Basic Trial Information
Trial Description
     Summary
     Further Trial Information
     Eligibility Criteria
Trial Contact Information

Basic Trial Information

Trial Description

Summary

This randomized phase III trial is studying chemotherapy to see how well it works with or without bevacizumab in treating patients with recurrent or metastatic head and neck cancer. Drugs used in chemotherapy, such as docetaxel, cisplatin, carboplatin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may also make tumor cells more sensitive to chemotherapy and stop the growth of head and neck cancer by blocking blood flow to the tumor. It is not yet known whether combination chemotherapy is more effective when given with or without bevacizumab in treating patients with head and neck cancer.

Further Study Information

PRIMARY OBJECTIVES:

I. To compare the overall survival of patients with recurrent or metastatic squamous cell carcinoma of the head and neck treated with standard platinum-based chemotherapy with or without bevacizumab.

SECONDARY OBJEC TIVES:

I. To assess toxicities with the addition of bevacizumab to each platinum-doublet (cisplatin/docetaxel, carboplatin/docetaxel, cisplatin/fluorouracil, carboplatin/fluorouracil.

II. To compare the objective response rates and the progression-free survival achieved with the above therapies.

III. To collect blood samples before and after therapy for future correlative studies.

IV. To collect tumor tissue samples available at baseline from prior diagnostic procedures for future correlative studies.

OUTLINE: After the physician decides which chemotherapy doublet to use, patients are randomized to1 of 2 treatment arms for that chemotherapy combination.

ARM IA: Patients receive chemotherapy comprising docetaxel intravenously (IV) over 1 hour and cisplatin IV over 1-2 hours on day 1. Treatment repeats every 21 days in the absence of disease progression or unacceptable toxicity.

ARM IB: Patients receive bevacizumab IV over 30-90 minutes on day 1 and docetaxel and cisplatin as in arm IA.

ARM IIA: Patients receive docetaxel IV over 1 hour and carboplatin IV over 30 minutes on day 1. Treatment repeats every 21 days in the absence of disease progression or unacceptable toxicity.

ARM IIB: Patients receive bevacizumab as in arm IB and docetaxel and carboplatin as in arm IIA.

ARM IIIA: Patients receive cisplatin IV over 1-2 hours on day 1 and fluorouracil IV continuously over days 1-4. Treatment repeats every 21 days in the absence of disease progression or unacceptable toxicity.

ARM IIIB: Patients receive bevacizumab as in arm IB and cisplatin and fluorouracil as in arm IIIA.

ARM IVA: Patients receive carboplatin IV over 30 minutes on day 1 and fluorouracil IV continuously over days 1-4. Treatment repeats every 21 days in the absence of disease progression or unacceptable toxicity.

ARM IVB: Patients receive bevacizumab as in arm IB and carboplatin and fluorouracil as in arm IVA.

After completion of study treatment, patients are followed up every 3-6 months for 5 years.

Eligibility Criteria

Inclusion Criteria:

• Histologically or cytologically confirmed squamous cell carcinoma of the head and neck (SCCHN) from any primary site, including unknown primary cancers of the head and neck

• No nasopharyngeal carcinoma of histologic types World Health Organization (WHO) 2 or 3

• No squamous cell carcinoma that originated in the skin

• Recurrent disease, incurable disease as determined by surgery or radiation, or metastatic disease

• A second primary SCCHN allowed if eligibility is based on a recurrent or metastatic first primary SCCHN

• Patients who refuse radical resection for recurrent disease are eligible

• Patients must have measurable disease based on Response Evaluation Criteria in Solid Tumors (RECIST)

• Disease in previously irradiated sites is considered measurable if there has been unequivocal disease progression or biopsy-proven residual carcinoma after radiotherapy

• Persistent disease after radiotherapy must be biopsy proven at least 8 weeks after completion of radiotherapy (radiographic findings are acceptable providing that clear cut measurements can be made)

• Patients must be progression-free for at least 6 months after completion of chemotherapy or chemoradiotherapy or radiotherapy plus cetuximab given as part of initial potential curative therapy (if received such prior therapy)

• At least 6 months since completion of prior concurrent radiotherapy plus cetuximab (8 weeks for cetuximab given as part of adjuvant regimen post radiotherapy)

• Patients having progression after 2 courses of induction chemotherapy are not eligible

• No tumors that invade major vessels (e.g., the carotid) as shown unequivocally by imaging studies

• No known brain metastases

• Eastern Cooperative Oncology Group (ECOG) performance status 0-1

• Absolute neutrophil count (ANC) >= 1,500/mm^3

• Hemoglobin >= 8.0 g/dL

• Platelet count >= 100,000/mm^3

• Creatinine clearance >= 60 mL/min

• Total bilirubin normal

• Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) and alkaline phosphatase must meet one of the following criteria:

• Alkaline phosphatase normal AND AST or ALT =< 5 x upper limit of normal (ULN)

• Alkaline phosphatase > 1 but =< 2.5 x ULN AND AST or ALT > 1 but =< 1.5 x ULN

• Alkaline phosphatase > 2.5 but =< 5 x ULN AND AST or ALT normal

• Urine dipstick must be < 0-1+ within 2 weeks (14 days) of randomization; if urine dipstick result is > 1+, a calculation of Urine Protein Creatinine (UPC) ratio is required; patients must have a UPC ratio < 1.0 to participate in the study

• Not pregnant or nursing

• Negative pregnancy test

• Fertile patients must use effective contraception

• Patients who meet the following criteria will be excluded due to the possibility of increased risk for tumor bleeding with bevacizumab therapy:

• Tumors that invade major vessels (e.g. the carotid) as shown unequivocally by imaging studies

• Central (i.e. within 2 cm from the hilum) lung metastases that are cavitary as shown unequivocally by imaging studies

• Any prior history of bleeding related to the current head and neck cancer

• History of gross hemoptysis (bright red blood of 0.5 teaspoon or more per episode of coughing) =< 3 months prior to enrollment

• No history of coagulopathy or hemorrhagic disorders

• No history of thrombosis (e.g., pulmonary embolism or deep venous thrombosis) currently requiring therapeutic anticoagulation (prophylactic use of warfarin 1 mg/day is allowed)

• International normalized ratio (INR) < 1.5 at registration

• No hypercalcemia related to head and neck cancer

• Patients with a prior history of squamous cell or basal cell carcinoma of the skin or in situ carcinoma of the cervix must have been curatively treated

• Patients with a history of other prior malignancy must have been treated with curative intent and must have remained disease free for 5 years post diagnosis

• No current peripheral neuropathy >= grade 2

• Patients must not have any co-existing condition that would preclude full compliance with the study

• No history of severe hypersensitivity reaction to docetaxel or other drugs formulated with polysorbate 80 (if the physician's choice of chemotherapy is docetaxel)

• Patients must have a blood pressure (BP) =< 150/90 mm Hg within 2 weeks prior to randomization

• Patients with a history of hypertension must be well-controlled upon study entry (BP =< 150/90 mm Hg) on a stable regimen of anti-hypertensive therapy

• No history of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within 6 months prior to registration

• No significant traumatic injury within the past 28 days

• No serious nonhealing wound, ulcer, or bone fracture

• No unstable angina or myocardial infarction within the past 6 months

• No symptomatic congestive heart failure or New York Heart Association (NYHA) class II-IV heart disease

• No history of aortic dissection or presence of aneurysm > 6 cm (or at high risk for rupture)

• No serious cardiac arrhythmia requiring medication (history of chronic atrial fibrillation or other atrial arrhythmia with controlled rate on medication is allowed)

• No clinically significant peripheral vascular disease manifested by intermittent claudication or need for vascular intervention

• No history of any central nervous system (CNS) cerebrovascular ischemia or stroke within the past 6 months

• No active serious infection

• No history of a serious human anti-human antibody (HAHA) reaction

• Patients with known hypersensitivity to Chinese hamster ovary cell products or other recombinant human antibodies are not eligible

• Chronic latex xerostomia, speech and swallowing abnormalities, resulting from prior radiation or surgery, allowed provided nutritional status is stable

