Alternate Title
Basic Trial Information
Objectives
Entry Criteria
Expected Enrollment
Outcomes
Outline
Trial Contact Information
Related Information
Registry Information

Alternate Title

Radiation Therapy in Treating Patients With Stage II Prostate Cancer

Basic Trial Information

Phase	Type	Status	Age	Sponsor	Protocol IDs
Phase III	Treatment	Active	18 and over	NCI	RTOG-0415 NCT00331773

Special Category: NCI Web site featured trial, CTSU trial

Objectives

Primary

1. Compare the disease-free survival (DFS) of patients with favorable-risk stage II prostate cancer treated with hypofractionated vs conventionally fractionated three-dimensional conformal radiotherapy (3D-CRT) or intensity-modulated radiotherapy (IMRT).

Secondary

1. Compare time to local progression, freedom from biochemical recurrence, and disease-specific and overall survival of patients treated with these regimens.
2. Determine the incidence of gastrointestinal and genitourinary toxic effects in patients treated with these regimens.
3. Compare the degree, duration, and significant differences in disease-specific health-related quality of life (HRQOL) decrements, using the Expanded Prostate Cancer Index Composite (EPIC), in patients treated with these regimens.
4. Determine whether anxiety and/or depression, as measured by the Hopkins Symptom Checklist-25 (HSCL-25), are decreased with therapy that improves DFS of these patients .
5. Determine whether the incremental gain in DFS outweighs decrements in the generic domains of HRQOL (i.e., mobility, self care, usual activities, pain/discomfort, and anxiety/depression) in patients treated with these regimens.
6. Conduct a cost-utility analysis of hypofractionated 3D-CRT or IMRT as a prostate cancer therapy if this regimen is shown to be as effective as conventionally fractionated 3D-CRT or IMRT in improving DFS.

Entry Criteria

Disease Characteristics:

• Histologically confirmed adenocarcinoma of the prostate within the past 6 months
  • Clinical stage T1-2c
• Combined Gleason score 2-6
• Prostate-specific antigen (PSA) < 10 ng/mL within the past 6 months
  • No PSA measurement for ≥ 10 days after prostate biopsy
  • No PSA measurement for ≥ 30 days after discontinuation of finasteride (90 days after discontinuation of dutasteride)
• No regional lymph node involvement
• No distant metastases

Prior/Concurrent Therapy:

• See Disease Characteristics
• No prior radical prostatectomy or cryosurgery for prostate cancer
• No prior hormonal therapy, including any of the following:
  • Luteinizing hormone-releasing hormone agonists (e.g., goserelin or leuprolide)
  • Antiandrogens (e.g., flutamide or bicalutamide)
  • Estrogens (e.g., diethylstilbestrol [DES])
  • Surgical castration (bilateral orchiectomy)
• No prior pelvic radiotherapy or prostate brachytherapy
• No prior or concurrent cytotoxic chemotherapy for prostate cancer
• At least 30 days since prior finasteride
• At least 90 days since prior dutasteride
• No concurrent neoadjuvant or adjuvant hormonal therapy
• Concurrent warfarin or other blood-thinning agents allowed

Patient Characteristics:

• Zubrod performance status 0-1
• No unstable angina and/or congestive heart failure requiring hospitalization within the past 6 months
• No transmural myocardial infarction within the past 6 months
• No acute bacterial or fungal infection requiring IV antibiotics
• No chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study treatment
• No hepatic insufficiency resulting in clinical jaundice and/or coagulation defects
• No known AIDS
• No prior or concurrent lymphomatous/hematogenous malignancy or other invasive malignancy except nonmelanomatous skin cancer or any other cancer for which the patient has been continually disease-free for ≥ 5 years (e.g., carcinoma in situ of the bladder or oral cavity)
• No other severe, active comorbidity

Expected Enrollment

A total of 1,067 patients will be accrued to this study.

Outcomes

Disease-free survival at 5 years as measured by Kaplan-Meier

Time to failure
Disease-specific survival
Freedom from biochemical recurrence (FFBR)
Overall survival
Incidence of GU and GI acute and late toxicity
Statistical modeling of genomic biomarkers
Comparison of disease-specific HRQOL change in EPIC; the Utilization of Sexual Medications/Devices supplements the EPIC
Assessment of anxiety and depression change using the HSCL-25
Evaluation and comparison of the cost-utility of each treatment arm using EQ-5D if the primary endpoint supports the primary hypothesis
Collection of paraffin-embedded tissue block, serum, plasma, and buffy coat cells for future translational research analyses

Outline

This is a randomized, controlled, multicenter study. Patients are stratified according to Gleason score (2-4 vs 5-6), prostate-specific antigen (PSA) level (< 4 ng/mL vs 4-9 ng/mL), and planned radiotherapy modality (three-dimensional conformal radiotherapy [3D-CRT] vs intensity-modulated radiotherapy [IMRT]). Patients are randomized to 1 of 2 treatment arms.

• Arm I: Patients undergo conventionally fractionated 3D-CRT or IMRT once daily 5 days a week for 8.2 weeks (total of 41 treatments).
• Arm II: Patients undergo hypofractionated 3D-CRT or IMRT once daily 5 days a week for 5.6 weeks (total of 28 treatments).

Quality of life, anxiety, and depression are assessed at baseline and then at 6 months and 1, 2, and 5 years after the start of radiotherapy.

After completion of study treatment, patients are followed every 3 months for 2 years, every 6 months for 3 years, and then annually thereafter.

