Alternate Title
Basic Trial Information
Objectives
Entry Criteria
Expected Enrollment
Outcomes
Outline
Trial Contact Information
Related Information
Registry Information

Alternate Title

Paclitaxel, Cisplatin, and Radiation Therapy With or Without Cetuximab in Treating Patients With Locally Advanced Esophageal Cancer

Basic Trial Information

Phase	Type	Status	Age	Sponsor	Protocol IDs
Phase III	Treatment	Active	18 and over	NCI	RTOG-0436 RTOG 0436, NCT00655876

Special Category: NCI Web site featured trial, CTSU trial

Objectives

Primary

1. To evaluate whether the addition of cetuximab to chemotherapy comprising paclitaxel, cisplatin, and radiotherapy improves overall survival compared with paclitaxel, cisplatin, and radiotherapy alone in patients with esophageal cancer treated without surgery.

Secondary

1. To evaluate whether the addition of cetuximab to paclitaxel, cisplatin, and radiotherapy improves local control by increasing the clinical complete response and decreasing local recurrence in these patients.
2. To evaluate adverse events in these patients.
3. To evaluate endoscopic complete response rates in these patients.
4. To evaluate if the addition of cetuximab to paclitaxel, cisplatin, and radiotherapy improves the Esophageal Cancer Subscale score of the FACT-E quality of life tool.
5. To evaluate the quality-adjusted survival of each treatment arm using EQ-5D if the primary endpoint supports the primary hypothesis.

Entry Criteria

Disease Characteristics:

• Histologically confirmed primary squamous cell or adenocarcinoma of the esophagus or gastroesophageal junction
  • Patients with involvement of the gastroesophageal junction with Siewert type I or II tumors (tumors arising from the distal esophagus and involving the esophagogastric junction or tumors starting at the esophagogastric junction and involving the cardia) are eligible
  • Patients with cervical esophageal carcinoma are eligible
  • Patients with celiac, perigastric, mediastinal, or supraclavicular adenopathy are eligible
• Stage T1, N1, M0; T2-4, Any N, M0; or Any T, Any N, M1a disease based on history/physical examination, endoscopy with biopsy, AND PET/PET-CT scan or chest/abdominal CT scan within 6 weeks prior to registration
• Disease must be encompassed in a radiotherapy field
• No evidence of tracheoesophageal fistulas or invasion into the trachea or major bronchi
  • Patients with T3-4 proximal thoracic esophageal tumors (15-25 cm) must undergo bronchoscopy to exclude fistula

Prior/Concurrent Therapy:

• No prior systemic chemotherapy for esophageal cancer (prior chemotherapy for another cancer allowed)
• No prior therapy that specifically and directly targets the EGFR pathway
• No prior platinum-based and/or paclitaxel-based therapy
• No prior radiotherapy that would result in overlap of planned study radiotherapy fields
• No concurrent investigational agent
• No concurrent cytotoxic agent
• No other concurrent radiotherapy

Patient Characteristics:

• Zubrod performance status 0-2
• ANC ≥ 1,500/mm³
• Platelets ≥ 100,000 cells/mm³
• Hemoglobin ≥ 8.0 g/dL (transfusion or other intervention to achieve Hgb ≥ 8.0 g/dL allowed)
• Creatinine ≤ 1.5 mg/dL
• Bilirubin ≤ 1.5 times upper limit of normal (ULN)
• AST ≤ 3 times ULN
• Negative pregnancy test
• Not pregnant or nursing
• Fertile patients must use effective contraception
• Total intake (oral/enteral) must be ≥ 1,500 kCal/day
• No prior invasive malignancy except nonmelanomatous skin cancer (e.g., carcinoma in situ of the breast, oral cavity, or cervix) unless disease-free for ≥ 2 years
• No prior allergic reaction to the study drugs
• No prior severe infusion reaction to a monoclonal antibody
• No severe, active comorbidity, including any of the following:
  • Unstable angina and/or congestive heart failure requiring hospitalization within the past 3 months
  • Transmural myocardial infarction within the past 6 months
  • Acute bacterial or fungal infection requiring intravenous antibiotics
  • Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy
  • Acquired immune deficiency syndrome based upon current CDC definition
    • HIV testing is not required for entry into this study

