Basic Trial Information
Trial Description
     Summary
     Further Trial Information
     Eligibility Criteria
Trial Contact Information

Basic Trial Information

Trial Description

Summary

RATIONALE: Radiation therapy uses high-energy x-rays and other types of radiation to kill tumor cells. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether giving radiation therapy together with cisplatin is more effective than radiation therapy alone in treating patients with endometrial cancer.

PURPOSE: This randomized phase II trial is studying radiation therapy and cisplatin to see how well they work compared with radiation therapy alone in treating patients with recurrent endometrial cancer.

Further Study Information

OBJECTIVES:

Primary

• Determine whether pelvic radiotherapy and cisplatin are more promising with respect to progression-free survival than pelvic radiotherapy alone in patients with recurrent endometrial cancer limited to the pelvis and vagina.

Secondary

• Compare the sites of recurrence in patients treated with these regimens.

• Compare overall survival of patients treated with these regimens.

• Compare the prognostic significance of the location (central pelvis versus vagina) and size of the recurrence, in addition to the prognostic significance in the salvage setting, in terms of histological subtype, grade, age, race, performance status, and the presence of lymph-vascular space involvement of the original tumor at the time of initial hysterectomy, in patients treated with these regimens.

• Compare the toxicity of these regimens in these patients.

OUTLINE: This is a multicenter, randomized study. Patients are randomized to 1 of 2 treatment arms.

• Arm I: Patients undergo external-beam radiotherapy (EBRT) to the pelvis on days 1-5, 8-12, 15-19, 22-26, 29-33, and 36-40. After completion of EBRT, patients undergo intracavitary low-dose rate or high-dose rate brachytherapy* or low-dose rate interstitial brachytherapy*.

• Arm II: Patients undergo EBRT as in arm I and receive cisplatin IV over 1-2 hours on days 1, 8, 15, 22, 29, and 36. Patients then undergo brachytherapy* as in arm I.

NOTE: *IMRT will be allowed for the entire course of therapy, this is for the treatment of the whole pelvis and/or the boost in those cases not undergoing brachytherapy.

In both arms, treatment continues in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed monthly for 3 months, every 3 months for 2 years, and then every 6 months for 3 years.

Eligibility Criteria

DISEASE CHARACTERISTICS:

• Histologically confirmed diagnosis of endometrial cancer, including the following histological subtypes:

• Adenocarcinoma

• Adenocarcinoma with squamous differentiation

• Mucinous adenocarcinoma

• Squamous cell carcinoma

• Mixed carcinoma

• Undifferentiated carcinoma

• Clear cell adenocarcinoma

• Serous adenocarcinoma

• Must have undergone prior complete hysterectomy and bilateral salpingo-oophorectomy at the time of original therapy

• Recurrent disease confined to the pelvis and/or vagina

• No evidence of extrapelvic disease, including positive periaortic or inguino-femoral nodes by chest x-ray or CT scan

• Prior primary surgical debulking (including removal of gross symptomatic disease in the pelvis and/or vagina) allowed provided there is residual disease that is evaluable clinically and/or by CT scan or MRI

• Exenterative surgery is not permissible

• Patients who have undergone prior complete surgical resection of the recurrent tumor and have no evidence of residual disease evaluable clinically and by CT scan or MRI after resection are not eligible

• Patients enrolled subsequent to revision 11 with complete resection of gross recurrent disease are eligible

• Patients with ureteral obstruction must undergo stent or nephrostomy tube placement prior to study entry

PATIENT CHARACTERISTICS:

• GOG performance status 0-2

• Life expectancy ≥ 3 months

• Absolute neutrophil count ≥ 1,500/mm³

• Platelet count ≥ 100,000/mm³

• Creatinine normal OR creatinine clearance > 50 mL/min

• Bilirubin ≤ 1.5 times upper limit of normal (ULN)

• SGOT ≤ 2.5 times ULN

• Alkaline phosphatase ≤ 2.5 times ULN

• No sensory or motor neuropathy > grade 1

• No septicemia or severe infection

• No circumstances that would preclude study participation

• No renal abnormalities (i.e., pelvic kidney, horseshoe kidney, or prior renal transplantation) that would require modification of radiation fields

