NLST Updates
2010 Updates
- Lung cancer trial results show mortality benefit with low-dose CT: 1
Twenty percent fewer lung cancer deaths seen among those who were screened with low-dose spiral CT than with chest X-ray
(Posted: 11/04/2010) - The NCI has released initial results from a large-scale test of screening methods to reduce deaths from lung cancer by detecting cancers at relatively early stages. The National Lung Screening Trial, a randomized national trial involving more than 53,000 current and former heavy smokers ages 55 to 74, compared the effects of two screening procedures for lung cancer -- low-dose helical computed tomography (CT) and standard chest X-ray -- on lung cancer mortality and found 20 percent fewer lung cancer deaths among trial participants screened with low-dose helical CT. - National Lung Screening Trial (NLST) Initial Results: Fast Facts 2
(Posted: 11/04/2010, Updated: 06/29/2011) - On November 4, 2010, the NLST reported initial trial results, showing 20 percent fewer lung cancer deaths among trial participants screened with low-dose helical CT (also known as spiral CT) compared to those who got screened with chest X-rays. - National Lung Screening Trial: Questions and Answers 3
(Posted: 09/18/2002, Updated: 06/29/2011) - The NLST, a cancer screening clinical trial, will compare two ways of detecting lung cancer: spiral computed tomography (CT) and standard chest X-ray. - November 2010 Letter to Participants 4
A downloadable PDF document. - October 2010 DSMB Statement Concerning the National Lung Screening Trial 5
A downloadable PDF document. - NLST Presentations from the 2010 RSNA meeting 6
Earlier Information From the NCI Press Office
- National Lung Screening Trial Reaches Goal of 50,000 Participants 7
(Posted: 01/27/2004) - The National Cancer Institute (NCI), part of the National Institutes of Health, in partnership with the American Cancer Society, has enrolled its goal of 50,000 current or former smokers in the National Lung Screening Trial (NLST). - Fifty Thousand Current and Former Smokers Needed for National Lung Screening Trial 8
The National Cancer Institute (NCI) has launched a new study - the National Lung Screening Trial, or NLST - to determine if screening people with either spiral computerized tomography (CT) or chest X-ray before they have symptoms can reduce deaths from lung cancer.
Published Results
Study Design
The National Lung Screening Trial: Overview and Study Design 9
Baseline Characteristics of Participants in the Randomized National Lung Screening Trial 10
Direct Mailing Was a Successful Recruitment Strategy for a Lung-Cancer Screening Trial 11
Chest Radiography as the Comparison for Spiral CT in the National Lung Screening Trial 12
Psychosocial and Behavioral Issues
Risk Perceptions Among Participants Undergoing Lung Cancer Screening: Baseline Results From the National Lung Screening Trial 13
Lung Cancer Screening as a Teachable Moment for Smoking Cessation 14
Technical Publications
Normalized CT Dose Index of the CT Scanners Used in the National Lung Screening Trial 15
Collecting 48,000 CT Exams for the Lung Screening Study of the National Lung Screening Trial 16
CT Quality Assurance in the Lung Screening Study Component of the National Lung Screening Trial: Implications for Multicenter Imaging Trials 17
Automated Matching of Pulmonary Nodules: Evaluation in Serial Screening Chest CT 18
Lung Cancer: Interobserver Agreement on Interpretation of Pulmonary Findings at Low-Dose CT Screening 19
Creation of a CT Image Library for the Lung Screening Study of the National Lung Screening Trial 20
Description and Implementation of a Quality Control Program in an Imaging-Based Clinical Trial 21
Accuracy of the CT Numbers of Simulated Lung Nodules Imaged With Multi-detector CT Scanners 22
Publications From the Feasibility Study for the NLST
Cumulative Incidence of False-Positive Test Results in Lung Cancer Screening: A Randomized Trial 23
Final Results of the Lung Screening Study, a Randomized Feasibility Study of Spiral CT Versus Chest X-ray Screening for Lung Cancer 24
Baseline Findings of a Randomized Feasibility Trial of Lung Cancer Screening With Spiral CT Scan vs Chest Radiograph: The Lung Screening Study of the National Cancer Institute 25
Diagnostic Procedures After a Positive Spiral Computed Tomography Lung Carcinoma Screen 26