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National Lung Screening Trial (NLST)

  • Updated: 01/11/2011

NLST Presentations from the 2010 Radiological Society of North America meeting

Presentations given November 29, 2010, at the Radiological Society of North America (RSNA) meeting provide more background on some aspects of the initial findings.

Denise Aberle, M.D., co-principal investigator for NLST and a professor of radiology and bioengineering at the David Geffen School of Medicine at the University of California, Los Angeles, discussed the initial results of the trial, with an emphasis on the primary endpoint of lung cancer-specific mortality. [Download PDF]

Frederick J. Larke, M.S., a medical physicist and associate professor of radiology at the University of Colorado, Denver, looked at radiation exposure risk. In the trial, a team of physicists ensured as much uniformity as possible across scanners and protocols and sought to achieve relatively low radiation doses to patients. The NLST results showed that acceptable chest CT screening can be accomplished at a small fraction of the dose of standard chest CT. [Download PDF]

David S. Gierada, M.D., professor of radiology at Washington University School of Medicine, St. Louis, Missouri, looked at false-positive rates and how the NLST evaluated positive screens, including issues of reader variability. [Download PDF]

Constantine Gatsonis, Ph.D., professor of biostatistics and director for Statistical Sciences at Brown University, Providence, Rhode Island, discussed cost-effectiveness studies that will be part of future NLST sub-analyses to examine non-medical expenses associated with screening, such as lost wages and travel and lodging. Additional sub-studies will look at quality of life, including patient anxiety about screening, as well as screening's effects on smoking behavior and healthcare utilization. [Download PDF]

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