• No other invasive malignancies within the past 5 years except nonmelanoma skin cancer

• No significant history of cardiac disease, including uncontrolled hypertension, unstable angina, congestive heart failure, or uncontrolled arrhythmias within the past 6 months

• No history of active collagen vascular disease

PRIOR CONCURRENT THERAPY:

• At least 6 months since prior hormone therapy and/or systemic chemotherapy

• No prior neoadjuvant chemotherapy for recurrent disease

• No prior exenterative surgery

• No prior vaginal, pelvic, or abdominal irradiation

• No prior chemotherapy directed at the present recurrent disease

• No prior cancer treatment that would preclude study treatment

Trial Contact Information

Trial Lead Organizations/Sponsors

Gynecologic Oncology Group

Shu-Yuan Liao, MD

Study Chair

U.S.A.
California
	Burbank
	Roy and Patricia Disney Family Cancer Center at Providence Saint Joseph Medical Center
		Richard Friedman	Ph: 818-847-3220
	Modesto
	Memorial Medical Center
		Jorge A Garcia-Young	Ph: 209-572-7116
	Mountain View
	Palo Alto Medical Foundation
		Albert L Pisani	Ph: 650-934-7000
	San Diego
	Rebecca and John Moores UCSD Cancer Center
		Michael T. McHale	Ph: 858-822-5354
			Email: cancercto@ucsd.edu
	Sylmar
	Olive View - UCLA Medical Center Foundation
		Christine Holschneider	Ph: 888-798-0719
Connecticut
	Hartford
	Helen and Harry Gray Cancer Center at Hartford Hospital
		James S. Hoffman	Ph: 860-224-5660
	Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center
		Philip J. Stella	Ph: 734-712-3456
	New Britain
	George Bray Cancer Center at the Hospital of Central Connecticut - New Britain Campus
		James S. Hoffman	Ph: 860-224-5660
Delaware
	Lewes
	Tunnell Cancer Center at Beebe Medical Center
		Mark E Borowsky	Ph: 302-733-6227
	Newark
	Helen F. Graham Cancer Center at Christiana Hospital
		Mark E Borowsky	Ph: 302-733-6227
Georgia
	Savannah
	Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler
		William Edward Richards	Ph: 800-622-6877
			Email: uchealthnews@uc.edu
Idaho
	Boise
	Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
		Philip J. Stella	Ph: 734-712-3456
Illinois
	Bloomington
	St. Joseph Medical Center
		John W. Kugler	Ph: 800-793-2262
	Chicago
	Robert H. Lurie Comprehensive Cancer Center at Northwestern University
		Julian C. Schink	Ph: 312-695-1301
			Email: cancer@northwestern.edu
	Hinsdale
	Gynecologic Oncology
		Sudarshan K. Sharma	Ph: 630-856-6757
	Moline
	Trinity Cancer Center at Trinity Medical Center - 7th Street Campus
		Costas L. Constantinou	Ph: 319-363-2690
	Normal
	BroMenn Regional Medical Center
		John W. Kugler	Ph: 800-793-2262
	Community Cancer Center
		John W. Kugler	Ph: 800-793-2262
	Oak Lawn
	Advocate Christ Medical Center
		Yvonne Cathleen Collins	Ph: 800-323-8622
	Ottawa
	Community Hospital of Ottawa
		John W. Kugler	Ph: 800-793-2262
	Illinois CancerCare - Ottawa
		John W. Kugler	Ph: 800-793-2262
	Peoria
	CCOP - Illinois Oncology Research Association
		John W. Kugler	Ph: 800-793-2262
	Illinois CancerCare - Peoria
		John W. Kugler	Ph: 800-793-2262
	OSF Saint Francis Medical Center Radiation Oncology Service at the Central Illinois Comprehensive CC
		John W. Kugler	Ph: 800-793-2262
	OSF St. Francis Medical Center
		John W. Kugler	Ph: 800-793-2262
	Spring Valley
	Valley Cancer Center
		John W. Kugler	Ph: 800-793-2262
Indiana
	Indianapolis
	Indiana University Melvin and Bren Simon Cancer Center
		Jeanne M Schilder	Ph: 317-274-2552
