staten Island University Hospital
 Terenig Terjanian, MD
Ph: 718-226-6400
  Troy
 Samaritan Hospital at Northeast Health
 Regina Resta
Ph: 518-271-3775
North Carolina
  Asheboro
 Randolph Hospital
 Clinical Trails Office - Randolph Hospital
Ph: 336-832-0821
  Asheville
 Mission Hospitals - Memorial Campus
 Clinical Trials Office - Mission Hospitals - Memorial Campus
Ph: 828-213-4150
  Charlotte
 Blumenthal Cancer Center at Carolinas Medical Center
 Clinical Trials Office - Blumenthal Cancer Center at Carolinas Medical Center
Ph: 704-355-2884
  Gastonia
 CaroMont Cancer Center at Gaston Memorial Hospital
 Clinical Trials Office - CaroMont Cancer Center at Gaston Memorial Hospital
Ph: 704-834-2932
  Greensboro
 Moses Cone Regional Cancer Center at Wesley Long Community Hospital
 Clinical Trials Office - Moses Cone Regional Cancer Center at Wesley Long Community Hospital
Ph: 336-621-8374
  Kinston
 Kinston Medical Specialists
 Peter Watson, MD
Ph: 252-559-2200ext.201
  Reidsville
 Annie Penn Cancer Center
 Clinical Trials Office - Annie Penn Cancer Center
Ph: 336-621-8374
  Rutherfordton
 Rutherford Hospital
 James Bearden, MD
Ph: 864-560-6812
  Statesville
 Iredell Memorial Hospital
 Ruby Grimm, MD
Ph: 704-873-2219
  Washington
 Marion L. Shepard Cancer Center at Beaufort County Hospital
 Jennie Crews
Ph: 252-975-4308
  Winston-Salem
 Wake Forest University Comprehensive Cancer Center
 Clinical Trials Office - Wake Forest University Comprehensive Cancer Center
Ph: 336-713-6771
North Dakota
  Bismarck
 Bismarck Cancer Center
 Edward Wos, DO
Ph: 701-323-5741
 Medcenter One Hospital Cancer Care Center
 Edward Wos, DO
Ph: 701-323-5741
 Mid Dakota Clinic, PC
 Clinical Trials Office - Mid Dakota Clinic, PC
Ph: 701-530-6950
 St. Alexius Medical Center Cancer Center
 Clinical Trials Office - St. Alexius Medical Center Cancer Center
Ph: 701-530-6950
  Fargo
 CCOP - MeritCare Hospital
 Preston Steen, MD
Ph: 701-234-2397
 MeritCare Broadway
 Preston Steen, MD
Ph: 701-234-2397
Ohio
  Akron
 McDowell Cancer Center at Akron General Medical Center
 Andrew Fenton, MD
Ph: 330-344-6500
 Summa Center for Cancer Care at Akron City Hospital
 Clinical Trials Office - Akron City Hospital
Ph: 330-375-6101
  Barberton
 Barberton Citizens Hospital
 Michael Seider, MD, PhD, FACR
Ph: 330-375-3557
  Bellefontaine
 Mary Rutan Hospital
 J. Philip Kuebler, MD, PhD
Ph: 614-442-3130
  Canton
 Aultman Cancer Center at Aultman Hospital
 Clinical Trials Office - Aultman Cancer Center at Aultman Hospital
Ph: 330-363-6891
  Chillicothe
 Adena Regional Medical Center
 Clinical Trials Office - Adena Regional Medical Center
Ph: 877-779-7585
  Cleveland
 Case Comprehensive Cancer Center
 Clinical Trials Office - Case Comprehensive Cancer Center
Ph: 800-641-2422
  Columbus
 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center
 Ohio State University Cancer Clinical Trial Matching Service
Ph: 866-627-7616
 Email: osu@emergingmed.com
 CCOP - Columbus
 J. Philip Kuebler, MD, PhD
Ph: 614-442-3130
 Doctors Hospital at Ohio Health
 Clinical Trials Office - Doctors Hospital at Ohio Health
Ph: 614-566-3275
 Grant Medical Center Cancer Care
 Clinical Trials Office - Grant Medical Center Cancer Care
Ph: 614-566-4475
 Mount Carmel Health - West Hospital
 J. Philip Kuebler, MD, PhD
Ph: 614-442-3130
 Riverside Methodist Hospital Cancer Care
 Clinical Trials Office - Riverside Methodist Hospital Cancer Care
Ph: 614-566-4475