• No other prior malignancy except curatively treated squamous cell or basal carcinoma of the skin, in situ cervical cancer, or malignancy for which the patient has been curatively treated and remains disease-free for the past 3 years

• No concurrent bisphosphonates for bone metastasis unless initiated > 3 months before study entry

• Patients must have recovered to grade 1 or better from the effects of any prior surgery, chemotherapy, or radiotherapy AND > 4 weeks post-surgery

• A maximum of one prior radiotherapy regimen, curative or palliative, to the head and neck is allowed; if the radiation is combined with chemotherapy and/or cetuximab, a minimum of 4 months must elapse between the end of radiotherapy and registration; if the radiation is given alone, a minimum of 8 weeks must elapse between the end of radiotherapy and registration; a minimum of 3 weeks must elapse between prior radiation to other areas and registration

• No prior bevacizumab

• No prior chemotherapy or biologic/molecular-targeted therapy for recurrent or metastatic SCCHN

• Patients may have received one regimen of induction, concurrent chemoradiotherapy, and/or adjuvant chemotherapy as part of initial potential curative therapy

• A minimum of 6 months is required between last dose of chemotherapy or chemoradiotherapy and study treatment

• No major surgical procedure or open biopsy within 28 days prior to study enrollment, or anticipation of need for major surgical procedure during the course of the study

• More than 4 weeks since prior surgery

• No other concurrent investigational agent

• Patients must not be receiving chronic daily treatment with aspirin (> 325 mg/day) or nonsteroidal anti-inflammatory agents (NSAIDs) known to inhibit platelet function

• The use of anti-platelet agents (e.g., dipyridamole [Persantine], ticlopidine [Ticlid], or clopidogrel [Plavix]) is allowed only if patient is not receiving aspirin or NSAIDs known to inhibit platelet function

• No human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy

• No other concurrent chemotherapy, immunotherapy, antitumor hormonal therapy (excluding contraceptives and replacement steroids), radiotherapy, or experimental medications

