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National Lung Screening Trial (NLST)

Publications from NLST

The following citations are of reports that have been published in the scientific literature.

Primary Results

Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening

  • Authors: National Lung Screening Trial Research Team.
  • Journal: N Engl J Med. 2011 Aug 4;365(5):395-409. Epub 2011 Jun 29.

Study Design

The National Lung Screening Trial: Overview and Study Design

  • Authors: National Lung Screening Trial Research Team.
  • Journal: Radiology. 2011 Jan;258(1):243-53. Epub 2010 Nov 2.

Baseline Characteristics of Participants in the Randomized National Lung Screening Trial

  • Authors: National Lung Screening Trial Research Team.
  • Journal: J Natl Cancer Inst. 2010 Dec 1;102(23):1771-9. Epub 2010 Nov 22.
Direct Mailing Was a Successful Recruitment Strategy for a Lung-Cancer Screening Trial
  • Authors: Hinshaw LB, Jackson SA, Chen MY.
  • Journal: J Clin Epidemiol. 2007 Aug;60(8):853-7. Epub 2007 Mar 26.
Chest Radiography as the Comparison for Spiral CT in the National Lung Screening Trial
  • Authors: Church TR; National Lung Screening Trial Executive Committee.
  • Journal:Acad Radiol. 2003 Jun;10(6):713-5.

Publications from the Feasibility Study for the NLST

Cumulative Incidence of False-Positive Test Results in Lung Cancer Screening: A Randomized Trial

  • Authors: Croswell JM, Baker SG, Marcus PM, Clapp JD, Kramer BS.
  • Journal: Ann Intern Med. 2010 Apr 20;152(8):505-12, W176-80.
Final Results of the Lung Screening Study, a Randomized Feasibility Study of Spiral CT Versus Chest X-ray Screening for Lung Cancer
  • Authors: Gohagan JK, Marcus PM, Fagerstrom RM, et al.
  • Journal: Lung Cancer. 2005 Jan;47(1):9-15.
Baseline Findings of a Randomized Feasibility Trial of Lung Cancer Screening With Spiral CT Scan vs Chest Radiograph: The Lung Screening Study of the National Cancer Institute
  • Authors: Gohagan J, Marcus P, Fagerstrom R, Pinsky P, Kramer B, Prorok P; Writing Committee, Lung Screening Study Research Group.
  • Journal: Chest. 2004 Jul;126(1):114-21.
Diagnostic Procedures After a Positive Spiral Computed Tomography Lung Carcinoma Screen
  • Authors: Pinsky PF, Marcus PM, Kramer BS, Freedman M, Nath H, Kvale P, Reding D.
  • Journal: Cancer. 2005 Jan 1;103(1):157-63.

Psychosocial and Behavioral Issues

Risk Perceptions Among Participants Undergoing Lung Cancer Screening: Baseline Results From the National Lung Screening Trial

  • Authors: Park ER, Ostroff JS, Rakowski W, Gareen IF, Diefenbach MA, Feibelmann S, Rigotti NA.
  • Journal: Ann Behav Med. 2009 Jun;37(3):268-79. Epub 2009 Aug 27.
Lung Cancer Screening as a Teachable Moment for Smoking Cessation
  • Authors: Taylor KL, Cox LS, Zincke N, Mehta L, McGuire C, Gelmann E.
  • Journal: Lung Cancer. 2007 Apr;56(1):125-34. Epub 2006 Dec 28.

Technical Publications

Normalized CT Dose Index of the CT Scanners Used in the National Lung Screening Trial

  • Authors: Cody DD, Kim HJ, Cagnon CH, et al.
  • Journal: AJR Am J Roentgenol. 2010 Jun;194(6):1539-46.
Collecting 48,000 CT Exams for the Lung Screening Study of the National Lung Screening Trial
  • Authors: Clark KW, Gierada DS, Marquez G, et al.
  • Journal: J Digit Imaging. 2009 Dec;22(6):667-80. Epub 2008 Sep 6.
CT Quality Assurance in the Lung Screening Study Component of the National Lung Screening Trial: Implications for Multicenter Imaging Trials
  • Authors:Gierada DS, Garg K, Nath H, Strollo DC, Fagerstrom RM, Ford MB.
  • Journal: AJR Am J Roentgenol. 2009 Aug;193(2):419-24.
Automated Matching of Pulmonary Nodules: Evaluation in Serial Screening Chest CT
  • Authors: Tao C, Gierada DS, Zhu F, Pilgram TK, Wang JH, Bae KT.
  • Journal: AJR Am J Roentgenol. 2009 Mar;192(3):624-8.
Lung Cancer: Interobserver Agreement on Interpretation of Pulmonary Findings at Low-Dose CT Screening
  • Authors: Gierada DS, Pilgram TK, et al.
  • Journal: Radiology. 2008 Jan;246(1):265-72. Epub 2007 Nov 16.
Creation of a CT Image Library for the Lung Screening Study of the National Lung Screening Tria
  • Authors: Clark KW, Gierada DS, Moore SM, Maffitt DR, Koppel P, Phillips SR, Prior FW.
  • Journal: J Digit Imaging. 2007 Mar;20(1):23-31.

Description and Implementation of a Quality Control Program in an Imaging-Based Clinical Trial

  • Authors: Cagnon CH, Cody DD, McNitt-Gray MF, Seibert JA, Judy PF, Aberle DR.
  • Journal: Acad Radiol. 2006 Nov;13(11):1431-41.

Accuracy of the CT Numbers of Simulated Lung Nodules Imaged With Multi-detector CT Scanners

  • Authors: Goodsitt MM, Chan HP, Way TW, Larson SC, Christodoulou EG, Kim J.
  • Journal: Med Phys. 2006 Aug;33(8):3006-17.