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Clinical Trials (PDQ®)

Early Diagnosis of Lung Cancer and Mesothelioma in Prior Asbestos Workers

Basic Trial Information
Trial Description
     Eligibility Criteria
Trial Contact Information

Basic Trial Information

PhaseTypeStatusAgeSponsorProtocol IDs
No phase specifiedScreeningActive50 to 85OtherAsbestos Screening Study

Trial Description


Occupational exposure to asbestos is known increase the risk of developing cancer of the lungs (bronchogenic carcinoma) or of the pleura (mesothelioma). Symptoms are subtle and non-specific, diagnosis is often late and the prognosis consequently is dismal. Currently there is no accepted non-invasive tool for the early diagnosis of mesothelioma or lung cancer in asbestos-exposed subjects. In the last decade, low-dose computed tomography (LDCT) has been successfully developed and validated for the early diagnosis of lung cancer in high-risk smokers. Malignant mesothelioma might, in an early stage, resemble a benign pleural plaque, which is a common finding after asbestos exposure. We target to develop low-dose CT as a tool to serially image the pleural plaques, quantify their individual and overall volume, compute the growth rate with time, and, as such, identify the presence of mesothelioma early, before symptoms occur.

Eligibility Criteria

Inclusion Criteria:

prior asbestos exposure at least 20 years ago and/or documented pleural plaques (chest x-ray evidence)

Resident of Ontario, Canada

Exclusion Criteria:

prior cancer (except non-melanotic skin cancer)

Trial Contact Information

Trial Lead Organizations/Sponsors

Toronto Western Hospital

Demetris Patsios, MDPrincipal Investigator

Marc de Perrot, MDPrincipal Investigator

Demetris Patsios, MDPh: Tel: (416) 603-5800 Ext.2583

Trial Sites

 Princess Margaret Hospital
 Demetris Patsios, MD Ph: Tel: (416) 603-5800 Ext.2583
 Brenda O'Sullivan, MD Ph: 416-340-4800 Ext.5686
  Email: brenda.o'

Link to the current record.
NLM Identifer NCT00188890 processed this data on August 01, 2014

Note: Information about this trial is from the database. The versions designated for health professionals and patients contain the same text. Minor changes may be made to the record to standardize the names of study sponsors, sites, and contacts. only lists sites that are recruiting patients for active trials, whereas lists all sites for all trials. Questions and comments regarding the presented information should be directed to

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