  Dayton
 CCOP - Dayton
 Howard Gross, MD
Ph: 937-832-1093
 David L. Rike Cancer Center at Miami Valley Hospital
 Clinical Trials Office - David L. Rike Cancer Center at Miami Valley Hospital
Ph: 937-208-2079
 Good Samaritan Hospital
 Howard Gross, MD
Ph: 937-832-1093
 Grandview Hospital
 Howard Gross, MD
Ph: 937-832-1093
 Samaritan North Cancer Care Center
 Howard Gross, MD
Ph: 937-832-1093
  Delaware
 Grady Memorial Hospital
 J. Philip Kuebler, MD, PhD
Ph: 614-442-3130
  Elyria
 Hematology Oncology Center
 Paul Schaefer, MD
Ph: 419-479-5605
  Findlay
 Blanchard Valley Medical Associates
 Howard Gross, MD
Ph: 937-832-1093
  Franklin
 Middletown Regional Hospital
 Howard Gross, MD
Ph: 937-832-1093
  Greenville
 Wayne Hospital
 Howard Gross, MD
Ph: 937-832-1093
  Kettering
 Charles F. Kettering Memorial Hospital
 Clinical Trials Office - Charles F. Kettering Memorial Hospital
Ph: 937-298-3399 ext. 57556
  Lancaster
 Fairfield Medical Center
 J. Philip Kuebler, MD, PhD
Ph: 614-442-3130
  Lima
 Lima Memorial Hospital
 Paul Schaefer, MD
Ph: 419-479-5605
 St. Rita's Medical Center
 Clinical Trials Office - St. Rita's Medical Center
Ph: 419-226-9617
  Marietta
 Strecker Cancer Center at Marietta Memorial Hospital
 J. Philip Kuebler, MD, PhD
Ph: 614-442-3130
  Maumee
 Northwest Ohio Oncology Center
 Paul Schaefer, MD
Ph: 419-479-5605
 St. Luke's Hospital
 Paul Schaefer, MD
Ph: 419-479-5605
  Newark
 Licking Memorial Cancer Care Program at Licking Memorial Hospital
 J. Philip Kuebler, MD, PhD
Ph: 614-442-3130
  Oregon
 St. Charles Mercy Hospital
 Paul Schaefer, MD
Ph: 419-479-5605
  Sandusky
 North Coast Cancer Care, Incorporated
 Paul Schaefer, MD
Ph: 419-479-5605
  Springfield
 Community Hospital of Springfield and Clark County
 J. Philip Kuebler, MD, PhD
Ph: 614-442-3130
 Mercy Medical Center
 J. Philip Kuebler, MD, PhD
Ph: 614-442-3130
  Sylvania
 Flower Hospital Cancer Center
 Clinical Trials Office - Flower Hospital Cancer Center
Ph: 419-824-1842
  Tiffin
 Mercy Hospital of Tiffin
 Paul Schaefer, MD
Ph: 419-479-5605
  Toledo
 CCOP - Toledo Community Hospital
 Paul Schaefer, MD
Ph: 419-479-5605
 Medical University of Ohio Cancer Center
 Clinical Trials Office - Medical University of Ohio Cancer Center
Ph: 419-383-6583
 St. Anne Mercy Hospital
 Paul Schaefer, MD
Ph: 419-479-5605
 St. Vincent Mercy Medical Center
 Paul Schaefer, MD
Ph: 419-479-5605
 Toledo Clinic, Incorporated - Main Clinic
 Paul Schaefer, MD
Ph: 419-479-5605
 Toledo Hospital
 Clinical Trials Office - Toledo Hospital
Ph: 419-824-1842
  Troy
 UVMC Cancer Care Center at Upper Valley Medical Center
 Clinical Trials Office - UVMC Cancer Care Center at Upper Valley Medical Center
Ph: 937-440-4842
  Wauseon
 Fulton County Health Center
 Clinical Trials Office - Fulton County Health Center
Ph: 419-330-2708
  Westerville
 Mount Carmel St. Ann's Cancer Center
 J. Philip Kuebler, MD, PhD
Ph: 614-442-3130
  Wilmington
 Clinton Memorial Hospital
 Howard Gross, MD
Ph: 937-832-1093
  Wooster
 Cancer Treatment Center
 Clinical Trials Office - Cancer Treatment Center
Ph: 330-375-4221
  Xenia
 Ruth G. McMillan Cancer Center at Greene Memorial Hospital
 Howard Gross, MD
Ph: 937-832-1093
  Zanesville
 Genesis - Good Samaritan Hospital
 Clinical Trials Office - Genesis - Good Samaritan Hospital
Ph: 740-454-5232
Oklahoma
  Oklahoma City
 Integris Oncology Services
 Karl Boatman, MD
Ph: 405-949-3870
Oregon
  Eugene
