Basic Trial Information
Trial Description
     Summary
     Further Trial Information
     Eligibility Criteria
Trial Contact Information

Basic Trial Information

Trial Description

Summary

This randomized phase III trial is studying gemcitabine hydrochloride, cisplatin, and bevacizumab to see how well they work compared with gemcitabine hydrochloride, cisplatin, and placebo in treating patients with advanced urinary tract cancer. Drugs used in chemotherapy, such as gemcitabine hydrochloride and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. It is not yet known whether gemcitabine hydrochloride and cisplatin are more effective when given together with or without bevacizumab in treating patients with urinary tract cancer.

Further Study Information

PRIMARY OBJECTIVE:

I. To determine if patients with advanced transitional cell carcinoma treated with bevacizumab, gemcitabine and cisplatin will have increased overall survival when compared to patients treated with gemcitabine, cisplatin, and placebo.

SECONDARY OBJECTIVES:

I. To compare the progression-free survival of these two regimens in patients with advanced transitional cell carcinoma.

II. To compare the proportion of patients who experience an objective response on each regimen.

III. To compare the grade 3 and greater toxicities in patients treated on the two regimens.

OUTLINE: This is a multicenter study. Patients are stratified according to presence of visceral (lung, liver, bone, splenic, or intra-abdominal) metastases (no vs yes) and prior chemotherapy (including adjuvant therapy, neoadjuvant therapy, and single-agent radiosensitizers) (no vs yes). Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive gemcitabine hydrochloride intravenously (IV) over 30 minutes on days 1 and 8 and cisplatin IV over 1 hour and placebo IV over 30-90 minutes on day 1. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity. Patients then receive placebo IV over 30-90 minutes every 21 days in the absence of disease progression or unacceptable toxicity.

ARM II: Patients receive gemcitabine hydrochloride and cisplatin as in arm I. Patients also receive bevacizumab IV over 30-90 minutes on day 1. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity. Patients then receive bevacizumab IV over 30-90 minutes every 21 days in the absence of disease progression or unacceptable toxicity.

After completion of study therapy, patients are followed up periodically for up to 7 years.

Eligibility Criteria

Inclusion Criteria:

• Patients must have histologically or cytologically documented metastatic or unresectable transitional cell (urothelial) carcinoma of the urinary tract (renal pelvis, ureter, bladder, prostate, or urethra), with metastatic or locally advanced disease (T4b, N2, N3, or M1); patients must not be candidates for potentially curative surgery or radiotherapy

• Patients may not have received prior combination systemic chemotherapy for metastatic disease

• For the purposes of this study, radiosensitizing single-agent chemotherapy is not considered prior systemic therapy

• Prior neoadjuvant or adjuvant systemic chemotherapy is permissible provided it was completed >= 1 year prior to the diagnosis of metastatic disease

• At least 4 weeks since prior radiation (including palliative) or major surgery and fully recovered

• At least 7 days since any minor surgery such as port placement

• At least 4 weeks since any intravesical therapy

• No prior treatment with bevacizumab or other angiogenesis inhibitors

• No known history of brain metastases; brain imaging (magnetic resonance imaging [MRI]/computed tomography [CT]) is not required

• No current congestive heart failure; New York Heart Association (NYHA) class II, III or IV

• Patients with history of hypertension must be well controlled (< 150/90) on a regimen of anti-hypertensive therapy

• Patients on full-dose anticoagulants must be on a stable dose of warfarin and have an in-range international normalized ratio (INR) (usually between 2 and 3) or be on a stable dose of low molecular weight (LMW) heparin; patients receiving anti-platelet agents are also eligible; in addition, patients who are on daily prophylactic aspirin or anticoagulation for atrial fibrillation are eligible

• No significant history of bleeding events or gastrointestinal (GI) perforation

• Patients with a history of a significant bleeding episode (e.g. hemoptysis, upper or lower GI bleeding, grade 3 or 4 gross hematuria unable to be controlled by trans-urethral resection of the bladder tumor) within 6 months of registration are not eligible

• Patients with a history of GI perforation within 12 months of registration are not eligible

• Patients with a history of peritoneal carcinomatosis are not eligible

• No arterial thrombotic events within 6 months of registration, including transient ischemic attack (TIA), cerebrovascular accident (CVA), peripheral arterial thrombus, unstable angina or angina requiring surgical or medical intervention in the past 6 months, or myocardial infarction (MI); patients with clinically significant peripheral artery disease (i.e., claudication on less than one block) are ineligible

• Patients who have experienced a deep venous thrombosis or pulmonary embolus within the past 6 months must be on stable therapeutic anticoagulation to be enrolled to this study

• No serious or non-healing wound, ulcer, or bone fracture

• No sensory or motor peripheral neuropathy >= grade 2

• Patients with known hypersensitivity to Chinese hamster ovary cell products or other recombinant human antibodies are not eligible

• Patients that are pregnant or nursing are not eligible; women of child bearing potential must have a negative serum or urine pregnancy test (minimum sensitivity 25 IU/L or equivalent units of human chorionic gonadotropin [HCG]) within 72 hours prior to registration

• For women of child-bearing potential with an elevated beta-HCG that is believed to be related to cancer and not pregnancy, a negative trans-vaginal ultrasound and gynecological examination are required

• Women of child-bearing potential include any female who has experienced menarche and who has not undergone surgical sterilization (hysterectomy, bilateral tubal ligation or bilateral oophorectomy) or is not postmenopausal [defined as amenorrhea >= 12 consecutive months; or women on hormone replacement therapy [HRT] with documented serum follicle stimulating hormone [FSH] level > 35mIU/mL); even women who are using oral, implanted or injectable contraceptive hormones or mechanical products such as an intrauterine device or barrier methods (diaphragm, condoms, spermicides) to prevent pregnancy or practicing abstinence or where partner is sterile (e.g., vasectomy), should be considered to be of child bearing potential

• Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0-1 OR Karnofsky PS >= 80

• Absolute neutrophil count (ANC) >= 1,500/mm^3

• Platelet count >= 100,000/mm^3

• Calculated or measured creatinine clearance >= 50 mL/minute

• Bilirubin =< 1.25 times upper limit of normal (ULN) (for patients with Gilbert's Disease, =< 2.5 X ULN is allowed)

• Aspartate aminotransferase (AST) =< 2.0 times ULN

• Urine protein to creatinine ratio < 1.0 OR urine protein =< 1+ OR 24-hour urine protein =< 1 gram

