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Featured Clinical Trials Supported by the National Cancer Institute

Today, thousands of cancer clinical trials are under way in the United States. Clinical trials answer vital research questions that lead to better screening, prevention, diagnosis, and treatment options for all cancers. This section highlights NCI-supported cancer trials and demonstrates the breadth of clinical cancer research supported by the Institute.

To find other cancer trials open to enrollment:

  • Call NCI's Cancer Information Service at 1-800-4-CANCER (1-800-422-6237) for information about trials all across the country. The call is toll-free and completely confidential.
  • Use the clinical trials search form to look online for trials listed on NCI's website. The form has a Help link for tips about searching for clinical trials.
  • For information about cancer trials taking place on the National Institutes of Health campus in Bethesda, Maryland, call NCI’s Clinical Trials Referral Office at 1-888-NCI-1937 (1-888-624-1937). The call is toll-free and completely confidential.
  • Testing a New Drug in Advanced BRCA-related Cancer
    (Posted: 09/08/2009) - In this clinical trial, women with advanced breast or ovarian cancer who carry a known BRCA gene mutation or who have a strong family history of these diseases (and are, therefore, likely to carry such a mutation) will be treated with a new drug called AZD2281 (olaparib) together with the chemotherapy drug carboplatin.
  • Refining Treatment for High-risk Early Stage Endometrial Cancer
    (Posted: 08/14/2009) - In this clinical trial, women with high-risk early stage endometrial cancer will be randomly assigned following surgery to receive one of two types of adjuvant therapy: brachytherapy targeted to the vaginal cuff in combination with chemotherapy or standard pelvic external-beam radiotherapy.
  • Imaging the Extent of Prostate Cancer
    (Posted: 06/02/2009, Updated: 07/31/2009) - In this clinical trial, researchers are testing PET scans using carbon-11 (C-11) acetate in conjunction with subsequent MRI to see if the resulting images allow better characterization of both the physical extent and the relative level of cellular growth of prostate tumors in patients known to have prostate cancer.
  • Study of the Natural History of Neurofibromatosis Type 1
    (Posted: 03/10/2009, Updated: 07/31/2009) - Researchers are conducting a long-term study of children and adults with neurofibromatosis type 1 and their healthy siblings to help gain a better understanding of the natural history of the disease and how to better detect and treat its symptoms.
  • Comparing Second-Line Therapies for Advanced Lung Cancer
    (Posted: 07/28/2009) - In this trial, patients with advanced non-small cell lung cancer that has recurred or progressed after initial chemotherapy will be tested for EGFR gene amplification and then randomly assigned to receive either pemetrexed or erlotinib.
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