• No concurrent amifostine

Trial Contact Information

Trial Lead Organizations/Sponsors

National Cancer Institute

Athanassios Argiris

Principal Investigator

U.S.A.
Alabama
	Mobile
	Providence Cancer Center at Providence Hospital
		Thaddeus A Beeker	Ph: 877-904-4367
	University of South Alabama Mitchell Cancer Institute
		Daniel G Cameron	Ph: 251-445-9870
			Email: pfrancisco@usouthal.edu
Arkansas
	Ft. Smith
	Hembree Mercy Cancer Center at St. Edward Mercy Medical Center
		John Dalie Wells	Ph: 800-378-9373
	Little Rock
	Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
		Rangaswamy Govindarajan	Ph: 501-686-8274
California
	Anaheim
	Kaiser Permanente Medical Center - Anaheim/Orange County
		Han A Koh	Ph: 626-564-3455
	Baldwin Park
	Kaiser Permanente Medical Center - Baldwin Park
		Han A Koh	Ph: 626-564-3455
	Bellflower
	Kaiser Permanente Medical Center - Bellflower
		Han A Koh	Ph: 626-564-3455
	Berkeley
	Alta Bates Summit Comprehensive Cancer Center
		David H. Irwin	Ph: 510-204-3428
	Burlingame
	Peninsula Medical Center
		David H. Irwin	Ph: 510-204-3428
	Castro Valley
	East Bay Radiation Oncology Center
		James H. Feusner	Ph: 510-450-7600
	Fontana
	Kaiser Permanente Medical Center - Fontana
		Han A Koh	Ph: 626-564-3455
	Greenbrae
	Sutter Health Western Division Cancer Research Group
		David H. Irwin	Ph: 510-204-3428
	Harbor City
	Kaiser Permanente Medical Center - Harbor City
		Han A Koh	Ph: 626-564-3455
	Irvine
	Kaiser Permanente - Irvine
		Han A Koh	Ph: 626-564-3455
	Los Angeles
	Kaiser Foundation Hospital - West Los Angeles
		Han A Koh	Ph: 626-564-3455
	Kaiser Permanente Medical Center - Los Angeles
		Han A Koh	Ph: 626-564-3455
		Han A Koh	Ph: 626-564-3455
	Martinez
	Contra Costa Regional Medical Center
		James H. Feusner	Ph: 510-450-7600
	Modesto
	Memorial Medical Center
		Jorge A Garcia-Young	Ph: 209-572-7116
	Mountain View
	El Camino Hospital Cancer Center
		James H. Feusner	Ph: 510-450-7600
	Oakland
	Alta Bates Summit Medical Center - Summit Campus
		James H. Feusner	Ph: 510-450-7600
	Bay Area Breast Surgeons, Incorporated
		James H. Feusner	Ph: 510-450-7600
	CCOP - Bay Area Tumor Institute
		James H. Feusner	Ph: 510-450-7600
	Epic Care - Oakland
		James H. Feusner	Ph: 510-450-7600
	Highland General Hospital
		James H. Feusner	Ph: 510-450-7600
	Larry G Strieff MD Medical Corporation
		James H. Feusner	Ph: 510-450-7600
	Tom K Lee, Incorporated
		James H. Feusner	Ph: 510-450-7600
	Palo Alto
	Veterans Affairs Medical Center - Palo Alto
		Harlan A. Pinto	Ph: 800-455-0057
	Panorama City
	Kaiser Permanente Medical Group
		Han A Koh	Ph: 626-564-3455
	Riverside
	Kaiser Permanente Medical Center - Riverside
		Han A Koh	Ph: 626-564-3455
	Saint Helena
	Saint Helena Hospital
		Gregory B Smith	Ph: 707-967-3698
	San Diego
	Kaiser Permanente Medical Center - Kaiser Foundation Hospital - San Diego
		Han A Koh	Ph: 626-564-3455
	Rebecca and John Moores UCSD Cancer Center
		William Read	Ph: 404-778-1868
			Email: cancercto@ucsd.edu
	San Francisco
	California Pacific Medical Center - California Campus
		David H. Irwin	Ph: 510-204-3428
	San Marcos
	Kaiser Permanente Health Care
		Han A Koh	Ph: 626-564-3455
	San Pablo
	Doctors Medical Center - San Pablo Campus
		James H. Feusner	Ph: 510-450-7600
	Santa Rosa
	Sutter Pacific Medical Foundation
		David H. Irwin	Ph: 510-204-3428
	Stanford
	Stanford Cancer Center
		Harlan A. Pinto	Ph: 800-455-0057
	Vallejo
	Sutter Solano Medical Center
		David H. Irwin	Ph: 510-204-3428
	Woodland Hills
	Kaiser Permanente Medical Cener - Woodland Hills
		Han A Koh	Ph: 626-564-3455
Colorado
	Aurora
	Medical Center of Aurora - South Campus
		Eduardo R. Pajon	Ph: 888-785-6789
	Boulder
	Boulder Community Hospital
		Eduardo R. Pajon	Ph: 888-785-6789
	Colorado Springs
	Penrose Cancer Center at Penrose Hospital
		Eduardo R. Pajon	Ph: 888-785-6789
	Denver
	CCOP - Colorado Cancer Research Program
		Eduardo R. Pajon	Ph: 888-785-6789
	Kaiser Permanente of Colorado
		Alexander Menter	Ph: 303-614-1300
	Porter Adventist Hospital
		Eduardo R. Pajon	Ph: 888-785-6789
	Presbyterian - St. Luke's Medical Center
		Eduardo R. Pajon	Ph: 888-785-6789
	Rose Medical Center
		Eduardo R. Pajon	Ph: 888-785-6789
	St. Anthony Central Hospital
		Eduardo R. Pajon	Ph: 888-785-6789
	St. Joseph Hospital
		Eduardo R. Pajon	Ph: 888-785-6789
	Englewood
	Swedish Medical Center
		Eduardo R. Pajon	Ph: 888-785-6789
	Fort Collins
	Front Range Cancer Specialists
		Diana C. Medgyesy	Ph: 970-212-7600
	Poudre Valley Hospital
		Paolo Romero	Ph: 970-495-8226
	Greeley
	North Colorado Medical Center
		Eduardo R. Pajon	Ph: 888-785-6789
	Lafayette
	Kaiser Permanente - Lafayette
		Alexander Menter	Ph: 303-614-1300
	Littleton
	Littleton Adventist Hospital
		Eduardo R. Pajon	Ph: 888-785-6789
	Lone Tree
	Sky Ridge Medical Center
		Eduardo R. Pajon	Ph: 888-785-6789
	Longmont
	Hope Cancer Care Center at Longmont United Hospital
		Eduardo R. Pajon	Ph: 888-785-6789
	Loveland
	McKee Medical Center
		Eduardo R. Pajon	Ph: 888-785-6789
	Parker
	Parker Adventist Hospital
		Eduardo R. Pajon	Ph: 888-785-6789
	Pueblo
	St. Mary - Corwin Regional Medical Center
		Eduardo R. Pajon	Ph: 888-785-6789
	Wheat Ridge
	Exempla Lutheran Medical Center
		Eduardo R. Pajon	Ph: 888-785-6789
Connecticut
	Farmington
	Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center
		Upendra P Hegde	Ph: 800-579-7822
	Hartford
	Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center
		Philip J. Stella	Ph: 734-712-3456
	New Britain
	George Bray Cancer Center at the Hospital of Central Connecticut - New Britain Campus
		Brian J Byrne	Ph: 860-224-5660
	New Haven
	Yale Cancer Center
		Hari A. Deshpande	Ph: 203-785-5702
	Norwich
	Eastern Connecticut Hematology and Oncology Associates
		Dennis E. Slater	Ph: 860-886-8362
Delaware
	Lewes
	Tunnell Cancer Center at Beebe Medical Center
		Gregory A. Masters	Ph: 302-733-6227
	Newark
	Helen F. Graham Cancer Center at Christiana Hospital
		Gregory A. Masters	Ph: 302-733-6227
Florida
	Boca Raton
	Eugene M. and Christine E. Lynn Cancer Institute at Boca Raton Community Hospital - Main Campus
		Hilary I Gomolin	Ph: 561-955-6400
	Fort Lauderdale
	Broward General Medical Center Cancer Center
		Archana Maini	Ph: 954-355-5346
	Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
		Mike Cusnir	Ph: 305-674-2625
			Email: info@msccop.com
	Gainesville
	University of Florida Shands Cancer Center
		Priya K Gopalan	Ph: 352-273-8675
			Email: trials@cancer.ufl.edu
	Jacksonville
	Baptist Cancer Institute - Jacksonville
		Troy Hancil Guthrie	Ph: 904-202-7051
	Jupiter
	Ella Milbank Foshay Cancer Center at Jupiter Medical Center
		Mike Cusnir	Ph: 305-674-2625
			Email: info@msccop.com
	Miami
	University of Miami Sylvester Comprehensive Cancer Center - Miami
		Chukwuemeka Ikpeazu	Ph: 800-545-2292
	Miami Beach
	CCOP - Mount Sinai Medical Center
		Mike Cusnir	Ph: 305-674-2625
			Email: info@msccop.com
	Pensacola
	Sacred Heart Cancer Center at Sacred Heart Hospital
		Ranjith B Dissanayake	Ph: 850-416-6316
			Email: ttamayo@shhpens.org
	Sacred Heart Medical Oncology Group
		Ranjith B Dissanayake	Ph: 850-416-6316
			Email: ttamayo@shhpens.org
	Titusville