 Willamette Valley Cancer Center - Eugene
 Vivek Kavadi
Ph: 541-683-5001
  Gresham
 Legacy Mount Hood Medical Center
 Clinical Trials Office - Legacy Mount Hood Medical Center
Ph: 503-413-2150
  Milwaukie
 Providence Milwaukie Hospital
 Janet Ruzich
Ph: 503-513-8300
  Portland
 Adventist Medical Center
 Janet Ruzich
Ph: 503-257-2500
 CCOP - Columbia River Oncology Program
 Janet Ruzich
Ph: 503-216-6260
 Kaiser Permanente Health Care - Portland
 Nagendra Tirumali, MD
Ph: 503-331-6500
 Knight Cancer Institute at Oregon Health and Science University
 Clinical Trials Office - Knight Cancer Institute at Oregon Health and Science University
Ph: 503-494-1080
 Email: trials@ohsu.edu
 Legacy Emanuel Hospital and Health Center and Children's Hospital
 Clinical Trials Office - Legacy Emanuel Hospital and Health Center and Children's Hospital
Ph: 503-413-8199
 Legacy Good Samaritan Hospital & Comprehensive Cancer Center
 Clinical Trials Office - Legacy Good Samaritan Hospital & Comprehensive Cancer Center
Ph: 503-413-1742
 Providence Cancer Center at Providence Portland Medical Center
 Clinical Trials Office - Providence Cancer Center at Providence Portland Medical Center
Ph: 503-215-6412
 Providence St. Vincent Medical Center
 Clinical Trials Office - Providence St. Vincent Medical Center
Ph: 503-215-6412
  The Dalles
 Celilo Cancer Center at Mid-Columbia Medical Center
 Samuel Taylor, MD
Ph: 514-296-7587
  Tualatin
 Legacy Meridian Park Hospital
 Clinical Trials Office - Legacy Meridian Park Hospital
Ph: 503-413-1742
Pennsylvania
  Abington
 Rosenfeld Cancer Center at Abington Memorial Hospital
 Clinical Trials Office - Rosenfeld Cancer Center at Abington Memorial Hospital
Ph: 215-481-2402
  Allentown
 Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest
 Aaron Bleznak, MD, FACS
Ph: 610-402-5498
  Bethlehem
 St. Luke's Cancer Network at St. Luke's Hospital
 Hikaru Nakajima
Ph: 610-954-3580
  Bryn Mawr
 Bryn Mawr Hospital
 Clinical Trials Office - Bryn Mawr Hospital
Ph: 610-645-2680
  Danville
 Geisinger Cancer Institute at Geisinger Health
 Clinical Trials Office - Geisinger Cancer Institute
Ph: 570-271-5251
  Dubois
 Oncology Hematology Associates of Northern Pennsylvania, PC at Hahne Regional Cancer Center
 Carmine Marchioli, MD
Ph: 814-375-3535
  Ephrata
 Ephrata Cancer Center at Ephrata Community Hospital
 Rebecca Jaslow
Ph: 717-738-4070
  Hazleton
 Geisinger Hazleton Cancer Center
 James Evans, MD, MPH
Ph: 570-271-6361
  Hershey
 Penn State Cancer Institute at Milton S. Hershey Medical Center
 Clinical Trials Office - Penn State Cancer Institute at Milton S. Hershey Medical Center
Ph: 717-531-3779
 Email: CTO@hmc.psu.edu
  Kittanning
 Richard G. Laube Cancer Center at ACMH
 Diane Buchbarker
Ph: 412-623-3205
  Meadowbrook
 Charles A. & Betty Bott Cancer Center at Holy Redeemer Hospital
 Joseph Potz
Ph: 215-938-3555
  Paoli
 Cancer Center of Paoli Memorial Hospital
 Clinical Trials Office - Cancer Center of Paoli Memorial Hospital
Ph: 610-648-1637
  Philadelphia
 Albert Einstein Cancer Center
 Ajit Desai, MD
Ph: 215-827-1570
 Fox Chase Cancer Center - Philadelphia
 Clinical Trials Office - Fox Chase Cancer Center - Philadelphia
Ph: 215-728-4790
 Frankford Hospital Cancer Center - Torresdale Campus
 Rebecca Jaslow
Ph: 215-612-4880
 Joan Karnell Cancer Center at Pennsylvania Hospital
 Bernard Mason, MD
Ph: 215-829-6088
 Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
