Study of Individuals and Families at High Risk for Blood CancersName of the Trial
Prospective Study of Clinical, Laboratory, Genetic, and Epidemiologic Characterization of
Individuals and Families at High Risk for Hematologic Cancers (NCI-02-C-0210). See the protocol summary.
Principal Investigators
Dr. Neil Caporaso and Dr. Mary McMaster, NCI’s Division of Cancer Epidemiology and
Genetics.
Why This Trial Is Important
Hematologic cancers are cancers of the blood, lymphatic system, or bone marrow, such as leukemia, lymphoma, and myeloma. Together,
these diseases constitute the fourth most common form of cancer, with more than 100,000 new
cases a year in the United States.
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Dr. Neil Caporaso and
Dr. Mary McMaster
Principal Investigators |
Researchers want to study individuals and families who may have a genetic predisposition
to developing hematologic cancers. Studying this population may help identify other persons
at risk, precursor conditions, clues to etiology, and the genes involved in these malignancies.
“We have compared DNA from family members affected by chronic lymphocytic leukemia
(CLL) with those family members not affected by CLL through linkage analysis,” said
Dr. Caporaso. “This allows us to identify areas of the DNA that may harbor a gene or
genes responsible for causing the disease.”
“We are also recruiting families having more than one member diagnosed with
Waldenstrom’s macroglobulinemia, Hodgkin’s lymphoma, and non-Hodgkin’s
lymphoma so that we can conduct analyses to identify genes that may predispose people to
these cancers,” said Dr. McMaster.
Who Can Join This Trial
Researchers seek to enroll participants who may be at high risk for developing
hematologic cancers. See the full list
of eligibility criteria for this study.
Study Site and Contact Information
The study will be conducted at the NIH Clinical Center in Bethesda, Md. Contact the NCI
Division of Cancer Epidemiology and Genetics, Genetic Epidemiology Branch referral nurse at
1-800-518-8474, or call the NCI Clinical Studies Support Center (CSSC) at 1-888-NCI-1937.
The call is toll free and confidential.
Published Results
Goldin LR, Ishibe N, Sgambati M, et al.: A genome scan of 18 families with chronic
lymphocytic leukaemia. Br J Haematol 121 (6): 866-73, 2003.[PUBMED Abstract]
Marti GE, Carter P, Abbasi F, et al.: B-cell monoclonal lymphocytosis and B-cell
abnormalities in the setting of familial B-cell chronic lymphocytic leukemia. Cytometry 52B
(1): 1-12, 2003.[PUBMED Abstract]
Ishibe N, Prieto D, Hosack DA, et al.: Telomere length and heavy-chain mutation status in
familial chronic lymphocytic leukemia. Leuk Res 26 (9): 791-4, 2002.[PUBMED Abstract]
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