Expected Enrollment

Outcomes

Overall survival (failure: death due to any cause)

Local control (failure: residual cancer on post-treatment endoscopic biopsy or recurrent primary disease as defined in protocol)
Adverse events as assessed by NCI CTCAE v3.0
Endoscopic complete response rate
Health-related quality of life (FACT-E)
Quality-adjusted survival (using EQ-5D), if primary hypothesis is supported
Tissue handling/storage for future studies

Outline

This is a multicenter study. Patients are stratified according to histology (adenocarcinoma vs squamous), cancer lesion size (< 5 cm vs ≥ 5cm), and disease status of celiac nodes (present vs absent). Patients are randomized to 1 of 2 treatment arms.

• Arm I: Patients receive cetuximab IV over 1-2 hours, paclitaxel IV over 1 hour, and cisplatin IV over 30-60 minutes on days 1, 8, 15, 22, 29, and 36. Patients also undergo radiotherapy once daily, 5 days a week, for 5½ weeks for a total dose of 50.4Gy.
• Arm II: Patients receive paclitaxel and cisplatin as in arm I. Patients also undergo radiotherapy as in arm I.

Patients undergo endoscopy 6 to 8 weeks after completion of chemoradiotherapy. Quality of life is assessed at baseline, within 1 week of post-treatment endoscopy, and at 1 and 2 years from beginning of study treatment.

After completion of study treatment, patients are followed periodically.

Trial Contact Information

Trial Lead Organizations

Radiation Therapy Oncology Group

Mohan Suntharalingam, MD, Protocol chair		Ph: 410-328-6080; 800-888-8823 Email: msuntha@umm.edu
David Ilson, MD, PhD, Protocol co-chair		Ph: 212-639-8306; 800-525-2225