	Space Coast Medical Associates - Titusville
		Richard L. Levine	Ph: 321-268-4200
	Weston
	Cleveland Clinic Florida - Weston
		Bruno R Bastos	Ph: 954-659-5705
Georgia
	Atlanta
	CCOP - Atlanta Regional
		Thomas E. Seay	Ph: 678-843-7119
			Email: kpackard@sjha.org
	Northside Hospital Cancer Center
		Thomas E. Seay	Ph: 678-843-7119
			Email: kpackard@sjha.org
	Piedmont Hospital
		Thomas E. Seay	Ph: 678-843-7119
			Email: kpackard@sjha.org
	Saint Joseph's Hospital of Atlanta
		Thomas E. Seay	Ph: 678-843-7119
			Email: kpackard@sjha.org
	Columbus
	John B. Amos Cancer Center
		Thomas E. Seay	Ph: 678-843-7119
			Email: kpackard@sjha.org
	Decatur
	Charles B. Eberhart Cancer Center at DeKalb Medical Center
		Thomas E. Seay	Ph: 678-843-7119
			Email: kpackard@sjha.org
	Veterans Affairs Medical Center - Atlanta (Decatur)
		Samuel N Chan	Ph: 404-321-6111ext7632
	Fayetteville
	Piedmont Fayette Hospital
		Thomas E. Seay	Ph: 678-843-7119
			Email: kpackard@sjha.org
	Gainesville
	Northeast Georgia Medical Center
		Richard J. LoCicero	Ph: 770-219-8800
			Email: cancerpatient.navigator@nghs.com
	Lawrenceville
	Gwinnett Medical Center
		Thomas E. Seay	Ph: 678-843-7119
			Email: kpackard@sjha.org
	Riverdale
	Southern Regional Medical Center
		Thomas E. Seay	Ph: 404-303-3355
	Rome
	Harbin Clinic Cancer Center - Medical Oncology
		Thomas E. Seay	Ph: 678-843-7119
			Email: kpackard@sjha.org
	Savannah
	Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center
		Harvey C. Lebos	Ph: 912-350-8568
Hawaii
	Aiea
	Kapiolani Medical Center at Pali Momi
		Jonathan K Cho	Ph: 808-586-2979
	Honolulu
	Cancer Research Center of Hawaii
		Jonathan K Cho	Ph: 808-586-2979
	Hawaii Medical Center - East
		Jonathan K Cho	Ph: 808-586-2979
	Kapiolani Medical Center for Women and Children
		Jonathan K Cho	Ph: 808-586-2979
	OnCare Hawaii, Incorporated - Kuakini
		Jonathan K Cho	Ph: 808-586-2979
	OnCare Hawaii, Incorporated - Lusitana
		Jonathan K Cho	Ph: 808-586-2979
	Queen's Cancer Institute at Queen's Medical Center
		Jonathan K Cho	Ph: 808-586-2979
	Straub Clinic and Hospital, Incorporated
		Jonathan K Cho	Ph: 808-586-2979
	Wailuku
	Maui Memorial Medical Center
		Jonathan K Cho	Ph: 808-586-2979
	Pacific Cancer Institute - Maui
		Jonathan K Cho	Ph: 808-586-2979
Idaho
	Boise
	Mountain States Tumor Institute at St. Luke's Regional Medical Center
		Paul G. Montgomery	Ph: 800-845-4624
	Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
		Philip J. Stella	Ph: 734-712-3456
	Fruitland
	Saint Luke's Mountain States Tumor Institute - Fruitland
		Theodore A. Walters	Ph: 800-845-4624
	Meridian
	Mountain States Tumor Institute - Meridian
		Theodore A. Walters	Ph: 800-845-4624
	Nampa
	Saint Luke's Mountain States Tumor Institute
		Theodore A. Walters	Ph: 800-845-4624
	Twin Falls
	Mountain States Tumor Institute at St. Luke's
		Theodore A. Walters	Ph: 800-845-4624
Illinois
	Chicago
	John H. Stroger, Jr. Hospital of Cook County
		Fred R. Rosen	Ph: 312-864-6000
	Louis A. Weiss Memorial Hospital
		Keith L. Shulman	Ph: 773-564-5044
	Mount Sinai Hospital Medical Center
		Pam G. Khosla	Ph: 773-257-5960
			Email: suhi@sinai.org
	Resurrection Medical Center
		Christopher G. Rose	Ph: 773-792-5116
	Robert H. Lurie Comprehensive Cancer Center at Northwestern University
		Mark Agulnik	Ph: 312-695-1301
			Email: cancer@northwestern.edu
	Decatur
	Decatur Memorial Hospital Cancer Care Institute
		James L. Wade	Ph: 217-876-4740
			Email: kcheek@dmhhs.org
	Elmhurst
	Elmhurst Memorial Hospital
		Robert M Eisner	Ph: 630-352-5300
	Galesburg
	Galesburg Clinic, PC
		John W. Kugler	Ph: 800-793-2262
	Harvey
	Ingalls Cancer Care Center at Ingalls Memorial Hospital
		Mark F. Kozloff	Ph: 708-915-4673
			Email: clinicaltrials@ingalls.org
	Highland Park
	Hematology Oncology Associates of Illinois-Highland Park
		Mark Agulnik	Ph: 312-695-1301
			Email: cancer@northwestern.edu
	Hinsdale
	Hinsdale Hematology Oncology Associates
		Elyse Cheryl Schneiderman	Ph: 630-654-1790
			Email: info@hhoaltd.com
	Joliet
	Joliet Oncology-Hematology Associates, Limited - West
		Kulumani M Sivarajan	Ph: 815-730-3098
			Email: maureenc@jolietoncology.com
	Kankakee
	Provena St. Mary's Regional Cancer Center - Kankakee
		Mark Agulnik	Ph: 312-695-1301
			Email: cancer@northwestern.edu
	La Grange
	La Grange Memorial Hospital
		Renee H. Jacobs	Ph: 630-856-7526
	Libertyville
	North Shore Oncology and Hematology Associates, Limited - Libertyville
		Mark Agulnik	Ph: 312-695-1301
			Email: cancer@northwestern.edu
	Maywood
	Cardinal Bernardin Cancer Center at Loyola University Medical Center
		Cheryl M Czerlanis	Ph: 708-226-4357
	Moline
	Garneau, Stewart C MD (UIA Investigator)
		Costas L. Constantinou	Ph: 319-363-2690
	Porubcin, Michael MD (UIA Investigator)
		Costas L. Constantinou	Ph: 319-363-2690
	Spector, David MD (UIA Investigator)
		Costas L. Constantinou	Ph: 319-363-2690
	Trinity Cancer Center at Trinity Medical Center - 7th Street Campus
		Costas L. Constantinou	Ph: 319-363-2690
	Niles
	Cancer Care and Hematology Specialists of Chicagoland - Niles
		Mark Agulnik	Ph: 312-695-1301
			Email: cancer@northwestern.edu
	River Forest
	West Suburban Center for Cancer Care
		Isoken Koko	Ph: 708-488-0882
	Rockford
	Swedish-American Regional Cancer Center
		Harvey Eric Einhorn	Ph: 815-489-4413
	Skokie
	Hematology Oncology Associates - Skokie
		Mark Agulnik	Ph: 312-695-1301
			Email: cancer@northwestern.edu
	Springfield
	Regional Cancer Center at Memorial Medical Center
		James L. Wade	Ph: 217-876-4740
			Email: kcheek@dmhhs.org
Indiana
	Elkhart
	Elkhart Clinic, LLC
		Bilal Ansari	Ph: 574-237-1328
	Elkhart General Hospital
		Bilal Ansari	Ph: 574-237-1328
	Michiana Hematology-Oncology, PC - Elkhart
		Bilal Ansari	Ph: 574-237-1328
	Fort Wayne
	Fort Wayne Medical Oncology and Hematology
		Sreenivasa Rao Nattam	Ph: 260-484-8830
			Email: ledgar@fwmoh.com
	Indianapolis
	St. Vincent Indianapolis Hospital
		Niraj Gupta	Ph: 317-228-3393
	Kokomo
	Community Cancer Care at Howard Regional Health System
		Bilal Ansari	Ph: 574-237-1328
	La Porte
	Center for Cancer Therapy at LaPorte Hospital and Health Services
		Bilal Ansari	Ph: 574-237-1328
	Lafayette
	Clarian Arnett Cancer Care
		Thomas Isaac Jones	Ph: 800-899-8448ext7431
			Email: sstidham@clarianarnett.com
	Mishawaka
	Michiana Hematology-Oncology, PC - Mishawaka
		Bilal Ansari	Ph: 574-237-1328
	Saint Joseph's Medical Center
		Bilal Ansari	Ph: 574-237-1328
	Muncie
	Cancer Center at Ball Memorial Hospital
		William B. Fisher	Ph: 765-751-5850
			Email: alpatterson@medicalconsultantspc.com
	Plymouth
	Michiana Hematology Oncology PC - Plymouth
		Bilal Ansari	Ph: 574-237-1328
	South Bend
	CCOP - Northern Indiana CR Consortium
		Bilal Ansari	Ph: 574-237-1328
	Memorial Hospital of South Bend
		Bilal Ansari	Ph: 574-237-1328
	Michiana Hematology-Oncology, PC - South Bend
		Bilal Ansari	Ph: 574-237-1328
	Westville
	Michiana Hematology Oncology-PC Westville
		Bilal Ansari	Ph: 574-237-1328
Iowa
	Ames
	McFarland Clinic, PC
		Joseph James Merchant	Ph: 515-239-2621
	Bettendorf
	Constantinou, Costas L MD (UIA Investigator)
		Costas L. Constantinou	Ph: 319-363-2690
	Cedar Rapids
	Cedar Rapids Oncology Associates
