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The Modafinil and Fatigue Trial

Name of the Trial

Phase III Randomized Study of Modafinil for Fatigue in Cancer Patients Receiving Chemotherapy (URCC-U2901). See the protocol summary.

Principal Investigator

Dr. Gary Morrow, University of Rochester Cancer Center.

Gary Morrow, Ph.D.
Gary Morrow, Ph.D., Principal Investigator
(Courtesy of ASCO, 2001)

Why This Trial Is Important

Fatigue affects many people with cancer, especially those receiving treatment. Fatigue is complex and has biological, psychological, and behavioral causes.

Research suggests that the drug modafinil, a stimulant, may be effective in relieving fatigue. This study is testing the ability of modafinil to reduce fatigue in cancer patients who are receiving chemotherapy. The study will also examine the relationship between depression and fatigue in patients treated with modafinil.

“Fatigue related to cancer and to cancer treatment are important issues, especially for patients,” said Dr. Lori Minasian, chief of the National Cancer Institute’s Community Oncology and Prevention Trials Research Group. “Modafinil is one of the more innovative means of treating fatigue, since it works on the body’s central nervous system. With this trial, NCI-supported researchers are pursuing a different approach in combating the fatigue that often accompanies treatment for cancer.”

Contact Information

This trial is no longer accepting new patients. To locate other cancer supportive care clinical trials, search the NCI's database of clinical trials or call the NCI's Cancer Information Service at 1-800-4-CANCER (1-800-422-6237). The call is toll-free and completely confidential.

  • Posted: January 6, 2004
  • Updated: June 4, 2007