Trial Contact Information

Trial Lead Organizations

Radiation Therapy Oncology Group

W. Robert Lee, MD, Protocol chair		Ph: 919-668-7342

U.S.A.
Arizona
	Phoenix
	Arizona Oncology Services Foundation
		David Brachman, MD, FACRO	Ph:  602-274-4484
	Tucson
	Arizona Oncology - Tucson
		Vivek Kavadi	Ph:  520-797-4468
California
	Auburn
	Auburn Radiation Oncology
		Seth Rosenthal	Ph:  916-888-1266
	Berkeley
	Alta Bates Summit Comprehensive Cancer Center
		Clinical Trials Office - Alta Bates Summit Comprehensive Cancer Center	Ph:  510-204-3428
	Burbank
	Providence Saint Joseph Medical Center - Burbank
		Clinical Trials Office - Providence Saint Joseph Medical Center - Burbank	Ph:  818-847-3220
	Burlingame
	Peninsula Medical Center
		David Irwin, MD	Ph:  510-204-1591
	Cameron Park
	Radiation Oncology Centers - Cameron Park
		Seth Rosenthal	Ph:  916-622-9700
	Carmichael
	Mercy Cancer Center at Mercy San Juan Medical Center
		Seth Rosenthal	Ph:  916-904-3440
	Castro Valley
	East Bay Radiation Oncology Center
		James Feusner, MD	Ph:  510-428-3689
	Valley Medical Oncology Consultants - Castro Valley
		James Feusner, MD	Ph:  510-428-3689
	Fremont
	Valley Medical Oncology
		James Feusner, MD	Ph:  510-428-3689
	Greenbrae
	Marin Cancer Institute at Marin General Hospital
		David Irwin, MD	Ph:  510-204-1591
	Sutter Health - Western Division Cancer Research Group
		David Irwin, MD	Ph:  510-204-1591
	Hayward
	Kaiser Permanente Medical Center - Hayward
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Long Beach
	Veterans Affairs Medical Center - Long Beach
		Samar Azawi, MD	Ph:  562-826-5606
	Los Angeles
	Kaiser Permanente Medical Center - Los Angeles
		Michael Girvigian	Ph:  323-667-4011 800-954-8000
	Oakland
	Alta Bates Summit Medical Center - Summit Campus
		Clinical Trials Office - Alta Bates Summit Medical Center - Summit Campus	Ph:  510-204-1414
	Bay Area Breast Surgeons, Incorporated
		James Feusner, MD	Ph:  510-428-3689
	CCOP - Bay Area Tumor Institute
		James Feusner, MD	Ph:  510-428-3689
	Kaiser Permanente - Division of Research - Oakland
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Kaiser Permanente Medical Center - Oakland
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Larry G Strieff MD Medical Corporation
		James Feusner, MD	Ph:  510-428-3689
	Tom K Lee, Incorporated
		James Feusner, MD	Ph:  510-428-3689
	Pleasanton
	Valley Medical Oncology Consultants - Pleasanton
		James Feusner, MD	Ph:  510-428-3689
	Rancho Cardova
	Kaiser Permanente Medical Center - Rancho Cordova
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Redwood City
	Kaiser Permanente Medical Center - Redwood City
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Richmond
	Kaiser Permanente Medical Center - Richmond
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Rohnert Park
	Rohnert Park Cancer Center
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Roseville
	Kaiser Permanente Medical Center - Roseville
		Louis Fehrenbacher, MD	Ph:  707-651-2577
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Radiation Oncology Center - Roseville
		Seth Rosenthal	Ph:  916-969-4422
	Sacramento
	Kaiser Permanente Medical Center - Sacramento
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Mercy General Hospital
		Seth Rosenthal	Ph:  916-453-4453
	Radiological Associates of Sacramento Medical Group, Incorporated
		Seth Rosenthal	Ph:  916-646-8300
	South Sacramento Cancer Center
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	South Sacramento Kaiser-Permanente Medical Center
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	University of California Davis Cancer Center
		Clinical Trials Office - University of California Davis Cancer Center	Ph:  916-734-3089
	San Francisco
	California Pacific Medical Center - California Campus
		David Irwin, MD	Ph:  510-204-1591
	Kaiser Permanente Medical Center - San Francisco Geary Campus
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	UCSF Helen Diller Family Comprehensive Cancer Center
		Clinical Trials Office - UCSF Helen Diller Family Comprehensive Cancer Center	Ph:  877-827-3222
	San Jose
	Kaiser Permanente Medical Center - Santa Teresa
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	San Pablo
	Doctors Medical Center - San Pablo Campus
		James Feusner, MD	Ph:  510-428-3689
	San Rafael
	Kaiser Foundation Hospital - San Rafael
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Santa Clara
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Kaiser Permanente Medical Center - Santa Clara Kiely Campus
