Featured Clinical Trials Supported by the National Cancer Institute
Today, thousands of cancer clinical trials are under way in the United States. Clinical trials answer vital research questions that lead to better screening, prevention, diagnosis, and treatment options for all cancers. This section highlights NCI-supported cancer trials and demonstrates the breadth of clinical cancer research supported by the Institute.
To find other cancer trials open to enrollment:
- Call NCI's Cancer Information Service at 1-800-4-CANCER (1-800-422-6237) for information about trials all across the country. The call is toll-free and completely confidential.
- Use the clinical trials search form to look online for trials listed on NCI's Cancer.gov website. The form has a Help link for tips about searching for clinical trials.
- For information about cancer trials taking place on the National Institutes of Health campus in Bethesda, Maryland, call NCI’s Clinical Trials Referral Office at 1-888-NCI-1937 (1-888-624-1937). The call is toll-free and completely confidential.
- Treating KSHV-Associated Multicentric Castleman Disease
(Posted: 09/18/2012) - In this pilot study, patients with KSHV-associated multicentric Castleman disease will receive intravenous tocilizumab every other week for up to 12 weeks. Patients who do not benefit from tocilizumab therapy alone may go on to receive high-dose AZT and valganciclovir in addition to tocilizumab.
- Targeting Invasive Glioma Cells
(Posted: 09/04/2012) - In this trial, patients with glioblastoma that has not responded to standard postoperative therapy or that has progressed will be treated with varying amounts of a Trk inhibitor called AZD7451 to determine the maximum tolerated dose and the side effects of this drug.
- Genetically Engineered Immunotherapy for Advanced Cancer
(Posted: 08/07/2012) - In this trial, doctors will collect T lymphocytes from the blood of patients with advanced mesothelin-expressing cancer and genetically engineer these cells to recognize mesothelin. The gene-engineered cells will then be multiplied and infused into the patients to fight their cancer.
- MRI-Guided Focal Laser Therapy for Low-risk Prostate Cancer
(Posted: 07/10/2012) - In this pilot study, men diagnosed with or suspected of having low-risk prostate cancer will undergo advanced MRI techniques to guide a biopsy to the tumor area; subsequently, they will be treated using MRI-guided focal laser ablation therapy to only that area of the prostate.
- Trastuzumab for Women with HER2-Low Breast Cancer
(Posted: 06/26/2012) - In this clinical trial, women who have recently undergone surgical resection for HER2-low breast cancer and are at high risk for recurrence will undergo adjuvant chemotherapy and be randomly assigned to 1 year of trastuzumab treatment or no trastuzumab.