Breast Cancer Trial Results
- Lasofoxifene Is Potential New Option for Breast Cancer Risk Reduction
(Posted: 12/07/2010) - An investigational agent in the same family of drugs as tamoxifen and raloxifene may be as or more effective in reducing breast cancer risk in some women. The drug, lasofoxifene, also appears to have important benefits for both bone and heart health and, with one exception, appears to lack the rare but potentially serious side effects associated with tamoxifen and raloxifene, according to results published November 4, 2010, in the Journal of the National Cancer Institute.
- Less-Invasive Lymph Node Surgery Safe for Women with Breast Cancer
(Posted: 11/04/2010) - Breast cancer patients who had sentinel lymph node biopsy followed by axillary lymph node dissection (ALND) only if cancer cells were detected in the sentinel nodes had the same overall survival as those who underwent ALND regardless of sentinel node status, according to a randomized trial published online September 20, 2010, in Lancet Oncology.
- Hormone Therapy Linked to Modest Increase in Breast Cancer Deaths
(Posted: 10/20/2010) - Women who used combined estrogen and progestin hormone replacement therapy to treat menopausal symptoms during the Women’s Health Initiative (WHI) study had more cases of invasive breast cancer, more lymph-node positive breast cancer, and a slightly higher death rate from breast cancer and other causes than women who received a placebo, researchers reported in an 11-year follow-up report on the study's participants.
- For Women with BRCA Mutations, Prophylactic Surgery Reduces Cancer Risk
(Posted: 09/23/2010) - Prophylactic surgery to remove the breasts and ovaries is an effective way to reduce the risk of breast and ovarian cancer among women with inherited mutations in the BRCA1 or BRCA2 genes, according to one of the largest prospective studies on the subject to date.
- Single-Dose Partial Breast Irradiation Safe for Some Women with Invasive Breast Cancer
(Posted: 07/08/2010, Updated: 08/04/2010) - A study published online June 5, 2010, in The Lancet shows that for some women with invasive breast cancer a single dose of radiotherapy delivered at the time of surgery may be an alternative to a standard course of external beam radiotherapy.