Iowa
	Clive
	Medical Oncology and Hematology Associates-West Des Moines
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Mercy Cancer Center - West Lakes
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Des Moines
	CCOP - Iowa Oncology Research Association
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	John Stoddard Cancer Center at Iowa Lutheran Hospital
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	John Stoddard Cancer Center at Iowa Methodist Medical Center
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Medical Oncology and Hematology Associates at John Stoddard Cancer Center
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Medical Oncology and Hematology Associates at Mercy Cancer Center
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Mercy Cancer Center at Mercy Medical Center - Des Moines
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Iowa City
	Holden Comprehensive Cancer Center at University of Iowa
		Koen De Geest	Ph: 800-237-1225
	Sioux City
	Mercy Medical Center - Sioux City
		Donald Bruce Wender	Ph: 712-252-0088
	Siouxland Hematology-Oncology Associates, LLP
		Donald Bruce Wender	Ph: 712-252-0088
	St. Luke's Regional Medical Center
		Donald Bruce Wender	Ph: 712-252-0088
	West Des Moines
	Methodist West Hospital
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
Kansas
	Chanute
	Cancer Center of Kansas, PA - Chanute
		Shaker R. Dakhil	Ph: 316-262-4467
	Dodge City
	Cancer Center of Kansas, PA - Dodge City
		Shaker R. Dakhil	Ph: 316-262-4467
	El Dorado
	Cancer Center of Kansas, PA - El Dorado
		Shaker R. Dakhil	Ph: 316-262-4467
	Fort Scott
	Cancer Center of Kansas - Fort Scott
		Shaker R. Dakhil	Ph: 316-262-4467
	Independence
	Cancer Center of Kansas-Independence
		Shaker R. Dakhil	Ph: 316-262-4467
	Kingman
	Cancer Center of Kansas, PA - Kingman
		Shaker R. Dakhil	Ph: 316-262-4467
	Lawrence
	Lawrence Memorial Hospital
		Shaker R. Dakhil	Ph: 316-262-4467
	Liberal
	Cancer Center of Kansas, PA - Liberal
		Shaker R. Dakhil	Ph: 316-262-4467
	Newton
	Cancer Center of Kansas, PA - Newton
		Shaker R. Dakhil	Ph: 316-262-4467
	Parsons
	Cancer Center of Kansas, PA - Parsons
		Shaker R. Dakhil	Ph: 316-262-4467
	Pratt
	Cancer Center of Kansas, PA - Pratt
		Shaker R. Dakhil	Ph: 316-262-4467
	Salina
	Cancer Center of Kansas, PA - Salina
		Shaker R. Dakhil	Ph: 316-262-4467
	Wellington
	Cancer Center of Kansas, PA - Wellington
		Shaker R. Dakhil	Ph: 316-262-4467
	Wichita
	Associates in Women's Health, PA - North Hillside
		Shaker R. Dakhil	Ph: 316-262-4467
	Cancer Center of Kansas, PA - Medical Arts Tower
		Shaker R. Dakhil	Ph: 316-262-4467
	Cancer Center of Kansas, PA - Wichita
		Shaker R. Dakhil	Ph: 316-262-4467
	CCOP - Wichita
		Shaker R. Dakhil	Ph: 316-262-4467
	Via Christi Cancer Center at Via Christi Regional Medical Center
		Shaker R. Dakhil	Ph: 316-262-4467
	Wesley Medical Center
		Shaker R. Dakhil	Ph: 316-262-4467
	Winfield
	Cancer Center of Kansas, PA - Winfield
		Shaker R. Dakhil	Ph: 316-262-4467
Kentucky
	Edgewood
	St. Elizabeth Medical Center
		Jack Basil	Ph: 859-301-5473
			Email: darla.hehman@stelizabeth.com
	Lexington
	University of Kentucky Chandler Medical Center
		Frederick Ueland	Ph: 859-257-3379
Louisiana
	Baton Rouge
	Woman's Hospital
		Giles Fort	Ph: 225-215-1353
			Email: clinicalreserach@marybird.com
Maryland
	Baltimore
	Alvin and Lois Lapidus Cancer Institute at Sinai Hospital
		Fouad M Abbas	Ph: 410-601-6120