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Santa Rosa
	Kaiser Permanente Medical Center - Santa Rosa
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	South San Francisco
	Kaiser Permanente Medical Center - South San Francisco
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Stockton
	Kaiser Permanente Medical Facility - Stockton
		Louis Fehrenbacher, MD	Ph:  707-651-2577
	Travis AFB
	General Robert Huyser Cancer Center at David Grant Medical Center
		Roland Engel, MD	Ph:  707-423-7691
	Vacaville
	Solano Radiation Oncology Center
		Seth Rosenthal	Ph:  707-447-0400
	Vallejo
	Sutter Solano Medical Center
		David Irwin, MD	Ph:  510-204-1591
	Walnut Creek
	Kaiser Permanente Medical Center - Walnut Creek
		Louis Fehrenbacher, MD	Ph:  707-651-2577
Colorado
	Aurora
	Aurora Presbyterian Hospital
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Rocky Mountain Cancer Centers - Aurora
		Vivek Kavadi	Ph:  303-418-7600
	Boulder
	Boulder Community Hospital
		Clinical Trials Office - Boulder Community Hospital	Ph:  303-938-5253
	Colorado Springs
	Penrose Cancer Center at Penrose Hospital
		Clinical Trials Office - Penrose Cancer Center	Ph:  719-776-5275
	Denver
	Porter Adventist Hospital
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Presbyterian - St. Luke's Medical Center
		Clinical Trials Office - Presbyterian - St. Luke's Medical Center	Ph:  303-839-6000
	St. Joseph Hospital
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Englewood
	Swedish Medical Center
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Fort Collins
	Poudre Valley Radiation Oncology
		C. Kelley Simpson, MD	Ph:  970-482-3328
	Grand Junction
	St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Greeley
	North Colorado Medical Center
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Lone Tree
	Sky Ridge Medical Center
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Longmont
	Hope Cancer Care Center at Longmont United Hospital
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Loveland
	McKee Medical Center
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Pueblo
	St. Mary - Corwin Regional Medical Center
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Thornton
	North Suburban Medical Center
		Eduardo Pajon, MD	Ph:  303-399-8020ext2261
	Wheat Ridge
	Exempla Lutheran Medical Center
		Clinical Trials Office - Exempla Lutheran Medical Center	Ph:  303-403-3605
Delaware
	Newark
	CCOP - Christiana Care Health Services
		Clinical Trial Office - CCOP - Christiana Care Health Services	Ph:  302-733-6227
Florida
	Gainesville
	University of Florida Shands Cancer Center
		Clinical Trials Office - University of Florida Shands Cancer Center	Ph:  888-254-7581
	Jacksonville
	Mayo Clinic - Jacksonville
		Clinical Trials Office - All Mayo Clinic Locations	Ph:  507-538-7623
	Miami
	Baptist-South Miami Regional Cancer Program
		Andre Abitbol, MD	Ph:  786-596-6566
	Panama City
	Bay Medical
		Hasan Murshed	Ph:  850-747-6972
Georgia
	Altanta
	Winship Cancer Institute of Emory University
		Ashesh Jani	Ph:  773-702-2526
	Atlanta
	Emory Crawford Long Hospital
		Ashesh Jani	Ph:  773-702-2526
	Georgia Cancer Center for Excellence at Grady Memorial Hospital
		Ashesh Jani	Ph:  773-702-2526
	Decatur
	Veterans Affairs Medical Center - Atlanta (Decatur)
		Scott Edelman	Ph:  404-728-7680
Illinois
	Alton
	Saint Anthony's Hospital at Saint Anthony's Health Center
		Bethany Sleckman, MD	Ph:  314-251-7057
	Bloomington
	St. Joseph Medical Center
		John Kugler, MD	Ph:  309-243-3605
	Chicago
	University of Chicago Cancer Research Center
		Clinical Trials Office - University of Chicago Cancer Research Center	Ph:  773-834-7424
	Decatur
	Decatur Memorial Hospital Cancer Care Institute
		Clinical Trials Office - Decatur Memorial Hospital Cancer Care Institute	Ph:  217-876-6601
	Normal
	BroMenn Regional Medical Center
		John Kugler, MD	Ph:  309-243-3605
	Community Cancer Center
		John Kugler, MD	Ph:  309-243-3605
	Olympia Fields
	Saint James Hospital and Health Centers Comprehensive Cancer Institute - Olympia Fields
		Clinical Trials Office - Saint James Hospital and Health Centers Comprehensive Cancer Institute - Olympia Fields	Ph:  708-679-2217
	Pekin
	Cancer Treatment Center at Pekin Hospital
		John Kugler, MD	Ph:  309-243-3605
	Peoria
	CCOP - Illinois Oncology Research Association
		John Kugler, MD	Ph:  309-243-3605
	Methodist Medical Center of Illinois