 Clinical Trials Office - Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
Ph: 215-955-6084
  Phoenixville
 Cancer Center at Phoenixville Hospital
 Carl Sharer, DO
Ph: 610-983-1800
  Pittsburgh
 Allegheny Cancer Center at Allegheny General Hospital
 Thomas Julian
Ph: 412-359-3336
866-680-0004
 UPMC Cancer Centers
 Clinical Trials Office - UPMC Cancer Centers
Ph: 412-647-8073
 Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital
 Judith Figura, MD
Ph: 412-578-1923
  Reading
 McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center
 Clinical Trials Office - McGlinn Family Regional Cancer Center
Ph: 610-988-9323
 St. Joseph Medical Center
 Patrick Colarusso, DO
Ph: 610-378-2385
  Scranton
 Hematology and Oncology Associates of Northeastern Pennsylvania
 Martin Hyzinski, MD
Ph: 570-558-3020
 Rebecca Jaslow
Ph: 570-342-3675
 Mercy Hospital Cancer Center - Scranton
 Martin Hyzinski, MD
Ph: 570-558-3020
  State College
 Geisinger Medical Group - Scenery Park
 James Evans, MD, MPH
Ph: 570-271-6361
 Mount Nittany Medical Center
 J. Smith, MD
Ph: 717-531-4488
  West Chester
 Chester County Hospital
 Clinical Trials Office - Chester County Hospital
Ph: 610-431-5297
  Wilkes-Barre
 Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
 Clinical Trials Office - Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
Ph: 570-271-5251
  Wynnewood
 CCOP - Main Line Health
 Paul Gilman, MD
Ph: 610-645-2000
 Lankenau Cancer Center at Lankenau Hospital
 Paul Gilman, MD
Ph: 610-645-2000
  York
 York Cancer Center at Apple Hill Medical Center
 Amaury Barbosa Da Silva
Ph: 717-741-8100
877-441-7957
South Carolina
  Anderson
 AnMed Cancer Center
 Clinical Trials Office - AnMed Cancer Center
Ph: 864-512-1000
  Charleston
 Hollings Cancer Center at Medical University of South Carolina
 Clinical Trials Office - Hollings Cancer Center at Medical University of South Carolina
Ph: 843-792-9321
 Roper St. Francis Cancer Center at Roper Hospital
 James Orcutt, MD
Ph: 843-577-2276
  Greenville
 CCOP - Greenville
 Jeffrey Giguere, MD, FACP
Ph: 864-987-7000
  Spartanburg
 CCOP - Upstate Carolina
 Clinical Trials Office - CCOP - Upstate Carolina
Ph: 800-486-5941
 Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
 Clinical Trials Office - Gibbs Regional Cancer Center
Ph: 800-486-5941
South Dakota
  Sioux Falls
 Avera Cancer Institute
 Addison Tolentino
Ph: 605-322-3000
 Medical X-Ray Center, PC
 Loren Tschetter, MD
Ph: 605-328-8000
 Sanford Cancer Center at Sanford USD Medical Center
 Clinical Trials Office - Sanford Cancer Center
Ph: 605-328-1367
Tennessee
  Kingsport
 Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center
 Clinical Trials Office - Christine LaGuardia Phillips Cancer Center
Ph: 423-224-5593
  Knoxville
 Thompson Cancer Survival Center
 Clinical Trials Office - Thompson Cancer Survival Center
Ph: 865-541-1812
 U.T. Medical Center Cancer Institute
 Clinical Trials Office - U.T. Medical Center Cancer Institute
Ph: 865-544-9773
Texas
  Arlington
 Texas Oncology, PA at Texas Cancer Center - Arlington South
 Vivek Kavadi
Ph: 817-467-6092
  Bedford
 Texas Oncology, PA at Harris Center HEB
 Vivek Kavadi
Ph: 817-359-9000
  Dallas
 Medical City Dallas Hospital
 Vivek Kavadi
Ph: 972-566-7000
 Texas Oncology, PA at Texas Cancer Center Dallas Southwest
 Vivek Kavadi
Ph: 972-709-2580
  Denton
 Texas Oncology, PA at Texas Cancer Center - Denton South
 Vivek Kavadi
Ph: 940-382-1022
  Fort Worth