		Deborah W Wilbur	Ph: 319-363-2690
		Deborah W Wilbur	Ph: 319-363-2690
	Mercy Regional Cancer Center at Mercy Medical Center
		Deborah W Wilbur	Ph: 319-363-2690
	Clive
	Medical Oncology and Hematology Associates-West Des Moines
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Des Moines
	CCOP - Iowa Oncology Research Association
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	John Stoddard Cancer Center at Iowa Lutheran Hospital
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	John Stoddard Cancer Center at Iowa Methodist Medical Center
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Medical Oncology and Hematology Associates at John Stoddard Cancer Center
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Medical Oncology and Hematology Associates at Mercy Cancer Center
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Mercy Cancer Center at Mercy Medical Center - Des Moines
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Iowa City
	Holden Comprehensive Cancer Center at University of Iowa
		Daniel A Vaena	Ph: 800-237-1225
	Ottumwa
	South Iowa Radiation Oncology Center at Ottumwa Regional Health Center
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Sioux City
	Mercy Medical Center - Sioux City
		Donald Bruce Wender	Ph: 712-252-0088
	Siouxland Hematology-Oncology Associates, LLP
		Donald Bruce Wender	Ph: 712-252-0088
	St. Luke's Regional Medical Center
		Donald Bruce Wender	Ph: 712-252-0088
Kansas
	Chanute
	Cancer Center of Kansas, PA - Chanute
		Shaker R. Dakhil	Ph: 316-262-4467
	Dodge City
	Cancer Center of Kansas, PA - Dodge City
		Shaker R. Dakhil	Ph: 316-262-4467
	El Dorado
	Cancer Center of Kansas, PA - El Dorado
		Shaker R. Dakhil	Ph: 316-262-4467
	Fort Scott
	Cancer Center of Kansas - Fort Scott
		Shaker R. Dakhil	Ph: 316-262-4467
	Independence
	Cancer Center of Kansas-Independence
		Shaker R. Dakhil	Ph: 316-262-4467
	Kansas City
	Providence Medical Center
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Kingman
	Cancer Center of Kansas, PA - Kingman
		Shaker R. Dakhil	Ph: 316-262-4467
	Lawrence
	Lawrence Memorial Hospital
		Shaker R. Dakhil	Ph: 316-262-4467
	Liberal
	Cancer Center of Kansas, PA - Liberal
		Shaker R. Dakhil	Ph: 316-262-4467
	McPherson
	Cancer Center of Kansas, PA - McPherson
		Shaker R. Dakhil	Ph: 316-262-4467
	Newton
	Cancer Center of Kansas, PA - Newton
		Shaker R. Dakhil	Ph: 316-262-4467
	Overland Park
	Menorah Medical Center
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Saint Luke's Hospital - South
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Parsons
	Cancer Center of Kansas, PA - Parsons
		Shaker R. Dakhil	Ph: 316-262-4467
	Prairie Village
	CCOP - Kansas City
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Pratt
	Cancer Center of Kansas, PA - Pratt
		Shaker R. Dakhil	Ph: 316-262-4467
	Salina
	Cancer Center of Kansas, PA - Salina
		Shaker R. Dakhil	Ph: 316-262-4467
	Wellington
	Cancer Center of Kansas, PA - Wellington
		Shaker R. Dakhil	Ph: 316-262-4467
	Wichita
	Associates in Women's Health, PA - North Hillside
		Shaker R. Dakhil	Ph: 316-262-4467
	Cancer Center of Kansas, PA - Medical Arts Tower
		Shaker R. Dakhil	Ph: 316-262-4467
	Cancer Center of Kansas, PA - Wichita
		Shaker R. Dakhil	Ph: 316-262-4467
	CCOP - Wichita
		Shaker R. Dakhil	Ph: 316-262-4467
	Via Christi Cancer Center at Via Christi Regional Medical Center
		Shaker R. Dakhil	Ph: 316-262-4467
	Winfield
	Cancer Center of Kansas, PA - Winfield
		Shaker R. Dakhil	Ph: 316-262-4467
Kentucky
	Lexington
	University of Kentucky Chandler Medical Center
		Susanne M. Arnold	Ph: 859-257-3379
Louisiana
	Baton Rouge
	Hematology-Oncology Clinic
		Hana F Safah	Ph: 504-988-6121
	Mary Bird Perkins Cancer Center - Baton Rouge
		Robert W Veith	Ph: 504-568-3410
			Email: aconne1@lsuhsc.edu
	Monroe
	Louisiana State University Health Sciences Center - Monroe
		Syed H Jafri	Ph: 318-813-1412
	New Orleans
	Medical Center of Louisiana - New Orleans
		Robert W Veith	Ph: 504-568-3410
			Email: aconne1@lsuhsc.edu
	Stanley S. Scott Cancer Center at Louisiana State University Medical Center - New Orleans
		Robert W Veith	Ph: 504-568-3410
			Email: aconne1@lsuhsc.edu
	Tulane Cancer Center at Tulane University Hospital and Clinic
		Hana F Safah	Ph: 504-988-6121
	Shreveport
	Feist-Weiller Cancer Center at Louisiana State University Health Sciences
		Syed H Jafri	Ph: 318-813-1412
	Highland Clinic
		Glenn M. Mills	Ph: 318-813-1412
Maryland
	Baltimore
	Greater Baltimore Medical Center Cancer Center
		Marshall A. Levine	Ph: 443-849-3706
	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
		Arlene A. Forastiere	Ph: 410-955-8804
			Email: jhcccro@jhmi.edu
	Elkton MD
	Union Hospital of Cecil County
		Stephen Scott Grubbs	Ph: 302-733-6227
	Frederick
	Frederick Memorial Hospital Regional Cancer Therapy Center
		Mark G Goldstein	Ph: 240-566-3584
			Email: clinicaltrials@fmh.org
Massachusetts
	Attleboro
	Sturdy Memorial Hospital
		Jonathan B Croopnick	Ph: 508-236-7059
			Email: research.department@mwmc.com
	Gloucester
	Addison Gilbert Hospital
		Angus P. McIntyre	Ph: 978-283-4000ext559
	Methuen
	Caritas Holy Family Hospital
		Han-Ting Lin	Ph: 978-687-0156ext2117
	Pittsfield
	Berkshire Hematology Oncology, PC
		Harvey Zimbler	Ph: 413-496-8205
			Email: Gloria.Gero@berkshirehemonc.com
	Springfield
	Baystate Medical Center
		John McCann	Ph: 413-794-3565
			Email: tamara.wrenn@baystatehealth.org
Michigan
	Ann Arbor
	CCOP - Michigan Cancer Research Consortium
		Philip J. Stella	Ph: 734-712-3456
	Saint Joseph Mercy Cancer Center
		Philip J. Stella	Ph: 734-712-3456
	Battle Creek
	Battle Creek Health System Cancer Care Center
		Gilbert D Padula	Ph: 616-685-5225
	Big Rapids
	Mecosta County Medical Center
		Gilbert D Padula	Ph: 616-685-5225
	Dearborn
	Oakwood Cancer Center at Oakwood Hospital and Medical Center
		Philip J. Stella	Ph: 734-712-3456
	Detroit
	Van Elslander Cancer Center at St. John Hospital and Medical Center
		Philip J. Stella	Ph: 734-712-3456
	Escanaba
	Green Bay Oncology, Limited - Escanaba
		Gerald K. Bayer	Ph: 800-432-6049
	Flint
	Genesys Hurley Cancer Institute
		Philip J. Stella	Ph: 734-712-3456
		Philip J. Stella	Ph: 734-712-3456
	Hurley Medical Center
		Philip J. Stella	Ph: 734-712-3456
	Grand Rapids
	Butterworth Hospital at Spectrum Health
		Gilbert D Padula	Ph: 616-685-5225
	CCOP - Grand Rapids
		Gilbert D Padula	Ph: 616-685-5225
	Lacks Cancer Center at Saint Mary's Health Care
		Gilbert D Padula	Ph: 616-685-5225
	Iron Mountain
	Green Bay Oncology - Iron Mountain
		Gerald K. Bayer	Ph: 800-432-6049
	Jackson
	Gayle M. Jacob Cancer Center at Allegiance Health
		Philip J. Stella	Ph: 734-712-3456
	Kalamazoo
	Borgess Medical Center
		Raymond Sterling Lord	Ph: 269-373-7458
	Bronson Methodist Hospital
		Raymond Sterling Lord	Ph: 269-373-7458
	West Michigan Cancer Center
		Raymond Sterling Lord	Ph: 269-373-7458
	Lansing
	Sparrow Regional Cancer Center
		Philip J. Stella	Ph: 734-712-3456
	Livonia
	St. Mary Mercy Hospital
		Philip J. Stella	Ph: 734-712-3456
	Marquette
	Upper Michigan Cancer Center at Marquette General Hospital
		Aaron P. Scholnik	Ph: 906-225-3467
	Muskegon
	Mercy General Health Partners