U.S.A.
Arizona
	Tucson
	Arizona Oncology - Tucson
		Vivek Kavadi	Ph:  520-797-4468
California
	Auburn
	Auburn Radiation Oncology
		Christopher Jones, MD	Ph:  916-646-6600
	Burbank
	Providence Saint Joseph Medical Center - Burbank
		Clinical Trials Office - Providence Saint Joseph Medical Center - Burbank	Ph:  818-847-3220
	Cameron Park
	Radiation Oncology Centers - Cameron Park
		Christopher Jones, MD	Ph:  916-646-6600
	Carmichael
	Mercy Cancer Center at Mercy San Juan Medical Center
		Christopher Jones, MD	Ph:  916-646-6600
	Modesto
	Memorial Medical Center
		Clinical Trials Office - Memorial Medical Center	Ph:  209-572-7116
	Roseville
	Radiation Oncology Center - Roseville
		Christopher Jones, MD	Ph:  916-646-6600
	Sacramento
	Mercy General Hospital
		Christopher Jones, MD	Ph:  916-646-6600
	Radiological Associates of Sacramento Medical Group, Incorporated
		Christopher Jones, MD	Ph:  916-646-6600
	University of California Davis Cancer Center
		Clinical Trials Office - University of California Davis Cancer Center	Ph:  916-734-3089
	Vacaville
	Solano Radiation Oncology Center
		Christopher Jones, MD	Ph:  916-646-6600
Connecticut
	Greenwich
	Bendheim Cancer Center at Greenwich Hospital
		Clinical Trials Office - Bendheim Cancer Center	Ph:  203-863-3698
Delaware
	Newark
	CCOP - Christiana Care Health Services
		Clinical Trial Office - CCOP - Christiana Care Health Services	Ph:  302-733-6227
Florida
	Gainesville
	University of Florida Shands Cancer Center
		Clinical Trials Office - University of Florida Shands Cancer Center	Ph:  888-254-7581
	Jacksonville
	Baptist Cancer Institute - Jacksonville
		Clinical Trials Office - Baptist Cancer Institute - Jacksonville	Ph:  904-202-7051
	Integrated Community Oncology Network at Southside Cancer Center
		Douglas Johnson, MD	Ph:  904-202-2273
	Jacksonville Beach
	Integrated Community Oncology Network
		Douglas Johnson, MD	Ph:  904-202-2273
	Jascksonville
	Baptist Medical Center South
		Douglas Johnson, MD	Ph:  904-202-2273
	Jupiter
	Ella Milbank Foshay Cancer Center at Jupiter Medical Center
		Clinical Trials Office - Ella Milbank Foshay Cancer Center	Ph:  561-745-5768
	Miami Beach
	CCOP - Mount Sinai Medical Center
		Mike Cusnir, MD	Ph:  305-674-2625
	Orange Park
	Integrated Community Oncology Network - Orange Park
		Douglas Johnson, MD	Ph:  904-202-2273
	Orlando
	M.D. Anderson Cancer Center at Orlando
		Omar Kayaleh, MD	Ph:  407-648-3800
	Palatka
	Florida Cancer Center - Palatka
		Douglas Johnson, MD	Ph:  904-202-2273
	Saint Augustine
	Flagler Cancer Center
		Douglas Johnson, MD	Ph:  904-202-2273
Georgia
	Atlanta
	Emory Crawford Long Hospital
		Cynthia Anderson	Ph:  404-686-4411
Illinois
	Chicago
	Robert H. Lurie Comprehensive Cancer Center at Northwestern University
		Clinical Trials Office - Robert H. Lurie Comprehensive Cancer Center at Northwestern University	Ph:  312-695-1301
			Email: cancer@northwestern.edu
	Decatur
	Decatur Memorial Hospital Cancer Care Institute
		Clinical Trials Office - Decatur Memorial Hospital Cancer Care Institute	Ph:  217-876-6601
	Evanston
	Evanston Hospital
		Clinical Trials Office - Evanston Hospital	Ph:  847-570-1381
	Moline
	Trinity Cancer Center at Trinity Medical Center - 7th Street Campus
		Costas Constantinou, MD	Ph:  563-359-9876
	Springfield
	Cancer Institute at St. John's Hospital
		Cathy Clausen, MD	Ph:  765-646-8358
Indiana
	Anderson
	Saint John's Cancer Center at Saint John's Medical Center
		Darrel Ross	Ph:  765-646-8459
	Bloomington
	Bloomington Hospital Regional Cancer Institute
		David Lee, MD	Ph:  812-353-2800
	Fort Wayne
	Parkview Regional Cancer Center at Parkview Health
		Brian Chang	Ph:  260-373-7850
	Radiation Oncology Associates Southwest
		Tony Lee	Ph:  260-373-7850
	Indianapolis
	Central Indiana Cancer Centers - East
		Vivek Kavadi	Ph:  317-964-5200
	Methodist Cancer Center at Methodist Hospital