			Email: pridgely@lifebridgehealth.org
	Greater Baltimore Medical Center Cancer Center
		Paul Celano	Ph: 443-849-3706
	Elkton MD
	Union Hospital of Cecil County
		Mark E Borowsky	Ph: 302-733-6227
Massachusetts
	Burlington
	Lahey Clinic Medical Center - Burlington
		Corrine L Zarwan	Ph: 781-744-8027
	Springfield
	Baystate Medical Center
		Tashanna K Myers	Ph: 413-794-3565
			Email: tamara.wrenn@baystatehealth.org
	Worcester
	Levine Cancer Center at UMass Medical Center - Memorial Campus
		Susan L. Zweizig	Ph: 508-856-2464
			Email: laura.lefko@umassmed.edu
Michigan
	Ann Arbor
	CCOP - Michigan Cancer Research Consortium
		Philip J. Stella	Ph: 734-712-3456
	Saint Joseph Mercy Cancer Center
		Philip J. Stella	Ph: 734-712-3456
	Dearborn
	Oakwood Cancer Center at Oakwood Hospital and Medical Center
		Philip J. Stella	Ph: 734-712-3456
	Detroit
	Van Elslander Cancer Center at St. John Hospital and Medical Center
		Philip J. Stella	Ph: 734-712-3456
	Wayne State University
		Robert T. Morris	Ph: 313-576-9363
	Flint
	Genesys Hurley Cancer Institute
		Philip J. Stella	Ph: 734-712-3456
	Hurley Medical Center
		Philip J. Stella	Ph: 734-712-3456
	Grand Blanc
	Genesys Regional Medical Center
		Philip J. Stella	Ph: 734-712-3456
	Jackson
	Gayle M. Jacob Cancer Center at Allegiance Health
		Philip J. Stella	Ph: 734-712-3456
	Kalamazoo
	Borgess Medical Center
		Raymond Sterling Lord	Ph: 269-373-7458
	Bronson Methodist Hospital
		Raymond Sterling Lord	Ph: 269-373-7458
	West Michigan Cancer Center
		Raymond Sterling Lord	Ph: 269-373-7458
	Lansing
	Sparrow Regional Cancer Center
		Philip J. Stella	Ph: 734-712-3456
	Livonia
	St. Mary Mercy Hospital
		Philip J. Stella	Ph: 734-712-3456
	Pontiac
	St. Joseph Mercy Oakland
		Philip J. Stella	Ph: 734-712-3456
	Port Huron
	Mercy Regional Cancer Center at Mercy Hospital
		Philip J. Stella	Ph: 734-712-3456
	Saginaw
	Seton Cancer Institute at Saint Mary's - Saginaw
		Philip J. Stella	Ph: 734-712-3456
	Warren
	St. John Macomb Hospital
		Philip J. Stella	Ph: 734-712-3456
Minnesota
	Burnsville
	Fairview Ridges Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Coon Rapids
	Mercy and Unity Cancer Center at Mercy Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Edina
	Fairview Southdale Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Fridley
	Mercy and Unity Cancer Center at Unity Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Hutchinson
	Hutchinson Area Health Care
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Maplewood
	HealthEast Cancer Care at St. John's Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Minnesota Oncology - Maplewood
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Minneapolis
	Hennepin County Medical Center - Minneapolis
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	New Ulm
	New Ulm Medical Center
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Robbinsdale
	Humphrey Cancer Center at North Memorial Outpatient Center
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Saint Louis Park
	CCOP - Metro-Minnesota
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Park Nicollet Cancer Center
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Saint Paul
	Regions Hospital Cancer Care Center
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	United Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Shakopee
	St. Francis Cancer Center at St. Francis Medical Center
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Stillwater