		Gilbert D Padula	Ph: 616-685-5225
	Pontiac
	St. Joseph Mercy Oakland
		Philip J. Stella	Ph: 734-712-3456
	Port Huron
	Mercy Regional Cancer Center at Mercy Hospital
		Philip J. Stella	Ph: 734-712-3456
	Reed City
	Spectrum Health Reed City Hospital
		Gilbert D Padula	Ph: 616-685-5225
	Royal Oak
	William Beaumont Hospital - Royal Oak Campus
		Padmaja V Venuturumilli	Ph: 248-551-7695
	Saginaw
	Seton Cancer Institute at Saint Mary's - Saginaw
		Philip J. Stella	Ph: 734-712-3456
	Saint Joseph
	Lakeside Cancer Specialists, PLLC
		Bilal Ansari	Ph: 574-237-1328
	St. Joseph
	Lakeland Regional Cancer Care Center - St. Joseph
		Bilal Ansari	Ph: 574-237-1328
	Traverse City
	Munson Medical Center
		Gilbert D Padula	Ph: 616-685-5225
	Warren
	St. John Macomb Hospital
		Philip J. Stella	Ph: 734-712-3456
Minnesota
	Brainerd
	St. Joseph's Medical Center
		Daniel Nikcevich	Ph: 888-203-7267
	Burnsville
	Fairview Ridges Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Coon Rapids
	Mercy and Unity Cancer Center at Mercy Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Duluth
	CCOP - Duluth
		Daniel Nikcevich	Ph: 888-203-7267
	Essentia Health - Duluth Clinic
		Daniel Nikcevich	Ph: 888-203-7267
	Miller - Dwan Medical Center
		Daniel Nikcevich	Ph: 888-203-7267
	Edina
	Fairview Southdale Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Fridley
	Mercy and Unity Cancer Center at Unity Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Hutchinson
	Hutchinson Area Health Care
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Maplewood
	HealthEast Cancer Care at St. John's Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Minnesota Oncology - Maplewood
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Minneapolis
	Hennepin County Medical Center - Minneapolis
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	New Ulm
	New Ulm Medical Center
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Robbinsdale
	Humphrey Cancer Center at North Memorial Outpatient Center
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Saint Cloud
	CentraCare Clinic - Women and Children
		Donald J Jurgens	Ph: 877-229-4907
			Email: coborncancercenter@centracare.com
	Coborn Cancer Center
		Donald J Jurgens	Ph: 877-229-4907
			Email: coborncancercenter@centracare.com
	Saint Louis Park
	CCOP - Metro-Minnesota
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Park Nicollet Cancer Center
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Saint Paul
	Regions Hospital Cancer Care Center
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	United Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Shakopee
	St. Francis Cancer Center at St. Francis Medical Center
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Stillwater
	Lakeview Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Waconia
	Ridgeview Medical Center
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Willmar
	Willmar Cancer Center at Rice Memorial Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Woodbury
	Minnesota Oncology - Woodbury
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
Mississippi
	Gulfport
	Memorial Hospital at Gulfport
		Robert W Veith	Ph: 504-568-3410
			Email: aconne1@lsuhsc.edu
	Jackson
	University of Mississippi Cancer Clinic
		Robert D Hamilton	Ph: 601-815-6700
	Pascagoula
	Regional Cancer Center at Singing River Hospital
		James E. Clarkson	Ph: 228-809-5292
Missouri
	Bolivar
	Central Care Cancer Center at Carrie J. Babb Cancer Center
		Robert L Carolla	Ph: 417-269-4520
	Branson
	Skaggs Cancer Center at Skaggs Regional Medical Center
		Robert L Carolla	Ph: 417-269-4520
	Cape Girardeau
	Southeast Cancer Center
		Alan Philip Lyss	Ph: 800-392-0936
	Columbia
	Veterans Affairs Medical Center - Columbia (Truman Memorial)
		Shadi M Haddadin	Ph: 888-823-5923
			Email: ctsucontact@westat.com
	Jefferson City
	Goldschmidt Cancer Center
		Alan Philip Lyss	Ph: 800-392-0936
	Kansas City
	Heartland Hematology Oncology Associates, Incorporated
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	North Kansas City Hospital
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Parvin Radiation Oncology
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Research Medical Center
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Saint Luke's Hospital
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Lee's Summit
	Saint Luke's East - Lee's Summit
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Rolla
	Mercy Clinic Cancer and Hematology - Rolla
		Robert L Carolla	Ph: 417-269-4520
	Phelps County Regional Medical Center
		Robert L Carolla	Ph: 417-269-4520
	Saint Joseph
	Heartland Regional Medical Center
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Saint Joseph Oncology, Incorporated
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Saint Louis
	Missouri Baptist Cancer Center
		Alan Philip Lyss	Ph: 800-392-0936
	Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
		Douglas R. Adkins	Ph: 800-600-3606
			Email: info@siteman.wustl.edu
	Springfield
	Cancer Research for the Ozarks
		Robert L Carolla	Ph: 417-269-4520
	Hulston Cancer Center at Cox Medical Center South
		Robert L Carolla	Ph: 417-269-4520
	St. John's Regional Health Center
		Robert L Carolla	Ph: 417-269-4520
Montana
	Billings
	Billings Clinic Cancer Center - 801 N 29th Street
		Benjamin Thomas Marchello	Ph: 800-648-6274
	CCOP - Montana Cancer Consortium
		Benjamin Thomas Marchello	Ph: 800-648-6274
	Hematology-Oncology Centers of the Northern Rockies - Billings
		Benjamin Thomas Marchello	Ph: 800-648-6274
	St. Vincent Healthcare Cancer Care Services
		Benjamin Thomas Marchello	Ph: 800-648-6274
	Bozeman
	Bozeman Deaconess Cancer Center
		Benjamin Thomas Marchello	Ph: 800-648-6274
		Benjamin Thomas Marchello	Ph: 800-648-6274
	Butte
	St. James Healthcare Cancer Care
		Benjamin Thomas Marchello	Ph: 800-648-6274
	Great Falls
	Benefis Sletten Cancer Institute
		Grant William Harrer	Ph: 406-731-8217
	Great Falls Clinic - Main Facility
		Benjamin Thomas Marchello	Ph: 800-648-6274
	Helena
	St. Peter's Hospital
		Benjamin Thomas Marchello	Ph: 800-648-6274
	Kalispell
	Kalispell Regional Medical Center
		Benjamin Thomas Marchello	Ph: 800-648-6274
	Missoula
	Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
		Benjamin Thomas Marchello	Ph: 800-648-6274
	Montana Cancer Specialists at Montana Cancer Center
		Benjamin Thomas Marchello	Ph: 800-648-6274
Nebraska
	Kearney
	Good Samaritan Cancer Center at Good Samaritan Hospital
		George K. Bascom	Ph: 308-865-7963
	Lincoln
	Cancer Resource Center - Lincoln
		Gamini S. Soori	Ph: 800-253-4368
	Omaha
	Alegant Health Cancer Center at Bergan Mercy Medical Center
		Gamini S. Soori	Ph: 800-253-4368
	CCOP - Missouri Valley Cancer Consortium
		Gamini S. Soori	Ph: 800-253-4368
	Creighton University Medical Center
		Gamini S. Soori	Ph: 800-253-4368
	Immanuel Medical Center
		Gamini S. Soori	Ph: 800-253-4368
	Lakeside Hospital
		Gamini S. Soori	Ph: 800-253-4368
	Methodist Estabrook Cancer Center
		Yungpo B Su	Ph: 402-354-5144
Nevada
	Las Vegas
	CCOP - Nevada Cancer Research Foundation
		John Allan Ellerton	Ph: 702-731-8274
	Reno