		Contact Person	Ph:  317-962-8288 800-265-3220
	St. Vincent Oncology Center
		Robert Liebross	Ph:  317-415-6789 888-415-6789
Iowa
	Des Moines
	John Stoddard Cancer Center at Iowa Methodist Medical Center
		Clinical Trials Office - John Stoddard Cancer Center at Iowa Methodist Medical Center	Ph:  515-241-6727
	Mercy Cancer Center at Mercy Medical Center - Des Moines
		Robert Behrens	Ph:  515-643-8206 888-221-4849
	Sioux City
	Siouxland Hematology-Oncology Associates, LLP
		Donald Wender, MD, PhD	Ph:  712-252-0088
Kansas
	Overland Park
	Kansas City Cancer Centers - Southwest
		Vivek Kavadi	Ph:  913-234-0400
Maryland
	Baltimore
	Greater Baltimore Medical Center Cancer Center
		Clinical Trials Office - Greater Baltimore Medical Center Cancer Center	Ph:  443-849-3706
	Greenebaum Cancer Center at University of Maryland Medical Center
		Clinical Trials Office - Greenebaum Cancer Center at University of Maryladn Medical Center	Ph:  800-888-8823
	St. Agnes Hospital Cancer Center
		Richard Hudes, MD	Ph:  410-368-2965
Michigan
	Ann Arbor
	Saint Joseph Mercy Cancer Center
		Salam Jafar, MD	Ph:  734-712-3596
	Flint
	Genesys Hurley Cancer Institute
		Clinical Trials Office - Genesys Hurley Cancer Institute	Ph:  810-762-8057
	Royal Oak
	William Beaumont Hospital - Royal Oak Campus
		Clinical Trials Office - William Beaumont Hospital - Royal Oak Campus	Ph:  248-551-7695
Minnesota
	Duluth
	Miller - Dwan Medical Center
		Daniel Nikcevich, MD, PhD	Ph:  218-786-3625
	Rochester
	Mayo Clinic Cancer Center
		Clinical Trials Office - All Mayo Clinic Locations	Ph:  507-538-7623
Missouri
	Cape Girardeau
	Cancer Institute of Cape Girardeau, LLC
		Tapan Roy, MD	Ph:  573-334-2230
	Kansas City
	Kansas City Cancer Centers - North
		Vivek Kavadi	Ph:  816-746-4570
	Kansas City Cancer Centers - South
		Vivek Kavadi	Ph:  816-333-1326
	Saint Louis
	David C. Pratt Cancer Center at St. John's Mercy
		Clinical Trials Office - David C. Pratt Cancer Center at St. John's Mercy	Ph:  314-251-6770
	Missouri Baptist Cancer Center
		Alan Lyss, MD	Ph:  314-996-5514
	Springfield
	Hulston Cancer Center at Cox Medical Center South
		Robert Carolla	Ph:  417-269-5257
	St. John's Regional Health Center
		Robert Carolla	Ph:  417-820-2000
Montana
	Billings
	Northern Rockies Radiation Oncology Center
		Benjamin Marchello, MD	Ph:  406-238-6290
	Great Falls
	Sletten Cancer Institute at Benefis Healthcare
		Contact Person	Ph:  406-731-8200 866-466-6822
Nebraska
	Omaha
	Methodist Estabrook Cancer Center
		Tien-Shew Huang	Ph:  402-354-5890 877-850-3212
Nevada
	Las Vegas
	CCOP - Nevada Cancer Research Foundation
		John Ellerton, MD, CM	Ph:  702-384-0013
	Reno
	Renown Institute for Cancer at Renown Regional Medical Center
		Lawrence Dardick, MD	Ph:  775-982-5638
New Hampshire
	Concord
	Dartmouth - Hitchcock Concord
		Arul Mahadevan	Ph:  603-230-6100
	Dover
	Seacoast Cancer Center at Wentworth - Douglass Hospital
		Barbara Shea, MD	Ph:  603-740-2390
	Exeter
	Center for Cancer Care at Exeter Hospital
		Gary Proulx	Ph:  570-882-4048
	Lebanon
	Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
		Clinical Trials Office - Norris Cotton Cancer Center	Ph:  603-650-7609
			Email: cancerhelp@dartmouth.edu
	Manchester
	Elliot Regional Cancer Center at Elliot Hospital
		Andrea McKee, MD	Ph:  603-663-1800
New Jersey
	Long Branch
	Monmouth Medical Center
		Clinical Trials Office - Monmouth Medical Center	Ph:  732-923-7689
	Marlton
	Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton
		Clinical Trials Office - Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton	Ph:  888-847-8823
New Mexico
	Albuquerque
	University of New Mexico Cancer Center
		Clinical Trials Office - University of New Mexico Cancer Center	Ph:  505-272-6972
New York
	Albany
	New York Oncology Hematology, PC at Albany Regional Cancer Care
		Vivek Kavadi	Ph:  518-489-2607