		Clinical Trials Office - Methodist Medical Center of Illinois	Ph:  309-243-3000
	Oncology Hematology Associates of Central Illinois, PC - Peoria
		John Kugler, MD	Ph:  309-243-3605
	OSF St. Francis Medical Center
		John Kugler, MD	Ph:  309-243-3605
		John Kugler, MD	Ph:  309-243-3605
Indiana
	Indianapolis
	Central Indiana Cancer Centers - East
		Vivek Kavadi	Ph:  317-964-5200
	Methodist Cancer Center at Methodist Hospital
		Contact Person	Ph:  317-962-8288 800-265-3220
Iowa
	Ames
	McFarland Clinic, PC
		Clinical Trials Office - McFarland Clinic, PC	Ph:  515-239-2621
	Iowa City
	Holden Comprehensive Cancer Center at University of Iowa
		Cancer Information Service	Ph:  800-237-1225
	Mason City
	Mercy Cancer Center at Mercy Medical Center - North Iowa
		Clinical Trials Office - Mercy Cancer Center at Mercy Medical Center - North Iowa	Ph:  641-422-6304
	Sioux City
	Siouxland Hematology-Oncology Associates, LLP
		Donald Wender, MD, PhD	Ph:  712-252-0088
Kansas
	Kansas City
	Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center
		Clinical Trials Office - Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center	Ph:  913-588-4709
	Overland Park
	Kansas City Cancer Centers - Southwest
		Vivek Kavadi	Ph:  913-234-0400
Kentucky
	Louisville
	James Graham Brown Cancer Center at University of Louisville
		William Spanos, Jr.	Ph:  502-562-4158 866-530-5516
	Norton Suburban Hospital
		Mark Cornett	Ph:  502-893-1000
Maryland
	Baltimore
	Greenebaum Cancer Center at University of Maryland Medical Center
		Clinical Trials Office - Greenebaum Cancer Center at University of Maryladn Medical Center	Ph:  800-888-8823
	Columbia
	Central Maryland Oncology Center
		Young Kwok	Ph:  410-964-2212
	Glen Burnie
	Tate Cancer Center at Baltimore Washington Medical Center
		Young Kwok	Ph:  410-553-8100
	Olney
	Helen P. Denit Cancer Center at Montgomery General Hospital
		Young Kwok	Ph:  301-260-3700
Massachusetts
	Boston
	Beth Israel Deaconess Medical Center
		Clinical Trials Office - Beth Israel Deaconess Medical Center	Ph:  617-667-9925
	Boston University Cancer Research Center
		Clinical Trials Office - Boston University Cancer Research Center	Ph:  617-353-7571
	Dana-Farber/Brigham and Women's Cancer Center
		Clinical Trials Office	Ph:  617-724-5200
	Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute
		William Shipley, MD, FACR	Ph:  617-726-8146
	Massachusetts General Hospital
		Clinical Trials Office - Massachusetts General Hospital	Ph:  877-726-5130
	Fall River
	Hudner Oncology Center at Saint Anne's Hospital - Fall River
		Clinical Trials Office - Hudner Oncology Center at Saint Anne's Hospital - Fall River	Ph:  508-674-5600 ext. 2019
	Framingham
	MetroWest Medical Center - Framingham Union Hospital
		Allison Sacher, MD	Ph:  508-383-1260
	Lowell
	Lowell General Hospital
		William Shipley, MD, FACR	Ph:  617-726-8146
Michigan
	Ann Arbor
	University of Michigan Comprehensive Cancer Center
		Clinical Trials Office - University of Michigan Comprehensive Cancer Center	Ph:  800-865-1125
	Veterans Affairs Medical Center - Ann Arbor
		Shruti Jolly	Ph:  734-769-7100
	Detroit
	Barbara Ann Karmanos Cancer Institute
		Clinical Trials Office - Barbara Ann Karmanos Cancer Institute	Ph:  313-576-9363
	Josephine Ford Cancer Center at Henry Ford Hospital
		Eleanor Walker, MD	Ph:  313-916-1021
	Flint
	Great Lakes Cancer Institute at McLaren Regional Medical Center
		Clinical Trials Office - Great Lakes Cancer Institute at McLaren Regional Medical Center	Ph:  810-342-4071
	Jackson
	Foote Memorial Hospital
		Mary Feng	Ph:  517-788-4800
Minnesota
	Albert Lea
	Albert Lea Cancer Center at Albert Lea Medical Center
		Timothy Kozelsky, MD	Ph:  507-379-2050
	Bemidji
	MeritCare Bemidji
		Preston Steen, MD	Ph:  701-234-2397
	Burnsville
	Fairview Ridges Hospital
		Paul Sperduto, MD, MAPP	Ph:  952-442-6000
	Coon Rapids
	Mercy and Unity Cancer Center at Mercy Hospital
		Paul Sperduto, MD, MAPP	Ph:  952-442-6000
	Duluth
	CCOP - Duluth
		Daniel Nikcevich, MD, PhD	Ph:  218-786-3625
	Duluth Clinic Cancer Center - Duluth
		Clinical Trials Office - Duluth Clinic Cancer Center - Duluth	Ph:  218-786-3308
	Miller - Dwan Medical Center
		Daniel Nikcevich, MD, PhD	Ph:  218-786-3625
	St. Luke's Hospital Cancer Care Center
		Steven Bonin	Ph:  218-249-7800 877-249-7800
	Edina
	Fairview Southdale Hospital
		Clinical Trials Office - Fairview Southdale Hospital	Ph:  612-625-3650
	Fridley
	Mercy and Unity Cancer Center at Unity Hospital
		Paul Sperduto, MD, MAPP	Ph:  952-442-6000