Trial Contact Information

Trial Lead Organizations/Sponsors

National Cancer Institute

Jonathan Rosenberg

Principal Investigator

U.S.A.
Alaska
	Fairbanks
	Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital
		Craig R. Nichols	Ph: 503-215-6412
Arkansas
	Little Rock
	Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
		Rangaswamy Govindarajan	Ph: 501-686-8274
California
	Berkeley
	Alta Bates Summit Comprehensive Cancer Center
		David H. Irwin	Ph: 510-204-3428
	Burlingame
	Peninsula Medical Center
		David H. Irwin	Ph: 510-204-3428
	Castro Valley
	East Bay Radiation Oncology Center
		James H. Feusner	Ph: 510-450-7600
	Valley Medical Oncology Consultants - Castro Valley
		James H. Feusner	Ph: 510-450-7600
	Concord
	Cancer Care Center at John Muir Health - Concord Campus
		Kenneth C Hsiao	Ph: 925-674-2580
	Fremont
	Valley Medical Oncology
		James H. Feusner	Ph: 510-450-7600
	Greenbrae
	Sutter Health Western Division Cancer Research Group
		David H. Irwin	Ph: 510-204-3428
	LA Jolla
	Rebecca and John Moores UCSD Cancer Center
		Frederick E Millard	Ph: 858-822-5354
			Email: cancercto@ucsd.edu
	Los Angeles
	USC/Norris Comprehensive Cancer Center and Hospital
		James S Hu	Ph: 323-865-0451
	Martinez
	Contra Costa Regional Medical Center
		James H. Feusner	Ph: 510-450-7600
	Mountain View
	El Camino Hospital Cancer Center
		James H. Feusner	Ph: 510-450-7600
	Palo Alto Medical Foundation
		Peter P. Yu	Ph: 650-934-7000
	Oakland
	Alta Bates Summit Medical Center - Summit Campus
		James H. Feusner	Ph: 510-450-7600
	Bay Area Breast Surgeons, Incorporated
		James H. Feusner	Ph: 510-450-7600
	CCOP - Bay Area Tumor Institute
		James H. Feusner	Ph: 510-450-7600
	Highland General Hospital
		James H. Feusner	Ph: 510-450-7600
	Larry G Strieff MD Medical Corporation
		James H. Feusner	Ph: 510-450-7600
	Orange
	St. Joseph Hospital Regional Cancer Center - Orange
		Edward R Alexson	Ph: 714-734-6220
	Palo Alto
	Palo Alto Medical Foundation
		David S Leibowitz	Ph: 650-853-2906
			Email: waldorj@pamf.org
	Salinas
	Salinas Valley Memorial Hospital
		Shehzad Aziz	Ph: 831-759-3271
			Email: nvoogd@svmh.com
	San Francisco
	California Pacific Medical Center - California Campus
		David H. Irwin	Ph: 510-204-3428
	UCSF Helen Diller Family Comprehensive Cancer Center
		Andrea Harzstark	Ph: 877-827-3222
	San Pablo
	Doctors Medical Center - San Pablo Campus
		James H. Feusner	Ph: 510-450-7600
	Stanford
	Stanford Cancer Center
		Sandy Srinivas	Ph: 650-498-7061
			Email: clinicaltrials@med.stanford.edu
	Vallejo
	Sutter Solano Medical Center
		David H. Irwin	Ph: 510-204-3428
	Walnut Creek
	John Muir/Mt. Diablo Comprehensive Cancer Center
		Kenneth C Hsiao	Ph: 925-674-2580
Colorado
	Aurora
	Medical Center of Aurora - South Campus
		Eduardo R. Pajon	Ph: 888-785-6789
	University of Colorado Cancer Center at UC Health Sciences Center
		Thomas W Flaig	Ph: 720-848-0650
	Boulder
	Boulder Community Hospital
		Eduardo R. Pajon	Ph: 888-785-6789
	Colorado Springs
	Penrose Cancer Center at Penrose Hospital
		Eduardo R. Pajon	Ph: 888-785-6789
	Denver
	CCOP - Colorado Cancer Research Program
		Eduardo R. Pajon	Ph: 888-785-6789
	Porter Adventist Hospital
		Eduardo R. Pajon	Ph: 888-785-6789
	Presbyterian - St. Luke's Medical Center
		Eduardo R. Pajon	Ph: 888-785-6789
	Rose Medical Center
		Eduardo R. Pajon	Ph: 888-785-6789
	St. Anthony Central Hospital
		Eduardo R. Pajon	Ph: 888-785-6789
	St. Joseph Hospital
		Eduardo R. Pajon	Ph: 888-785-6789
	Edwards
	Shaw Regional Cancer Center
		Thomas W Flaig	Ph: 720-848-0650
	Englewood
	Swedish Medical Center
		Eduardo R. Pajon	Ph: 888-785-6789
	Fort Collins
	Front Range Cancer Specialists
		Diana C. Medgyesy	Ph: 970-212-7600
	Poudre Valley Hospital
		Paolo Romero	Ph: 970-495-8226
	Glenwood Springs
	Valley View Hospital Cancer Center
		Thomas W Flaig	Ph: 720-848-0650
	Grand Junction
	St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
		Thomas W Flaig	Ph: 720-848-0650
	Greeley
	North Colorado Medical Center
		Eduardo R. Pajon	Ph: 888-785-6789
	Littleton
	Littleton Adventist Hospital
		Eduardo R. Pajon	Ph: 888-785-6789
	Lone Tree
	Sky Ridge Medical Center
		Eduardo R. Pajon	Ph: 888-785-6789
	Longmont
	Hope Cancer Care Center at Longmont United Hospital
		Eduardo R. Pajon	Ph: 888-785-6789
	Loveland
	McKee Medical Center
		Eduardo R. Pajon	Ph: 888-785-6789
	Montrose
	Montrose Memorial Hospital Cancer Center
		Thomas W Flaig	Ph: 720-848-0650
	Parker
	Parker Adventist Hospital
		Eduardo R. Pajon	Ph: 888-785-6789
	Pueblo
	St. Mary - Corwin Regional Medical Center
		Eduardo R. Pajon	Ph: 888-785-6789
	Thornton
	North Suburban Medical Center
		Eduardo R. Pajon	Ph: 888-785-6789
	Wheat Ridge
	Exempla Lutheran Medical Center
		Eduardo R. Pajon	Ph: 888-785-6789
Connecticut
	Hartford
	Helen and Harry Gray Cancer Center at Hartford Hospital
		Robert D. Siegel	Ph: 860-545-5363
	Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center
		Philip J. Stella	Ph: 734-712-3456
	New Haven
	Yale Cancer Center
		Hari A. Deshpande	Ph: 203-785-5702
	Norwalk
	Norwalk Hospital
		Richard C. Frank	Ph: 203-852-2996
			Email: jennifer.long@norwalkhealth.org
	Norwich
	Eastern Connecticut Hematology and Oncology Associates
		Dennis E. Slater	Ph: 860-886-8362
	Stamford
	Carl and Dorothy Bennett Cancer Center at Stamford Hospital
		Neil Stuart Cohen	Ph: 203-323-8944
Delaware
	Lewes
	Tunnell Cancer Center at Beebe Medical Center
		Stephen Scott Grubbs	Ph: 302-733-6227
	Newark
	Helen F. Graham Cancer Center at Christiana Hospital
		Stephen Scott Grubbs	Ph: 302-733-6227
Florida
	Orlando
	Florida Hospital Cancer Institute at Florida Hospital Orlando
		Lee M. Zehngebot	Ph: 407-303-5623
	M.D. Anderson Cancer Center at Orlando
		Julio J. Hajdenberg	Ph: 321-841-7246
Georgia
	Gainesville
	Northeast Georgia Medical Center
		Richard J. LoCicero	Ph: 770-219-8800
			Email: cancerpatient.navigator@nghs.com
	Macon
	Medical Center of Central Georgia
		Frederick M. Schnell	Ph: 478-633-1226
	Savannah
	Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center
		Harvey C. Lebos	Ph: 912-350-8568
	Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler
		Mark A. Taylor	Ph: 912-350-8568
Idaho
	Boise
	Mountain States Tumor Institute at St. Luke's Regional Medical Center
		Paul G. Montgomery	Ph: 800-845-4624
Illinois
	Aurora
	Rush-Copley Cancer Care Center
		Ronnie F Luyun	Ph: 800-446-5532
	Bloomington
	St. Joseph Medical Center
		John W. Kugler	Ph: 800-793-2262
	Bloomington%
	Illinois CancerCare - Bloomington
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Canton
	Illinois CancerCare - Canton
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Carthage
	Illinois CancerCare - Carthage
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Chicago
	Robert H. Lurie Comprehensive Cancer Center at Northwestern University
		Gary R MacVicar	Ph: 312-695-1301
			Email: cancer@northwestern.edu
	University of Chicago Cancer Research Center
		Walter M. Stadler	Ph: 773-834-7424
	Decatur
	Decatur Memorial Hospital Cancer Care Institute
		James L. Wade	Ph: 217-876-4740
			Email: kcheek@dmhhs.org
	Elmhurst
	Elmhurst Memorial Hospital
		Lucio Di Nunno	Ph: 630-782-7900
	Eureka
	Eureka Community Hospital
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Illinois CancerCare - Eureka
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Galesburg
	Galesburg Clinic, PC
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Havana
	Illinois CancerCare - Havana
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Highland Park
	Hematology Oncology Associates of Illinois-Highland Park
		Gary R MacVicar	Ph: 312-695-1301
			Email: cancer@northwestern.edu
	Kankakee
	Provena St. Mary's Regional Cancer Center - Kankakee
		Gary R MacVicar	Ph: 312-695-1301
			Email: cancer@northwestern.edu
	Kewanee
	Illinois CancerCare - Kewanee Clinic
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Libertyville
	North Shore Oncology and Hematology Associates, Limited - Libertyville
		Gary R MacVicar	Ph: 312-695-1301
			Email: cancer@northwestern.edu
	Macomb
	Illinois CancerCare - Macomb
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Maywood
	Cardinal Bernardin Cancer Center at Loyola University Medical Center
		Ellen R. Gaynor	Ph: 708-226-4357
	Monmouth
	Illinois CancerCare - Monmouth
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	OSF Holy Family Medical Center
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Mt. Vernon
	Good Samaritan Regional Health Center
		Bethany G. Sleckman	Ph: 913-948-5588
	Niles
	Cancer Care and Hematology Specialists of Chicagoland - Niles
		Gary R MacVicar	Ph: 312-695-1301
			Email: cancer@northwestern.edu
	Normal
	BroMenn Regional Medical Center
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Community Cancer Center
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Illinois CancerCare - Community Cancer Center
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Ottawa
	Community Hospital of Ottawa
		John W. Kugler	Ph: 800-793-2262
	Illinois CancerCare - Ottawa
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Pekin
	Cancer Treatment Center at Pekin Hospital
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Illinois CancerCare - Pekin
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Peoria
	CCOP - Illinois Oncology Research Association
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Illinois CancerCare - Peoria
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Methodist Medical Center of Illinois
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	OSF St. Francis Medical Center
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Proctor Hospital
		John W. Kugler	Ph: 800-793-2262
	Peru
	Illinois CancerCare - Princeton
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Illinois Valley Community Hospital
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Princeton
	Illinois CancerCare - Princeton
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Rockford
	Swedish-American Regional Cancer Center
		Harvey Eric Einhorn	Ph: 815-489-4413
	Skokie
	Hematology Oncology Associates - Skokie
		Gary R MacVicar	Ph: 312-695-1301
			Email: cancer@northwestern.edu
	Spring Valley
	Illinois CancerCare - Spring Valley
		Nguyet A Le-Lindqwister	Ph: 800-793-2262
	Springfield
	Regional Cancer Center at Memorial Medical Center
		James L. Wade	Ph: 217-876-4740
			Email: kcheek@dmhhs.org
	Urbana
	Carle Cancer Center at Carle Foundation Hospital
		Ronnie F Luyun	Ph: 800-446-5532
Indiana
	Elkhart
	Elkhart Clinic, LLC
		Rafat H. Ansari	Ph: 574-234-5123
	Elkhart General Hospital
		Rafat H. Ansari	Ph: 574-234-5123
	Michiana Hematology-Oncology, PC - Elkhart
		Rafat H. Ansari	Ph: 574-234-5123
	Fort Wayne
	Fort Wayne Medical Oncology and Hematology
		Sreenivasa Rao Nattam	Ph: 260-484-8830
			Email: ledgar@fwmoh.com
	Indianapolis
	Indiana University Melvin and Bren Simon Cancer Center
		Noah M Hahn	Ph: 317-274-2552
	Veterans Affairs Medical Center - Indianapolis
		Noah M Hahn	Ph: 317-274-2552
	William N. Wishard Memorial Hospital
		Noah M Hahn	Ph: 317-274-2552
	Kokomo
	Community Cancer Care at Howard Regional Health System
		Rafat H. Ansari	Ph: 574-234-5123
	La Porte
	Center for Cancer Therapy at LaPorte Hospital and Health Services
		Rafat H. Ansari	Ph: 574-234-5123
	Lafayette
	Clarian Arnett Cancer Care
		Thomas Isaac Jones	Ph: 800-899-8448ext7431
			Email: sstidham@clarianarnett.com
	Merrillville
	Premier Oncology Hematology Associates
		Bharat H. Barai	Ph: 219-736-2800
	Michigan City
	Saint Anthony Memorial Health Centers
		Ronnie F Luyun	Ph: 800-446-5532
	Mishawaka
	Michiana Hematology-Oncology, PC - Mishawaka
		Rafat H. Ansari	Ph: 574-234-5123
	Saint Joseph's Medical Center
		Rafat H. Ansari	Ph: 574-234-5123
	Muncie
	Cancer Center at Ball Memorial Hospital
		Michael J Williamson	Ph: 765-751-5850
			Email: alpatterson@medicalconsultantspc.com
	Plymouth
	Michiana Hematology Oncology PC - Plymouth
		Rafat H. Ansari	Ph: 574-234-5123
	South Bend
	CCOP - Northern Indiana CR Consortium
		Rafat H. Ansari	Ph: 574-234-5123
	Memorial Hospital of South Bend
		Rafat H. Ansari	Ph: 574-234-5123
	Michiana Hematology-Oncology, PC - South Bend
		Rafat H. Ansari	Ph: 574-234-5123
	Westville