	Glens Falls
	Charles R. Wood Cancer Center at Glens Falls Hospital
		Clinical Trials Office - Charles R. Wood Cancer Center at Glens Falls Hospital	Ph:  518-926-6700
North Carolina
	Asheville
	Mission Hospitals - Memorial Campus
		Clinical Trials Office - Mission Hospitals - Memorial Campus	Ph:  828-213-4150
	Charlotte
	Presbyterian Cancer Center at Presbyterian Hospital
		Clinical Trials Office - Presbyterian Cancer Center at Presbyterian Hospital	Ph:  704-384-5369
	Gastonia
	CaroMont Cancer Center at Gaston Memorial Hospital
		Clinical Trials Office - CaroMont Cancer Center at Gaston Memorial Hospital	Ph:  704-834-2932
	Kinston
	Kinston Medical Specialists
		Peter Watson, MD	Ph:  252-559-2200ext.201
Ohio
	Akron
	McDowell Cancer Center at Akron General Medical Center
		Mitchell Fromm, MD	Ph:  330-344-6448
	Summa Center for Cancer Care at Akron City Hospital
		Clinical Trials Office - Akron City Hospital	Ph:  330-375-6101
	Canton
	Mercy Cancer Center at Mercy Medical Center
		Mitchell Haut, MD	Ph:  330-453-9993
	Cincinnati
	Charles M. Barrett Cancer Center at University Hospital
		Kevin Redmond, MD	Ph:  513-584-9089
	Cleveland
	Case Comprehensive Cancer Center
		Clinical Trials Office - Case Comprehensive Cancer Center	Ph:  800-641-2422
	Cleveland Clinic Taussig Cancer Center
		Clinical Trials Office - Cleveland Clinic Taussig Cancer Center	Ph:  866-223-8100
	Mayfield Heights
	Hillcrest Cancer Center at Hillcrest Hospital
		Janice Lyons	Ph:  216-844-2536
Oklahoma
	Tulsa
	Natalie Warren Bryant Cancer Center at St. Francis Hospital
		Charles Stewart	Ph:  918-494-2273
Oregon
	Eugene
	Willamette Valley Cancer Center - Eugene
		Vivek Kavadi	Ph:  541-683-5001
	Salem
	Salem Hospital Regional Cancer Care Services
		Clinical Trials Office - Salem Hospital Regional Cancer Care Services	Ph:  503-561-2618
Pennsylvania
	Beaver
	UPMC Cancer Center at Beaver Medical Center
		Michael Gibson	Ph:  724-773-7616
	Bryn Mawr
	Bryn Mawr Hospital
		Clinical Trials Office - Bryn Mawr Hospital	Ph:  610-645-2680
	Clairton
	UPMC Cancer Center at Jefferson Regional Medical Center
		Michael Gibson	Ph:  412-469-5500
	Danville
	Geisinger Cancer Institute at Geisinger Health
		Clinical Trials Office - Geisinger Cancer Institute	Ph:  570-271-5251
	Greensburg
	UPMC Cancer Center - Arnold Palmer Pavilion
		Michael Gibson	Ph:  724-838-1900 800-533-8762
	Philadelphia
	Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
		Clinical Trials Office - Kimmel Cancer Center at Thomas Jefferson University - Philadelphia	Ph:  215-955-6084
	Pittsburgh
	Allegheny Cancer Center at Allegheny General Hospital
		David Parda	Ph:  412-359-8084
	UPMC - Shadyside
		Clinical Trials Office - UPMC - Shadyside	Ph:  412-621-2334
	UPMC Cancer Center at UPMC Passavant
		Clinical Trials Office - UPMC Cancer Center at UPMC Passavant	Ph:  412-367-6454
	Reading
	McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center
		Clinical Trials Office - McGlinn Family Regional Cancer Center	Ph:  610-988-9323
	Seneca
	UPMC Cancer Center at UPMC Northwest
		Michael Gibson	Ph:  814-676-7900
	Wynnewood
	Lankenau Cancer Center at Lankenau Hospital
		Paul Gilman, MD	Ph:  610-645-2000
	York
	York Cancer Center at Apple Hill Medical Center
		Amit Shah	Ph:  717-741-8180
Rhode Island
	Providence
	Rhode Island Hospital Comprehensive Cancer Center
		Clinical Trials Office - Rhode Island Hospital Comprehensive Cancer Center	Ph:  401-444-1488
South Carolina
	Charleston
	Hollings Cancer Center at Medical University of South Carolina
		Clinical Trials Office - Hollings Cancer Center at Medical University of South Carolina	Ph:  843-792-9321
	Greenville
	CCOP - Greenville
		Jeffrey Giguere, MD, FACP	Ph:  864-987-7000
	Spartanburg
	CCOP - Upstate Carolina
		Clinical Trials Office - CCOP - Upstate Carolina	Ph:  800-486-5941
South Dakota
	Rapid City