	Lakeview Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Waconia
	Ridgeview Medical Center
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Willmar
	Willmar Cancer Center at Rice Memorial Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Woodbury
	Minnesota Oncology - Woodbury
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
Mississippi
	Jackson
	University of Mississippi Cancer Clinic
		James Tate Thigpen	Ph: 601-815-6700
	Pascagoula
	Regional Cancer Center at Singing River Hospital
		James E. Clarkson	Ph: 228-809-5292
Missouri
	Rolla
	Mercy Clinic Cancer and Hematology - Rolla
		Robert L Carolla	Ph: 417-269-4520
	Springfield
	Cancer Research for the Ozarks
		Robert L Carolla	Ph: 417-269-4520
	Hulston Cancer Center at Cox Medical Center South
		Robert L Carolla	Ph: 417-269-4520
	St. John's Regional Health Center
		Robert L Carolla	Ph: 417-269-4520
Montana
	Billings
	Billings Clinic Cancer Center - 801 N 29th Street
		Randall K Gibb	Ph: 800-996-2663
			Email: research@billingsclinic.org
Nebraska
	Omaha
	Methodist Estabrook Cancer Center
		Peter C. Morris	Ph: 402-354-7939
			Email: kathryn.bartz@nmhs.org
Nevada
	Las Vegas
	CCOP - Nevada Cancer Research Foundation
		John Allan Ellerton	Ph: 702-731-8274
	Women's Cancer Center - La Canada
		Nick M. Spirtos	Ph: 702-851-4672
New Hampshire
	Manchester
	Elliot Regional Cancer Center at Elliot Hospital
		Brian R Knab	Ph: 603-663-1800
New Jersey
	Mount Holly
	Virtua Fox Chase Health Cancer Program at Virtua Memorial Hospital Burlington County
		Randolph B Deger	Ph: 888-847-8823
	Ridgewood
	Valley Hospital - Ridgewood
		Noah A Goldman	Ph: 201-634-5792
	Toms River
	J. Phillip Citta Regional Cancer Center at Community Medical Center
		David J D'Ambrosio	Ph: 732-818-3882
	Voorhees
	Fox Chase Virtua Health Cancer Program at Virtua West Jersey
		Randolph B Deger	Ph: 888-847-8823
New Mexico
	Albuquerque
	Southwest Gynecologic Oncology Associates, Incorporated
		Teresa L Rutledge	Ph: 505-272-6972
	University of New Mexico Cancer Center
		Teresa L Rutledge	Ph: 505-272-6972
New York
	Brooklyn
	SUNY Downstate Medical Center
		Ovadia Abulafia	Ph: 718-270-8216
			Email: sima.terebelo@downstate.edu
	Lake Success
	Monter Cancer Center of the North Shore-LIJ Health System
		Veena S John	Ph: 516-562-3467
	Manhasset
	Don Monti Comprehensive Cancer Center at North Shore University Hospital
		Veena S John	Ph: 516-562-3467
	New Hyde Park
	Long Island Jewish Medical Center
		Veena S John	Ph: 516-562-3467
	Stony Brook
	Stony Brook University Cancer Center
		Michael L. Pearl	Ph: 800-862-2215
	Syracuse
	SUNY Upstate Medical University Hospital
		Mary J Cunningham	Ph: 315-464-5476
North Carolina
	Goldsboro
	Wayne Memorial Hospital, Incorporated
		James N. Atkins	Ph: 919-580-0000
	Winston-Salem
	Wake Forest University Comprehensive Cancer Center
		Samuel S. Lentz	Ph: 336-713-6771
Ohio
	Akron
	Summa Center for Cancer Care at Akron City Hospital
		Vivian von Gruenigen	Ph: 330-375-6101
	Canton
	Aultman Cancer Center at Aultman Hospital
		Michael P. Hopkins	Ph: 330-363-6891
	Chillicothe
	Adena Regional Medical Center
		J. Philip Kuebler	Ph: 614-566-3275
	Cincinnati
	Good Samaritan Hospital Cancer Treatment Center
		Jack Basil	Ph: 859-301-5473
			Email: darla.hehman@stelizabeth.com
	Cleveland
	Case Comprehensive Cancer Center
		Steven E. Waggoner	Ph: 800-641-2422
	Columbus
	CCOP - Columbus
		J. Philip Kuebler	Ph: 502-361-8496
	Doctors Hospital at Ohio Health
