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Multiple Myeloma Trial Results

  • Three-Drug Combination Benefits Some Patients with Relapsed Multiple Myeloma
    (Posted: 01/09/2015) - Interim results from an international, randomized phase III trial suggest that adding carfilzomib (Kyprolis®) to a standard treatment improves outcomes for patients with multiple myeloma whose cancer has relapsed. Participants in the study who received carfilzomib plus lenalidomide (Revlimid®) and dexamethasone lived a median of 8.7 months longer without the disease getting worse than patients who received lenalidomide and dexamethasone alone.
  • Pomalidomide plus Low-Dose Dexamethasone Improves Survival for Patients with Multiple Myeloma
    (Posted: 09/19/2013) - Results from a randomized phase III trial show that the combination of pomalidomide (Pomalyst®) and low-dose dexamethasone may benefit some patients with multiple myeloma that has progressed (worsened) despite other treatments. Patients who received the combination therapy lived longer without the disease getting worse than patients who received high-dose dexamethasone alone. Overall survival was also improved in the group that received the combination therapy compared with the other group.
  • Denosumab Effective for Multiple Myeloma and Solid Tumors
    (Posted: 06/08/2011) - Results from a randomized phase III trial of denosumab to prevent skeletal related events in several types of cancer were published online February 22, 2011, in the Journal of Clinical Oncology (JCO).
  • Less-intensive Treatment Regimen Effective against Multiple Myeloma
    (Posted: 09/23/2010) - Treating patients who have multiple myeloma with less-intensive dosing of bortezomib (Velcade®) reduced toxic side effects without making the treatment less effective, Spanish researchers reported online August 23, 2010, in The Lancet Oncology.
  • Double Transplantation of One's Own Stem Cells Is Not Warranted for Multiple Myeloma
    (Posted: 02/24/2009) - The addition of a second hematopoietic stem cell transplant procedure using one's own blood cells does not appear warranted in multiple myeloma, according to the Jan. 21, 2009, Journal of the National Cancer Institute.