	Rapid City Regional Hospital
		Eric Eastmo, MD	Ph:  605-719-2360
Tennessee
	Knoxville
	Thompson Cancer Survival Center
		Clinical Trials Office - Thompson Cancer Survival Center	Ph:  865-541-1812
Texas
	Amarillo
	Harrington Cancer Center
		Clinical Trials Officec - Harrington Cancer Center	Ph:  806-359-4673
			Email: ryokubaitis@harringtoncc.org
	Bedford
	Texas Oncology, PA at Harris Center HEB
		Vivek Kavadi	Ph:  817-359-9000
	Dallas
	Medical City Dallas Hospital
		Vivek Kavadi	Ph:  972-566-7000
	Texas Oncology, PA at Texas Cancer Center Dallas Southwest
		Vivek Kavadi	Ph:  972-709-2580
	Fort Worth
	Klabzuba Cancer Center at Harris Methodist Fort Worth Hospital
		Vivek Kavadi	Ph:  817-820-4820
	Lubbock
	Joe Arrington Cancer Research and Treatment Center
		Clinical Trials Office - Joe Arrington Cancer Research and Treatment Center	Ph:  806-725-8000
			Email: jaccresearch@covhs.org
	Odessa
	West Texas Cancer Center
		Ajay Dubey	Ph:  432-335-8275
	Sherman
	Texas Oncology, PA at Texas Cancer Center - Sherman
		Vivek Kavadi	Ph:  903-892-9455
	Sugar Land
	Texas Oncology, PA at Texas Oncology Cancer Center Sugar Land
		Vivek Kavadi	Ph:  281-277-5200
Utah
	Murray
	Jon and Karen Huntsman Cancer Center at Intermountain Medical Center
		R. Jeffrey Lee, MD	Ph:  801-408-1146
	Saint George
	Dixie Regional Medical Center - East Campus
		Clinical Trials Office - Dixie Regional Medical Center - East Campus	Ph:  435-688-4167
	Salt Lake City
	Huntsman Cancer Institute at University of Utah
		Clinical Trials Office - Huntsman Cancer Institute at University of Utah	Ph:  801-581-4477
			Email: clinical.trials@hci.utah.edu
Vermont
	Burlington
	Fletcher Allen Health Care - University Health Center Campus
		Clinical Trials Office - Fletcher Allen Health Care	Ph:  802-656-8990
	Saint Johnsbury
	Norris Cotton Cancer Center - North
		Alan Hartford, MD, PhD	Ph:  603-650-6600
Virginia
	Charlottesville
	University of Virginia Cancer Center
		Tyvin Rich, MD	Ph:  808-924-5564
Washington
	Yakima
	North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
		Clinical Trails Office - North Star Lodge Cancer Center	Ph:  509-574-3422
Wisconsin
	La Crosse
	Gundersen Lutheran Center for Cancer and Blood
		Clinical Trials Office - Gundersen Lutheran Cancer Center	Ph:  608-775-2385
			Email: cancerctr@gundluth.org
	Marinette
	Bay Area Cancer Care Center at Bay Area Medical Center
		Gregory Cooley, MD	Ph:  414-433-8184
	Milwaukee
	Medical College of Wisconsin Cancer Center
		Clinical Trials Office - Medical College of Wisconsin Cancer Center	Ph:  414-805-4380
	Veterans Affairs Medical Center - Milwaukee
		Elizabeth Gore, MD	Ph:  414-805-4465
	Oconomowoc
	Regional Cancer Center at Oconomowoc Memorial Hospital
		Clinical Trials Office - Regional Cancer Center at Oconomowoc Memorial Hospital	Ph:  262-928-7878
	Racine
	All Saints Cancer Center at Wheaton Franciscan Healthcare
		James Taylor, MD	Ph:  262-687-5000
	Sheboygan
	Vince Lombardi Cancer Clinic - Sheboygan
		Clinical Trials Office - Vince Lombardi Cancer Clinic - Sheboygan	Ph:  414-649-7200
	Sturgeon Bay
	Door County Cancer Center at Door County Memorial Hospital
		Gregory Cooley, MD	Ph:  414-433-8184
	Wausau
	University of Wisconcin Cancer Center at Aspirus Wausau Hospital
		Clinical Trials Office - University of Wisconsin Cancer Center	Ph:  608-262-5223

Related Information

Featured trial article

Registry Information
Official Title		A Phase III Trial Evaluating the Addition of Cetuximab to Paclitaxel, Cisplatin, and Radiation for Patients with Esophageal Cancer who are Treated without Surgery
Trial Start Date		2008-06-30
Trial Completion Date		2015-12-31 (estimated)
Registered in ClinicalTrials.gov		NCT00655876
Date Submitted to PDQ		2008-03-31
Information Last Verified		2009-11-21
NCI Grant/Contract Number		CA21661

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