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  • Posted: 10/10/2006
  • Updated: 01/15/2008

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Adjuvant Biological Therapy for Pancreatic Cancer

Name of the Trial

Phase II Randomized Study of Adjuvant Therapy Comprising Bevacizumab Versus Cetuximab in Combination With Gemcitabine Hydrochloride, Capecitabine, and Radiotherapy in Patients With Completely Resected Carcinoma of the Pancreas (ECOG-E2204). See the protocol summary.

Principal Investigators

Dr. Jordan Berlin Dr. Jordan Berlin
Principal Investigator

Dr. Jordan Berlin, ECOG; Dr. Arthur William Blackstock, CALGB; Dr. Andrew Lowy, SWOG; and Dr. Robert McWilliams, NCCTG.

Why This Trial Is Important

Pancreatic cancer is one of the most deadly types of cancer, with fewer than four percent of patients surviving five years or longer. The best chance for long-term survival is complete surgical removal (resection) of the tumor. However, even resectable patients face a high likelihood of recurrence. To help improve the outcome for patients with resectable pancreatic cancer, doctors currently treat these patients with post-operative (adjuvant) chemotherapy and radiation therapy.

In this trial, patients with completely resected pancreatic cancer will receive adjuvant chemotherapy and radiation therapy plus additional treatment with either bevacizumab or cetuximab. Bevacizumab and cetuximab are biological agents that target different proteins that are thought to be important for tumor growth and spread. Bevacizumab blocks the activity of vascular endothelial growth factor (VEGF), a protein used by some tumors to form new blood vessels. Cetuximab blocks the activity of epidermal growth factor receptor (EGFR), a protein that promotes cell growth and proliferation.

"Our primary goal with this trial is to assess the safety of these biologic therapies in combination with standard adjuvant treatment," said Dr. Berlin. "Additionally, we hope to see some measures of effectiveness that we can build on in future studies."

Contact Information

This clinical trial is no longer accepting new patients. To locate other clinical trials for pancreatic cancer, search the NCI's database of clinical trials or call the NCI's Cancer Information Service at 1-800-4-CANCER (1-800-422-6237) for more information. The toll-free call is confidential.