	Renown Institute for Cancer at Renown Regional Medical Center
		Steven A. Schiff	Ph: 775-982-4400
New Jersey
	Camden
	Cancer Institute of New Jersey at Cooper University Hospital - Camden
		Gregory A. Masters	Ph: 302-733-6227
	East Orange
	Veterans Affairs Medical Center - East Orange
		Basil S. Kasimis	Ph: 800-475-2336
			Email: patricia.goyer@med.va.gov
	Hackensack
	CCOP - Northern New Jersey
		Donna T McNamara	Ph: 201-996-2879
	Morristown
	Carol G. Simon Cancer Center at Morristown Memorial Hospital
		Bonni L Guerin	Ph: 908-522-2043
	Newark
	Newark Beth Israel Medical Center
		Lori Schleicher	Ph: 973-926-7230
	UMDNJ University Hospital
		Lillian F. Pliner	Ph: 732-235-8675
New Mexico
	Albuquerque
	University of New Mexico Cancer Center
		Fa-Chyi Lee	Ph: 505-727-8000
	Las Cruces
	Memorial Medical Center
		Fa-Chyi Lee	Ph: 505-727-8000
New York
	Bronx
	Jack D. Weiler Hospital at Montefiore Medical Center - East Campus
		Missak Haigentz	Ph: 718-904-2730
			Email: aecc@aecom.yu.edu
	Montefiore Medical Center
		Missak Haigentz	Ph: 718-904-2730
			Email: aecc@aecom.yu.edu
	Brooklyn
	Kings County Hospital Center
		Gurinderjit K Sidhu	Ph: 404-851-2359
	SUNY Downstate Medical Center
		Gurinderjit K Sidhu	Ph: 404-851-2359
	Veterans Affairs Medical Center - Brooklyn
		Andrea Nadine Wiesel Leaf	Ph: 800-877-6976
	Buffalo
	Veterans Affairs Medical Center - Buffalo
		Lynn Marie Steinbrenner	Ph: 716-862-3191
	Cooperstown
	Bassett Healthcare Regional Cancer Program at Mary Imogene Bassett Hospital
		Eric Bravin	Ph: 607-547-6965
			Email: jennifer.victory@bassett.org
	East Syracuse
	CCOP - Hematology-Oncology Associates of Central New York
		Jeffrey J. Kirshner	Ph: 315-472-7504
	Glens Falls
	Charles R. Wood Cancer Center at Glens Falls Hospital
		John P Stoutenburg	Ph: 518-926-6700
	Middletown
	Tucker Center for Cancer Care at Orange Regional Medical Center
		Jeffrey M. Stewart	Ph: 845-342-7609
	New York
	Beth Israel Medical Center - Petrie Division
		Bruce E. Culliney	Ph: 212-844-6286
North Carolina
	Charlotte
	Presbyterian Cancer Center at Presbyterian Hospital
		Mark J Mogul	Ph: 304-399-6617
	Goldsboro
	Wayne Memorial Hospital, Incorporated
		James N. Atkins	Ph: 919-580-0000
	Kinston
	Kinston Medical Specialists
		Peter R. Watson	Ph: 252-559-2200
North Dakota
	Bismarck
	Bismarck Cancer Center
		Edward J. Wos	Ph: 701-323-5760
			Email: tfischer@mohs.org
	Medcenter One Hospital Cancer Care Center
		Edward J. Wos	Ph: 701-323-5760
			Email: tfischer@mohs.org
	Mid Dakota Clinic, PC
		John T Reynolds	Ph: 701-323-5760
			Email: tfischer@mohs.org
	St. Alexius Medical Center Cancer Center
		John T Reynolds	Ph: 701-323-5760
			Email: tfischer@mohs.org
Ohio
	Akron
	McDowell Cancer Center at Akron General Medical Center
		Esther H. Rehmus	Ph: 330-344-6348
	Summa Center for Cancer Care at Akron City Hospital
		Jennifer E Payne	Ph: 330-375-6101
	Barberton
	Barberton Citizens Hospital
		Jennifer E Payne	Ph: 330-375-6101
	Canton
	Aultman Cancer Center at Aultman Hospital
		Kisa E Weeman	Ph: 330-363-6891
	Mercy Cancer Center at Mercy Medical Center
		Mitchell Haut	Ph: 888-293-4673
	Chillicothe
	Adena Regional Medical Center
		J. Philip Kuebler	Ph: 614-566-3275
	Cincinnati
	University of Cincinnati
		John Charles Morris	Ph: 513-558-4553
			Email: uchealthnews@uc.edu
	Cleveland
	Case Comprehensive Cancer Center
		Joseph Gibbons	Ph: 800-641-2422
	MetroHealth Cancer Care Center at MetroHealth Medical Center
		Bruce J. Averbook	Ph: 216-778-8526
			Email: kbauchens@metrohealth.org
	Columbus
	Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center
		Maura L Gillison	Ph: 866-627-7616
			Email: osu@emergingmed.com
	CCOP - Columbus
		J. Philip Kuebler	Ph: 614-566-3275
	Doctors Hospital at Ohio Health
		J. Philip Kuebler	Ph: 502-361-8496
	Grant Medical Center Cancer Care
		J. Philip Kuebler	Ph: 614-566-3275
	Mount Carmel Health - West Hospital
		J. Philip Kuebler	Ph: 614-566-3275
	Riverside Methodist Hospital Cancer Care
		J. Philip Kuebler	Ph: 502-361-8496
	Zangmeister Center
		J. Philip Kuebler	Ph: 614-566-3275
	Delaware
	Grady Memorial Hospital
		J. Philip Kuebler	Ph: 614-566-3275
	Lancaster
	Fairfield Medical Center
		J. Philip Kuebler	Ph: 614-566-3275
	Lima
	St. Rita's Medical Center
		Henry Gerad	Ph: 419-226-9617
	Marietta
	Strecker Cancer Center at Marietta Memorial Hospital
		J. Philip Kuebler	Ph: 614-566-3275
	Mentor
	Lake/University Ireland Cancer Center
		Panos Savvides	Ph: 866-627-7616
			Email: osu@emergingmed.com
	Mount Vernon
	Knox Community Hospital
		J. Philip Kuebler	Ph: 614-566-3275
	Newark
	Licking Memorial Cancer Care Program at Licking Memorial Hospital
		J. Philip Kuebler	Ph: 614-566-3275
	Orange Village
	UHHS Chagrin Highlands Medical Center
		Panos Savvides	Ph: 866-627-7616
			Email: osu@emergingmed.com
	Portsmouth
	Southern Ohio Medical Center Cancer Center
		J. Philip Kuebler	Ph: 502-361-8496
	Sandusky
	University Hospitals Ireland Cancer Center at Firelands Regional Medical Center
		Panos Savvides	Ph: 866-627-7616
			Email: osu@emergingmed.com
	Springfield
	Community Hospital of Springfield and Clark County
		J. Philip Kuebler	Ph: 614-566-3275
	Westerville
	Mount Carmel St. Ann's Cancer Center
		J. Philip Kuebler	Ph: 614-566-3275
	Westlake
	UHHS Westlake Medical Center
		Panos Savvides	Ph: 866-627-7616
			Email: osu@emergingmed.com
	Zanesville
	Genesis - Good Samaritan Hospital
		J. Philip Kuebler	Ph: 614-566-3275
Oklahoma
	Oklahoma City
	INTEGRIS Cancer Institute of Oklahoma - Proton Campus
		Romeo A Mandanas	Ph: 405-949-3870
	Oklahoma University Cancer Institute
		Carla Kurkjian	Ph: 405-271-4272
			Email: julie-traylor@ouhsc.edu
Oregon
	Salem
	Salem Hospital Regional Cancer Care Services
		Edward Peter Orlowski	Ph: 503-561-2618
Pennsylvania
	Allentown
	Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest
		Eliot Lawrence Friedman	Ph: 610-402-2273
	Danville
	Geisinger Cancer Institute at Geisinger Health
		Rajiv Panikkar	Ph: 570-271-5251
	Drexel Hill
	Delaware County Regional Cancer Center at Delaware County Memorial Hospital
		Stephen A. Shore	Ph: 610-284-8237
			Email: jolene.garney@crozer.org
	East Stroudsburg
	Dale and Frances Hughes Cancer Center at Pocono Medical Center
		Rita Susan Axelrod	Ph: 215-955-6084
	Hazleton
	Geisinger Hazleton Cancer Center
		Rajiv Panikkar	Ph: 570-271-5251
	Media
	Riddle Memorial Hospital Cancer Center
		Rita Susan Axelrod	Ph: 215-955-6084
	Philadelphia
	Fox Chase Cancer Center - Philadelphia
		Barbara A. Burtness	Ph: 215-728-4790
	Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
		Rita Susan Axelrod	Ph: 215-955-6084
	Pittsburgh
	Veterans Affairs Medical Center - Pittsburgh
		Andrew D Liman	Ph: 412-688-6104
	Reading
	St. Joseph Medical Center
		Marc Rovito	Ph: 610-378-2336
			Email: kevinkeller@catholichealth.net
	Sayre
	Guthrie Cancer Center at Guthrie Clinic Sayre
		Edward T. O'Brien	Ph: 800-836-0388
	Scranton
	Hematology and Oncology Associates of North East Pennsylvania
		Rita Susan Axelrod	Ph: 215-955-6084
	Mercy Hospital Cancer Center - Scranton
		Martin B. Hyzinski	Ph: 570-558-3020
	Scranton Hematology Oncology
		Martin B. Hyzinski	Ph: 570-558-3020
	State College
	Geisinger Medical Group - Scenery Park
