Featured Clinical Trials Supported by the National Cancer Institute
Today, thousands of cancer clinical trials are under way in the United States. Clinical trials answer vital research questions that lead to better screening, prevention, diagnosis, and treatment options for all cancers. This section highlights NCI-supported cancer trials and demonstrates the breadth of clinical cancer research supported by the Institute.
To find other cancer trials open to enrollment:
- Call NCI's Cancer Information Service at 1-800-4-CANCER (1-800-422-6237) for information about trials all across the country. The call is toll-free and completely confidential.
- Use the clinical trials search form to look online for trials listed on NCI's Cancer.gov website. The form has a Help link for tips about searching for clinical trials.
- For information about cancer trials taking place on the National Institutes of Health campus in Bethesda, Maryland, call NCI’s Clinical Trials Referral Office at 1-888-NCI-1937 (1-888-624-1937). The call is toll-free and completely confidential.
(Posted: 02/01/2005, Updated: 03/05/2008) - In this study, researchers are investigating the ability of pioglitazone, a drug used to treat type II diabetes, to reverse leukoplakia and prevent it from developing into head and neck cancer.
Continuing Bevacizumab Therapy for Metastatic Colorectal Cancer
(Posted: 03/04/2008) - In this trial, patients with metastatic colorectal cancer that has progressed on first-line therapy containing oxaliplatin and bevacizumab will be treated with the agents irinotecan and cetuximab. The patients will also be randomly assigned to receive continued bevacizumab or no additional bevacizumab.
Herbal Therapy for Brain Cancer
(Posted: 06/12/2007, Updated: 02/21/2008) - In this trial, patients with high-grade glioma will be randomly assigned to take an herbal preparation of Boswellia serrata (frankincense) and undergo standard treatment for six months or undergo standard treatment alone for six months. Researchers want to see the addition of herbal therapy can help relieve brain swelling in these patients.
Preventing Chemotherapy-Induced Neuropathy
(Posted: 04/03/2007, Updated: 02/19/2008) - In this trial, researchers are testing the ability of an antioxidant supplement called alpha-lipoic acid to prevent peripheral neuropathy caused by the platinum-containing drugs cisplatin and oxaliplatin.
Combination Therapy for Invasive Bladder Cancer
(Posted: 02/05/2008) - In this clinical trial, patients with invasive bladder cancer who are not suitable for cystectomy will be treated with the drug paclitaxel and daily radiation therapy. Additionally, patients whose tumors test positive for a protein called HER2 will be treated with the monoclonal antibody trastuzumab (Herceptin).