	Michiana Hematology Oncology-PC Westville
		Rafat H. Ansari	Ph: 574-234-5123
Iowa
	Ames
	McFarland Clinic, PC
		Joseph James Merchant	Ph: 515-239-2621
	Bettendorf
	Hematology Oncology Associates of the Quad Cities
		Shobha R. Chitneni	Ph: 563-355-7733
			Email: kedaprile@rccqc.com
	Clive
	Medical Oncology and Hematology Associates-West Des Moines
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Des Moines
	CCOP - Iowa Oncology Research Association
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	John Stoddard Cancer Center at Iowa Lutheran Hospital
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	John Stoddard Cancer Center at Iowa Methodist Medical Center
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Medical Oncology and Hematology Associates at John Stoddard Cancer Center
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Medical Oncology and Hematology Associates at Mercy Cancer Center
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Mercy Cancer Center at Mercy Medical Center - Des Moines
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Iowa City
	Holden Comprehensive Cancer Center at University of Iowa
		Daniel A Vaena	Ph: 800-237-1225
	Mason City
	Mercy Cancer Center at Mercy Medical Center - North Iowa
		Arvind Y Vemula	Ph: 800-433-3883
	Ottumwa
	South Iowa Radiation Oncology Center at Ottumwa Regional Health Center
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Sioux City
	Mercy Medical Center - Sioux City
		Donald Bruce Wender	Ph: 712-252-0088
	Siouxland Hematology-Oncology Associates, LLP
		Donald Bruce Wender	Ph: 712-252-0088
	St. Luke's Regional Medical Center
		Donald Bruce Wender	Ph: 712-252-0088
Kansas
	Chanute
	Cancer Center of Kansas, PA - Chanute
		Shaker R. Dakhil	Ph: 316-262-4467
	Dodge City
	Cancer Center of Kansas, PA - Dodge City
		Shaker R. Dakhil	Ph: 316-262-4467
	El Dorado
	Cancer Center of Kansas, PA - El Dorado
		Shaker R. Dakhil	Ph: 316-262-4467
	Fort Scott
	Cancer Center of Kansas - Fort Scott
		Shaker R. Dakhil	Ph: 316-262-4467
	Independence
	Cancer Center of Kansas-Independence
		Shaker R. Dakhil	Ph: 316-262-4467
	Kingman
	Cancer Center of Kansas, PA - Kingman
		Shaker R. Dakhil	Ph: 316-262-4467
	Lawrence
	Lawrence Memorial Hospital
		Shaker R. Dakhil	Ph: 316-262-4467
	Liberal
	Cancer Center of Kansas, PA - Liberal
		Shaker R. Dakhil	Ph: 316-262-4467
	Newton
	Cancer Center of Kansas, PA - Newton
		Shaker R. Dakhil	Ph: 316-262-4467
	Overland Park
	Menorah Medical Center
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Saint Luke's Hospital - South
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Parsons
	Cancer Center of Kansas, PA - Parsons
		Shaker R. Dakhil	Ph: 316-262-4467
	Prairie Village
	CCOP - Kansas City
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Pratt
	Cancer Center of Kansas, PA - Pratt
		Shaker R. Dakhil	Ph: 316-262-4467
	Salina
	Cancer Center of Kansas, PA - Salina
		Shaker R. Dakhil	Ph: 316-262-4467
	Wellington
	Cancer Center of Kansas, PA - Wellington
		Shaker R. Dakhil	Ph: 316-262-4467
	Wichita
	Associates in Women's Health, PA - North Hillside
		Shaker R. Dakhil	Ph: 316-262-4467
	Cancer Center of Kansas, PA - Medical Arts Tower
		Shaker R. Dakhil	Ph: 316-262-4467
	Cancer Center of Kansas, PA - Wichita
		Shaker R. Dakhil	Ph: 316-262-4467
	CCOP - Wichita
		Shaker R. Dakhil	Ph: 316-262-4467
	Via Christi Cancer Center at Via Christi Regional Medical Center
		Shaker R. Dakhil	Ph: 316-262-4467
	Winfield
	Cancer Center of Kansas, PA - Winfield
		Shaker R. Dakhil	Ph: 316-262-4467
Louisiana
	Baton Rouge
	Mary Bird Perkins Cancer Center - Baton Rouge
		Robert W Veith	Ph: 504-568-3410
			Email: aconne1@lsuhsc.edu
	New Orleans
	Medical Center of Louisiana - New Orleans
		Robert W Veith	Ph: 504-568-3410
			Email: aconne1@lsuhsc.edu
	Stanley S. Scott Cancer Center at Louisiana State University Medical Center - New Orleans
		Robert W Veith	Ph: 504-568-3410
			Email: aconne1@lsuhsc.edu
Maine
	Scarborough
	Maine Center for Cancer Medicine and Blood Disorders - Scarborough
		Frederick R. Aronson	Ph: 207-396-7600
Maryland
	Baltimore
	Greenebaum Cancer Center at University of Maryland Medical Center
		Heather D Mannuel	Ph: 800-888-8823
	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
		Jenny J Kim	Ph: 410-955-8804
			Email: jhcccro@jhmi.edu
	Veterans Affairs Medical Center - Baltimore
		Heather D Mannuel	Ph: 800-888-8823
	Elkton MD
	Union Hospital of Cecil County
		Stephen Scott Grubbs	Ph: 302-733-6227
Massachusetts
	Boston
	Dana-Farber/Brigham and Women's Cancer Center
		Aymen Elfiky	Ph: 866-790-4500
	Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute
		Aymen Elfiky	Ph: 866-790-4500
	Massachusetts General Hospital
		Aymen Elfiky	Ph: 866-790-4500
	Brighton
	Caritas St. Elizabeth's Medical Center
		Leslie A. Martin	Ph: 617-789-2903
	Methuen
	Caritas Holy Family Hospital
		Han-Ting Lin	Ph: 978-687-0156ext2117
	Worcester
	UMASS Memorial Cancer Center - University Campus
		Shakeeb A Yunus	Ph: 508-856-2464
			Email: laura.lefko@umassmed.edu
Michigan
	Adrian
	Hickman Cancer Center at Bixby Medical Center
		Rex B Mowat	Ph: 517-265-0116
		Rex B Mowat	Ph: 517-265-0116
	Ann Arbor
	CCOP - Michigan Cancer Research Consortium
		Philip J. Stella	Ph: 734-712-3456
	Saint Joseph Mercy Cancer Center
		Philip J. Stella	Ph: 734-712-3456
	Battle Creek
	Battle Creek Health System Cancer Care Center
		Gilbert D Padula	Ph: 616-685-5225
	Big Rapids
	Mecosta County Medical Center
		Gilbert D Padula	Ph: 616-685-5225
	Dearborn
	Oakwood Cancer Center at Oakwood Hospital and Medical Center
		Philip J. Stella	Ph: 734-712-3456
	Detroit
	Josephine Ford Cancer Center at Henry Ford Hospital
		Robert Anthony Chapman	Ph: 313-916-1784
	Van Elslander Cancer Center at St. John Hospital and Medical Center
		Philip J. Stella	Ph: 734-712-3456
	Escanaba
	Green Bay Oncology, Limited - Escanaba
		Anthony J. Jaslowski	Ph: 800-432-6049
	Flint
	Hurley Medical Center
		Philip J. Stella	Ph: 734-712-3456
	Grand Rapids
	Butterworth Hospital at Spectrum Health
		Gilbert D Padula	Ph: 616-685-5225
	CCOP - Grand Rapids
		Gilbert D Padula	Ph: 616-685-5225