	Mankato
	Immanuel St. Joseph's
		Ron Smith	Ph:  507-345-2929
	Maplewood
	HealthEast Cancer Care at St. John's Hospital
		Daniel Anderson	Ph:  651-232-7970
	Minnesota Oncology Hematology, PA - Maplewood
		Paul Sperduto, MD, MAPP	Ph:  952-442-6000
	Minneapolis
	Hennepin County Medical Center - Minneapolis
		Clinical Trials Office - Hennepin County Medical Center - Minneapolis	Ph:  612-873-5911
	Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
		Clinical Trials Office - Virginia Piper Cancer Institute	Ph:  612-863-5654
	Robbinsdale
	Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center
		Clinical Trials Office - Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center	Ph:  763-520-1893
	Rochester
	Mayo Clinic Cancer Center
		Clinical Trials Office - All Mayo Clinic Locations	Ph:  507-538-7623
	Saint Cloud
	CentraCare Clinic - River Campus
		Barbi Kaplan-Frenkel, DO	Ph:  320-229-4901
	Coborn Cancer Center
		Barbi Kaplan-Frenkel, DO	Ph:  320-229-4901
	Saint Louis Park
	CCOP - Metro-Minnesota
		Paul Sperduto, MD, MAPP	Ph:  952-442-6000
	Park Nicollet Cancer Center
		Paul Sperduto, MD, MAPP	Ph:  952-442-6000
	Saint Paul
	United Hospital
		Paul Sperduto, MD, MAPP	Ph:  952-442-6000
	Shakopee
	St. Francis Cancer Center at St. Francis Medical Center
		Paul Sperduto, MD, MAPP	Ph:  952-442-6000
	St. Paul
	Regions Hospital Cancer Care Center
		Clinical Trials Office - Regions Hospital Cancer Care Center	Ph:  651-254-1517
	Waconia
	Ridgeview Medical Center
		Paul Sperduto, MD, MAPP	Ph:  952-442-6000
	Woodbury
	Minnesota Oncology Hematology, PA - Woodbury
		Paul Sperduto, MD, MAPP	Ph:  952-442-6000
Missouri
	Cape Girardeau
	Saint Francis Medical Center
		Bethany Sleckman, MD	Ph:  314-251-7057
	Joplin
	St. John's Regional Medical Center
		Clinical Trials Office - St. John's Regional Medical Center	Ph:  417-625-2488 ext. 2949
	Kansas City
	Kansas City Cancer Centers - North
		Vivek Kavadi	Ph:  816-746-4570
	Kansas City Cancer Centers - South
		Vivek Kavadi	Ph:  816-333-1326
	Saint Louis
	CCOP - St. Louis-Cape Girardeau
		Bethany Sleckman, MD	Ph:  314-251-7057
	David C. Pratt Cancer Center at St. John's Mercy
		Clinical Trials Office - David C. Pratt Cancer Center at St. John's Mercy	Ph:  314-251-6770
	Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
		Jeff Michalski, MD	Ph:  314-362-8566
	Saint Peters
	Siteman Cancer Center at Barnes-Jewish St. Peters Hospital - St. Peters
		Jeff Michalski, MD	Ph:  314-362-8566
Montana
	Billings
	Billings Clinic - Downtown
		Clinical Trials Office - Billings Clinic - Downtown	Ph:  800-996-2663
			Email: research@billingsclinic.org
	CCOP - Montana Cancer Consortium
		Benjamin Marchello, MD	Ph:  406-238-6290
	Northern Rockies Radiation Oncology Center
		Benjamin Marchello, MD	Ph:  406-238-6290
	Bozeman
	Bozeman Deaconess Cancer Center
		Benjamin Marchello, MD	Ph:  406-238-6290
	Great Falls
		Benjamin Marchello, MD	Ph:  406-238-6290
	Big Sky Oncology
		Clinical Trail Office - Big Sky Oncology	Ph:  406-731-8217
	Great Falls Clinic - Main Facility
		Benjamin Marchello, MD	Ph:  406-238-6290
	Sletten Cancer Institute at Benefis Healthcare
		Grant Harrer, MD, FACP, CCTI	Ph:  406-731-8100
Nebraska
	Omaha
	Methodist Estabrook Cancer Center
		Tien-Shew Huang	Ph:  402-354-5890 877-850-3212
Nevada
	Las Vegas
	CCOP - Nevada Cancer Research Foundation
		John Ellerton, MD, CM	Ph:  702-384-0013
	Reno
	Radiation Oncology Associates - Reno
		Jonathan Tay	Ph:  702-823-1990
	Saint Mary's Regional Medical Center
		Jonathan Tay	Ph:  775-770-3194
New Hampshire
	Concord
	Dartmouth - Hitchcock Concord
		Arul Mahadevan	Ph:  603-230-6100
	Exeter
	Center for Cancer Care at Exeter Hospital
		Gary Proulx	Ph:  570-882-4048
	Keene
	Kingsbury Center for Cancer Care at Cheshire Medical Center
		Alan Hartford, MD, PhD	Ph:  603-650-6600
	Lebanon
	Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
		Clinical Trials Office - Norris Cotton Cancer Center	Ph:  603-650-7609
			Email: cancerhelp@dartmouth.edu
New Jersey
	Camden
	Cancer Institute of New Jersey at Cooper University Hospital - Camden
		Clinical Trial Office - Cancer Institute of New Jersey at Cooper Uniersity Hospital	Ph:  856-325-6757
	Freehold
	CentraState Medical Center
		Henry Tsai	Ph:  732-431-2000
	Jamesburg
	Princeton Radiation Oncology Center
		Douglas Fein	Ph:  609-655-5755
	Marlton
	Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton
		Clinical Trials Office - Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton	Ph:  888-847-8823