		J. Philip Kuebler	Ph: 502-361-8496
	Grant Medical Center Cancer Care
		J. Philip Kuebler	Ph: 502-361-8496
	Mount Carmel Health - West Hospital
		J. Philip Kuebler	Ph: 614-566-3275
	Riverside Methodist Hospital Cancer Care
		Jeffrey G. Bell	Ph: 614-566-4475
	Zangmeister Center
		J. Philip Kuebler	Ph: 614-566-3275
	Delaware
	Grady Memorial Hospital
		J. Philip Kuebler	Ph: 614-566-3275
	Kettering
	Charles F. Kettering Memorial Hospital
		Heather S Pulaski	Ph: 937-298-3399
	Marietta
	Strecker Cancer Center at Marietta Memorial Hospital
		J. Philip Kuebler	Ph: 614-566-3275
	Mentor
	Lake/University Ireland Cancer Center
		Steven E. Waggoner	Ph: 800-641-2422
	Newark
	Licking Memorial Cancer Care Program at Licking Memorial Hospital
		J. Philip Kuebler	Ph: 614-566-3275
	Portsmouth
	Southern Ohio Medical Center Cancer Center
		J. Philip Kuebler	Ph: 502-361-8496
	Springfield
	Community Hospital of Springfield and Clark County
		J. Philip Kuebler	Ph: 614-566-3275
	Westerville
	Mount Carmel St. Ann's Cancer Center
		J. Philip Kuebler	Ph: 614-566-3275
	Zanesville
	Genesis - Good Samaritan Hospital
		J. Philip Kuebler	Ph: 502-361-8496
Oklahoma
	Oklahoma City
	Oklahoma University Cancer Institute
		Robert S. Mannel	Ph: 405-271-4272
			Email: julie-traylor@ouhsc.edu
	Tulsa
	Cancer Care Associates-Yale
		Robert S. Mannel	Ph: 405-271-4272
			Email: julie-traylor@ouhsc.edu
Pennsylvania
	Abington
	Rosenfeld Cancer Center at Abington Memorial Hospital
		Parviz Hanjani	Ph: 215-481-2402
	Philadelphia
	Fox Chase Cancer Center - Philadelphia
		Penny R Anderson	Ph: 215-728-4790
	Wynnewood
	Lankenau Cancer Center at Lankenau Hospital
		Paul B. Gilman	Ph: 484-476-2649
			Email: wellenbachj@mlhs.org
South Dakota
	Sioux Falls
	Avera Cancer Institute
		Luis A Rojas-Espaillat	Ph: 800-657-4377
			Email: Jan.Healy@avera.org
Texas
	Dallas
	Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas
		David Scott Miller	Ph: 214-648-7097
	Houston
	Memorial Hermann - Texas Medical Center
		Larissa A Meyer
			Email: sgriffin@gog.org
Utah
	Salt Lake City
	Huntsman Cancer Institute at University of Utah
		Andrew P Soisson	Ph: 801-581-4477
			Email: clinical.trials@hci.utah.edu
Vermont
	Burlington
	Fletcher Allen Health Care - Medical Center Campus
		Cheung Wong	Ph: 802-656-8990
Wisconsin
	Green Bay
	Green Bay Oncology, Limited at St. Mary's Hospital
		Jonathan E Tammela	Ph: 920-433-8889
	Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center
		Jonathan E Tammela	Ph: 920-433-8889
	St. Mary's Hospital Medical Center - Green Bay
		Jonathan E Tammela	Ph: 920-433-8889
	St. Vincent Hospital Regional Cancer Center
		Jonathan E Tammela	Ph: 920-433-8889
	La Crosse
	Gundersen Lutheran Center for Cancer and Blood
		Alcee J Jumonville	Ph: 608-775-2385
			Email: cancerctr@gundluth.org
	Madison
	University of Wisconsin Paul P. Carbone Comprehensive Cancer Center
		David M Kushner	Ph: 877-405-6866
	Milwaukee
	Vince Lombardi Cancer Clinic at Aurora St. Luke's Medical Center
		Scott A Kamelle	Ph: 414-649-7200
	New Richmond
	Cancer Center of Western Wisconsin
		Joseph W Leach	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
Canada
Quebec
	Montreal
	Hopital Notre-Dame du CHUM
		Maroie Barkati	Ph: 514-890-8000ext23611
			Email: sylvie.beaudoin.chum@ssss.gouv.qc.ca

Link to the current ClinicalTrials.gov record.
NLM Identifer NCT00492778
Information obtained from ClinicalTrials.gov on May 09, 2013

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