	Lacks Cancer Center at Saint Mary's Health Care
		Gilbert D Padula	Ph: 616-685-5225
	Iron Mountain
	Green Bay Oncology - Iron Mountain
		Anthony J. Jaslowski	Ph: 800-432-6049
	Jackson
	Gayle M. Jacob Cancer Center at Allegiance Health
		Philip J. Stella	Ph: 734-712-3456
	Kalamazoo
	Borgess Medical Center
		Raymond Sterling Lord	Ph: 269-373-7458
	Bronson Methodist Hospital
		Raymond Sterling Lord	Ph: 269-373-7458
	West Michigan Cancer Center
		Raymond Sterling Lord	Ph: 269-373-7458
	Lansing
	Sparrow Regional Cancer Center
		Philip J. Stella	Ph: 734-712-3456
	Livonia
	St. Mary Mercy Hospital
		Philip J. Stella	Ph: 734-712-3456
	Marquette
	Upper Michigan Cancer Center at Marquette General Hospital
		Amy Weise	Ph: 313-576-9363
	Monroe
	Community Cancer Center of Monroe
		Rex B Mowat	Ph: 517-265-0116
	Mercy Memorial Hospital - Monroe
		Rex B Mowat	Ph: 517-265-0116
	Muskegon
	Mercy General Health Partners
		Gilbert D Padula	Ph: 616-685-5225
	Pontiac
	St. Joseph Mercy Oakland
		Philip J. Stella	Ph: 734-712-3456
	Port Huron
	Mercy Regional Cancer Center at Mercy Hospital
		Philip J. Stella	Ph: 734-712-3456
	Saginaw
	Seton Cancer Institute at Saint Mary's - Saginaw
		Philip J. Stella	Ph: 734-712-3456
	Saint Joseph
	Lakeside Cancer Specialists, PLLC
		Rafat H. Ansari	Ph: 574-234-5123
	St. Joseph
	Lakeland Regional Cancer Care Center - St. Joseph
		Rafat H. Ansari	Ph: 574-234-5123
	Traverse City
	Munson Medical Center
		Gilbert D Padula	Ph: 616-685-5225
	Warren
	St. John Macomb Hospital
		Philip J. Stella	Ph: 734-712-3456
Minnesota
	Bemidji
	MeritCare Bemidji
		Preston D. Steen	Ph: 701-234-6161
	Burnsville
	Fairview Ridges Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Coon Rapids
	Mercy and Unity Cancer Center at Mercy Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Duluth
	CCOP - Duluth
		Daniel Nikcevich	Ph: 888-203-7267
	Essentia Health - Duluth Clinic
		Daniel Nikcevich	Ph: 888-203-7267
	Miller - Dwan Medical Center
		Daniel Nikcevich	Ph: 888-203-7267
	Edina
	Fairview Southdale Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Fridley
	Mercy and Unity Cancer Center at Unity Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Hutchinson
	Hutchinson Area Health Care
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Maplewood
	HealthEast Cancer Care at St. John's Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Minnesota Oncology - Maplewood
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Minneapolis
	Hennepin County Medical Center - Minneapolis
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Robbinsdale
	Humphrey Cancer Center at North Memorial Outpatient Center
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Saint Cloud
	CentraCare Clinic - Women and Children
		Donald J Jurgens	Ph: 877-229-4907
			Email: coborncancercenter@centracare.com
	Coborn Cancer Center
		Donald J Jurgens	Ph: 877-229-4907
			Email: coborncancercenter@centracare.com
	Saint Louis Park
	CCOP - Metro-Minnesota
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Park Nicollet Cancer Center
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Saint Paul
	Regions Hospital Cancer Care Center
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	United Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Shakopee
	St. Francis Cancer Center at St. Francis Medical Center
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Stillwater
	Lakeview Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Waconia
	Ridgeview Medical Center
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Willmar
	Willmar Cancer Center at Rice Memorial Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Woodbury
	Minnesota Oncology - Woodbury
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
Mississippi
	Jackson
	University of Mississippi Cancer Clinic
		Louis V Puneky	Ph: 601-815-6700
Missouri
	Bolivar
	Central Care Cancer Center at Carrie J. Babb Cancer Center
		Robert L Carolla	Ph: 417-269-4520
	Branson
	Skaggs Cancer Center at Skaggs Regional Medical Center
		Robert L Carolla	Ph: 417-269-4520
	Cape Girardeau
	Saint Francis Medical Center
		Bethany G. Sleckman	Ph: 913-948-5588
	Southeast Cancer Center
		Alan Philip Lyss	Ph: 800-392-0936
	Jefferson City
	Goldschmidt Cancer Center
		Alan Philip Lyss	Ph: 800-392-0936
	Kansas City
	Heartland Hematology Oncology Associates, Incorporated
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	North Kansas City Hospital
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Parvin Radiation Oncology
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Research Medical Center
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Saint Luke's Hospital
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Truman Medical Center - Hospital Hill
		Peter J. VanVeldhuizen	Ph: 800-525-1483
	Veterans Affairs Medical Center - Kansas City
		Peter J. VanVeldhuizen	Ph: 800-525-1483
	Lee's Summit
	Saint Luke's East - Lee's Summit
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Rolla
	Phelps County Regional Medical Center
		Robert L Carolla	Ph: 417-269-4520
	Saint Joseph
	Heartland Regional Medical Center
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Saint Joseph Oncology, Incorporated
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Saint Louis
	CCOP - St. Louis-Cape Girardeau
		Bethany G. Sleckman	Ph: 913-948-5588
	David C. Pratt Cancer Center at St. John's Mercy
		Bethany G. Sleckman	Ph: 913-948-5588
	Mercy Clinic St. Louis Cancer and Breast Institute
		Bethany G. Sleckman	Ph: 913-948-5588
	Missouri Baptist Cancer Center
		Alan Philip Lyss	Ph: 800-392-0936
	Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
		Joel Picus	Ph: 800-600-3606
			Email: info@siteman.wustl.edu
	Springfield
	Cancer Research for the Ozarks
		Robert L Carolla	Ph: 417-269-4520
	Hulston Cancer Center at Cox Medical Center South
		Robert L Carolla	Ph: 417-269-4520
	St. John's Regional Health Center
		Robert L Carolla	Ph: 417-269-4520
Montana
	Billings
	Billings Clinic Cancer Center - 801 N 29th Street
		Benjamin Thomas Marchello	Ph: 800-648-6274
	CCOP - Montana Cancer Consortium
