Colon and Rectal Cancer Trial Results
- Celecoxib Reduces Risk of Precancerous Colorectal Polyps: Five-Year Results of APC Trial
(Posted: 04/23/2008, Updated: 05/21/2009) - The five-year results of the Adenoma Prevention with Celecoxib (APC) trial indicate that two years after daily use of celecoxib (Celebrex®) has ended, there continues to be a modest reduction in the recurrence of colorectal polyps, according to a presentation at the 2008 American Association for Cancer Research annual meeting.
- Combining Targeted Drugs Is Worse in Colorectal Cancer
(Posted: 02/24/2009) - A clinical trial testing chemotherapy combined with bevacizumab (Avastin) and cetuximab (Erbitux), and comparing this with chemotherapy and bevacizumab alone, found that the addition of cetuximab was actually worse for patients, according to the Feb. 5, 2009, New England Journal of Medicine.
- 5-FU-Based Chemotherapy Cures Some Patients with Colon Cancer
(Posted: 02/03/2009) - Researchers from the Adjuvant Colon Cancer Endpoints (ACCENT) Group used individual patient data from 18 phase III trials of adjuvant 5-FU-based chemotherapy for colon cancer to show that the regimens provide their survival benefit primarily by reducing the high risk of recurrence within the first two years after surgery, according to a study published online January 5, 2009, in the Journal of Clinical Oncology.
- Drug Combination Cuts Risk of Advanced Colon Polyps
(Posted: 04/21/2008, Updated: 10/19/2008) - Low doses of two chemopreventive agents are highly effective at preventing the recurrence of the lesions that are often precursors to colorectal cancer, according to results presented at the 2008 American Association for Cancer Research annual meeting.
- Large, Multi-Center Trial Demonstrates Comparable Accuracy for Virtual Colonoscopy and Standard Colonoscopy
(Posted: 09/17/2008) - Computerized tomographic colonography, also known as virtual colonoscopy, is comparable to standard colonoscopy, which uses a long, flexible tube with a camera to view the lining of the colon, in its ability to accurately detect cancer and precancerous polyps and could serve as an initial screening exam for colorectal cancer, according to the results of the American College of Radiology Imaging Network National CT Colonography Trial.