	New Brunswick
	Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School
		Clinical Trials Office - Cancer Institute of New Jersey	Ph:  732-235-8675
	Newark
	Newark Beth Israel Medical Center
		Clinical Trials Office - Newark Beth Israel Medical Center	Ph:  973-926-3136
	Princeton
	University Medical Center at Princeton
		Douglas Fein	Ph:  609-497-4000
	Sparta
	Frederick R. and Betty M. Smith Cancer Treatment Center
		Adam Dicker, MD, PhD	Ph:  215-955-6527
	Trenton
	Capital Health Regional Cancer Center
		Shirnett Williamson, MD	Ph:  340-775-5433
	Voorhees
	Cancer Institute of New Jersey at Cooper - Voorhees
		Clinical Trials Office - Cancer Institute of New Jersey at Cooper University Hospital - Voorhees	Ph:  856-325-6757
	Fox Chase Virtua Health Cancer Program at Virtua West Jersey
		Lemuel Ariaratnam, MD	Ph:  609-261-7074
New Mexico
	Albuquerque
	Lovelace Medical Center - Downtown
		Benny Liem, MD	Ph:  505-727-7900
	University of New Mexico Cancer Center
		Clinical Trials Office - University of New Mexico Cancer Center	Ph:  505-272-6972
New York
	Albany
	New York Oncology Hematology, PC at Albany Regional Cancer Care
		Vivek Kavadi	Ph:  518-489-2607
	Binghamton
	Lourdes Regional Cancer Center
		Michael Fallon	Ph:  607-798-5230
	Buffalo
	Roswell Park Cancer Institute
		Clinical Trials Office - Roswell Park Cancer Institute	Ph:  877-275-7724
	East Syracuse
	CCOP - Hematology-Oncology Associates of Central New York
		Jeffrey Kirshner, MD	Ph:  315-472-7504
	Ithaca
	Cayuga Medical Center of Ithaca
		David Cho	Ph:  607-274-4011
	Manhasset
	CCOP - North Shore University Hospital
		Louis Potters, MD, FACR	Ph:  516-632-3370
	Don Monti Comprehensive Cancer Center at North Shore University Hospital
		Clinical Trials Office - Don Monti Comprehensive Cancer Center at North Shore University Hospital	Ph:  516-734-8900
	New Hyde Park
	Long Island Jewish Medical Center
		Louis Potters, MD, FACR	Ph:  516-632-3370
	New York
	NYU Cancer Institute at New York University Medical Center
		Nicholas Sanfilippo	Ph:  212-263-6485
	Poughkeepsie
	Hudson Valley Oncology Associates
		Adam Dicker, MD, PhD	Ph:  215-955-6527
	Saint Francis Hospital Cancer Center
		Michael Gallagher	Ph:  845-483-5959 800-483-5000
	Rochester
	Highland Hospital of Rochester
		Paul Okunieff, MD	Ph:  585-275-5575
	James P. Wilmot Cancer Center at University of Rochester Medical Center
		Paul Okunieff, MD	Ph:  585-275-5575
North Carolina
	Durham
	Duke Comprehensive Cancer Center
		Clinical Trials Office - Duke Comprehensive Cancer Center	Ph:  888-275-3853
	Gastonia
	CaroMont Cancer Center at Gaston Memorial Hospital
		Clinical Trials Office - CaroMont Cancer Center at Gaston Memorial Hospital	Ph:  704-834-2932
	Goldsboro
	Wayne Memorial Hospital, Incorporated
		James Atkins, MD	Ph:  919-580-0000
	Wayne Radiation Oncology
		James Atkins, MD	Ph:  919-580-0000
North Dakota
	Bismarck
	Bismarck Cancer Center
		Edward Wos, DO	Ph:  701-323-5741
	Medcenter One Hospital Cancer Care Center
		Edward Wos, DO	Ph:  701-323-5741
	Mid Dakota Clinic, PC
		Clinical Trials Office - Mid Dakota Clinic, PC	Ph:  701-530-6950
	St. Alexius Medical Center Cancer Center
		Clinical Trials Office - St. Alexius Medical Center Cancer Center	Ph:  701-530-6950
	Fargo
	CCOP - MeritCare Hospital
		Preston Steen, MD	Ph:  701-234-2397
	MeritCare Broadway
		Preston Steen, MD	Ph:  701-234-2397
Ohio
	Akron
	McDowell Cancer Center at Akron General Medical Center
		Mitchell Fromm, MD	Ph:  330-344-6448
	Summa Center for Cancer Care at Akron City Hospital
		Clinical Trials Office - Akron City Hospital	Ph:  330-375-6101
	Barberton
	Barberton Citizens Hospital
		William Demas, MD	Ph:  330-375-3557
	Cincinnati
	Charles M. Barrett Cancer Center at University Hospital
		Kevin Redmond, MD	Ph:  513-584-9089
	Cleveland
	Cleveland Clinic Cancer Center at Fairview Hospital
		Clinical Trials Office - Cleveland Clinic Cancer Center at Fairview Hospital	Ph:  216-476-9362
	Cleveland Clinic Taussig Cancer Center
		Clinical Trials Office - Cleveland Clinic Taussig Cancer Center	Ph:  866-223-8100
	Independence
	Cleveland Clinic Cancer Center
		John Suh, MD	Ph:  216-444-5574
	Mayfield Heights
	Hillcrest Cancer Center at Hillcrest Hospital
		John Suh, MD	Ph:  216-444-5574
	Salem
	Cancer Care Center, Incorporated
		William Demas, MD	Ph:  330-375-3557
	West Chester
	Precision Radiotherapy at University Pointe
		Kevin Redmond, MD	Ph:  513-584-9089
	Wooster
	Cancer Treatment Center