		Benjamin Thomas Marchello	Ph: 800-648-6274
	Hematology-Oncology Centers of the Northern Rockies - Billings
		Benjamin Thomas Marchello	Ph: 800-648-6274
	St. Vincent Healthcare Cancer Care Services
		Benjamin Thomas Marchello	Ph: 800-648-6274
	Bozeman
	Bozeman Deaconess Cancer Center
		Benjamin Thomas Marchello	Ph: 800-648-6274
		Benjamin Thomas Marchello	Ph: 800-648-6274
	Butte
	St. James Healthcare Cancer Care
		Benjamin Thomas Marchello	Ph: 800-648-6274
	Great Falls
	Benefis Sletten Cancer Institute
		Grant William Harrer	Ph: 406-731-8217
	Helena
	St. Peter's Hospital
		Benjamin Thomas Marchello	Ph: 800-648-6274
	Kalispell
	Kalispell Regional Medical Center
		Benjamin Thomas Marchello	Ph: 800-648-6274
	Missoula
	Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
		Benjamin Thomas Marchello	Ph: 800-648-6274
	Montana Cancer Specialists at Montana Cancer Center
		Benjamin Thomas Marchello	Ph: 800-648-6274
Nebraska
	Grand Island
	Saint Francis Cancer Treatment Center at Saint Francis Memorial Health Center
		Jue Wang	Ph: 800-999-5465
	Kearney
	Good Samaritan Cancer Center at Good Samaritan Hospital
		George K. Bascom	Ph: 308-865-7963
	Lincoln
	Cancer Resource Center - Lincoln
		Gamini S. Soori	Ph: 800-253-4368
	North Platte
	Callahan Cancer Center at Great Plains Regional Medical Center
		Jue Wang	Ph: 800-999-5465
	Omaha
	Alegant Health Cancer Center at Bergan Mercy Medical Center
		Gamini S. Soori	Ph: 800-253-4368
	CCOP - Missouri Valley Cancer Consortium
		Gamini S. Soori	Ph: 800-253-4368
	Creighton University Medical Center
		Gamini S. Soori	Ph: 800-253-4368
	Immanuel Medical Center
		Gamini S. Soori	Ph: 800-253-4368
	Methodist Estabrook Cancer Center
		Robert M. Langdon	Ph: 402-354-5144
	UNMC Eppley Cancer Center at the University of Nebraska Medical Center
		Jue Wang	Ph: 800-999-5465
Nevada
	Las Vegas
	CCOP - Nevada Cancer Research Foundation
		John Allan Ellerton	Ph: 702-731-8274
	University Medical Center of Southern Nevada
		John Allan Ellerton	Ph: 702-731-8274
New Hampshire
	Concord
	New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care
		Douglas Jay Weckstein	Ph: 603-224-2556
	Hooksett
	New Hampshire Oncology - Hematology, PA - Hooksett
		Douglas Jay Weckstein	Ph: 603-224-2556
	Laconia
	Lakes Region General Hospital
		Douglas Jay Weckstein	Ph: 603-224-2556
	Lebanon
	Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
		Sara Chaffee	Ph: 800-639-6918
			Email: cancer.research.nurse@dartmouth.edu
	Londonderry
	Dana-Farber Cancer Institute at Londonderry
		Aymen Elfiky	Ph: 866-790-4500
New Jersey
	Camden
	Cancer Institute of New Jersey at Cooper University Hospital - Camden
		Stephen Scott Grubbs	Ph: 302-733-6227
	Hackensack
	CCOP - Northern New Jersey
		Donna T McNamara	Ph: 201-996-2879
	Morristown
	Carol G. Simon Cancer Center at Morristown Memorial Hospital
		Neil Morganstein	Ph: 908-522-2043
	Mount Holly
	Virtua Fox Chase Health Cancer Program at Virtua Memorial Hospital Burlington County
		Michael S. Entmacher	Ph: 888-847-8823
	Newark
	UMDNJ University Hospital
		Lillian F. Pliner	Ph: 732-235-8675
	Summit
	Overlook Hospital
		Neil Morganstein	Ph: 908-522-2043
	Voorhees
	Fox Chase Virtua Health Cancer Program at Virtua West Jersey
		Michael S. Entmacher	Ph: 888-847-8823
New Mexico
	Albuquerque
	University of New Mexico Cancer Center
		Richard C Lauer	Ph: 505-272-6972
New York
	Buffalo
	Roswell Park Cancer Institute
		Roberto Pili	Ph: 877-275-7724
	Veterans Affairs Medical Center - Buffalo
		Lynn Marie Steinbrenner	Ph: 716-862-3191
	East Syracuse
	CCOP - Hematology-Oncology Associates of Central New York
		Jeffrey J. Kirshner	Ph: 315-472-7504
	Glens Falls
	Charles R. Wood Cancer Center at Glens Falls Hospital
		Aqeel A Gillani	Ph: 518-926-6700
	Middletown
	Tucker Center for Cancer Care at Orange Regional Medical Center
		Jeffrey M. Stewart	Ph: 845-342-7609
	New York
	New York Weill Cornell Cancer Center at Cornell University
		Scott Tagawa	Ph: 212-746-1848
	Rochester
	James P. Wilmot Cancer Center at University of Rochester Medical Center
		Jonathan W Friedberg	Ph: 585-275-5830
	Staten Island
	Nalitt Cancer Institute at Staten Island University Hospital
		Frank J. Forte	Ph: 718-226-8888
	Syracuse
	SUNY Upstate Medical University Hospital
		Bernard J. Poiesz	Ph: 315-464-5476
North Carolina
	Asheboro
	Randolph Hospital
		Peter Rubin	Ph: 336-832-0821
	Durham
	Duke Cancer Institute
		Jeffrey Crawford	Ph: 888-275-3853
	Goldsboro
	Wayne Memorial Hospital, Incorporated
		James N. Atkins	Ph: 919-580-0000
	Greensboro
	Moses Cone Regional Cancer Center at Wesley Long Community Hospital
		Peter Rubin	Ph: 336-832-0821
	Greenville
	Leo W. Jenkins Cancer Center at ECU Medical School
		Prashanti Atluri	Ph: 252-744-2161
	Hendersonville
	Comprehensive Cancer Center at Pardee Hospital
		James E. Radford	Ph: 828-696-4716
	Kinston
	Kinston Medical Specialists
		Peter R. Watson	Ph: 252-559-2200
	Pinehurst
	FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center
		Charles S Kuzma	Ph: 910-715-2200
	Reidsville
	Annie Penn Cancer Center
		Peter Rubin	Ph: 336-832-0821
	Rutherfordton
	Rutherford Hospital
		Charles E Bowers	Ph: 800-486-5941
	Winston-Salem
	Wake Forest University Comprehensive Cancer Center
		Mebea Aklilu	Ph: 336-713-6771
North Dakota
	Bismarck
	Medcenter One Hospital Cancer Care Center
		John T Reynolds	Ph: 701-323-5760
			Email: tfischer@mohs.org
	Mid Dakota Clinic, PC
		Edward J. Wos	Ph: 701-323-5760
			Email: tfischer@mohs.org
	St. Alexius Medical Center Cancer Center
		Edward J. Wos	Ph: 701-323-5760
			Email: tfischer@mohs.org
	Fargo
	Roger Maris Cancer Center at MeritCare Hospital
		Preston D. Steen	Ph: 701-234-6161
	Sanford Clinic North-Fargo
		Preston D. Steen	Ph: 701-234-6161
Ohio
	Akron
	McDowell Cancer Center at Akron General Medical Center
		Esther H. Rehmus	Ph: 330-344-6348
	Beachwood
	Cleveland Clinic Taussig Cancer Center
		Robert Dreicer	Ph: 866-223-8100
	Bowling Green
	Wood County Oncology Center
		Rex B Mowat	Ph: 517-265-0116
	Canton
	Aultman Cancer Center at Aultman Hospital
		Kisa E Weeman	Ph: 330-363-6891
	Mercy Cancer Center at Mercy Medical Center