		Rajiv Panikkar	Ph: 570-271-5251
	Upland
	Associates in Hematology-Oncology, PC at Crozer Regional Cancer Center
		Rita Susan Axelrod	Ph: 215-955-6084
	West Chester
	Cancer Center of Chester County
		William E. Luginbuhl	Ph: 610-431-5297
	West Reading
	McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center
		Terrence P. Cescon	Ph: 610-988-9323
	Wilkes-Barre
	Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
		Rajiv Panikkar	Ph: 570-271-5251
	Williamsport
	Susquehanna Cancer Center at Divine Providence Hospital
		Warren L Robinson	Ph: 800-598-4282
South Carolina
	Florence
	McLeod Regional Medical Center
		Rajesh Bajaj	Ph: 843-679-7256
South Dakota
	Rapid City
	Rapid City Regional Hospital
		Mark T Schroeder	Ph: 605-716-3982
			Email: research@rcrh.org
	Sioux Falls
	Avera Cancer Institute
		Addison R Tolentino	Ph: 800-657-4377
			Email: Jan.Healy@avera.org
Tennessee
	Nashville
	MBCCOP - Meharry Medical College - Nashville
		Steven N. Wolff	Ph: 615-327-5724
			Email: jmurray@mmc.edu
	Vanderbilt-Ingram Cancer Center
		Jill Gilbert	Ph: 800-811-8480
Texas
	Houston
	Ben Taub General Hospital
		Anita L Sabichi	Ph: 713-792-3245
			Email: burton@bcm.edu
	Dan L. Duncan Cancer Center at Baylor College of Medicine
		Anita L Sabichi	Ph: 713-792-3245
			Email: burton@bcm.edu
	St. Luke's Texas Cancer Institute at St. Luke's Episcopal Hospital
		Anita L Sabichi	Ph: 713-792-3245
			Email: burton@bcm.edu
	Veterans Affairs Medical Center - Houston
		Anita L Sabichi	Ph: 713-792-3245
			Email: burton@bcm.edu
	San Antonio
	University Hospital - San Antonio
		Athanassios Argiris	Ph: 210-616-5798
	University of Texas Health Science Center at San Antonio
		Athanassios Argiris	Ph: 210-616-5798
	Veterans Affairs Medical Center - San Antonio (Murphy)
		Athanassios Argiris	Ph: 210-616-5798
Utah
	American Fork
	American Fork Hospital
		W. Graydon Harker	Ph: 801-933-6070
			Email: research@utahcancer.com
	Cedar City
	Sandra L. Maxwell Cancer Center
		W. Graydon Harker	Ph: 801-933-6070
			Email: research@utahcancer.com
	Logan
	Logan Regional Hospital
		W. Graydon Harker	Ph: 801-933-6070
			Email: research@utahcancer.com
	Murray
	Jon and Karen Huntsman Cancer Center at Intermountain Medical Center
		W. Graydon Harker	Ph: 801-933-6070
			Email: research@utahcancer.com
	Ogden
	Val and Ann Browning Cancer Center at McKay-Dee Hospital Center
		W. Graydon Harker	Ph: 801-933-6070
			Email: research@utahcancer.com
	Provo
	Utah Valley Regional Medical Center - Provo
		W. Graydon Harker	Ph: 801-933-6070
			Email: research@utahcancer.com
	Saint George
	Dixie Regional Medical Center - East Campus
		W. Graydon Harker	Ph: 801-933-6070
			Email: research@utahcancer.com
	Salt Lake City
	LDS Hospital
		W. Graydon Harker	Ph: 801-933-6070
			Email: research@utahcancer.com
	Utah Cancer Specialists at UCS Cancer Center
		W. Graydon Harker	Ph: 801-933-6070
			Email: research@utahcancer.com
Virginia
	Danville
	Danville Regional Medical Center
		Timothy W. Brotherton	Ph: 434-793-0044
	Richmond
	Virginia Commonwealth University Massey Cancer Center
		Sherman Baker	Ph: 804-628-1939
West Virginia
	Charleston
	West Virginia University Medical School - Charleston
		Steven J. Jubelirer	Ph: 304-388-9944
	Huntington
	Edwards Comprehensive Cancer Center at Cabell Huntington Hospital
		Maria-Rosalia B. Tria Tirona	Ph: 304-399-6617
	Morgantown
	Mary Babb Randolph Cancer Center at West Virginia University Hospitals
		Manish A Monga	Ph: 304-293-2745
			Email: sfilburn@hsc.wvu.edu
Wisconsin
	Antigo
	Langlade Memorial Hospital
		Hamied R. Rezazadeh	Ph: 877-405-6866
	Chippewa Falls
	Marshfield Clinic - Chippewa Center
		Elena N Theodosiou	Ph: 715-389-4457
	Eau Claire
	Marshfield Clinic Cancer Care at Regional Cancer Center
		Elena N Theodosiou	Ph: 715-389-4457
	Green Bay
	Green Bay Oncology, Limited at St. Mary's Hospital
		Gerald K. Bayer	Ph: 800-432-6049
	Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center
		Gerald K. Bayer	Ph: 800-432-6049
	St. Mary's Hospital Medical Center - Green Bay
		Gerald K. Bayer	Ph: 800-432-6049
	St. Vincent Hospital Regional Cancer Center
		Gerald K. Bayer	Ph: 800-432-6049
	Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center
		Dhimant R. Patel	Ph: 800-252-2990
	Johnson Creek
	UW Cancer Center Johnson Creek
		Tien Hoang	Ph: 877-405-6866
	La Crosse
	Gundersen Lutheran Center for Cancer and Blood
		Kurt Oettel	Ph: 608-775-2385
			Email: cancerctr@gundluth.org
	Madison
	University of Wisconsin Paul P. Carbone Comprehensive Cancer Center
		Tien Hoang	Ph: 877-405-6866
	Manitowoc
	Holy Family Memorial Medical Center Cancer Care Center
		Gerald K. Bayer	Ph: 800-432-6049
	Marinette
	Bay Area Cancer Care Center at Bay Area Medical Center
		Gerald K. Bayer	Ph: 800-432-6049
	Vince Lombardi Cancer Clinic - Marinette
		Dhimant R. Patel	Ph: 800-252-2990
	Marshfield
	Marshfield Clinic - Marshfield Center
		Elena N Theodosiou	Ph: 715-389-4457
	Mequon
	Columbia Saint Mary's Hospital - Ozaukee
		Charles H. I. Tiber	Ph: 414-326-2675
			Email: clinicaltrials@columbia-stmarys.org
	Milwaukee
	Columbia-Saint Mary's Cancer Care Center
		Charles H. I. Tiber	Ph: 414-326-2675
			Email: clinicaltrials@columbia-stmarys.org
	Minocqua
	Marshfield Clinic - Lakeland Center
		Elena N Theodosiou	Ph: 715-389-4457
	New Richmond
	Cancer Center of Western Wisconsin
		Joseph W Leach	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Oconto Falls
	Green Bay Oncology, Limited - Oconto Falls
		Gerald K. Bayer	Ph: 800-432-6049
	Oshkosh
	Vince Lombardi Cancer Clinic - Oshkosh
		Dhimant R. Patel	Ph: 800-252-2990
	Racine
	All Saints Cancer Center at Wheaton Franciscan Healthcare
		Young M Choi	Ph: 414-874-4541
			Email: Kelli.holton@wfhc.org
	Rhinelander
	Ministry Medical Group at Saint Mary's Hospital
		Elena N Theodosiou	Ph: 715-389-4457
	Rice Lake
	Marshfield Clinic - Indianhead Center
		Elena N Theodosiou	Ph: 715-389-4457
	Sheboygan
	Saint Nicholas Hospital
		Gerald K. Bayer	Ph: 800-432-6049
	Vince Lombardi Cancer Clinic - Sheboygan
		Dhimant R. Patel	Ph: 800-252-2990
	Stevens Point
	Marshfield Clinic at Saint Michael's Hospital
		Elena N Theodosiou	Ph: 715-389-4457
	Saint Michael's Hospital Cancer Center
		Elena N Theodosiou	Ph: 715-389-4457
	Sturgeon Bay
	Green Bay Oncology, Limited - Sturgeon Bay
		Gerald K. Bayer	Ph: 800-432-6049
	Summit
	Aurora Medical Center
		Dhimant R. Patel	Ph: 800-252-2990
	Two Rivers
	Vince Lombardi Cancer Clinic - Two Rivers
		Dhimant R. Patel	Ph: 800-252-2990
	Wausau
	University of Wisconcin Cancer Center at Aspirus Wausau Hospital
		Hamied R. Rezazadeh	Ph: 877-405-6866
	Weston
	Marshfield Clinic - Weston Center
		Elena N Theodosiou	Ph: 715-389-4457
	Wisconsin Rapids
	Marshfield Clinic - Wisconsin Rapids Center
		Elena N Theodosiou	Ph: 715-389-4457
	Riverview UW Cancer Center at Riverview Hospital
		Ron James Kirschling	Ph: 877-405-6866
Wyoming
	Casper
	Rocky Mountain Oncology
		Benjamin Thomas Marchello	Ph: 800-648-6274
	Sheridan
	Welch Cancer Center at Sheridan Memorial Hospital
		Benjamin Thomas Marchello	Ph: 800-648-6274
Republic of South Africa
	Pretoria
	University of Pretoria
		Lydia M Dreosti	Ph: 27 12 319 2449