		Clinical Trials Office - Cancer Treatment Center	Ph:  330-375-4221
	Cleveland Clinic - Wooster
		Clinical Trials Office - Cleveland Clinic - Wooster	Ph:  800-862-7798
Oklahoma
	Oklahoma City
	Oklahoma University Cancer Institute
		Terence Herman	Ph:  405-271-6822
Oregon
	Eugene
	Willamette Valley Cancer Center - Eugene
		Vivek Kavadi	Ph:  541-683-5001
	The Dalles
	Celilo Cancer Center at Mid-Columbia Medical Center
		Keith Stelzer, MD, PhD	Ph:  541-296-7204
Pennsylvania
	Abington
	Rosenfeld Cancer Center at Abington Memorial Hospital
		Clinical Trials Office - Rosenfeld Cancer Center at Abington Memorial Hospital	Ph:  215-481-2402
	Bryn Mawr
	Bryn Mawr Hospital
		Clinical Trials Office - Bryn Mawr Hospital	Ph:  610-645-2680
	Danville
	Geisinger Cancer Institute at Geisinger Health
		Clinical Trials Office - Geisinger Cancer Institute	Ph:  570-271-5251
	Darby
	Mercy Fitzgerald Hospital
		Clinical Trials Office - Mercy Fitzgerald Hospital	Ph:  610-237-4982
	Dunmore
	Northeast Radiation Oncology Center
		Adam Dicker, MD, PhD	Ph:  215-955-6527
	Langhorne
	St. Mary Regional Cancer Center
		Clinical Trials Office - St. Mary Regional Cancer Center	Ph:  215-710-4585
	Milford
	Upper Delaware Valley Cancer Center
		Adam Dicker, MD, PhD	Ph:  215-955-6527
	Paoli
	Cancer Center of Paoli Memorial Hospital
		Clinical Trials Office - Cancer Center of Paoli Memorial Hospital	Ph:  610-648-1637
	Philadelphia
	Albert Einstein Cancer Center
		Kenneth Zeitzer, MD	Ph:  215-456-6280
	Fox Chase Cancer Center - Philadelphia
		Clinical Trials Office - Fox Chase Cancer Center - Philadelphia	Ph:  215-728-4790
	Fox Chase Cancer Center CCOP Research Base
		Clinical Trials Office - Fox Chase Cancer Center CCOP Research Base	Ph:  215-728-2983
	Frankford Hospital Cancer Center - Torresdale Campus
		Adam Dicker, MD, PhD	Ph:  215-955-6527
	Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
		Clinical Trials Office - Kimmel Cancer Center at Thomas Jefferson University - Philadelphia	Ph:  215-955-6084
	MNAP Oncologic Center
		Noel Kramer	Ph:  215-673-9260
	Sayre
	Guthrie Cancer Center at Guthrie Clinic Sayre
		Clinical Trials Office - Guthrie Cancer Center at Guthrie Clinic Sayre	Ph:  800-836-0388
	Wilkes-Barre
	Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
		Clinical Trials Office - Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center	Ph:  570-271-5251
	Wynnewood
	CCOP - Main Line Health
		Paul Gilman, MD	Ph:  610-645-2000
	Lankenau Cancer Center at Lankenau Hospital
		Paul Gilman, MD	Ph:  610-645-2000
	York
	York Cancer Center at Apple Hill Medical Center
		Amit Shah	Ph:  717-741-8180
South Carolina
	Myrtle Beach
	Carolina Regional Cancer Center
		Todd Williams, MD	Ph:  843-449-9415
	Spartanburg
	CCOP - Upstate Carolina
		Clinical Trials Office - CCOP - Upstate Carolina	Ph:  800-486-5941
	Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
		Clinical Trials Office - Gibbs Regional Cancer Center	Ph:  800-486-5941
South Dakota
	Rapid City
	Rapid City Regional Hospital
		Eric Eastmo, MD	Ph:  605-719-2360
Texas
	Bedford
	Texas Oncology, PA at Harris Center HEB
		Vivek Kavadi	Ph:  817-359-9000
	Bryan
	St. Joseph Regional Cancer Center
		Scott Goble, MD	Ph:  979-774-0808
	Dallas
	Medical City Dallas Hospital
		Vivek Kavadi	Ph:  972-566-7000
	Texas Oncology, PA at Texas Cancer Center Dallas Southwest
		Vivek Kavadi	Ph:  972-709-2580
	Fort Worth
	Klabzuba Cancer Center at Harris Methodist Fort Worth Hospital
		Vivek Kavadi	Ph:  817-820-4820
	San Antonio
	Cancer Therapy and Research Center
		Clinical Trials Office - Cancer Therapy and Research Center	Ph:  210- 616-5798
	University of Texas Health Science Center at San Antonio
		Gregory Swanson, MD	Ph:  210-450-5648
	Sherman
	Texas Oncology, PA at Texas Cancer Center - Sherman
		Vivek Kavadi	Ph:  903-892-9455
	Sugar Land
	Texas Oncology, PA at Texas Oncology Cancer Center Sugar Land
		Vivek Kavadi	Ph:  281-277-5200
Utah
	Cedar City
	Sandra L. Maxwell Cancer Center
		R. Jeffrey Lee, MD	Ph:  801-408-1146
	Murray
	Jon and Karen Huntsman Cancer Center at Intermountain Medical Center
		R. Jeffrey Lee, MD	Ph:  801-408-1146
	Ogden
	Val and Ann Browning Cancer Center at McKay-Dee Hospital Center
		Clinical Trials Office - McKay-Dee Hospital Center	Ph:  801 387-7426
	Provo
	Utah Valley Regional Medical Center - Provo
		Clinical Trials Office - Utah Valley Regional Medical Center - Provo	Ph:  801-357-7965
	Saint George
	Dixie Regional Medical Center - East Campus