		Mitchell Haut	Ph: 888-293-4673
	Chillicothe
	Adena Regional Medical Center
		J. Philip Kuebler	Ph: 502-361-8496
	Cincinnati
	University of Cincinnati
		Nagla A Karim	Ph: 513-558-4553
			Email: uchealthnews@uc.edu
	Cleveland
	Case Comprehensive Cancer Center
		Matthew M. Cooney	Ph: 800-641-2422
	Cleveland Clinic Cancer Center at Fairview Hospital
		Robert Dreicer	Ph: 866-223-8100
	Cleveland Clinic Taussig Cancer Center
		Robert Dreicer	Ph: 866-223-8100
	MetroHealth Cancer Care Center at MetroHealth Medical Center
		Bruce J. Averbook	Ph: 216-778-8526
			Email: kbauchens@metrohealth.org
	Columbus
	Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center
		Amir Mortazavi	Ph: 866-627-7616
			Email: osu@emergingmed.com
	CCOP - Columbus
		J. Philip Kuebler	Ph: 614-566-3275
	Doctors Hospital at Ohio Health
		J. Philip Kuebler	Ph: 502-361-8496
	Grant Medical Center Cancer Care
		J. Philip Kuebler	Ph: 502-361-8496
	Mount Carmel Health - West Hospital
		J. Philip Kuebler	Ph: 502-361-8496
	Riverside Methodist Hospital Cancer Care
		J. Philip Kuebler	Ph: 502-361-8496
	Delaware
	Grady Memorial Hospital
		J. Philip Kuebler	Ph: 614-566-3275
	Elyria
	Hematology Oncology Center
		Rex B Mowat	Ph: 517-265-0116
	Mercy Cancer Center - Elyria
		Rex B Mowat	Ph: 517-265-0116
	Independence
	Cleveland Clinic Taussig Cancer Center
		Robert Dreicer	Ph: 866-223-8100
	Lancaster
	Fairfield Medical Center
		J. Philip Kuebler	Ph: 502-361-8496
	Lima
	Lima Memorial Hospital
		Rex B Mowat	Ph: 517-265-0116
	St. Rita's Medical Center
		Henry Gerad	Ph: 419-226-9617
	Marietta
	Strecker Cancer Center at Marietta Memorial Hospital
		J. Philip Kuebler	Ph: 502-361-8496
	Maumee
	Northwest Ohio Oncology Center
		Rex B Mowat	Ph: 517-265-0116
		Rex B Mowat	Ph: 517-265-0116
	Mayfield Heights
	Hillcrest Cancer Center at Hillcrest Hospital
		Robert Dreicer	Ph: 866-223-8100
	Mentor
	Lake/University Ireland Cancer Center
		Matthew M. Cooney	Ph: 800-641-2422
	Mount Vernon
	Knox Community Hospital
		J. Philip Kuebler	Ph: 502-361-8496
	Newark
	Licking Memorial Cancer Care Program at Licking Memorial Hospital
		J. Philip Kuebler	Ph: 502-361-8496
	Oregon
	St. Charles Mercy Hospital
		Rex B Mowat	Ph: 517-265-0116
	Toledo Clinic - Oregon
		Rex B Mowat	Ph: 517-265-0116
	Parma
	Parma Community General Hospital
		Robert Dreicer	Ph: 866-223-8100
	Portsmouth
	Southern Ohio Medical Center Cancer Center
		J. Philip Kuebler	Ph: 502-361-8496
	Sandusky
	North Coast Cancer Care, Incorporated
		Robert Dreicer	Ph: 866-223-8100
	Springfield
	Community Hospital of Springfield and Clark County
		J. Philip Kuebler	Ph: 502-361-8496
	Strongsville
	Cleveland Clinic Foundation - Strongsville
		Robert Dreicer	Ph: 866-223-8100
	Sylvania
	Flower Hospital Cancer Center
		Rex B Mowat	Ph: 517-265-0116
	Tiffin
	Mercy Hospital of Tiffin
		Rex B Mowat	Ph: 517-265-0116
	Toledo
	CCOP - Toledo Community Hospital
		Rex B Mowat	Ph: 517-265-0116
	St. Anne Mercy Hospital
		Rex B Mowat	Ph: 517-265-0116
	St. Vincent Mercy Medical Center
		Rex B Mowat	Ph: 517-265-0116
	Toledo Clinic, Incorporated - Main Clinic
		Rex B Mowat	Ph: 517-265-0116
	Toledo Hospital
		Rex B Mowat	Ph: 517-265-0116
	University of Toledo Medical Center
		Rex B Mowat	Ph: 517-265-0116
	Wauseon
	Fulton County Health Center
		Rex B Mowat	Ph: 517-265-0116
	Westerville
	Mount Carmel St. Ann's Cancer Center
		J. Philip Kuebler	Ph: 502-361-8496
	Wooster
	Cleveland Clinic - Wooster
		Robert Dreicer	Ph: 866-223-8100
	Zanesville
	Genesis - Good Samaritan Hospital
		J. Philip Kuebler	Ph: 502-361-8496
Oklahoma
	Lawton
	Cancer Centers of Southwest Oklahoma, LLC - Lawton
		Nadim F. Nimeh	Ph: 877-231-4440
	Norman
	Cancer Care Associates - Norman
		Vikki Ann Canfield
			Email: calgbco@calgb.org
	Oklahoma City
	Cancer Care Associates - Mercy Campus
		Vikki Ann Canfield
			Email: calgbco@calgb.org
	Oklahoma University Cancer Institute
		Carla Kurkjian	Ph: 405-271-4272
			Email: julie-traylor@ouhsc.edu
	Tulsa
	Natalie Warren Bryant Cancer Center at St. Francis Hospital
		Joseph P. Lynch	Ph: 918-494-2200
Pennsylvania
	Allentown
	Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest
		Eliot Lawrence Friedman	Ph: 610-402-2273
	Danville
	Geisinger Cancer Institute at Geisinger Health
		Rajiv Panikkar	Ph: 570-271-5251
	Hazleton
	Geisinger Hazleton Cancer Center
		Rajiv Panikkar	Ph: 570-271-5251
	Philadelphia
	Fox Chase Cancer Center - Philadelphia
		Elizabeth R Plimack	Ph: 215-728-4790
	Frankford Hospital Cancer Center - Torresdale Campus
		Allen Lord Terzian	Ph: 215-612-5296
	Joan Karnell Cancer Center at Pennsylvania Hospital
		Lee Hartner	Ph: 800-789-7366
	Pottstown
	Pottstown Memorial Regional Cancer Center
		Wei Song	Ph: 610-327-7544
	Sayre
	Guthrie Cancer Center at Guthrie Clinic Sayre
		Edward T. O'Brien	Ph: 800-836-0388
	State College
	Geisinger Medical Group - Scenery Park
		Rajiv Panikkar	Ph: 570-271-5251
	Wilkes-Barre
	Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
		Rajiv Panikkar	Ph: 570-271-5251
	Williamsport
	Susquehanna Cancer Center at Divine Providence Hospital
		Warren L Robinson	Ph: 800-598-4282
South Carolina
	Charleston
	Hollings Cancer Center at Medical University of South Carolina
		Ali-Reza Golshayan	Ph: 843-792-9321
	Easley
	Cancer Centers of the Carolinas - Easley
		Jeffrey Kent Giguere	Ph: 864-241-6251
	Greenville
	Cancer Centers of the Carolinas - Faris Road
		Jeffrey Kent Giguere	Ph: 864-241-6251
	Cancer Centers of the Carolinas - Grove Commons
		Jeffrey Kent Giguere	Ph: 864-241-6251
	CCOP - Greenville
		Jeffrey Kent Giguere	Ph: 864-241-6251
	Greenville Memorial Hospital
		Jeffrey Kent Giguere	Ph: 864-241-6251
	Greer
	Cancer Centers of the Carolinas - Greer Medical Oncology
		Jeffrey Kent Giguere	Ph: 864-241-6251
	Seneca
	Cancer Centers of the Carolinas - Seneca
		Jeffrey Kent Giguere	Ph: 864-241-6251
	Spartanburg
	Cancer Centers of the Carolinas - Spartanburg
		Jeffrey Kent Giguere	Ph: 864-241-6251
	CCOP - Upstate Carolina
		Charles E Bowers	Ph: 800-486-5941
	Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
		Charles E Bowers	Ph: 800-486-5941
South Dakota
	Sioux Falls
	Sanford Cancer Center at Sanford USD Medical Center
		Miroslaw A Mazurczak	Ph: 605-328-1367
		Miroslaw A Mazurczak	Ph: 605-328-1367
Tennessee
	Kingsport
	Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center
		Asheesh Shipstone	Ph: 423-578-8538
Texas
	Houston
	Ben Taub General Hospital
		Martha P Mims	Ph: 713-798-1354
			Email: burton@bcm.edu
	Dan L. Duncan Cancer Center at Baylor College of Medicine
		Martha P Mims	Ph: 713-798-1354
			Email: burton@bcm.edu
	Veterans Affairs Medical Center - Houston
		Martha P Mims	Ph: 713-798-1354
			Email: burton@bcm.edu
Vermont
	Berlin
	Mountainview Medical
		Steven Ades	Ph: 802-656-8990
	Burlington
	Vermont Cancer Center at University of Vermont
		Steven Ades	Ph: 802-656-8990
Virginia
	Danville
	Danville Regional Medical Center
		Timothy W. Brotherton	Ph: 434-793-0044
	Fredericksburg
	Fredericksburg Oncology Inc
		Rex B Mowat	Ph: 517-265-0116
	Hematology Oncology Associates of Fredericksburg Inc
		Christopher N Vaughn	Ph: 540-371-0079
	Lynchburg
	Lynchburg Hematology-Oncology Clinic
		John Leach MacNeill	Ph: 434-200-5925
	Martinsville
	Ravenel Oncology Center at Memorial Hospital of Martinsville and Henry County
		Arthur Sleeper	Ph: 276-666-7827
	Norton
	Southwest Virginia Regional Cancer Center at Wellmonth Health
		Asheesh Shipstone	Ph: 423-578-8538
Washington
	Anacortes
	Cancer Care Center at Island Hogs
		Gary E Goodman	Ph: 206-386-2323
			Email: patra.grevstad@swedish.org
	Bellingham
	St. Joseph Cancer Center
		Gary E Goodman	Ph: 206-386-2323
			Email: patra.grevstad@swedish.org
	Bremerton
	Olympic Hematology and Oncology
		Gary E Goodman	Ph: 206-386-2323
			Email: patra.grevstad@swedish.org
	Burien
	Highline Medical Center Cancer Center
		Gary E Goodman	Ph: 206-386-2323
			Email: patra.grevstad@swedish.org
	Centralia
	Providence Centralia Hospital
		Yoshio Inoue	Ph: 253-403-2394
	Federal Way
	St. Francis Hospital
		Yoshio Inoue	Ph: 253-403-2394
	Kennewick
	Columbia Basin Hematology
		Gary E Goodman	Ph: 206-386-2323
			Email: patra.grevstad@swedish.org
	Kirkland
	Cascade Cancer Center at Evergreen Hospital Medical Center
		Craig R. Nichols	Ph: 503-215-6412
	Mount Vernon
	Skagit Valley Hospital Cancer Care Center
		Gary E Goodman	Ph: 206-386-2323
			Email: patra.grevstad@swedish.org
	Olympia
	Providence St. Peter Hospital Regional Cancer Center
		Yoshio Inoue	Ph: 253-403-2394
	Poulsbo
	Harrison Poulsbo Hematology and Onocology
		Gary E Goodman	Ph: 206-386-2323
			Email: patra.grevstad@swedish.org
	Puyallup
	Good Samaritan Cancer Center
		Yoshio Inoue	Ph: 253-403-2394
	Seattle
	CCOP - Virginia Mason Research Center
		Craig R. Nichols	Ph: 503-215-6412
	Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium
		Gary E Goodman	Ph: 206-386-2323
			Email: patra.grevstad@swedish.org
	Group Health Central Hospital
		Gary E Goodman	Ph: 206-386-2323
			Email: patra.grevstad@swedish.org
	Harborview Medical Center
		Gary E Goodman	Ph: 206-386-2323
			Email: patra.grevstad@swedish.org
	Minor and James Medical, PLLC
		Gary E Goodman	Ph: 206-386-2323
			Email: patra.grevstad@swedish.org
	Pacific Medical Center
		Craig R. Nichols	Ph: 503-215-6412
	Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
		Gary E Goodman	Ph: 206-386-2323
			Email: patra.grevstad@swedish.org
	University Cancer Center at University of Washington Medical Center
		Gary E Goodman	Ph: 206-386-2323
			Email: patra.grevstad@swedish.org
	Virginia Mason Medical Center
		Craig R. Nichols	Ph: 503-215-6412
	Sedro-Woolley
	North Puget Oncology at United General Hospital
		Gary E Goodman	Ph: 206-386-2323
			Email: patra.grevstad@swedish.org
	Spokane
	Cancer Care Northwest - Spokane South
		Gary E Goodman	Ph: 206-386-2323
			Email: patra.grevstad@swedish.org
	Evergreen Hematology and Oncology, PS
		Gary E Goodman	Ph: 206-386-2323
			Email: patra.grevstad@swedish.org
	Tacoma
	Allenmore Hospital
		Yoshio Inoue	Ph: 253-403-2394
	CCOP - Northwest
		Yoshio Inoue	Ph: 253-403-2394
	Franciscan Cancer Center at St. Joseph Medical Center
		Yoshio Inoue	Ph: 253-403-2394
	MultiCare Regional Cancer Center at Tacoma General Hospital
		Yoshio Inoue	Ph: 253-403-2394
	St. Clare Hospital
		Yoshio Inoue	Ph: 253-403-2394
	Wenatchee
	Wenatchee Valley Medical Center
		Gary E Goodman	Ph: 206-386-2323
			Email: patra.grevstad@swedish.org
West Virginia
	Huntington
	Edwards Comprehensive Cancer Center at Cabell Huntington Hospital
		Maria-Rosalia B. Tria Tirona	Ph: 304-399-6617
Wisconsin
	Green Bay
	Green Bay Oncology, Limited at St. Mary's Hospital
		Anthony J. Jaslowski	Ph: 800-432-6049
	Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center
		Anthony J. Jaslowski	Ph: 800-432-6049
	St. Mary's Hospital Medical Center - Green Bay
		Anthony J. Jaslowski	Ph: 800-432-6049
	St. Vincent Hospital Regional Cancer Center
		Anthony J. Jaslowski	Ph: 800-432-6049
	Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center
		Dhimant R. Patel	Ph: 800-252-2990
	Johnson Creek
	UW Cancer Center Johnson Creek
		Jeremy P Cetnar	Ph: 608-262-5223
	Madison
	University of Wisconsin Paul P. Carbone Comprehensive Cancer Center
		Jeremy P Cetnar	Ph: 608-262-5223
	Manitowoc
	Holy Family Memorial Medical Center Cancer Care Center
		Anthony J. Jaslowski	Ph: 800-432-6049
	Marinette
	Bay Area Cancer Care Center at Bay Area Medical Center
		Anthony J. Jaslowski	Ph: 800-432-6049
	Vince Lombardi Cancer Clinic - Marinette
		Dhimant R. Patel	Ph: 800-252-2990
	Oconto Falls
	Green Bay Oncology, Limited - Oconto Falls
		Anthony J. Jaslowski	Ph: 800-432-6049
	Sheboygan
	Saint Nicholas Hospital
		Anthony J. Jaslowski	Ph: 800-432-6049
	Vince Lombardi Cancer Clinic - Sheboygan
		Dhimant R. Patel	Ph: 800-252-2990
	Sturgeon Bay
	Green Bay Oncology, Limited - Sturgeon Bay
		Anthony J. Jaslowski	Ph: 800-432-6049
	Summit
	Aurora Medical Center
		Dhimant R. Patel	Ph: 800-252-2990
	Two Rivers
	Vince Lombardi Cancer Clinic - Two Rivers
		Dhimant R. Patel	Ph: 800-252-2990
Wyoming
	Casper
	Rocky Mountain Oncology
		Benjamin Thomas Marchello	Ph: 800-648-6274
	Sheridan
	Welch Cancer Center at Sheridan Memorial Hospital
		Benjamin Thomas Marchello	Ph: 800-648-6274