		Clinical Trials Office - Dixie Regional Medical Center - East Campus	Ph:  435-688-4167
	Salt Lake City
	Huntsman Cancer Institute at University of Utah
		Clinical Trials Office - Huntsman Cancer Institute at University of Utah	Ph:  801-581-4477
			Email: clinical.trials@hci.utah.edu
	LDS Hospital
		R. Jeffrey Lee, MD	Ph:  801-408-1146
	Utah Cancer Specialists at UCS Cancer Center
		R. Jeffrey Lee, MD	Ph:  801-408-1146
Vermont
	Burlington
	Fletcher Allen Health Care - University Health Center Campus
		Clinical Trials Office - Fletcher Allen Health Care	Ph:  802-656-8990
	Rutland
	Community Cancer Center at Rutland Regional Medical Center
		Richard Lovett, MD	Ph:  802-747-1831
	Saint Johnsbury
	Norris Cotton Cancer Center - North
		Alan Hartford, MD, PhD	Ph:  603-650-6600
Virginia
	Alexandria
	INOVA Alexandria Hospital
		Matthew Poggi	Ph:  703-504-3000
	Danville
	Danville Regional Medical Center
		Clinical Trials Office - Danville Regional Medical Center	Ph:  434-799-3753
	Norfolk
	Sentara Cancer Institute at Sentara Norfolk General Hospital
		Clinical Trials Office - Sentara Cancer Institute at Sentara Norfolk General Hospital	Ph:  757-388-2406
	Portsmouth
	Naval Medical Center - Portsmouth
		Clinical Trials Office - Naval Medical Center - Portsmouth	Ph:  757-953-5939
	Richmond
	Veterans Affairs Medical Center - Richmond
		Clinical Trials Office - Veterans Affairs Medical Center - Richmond	Ph:  804-675-5646
Washington
	Bremerton
	Harrison Medical Center
		Stephen Springate	Ph:  360-792-6605
	Federal Way
	St. Francis Hospital
		Lauren Colman, MD	Ph:  253-403-1677
	Puyallup
	Good Samaritan Cancer Center
		Lauren Colman, MD	Ph:  253-403-1677
	Tacoma
	CCOP - Northwest
		Lauren Colman, MD	Ph:  253-403-1677
	Franciscan Cancer Center at St. Joseph Medical Center
		Clinical Trials Office - Franciscan Cancer Center	Ph:  253-426-6914
	MultiCare Regional Cancer Center at Tacoma General Hospital
		Clinical Trials Office - MultiCare Regional Cancer Center	Ph:  253-403-3229
West Virginia
	Charleston
	West Virginia University Health Sciences Center - Charleston
		Steven Jubelirer, MD	Ph:  304-388-8380
Wisconsin
	Appleton
	Theda Care Cancer Institute
		Clinical Trials Office - Theda Care Cancer Institute	Ph:  920-380-1500
	La Crosse
	Franciscan Skemp Healthcare - La Crosse Campus
		Kernan Minehan, MD	Ph:  608-791-9510
	Menomonee Falls
	Community Memorial Hospital Cancer Care Center
		Colleen Lawton, MD	Ph:  414-805-4472
	Mequon
	Columbia Saint Mary's Hospital - Ozaukee
		Carl Olson, MD	Ph:  414-291-1556
	Milwaukee
	Columbia-Saint Mary's Cancer Care Center
		Clinical Trials Office - Columbia-St. Mary's Cancer Care Center	Ph:  414-326-1739
	Medical College of Wisconsin Cancer Center
		Clinical Trials Office - Medical College of Wisconsin Cancer Center	Ph:  414-805-4380
	Veterans Affairs Medical Center - Milwaukee
		Elizabeth Gore, MD	Ph:  414-805-4465
	Racine
	All Saints Cancer Center at Wheaton Franciscan Healthcare
		James Taylor, MD	Ph:  262-687-5000
Wyoming
	Sheridan
	Welch Cancer Center at Sheridan Memorial Hospital
		Benjamin Marchello, MD	Ph:  406-238-6290
Canada
British Columbia
	Kelowna
	British Columbia Cancer Agency - Centre for the Southern Interior
		Ross Halperin	Ph:  250-712-3900
	Surrey
	BCCA - Fraser Valley Cancer Centre
		Alexander Agranovich	Ph:  604-930-2098 800-587-2885
	Vancouver
	British Columbia Cancer Agency - Vancouver Cancer Centre
		William Morris	Ph:  604-877-6000 800-663-3333
	Victoria
	British Columbia Cancer Agency - Vancouver Island Centre
		Abraham Alexander	Ph:  250-519-5500
New Brunswick
	Saint John
	Saint John Regional Hospital
		John Carson, MD	Ph:  506-648-6890
Nova Scotia
	Halifax
	Nova Scotia Cancer Centre
		Derek Wilke	Ph:  902-473-6000
Ontario
	Hamilton
	Margaret and Charles Juravinski Cancer Centre
		Ian Dayes	Ph:  905-387-9495
	London
	London Regional Cancer Program at London Health Sciences Centre
		Glenn Bauman	Ph:  519-685-8615
	Thunder Bay
	Cancer Care Program at Thunder Bay Regional Health Sciences
		Sunil Premial Gulavita	Ph:  807-684-7200
Quebec
	Montreal
	Hopital Notre-Dame du CHUM
		Carole Lambert	Ph:  514-281-6000
	McGill Cancer Centre at McGill University
		Sergio Faria	Ph:  514-398-1444
	Quebec City
	Centre Hospitalier Universitaire de Quebec
		Andre-Guy Martin	Ph:  418-525-4444
Saskatchewan
	Regina
	Allan Blair Cancer Centre at Pasqua Hospital
		Evgeny Sadikov	Ph:  306-766-2203
	Saskatoon
	Saskatoon Cancer Centre at the University of Saskatchewan
		Iain MacLennan	Ph:  306-655-2662