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Clinical Trials (PDQ®)

Lisinopril or Coreg CR® in Reducing Side Effects in Women With Breast Cancer Receiving Trastuzumab

Basic Trial Information
Trial Description
     Summary
     Further Trial Information
     Eligibility Criteria
Trial Contact Information

Basic Trial Information

PhaseTypeStatusAgeSponsorProtocol IDs
Phase IISupportive careActive18 and overNCI, OtherSCUSF 0806
5U10CA081920-11, HLMCC-0806, NCT01009918

Trial Description

Summary

RATIONALE: Lisinopril or Coreg CR®, may help reduce side effects caused by trastuzumab. It is not yet known whether lisinopril or Coreg CR® are more effective than a placebo in reducing side effects caused by trastuzumab.

PURPOSE: This phase II trial is studying lisinopril and Coreg CR® to see how well they work compared with a placebo in reducing side effects in patients with HER2-positive breast cancer receiving trastuzumab.

Further Study Information

OBJECTIVES:

Primary

  • The primary objective of this study is to determine if administration of lisinopril or Coreg CR®, compared to placebo, will reduce the incidence of trastuzumab-induced cardiotoxicity, as measured by LVEF, in patients receiving adjuvant, or neoadjuvant,therapy for HER2 positive breast cancer.

Secondary

  • To determine whether subjects randomized to active agent have fewer interruptions in trastuzumab therapy due to cardiomyopathy.
  • To determine whether the treatment effect is consistent in anthracycline and nonanthracycline patient cohorts
  • To compare changes in HRQL among the treatment groups during the study intervention
  • To evaluate the long term effects on the prevention of cardiomyopathy and impact on HRQL for either or both study agents
  • To compare the predictive value of troponin I and BNP in the identification of trastuzumab-induced cardiotoxicity

OUTLINE: This is a multicenter study. Patients are stratified according to chemotherapy comprising an anthracycline (yes vs no). Patients are randomized to 1 of 3 treatment arms.

  • Arm I: Patients receive oral lisinopril once daily.
  • Arm II: Patients receive oral Coreg CR® once daily.
  • Arm III: Patients receive oral placebo once daily.

In all arms, study treatment begins with the first dose of trastuzumab and continues for up to 52 weeks or until the end of trastuzumab therapy.

Quality of life is assessed using the EORTC QLQ-C30 questionnaire at baseline, at 52 weeks (or at the end of trastuzumab therapy), and at 18 and 24 months (or 6 and 12 months after the completion of trastuzumab).

After completion of study treatment, patients are followed up at 3, 6, 9, and 12 months.

Eligibility Criteria

INCLUSION CRITERIA

  • Males and Females ≥ 18 years old diagnosed with HER2 positive breast cancer
  • Scheduled to receive neoadjuvant or adjuvant trastuzumab (Herceptin®) therapy (anthracycline-containing regimens are permitted). Patients receiving Herceptin® with their chemotherapy are permitted for eligibility work-up. Taxanes are permitted. Trastuzumab (Herceptin®) therapy may be given with or after primary chemotherapy. Pertuzumab may be used in conjunction with trastuzumab.
  • Left Ventricular Ejection Fraction (LVEF) ≥ 50% by MUGA scan or echocardiogram
  • Adequate renal function for administration of trastuzumab-containing chemotherapy regimen.
  • Sitting systolic blood pressure of > 90 mm Hg
  • Pulse ≥ 60 beats/minute
  • Not pregnant or breastfeeding
  • Female patients of childbearing potential, who are sexually active, must have a negative pregnancy test before starting the study
  • Both men and women must be willing to use effective contraception during the study. Teratogenicity is documented for both active study agents
  • Able to swallow capsules

EXCLUSION CRITERIA:

  • Patients with metastatic disease
  • Prior treatment with trastuzumab or anthracyclines prior to this chemotherapy regimen
  • Current treatment with angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), such as losartan, β-blockers or digoxin
  • Known cardiac history: heart failure, myocardial infarction, radiation-induced cardiac dysfunction
  • Known allergy to either ACE inhibitors or β-blockers
  • History of bronchial asthma or related bronchospastic conditions
  • Hereditary or idiopathic angioedema
  • History of severe hypersensitivity reactions to drugs or other causes, i.e. bee stings
  • This protocol does not exclude patients who are participating on other investigational studies. Refer to the local IRB guidelines.

Trial Contact Information

Trial Lead Organizations/Sponsors

H. Lee Moffitt Cancer Center and Research Institute at University of South Florida

National Cancer Institute

Maya Guglin, MD, PhDStudy Chair

Pamela N. MunsterStudy Chair

Trial Sites

U.S.A.
Alabama
  Anniston
 Regional Medical Center
 Charles P. Lattuada Ph: 888-400-9357
California
  Long Beach
 Todd Cancer Institute at Long Beach Memorial Medical Center
 Bichlien Nguyen Ph: 562-933-0900
  Martinez
 Contra Costa Regional Medical Center
 Maya Guglin Ph: 813-259-0600
  Email: mguglin@health.usf.edu
  Rancho Mirage
 Lucy Curci Cancer Center at Eisenhower Memorial Hospital and Medical Center
 Luke P Dreisbach Ph: 760-834-3798
  Salinas
 Salinas Valley Memorial Hospital
 Laura V. Stampleman Ph: 831-759-1838
  Email: tnielsen2@svmh.com
Colorado
  Aurora
 Medical Center of Aurora - South Campus
 Keren Sturtz Ph: 888-785-6789
  Boulder
 Boulder Community Hospital
 Keren Sturtz Ph: 888-785-6789
  Colorado Springs
 Penrose Cancer Center at Penrose Hospital
 Keren Sturtz Ph: 888-785-6789
  Denver
 CCOP - Colorado Cancer Research Program
 Keren Sturtz Ph: 888-785-6789
 Porter Adventist Hospital
 Keren Sturtz Ph: 888-785-6789
 Presbyterian - St. Luke's Medical Center
 Keren Sturtz Ph: 888-785-6789
 Rose Medical Center
 Keren Sturtz Ph: 888-785-6789
 St. Joseph Hospital
 Keren Sturtz Ph: 888-785-6789
  Englewood
 Swedish Medical Center
 Keren Sturtz Ph: 888-785-6789
  Fort Collins
 Poudre Valley Hospital
 Regina J Brown Ph: 970-297-6150
  Greeley
 North Colorado Medical Center
 Keren Sturtz Ph: 888-785-6789
  Lakewood
 St. Anthony Central Hospital
 Keren Sturtz Ph: 888-785-6789
  Littleton
 Littleton Adventist Hospital
 Keren Sturtz Ph: 888-785-6789
  Lone Tree
 Sky Ridge Medical Center
 Keren Sturtz Ph: 888-785-6789
  Longmont
 Hope Cancer Care Center at Longmont United Hospital
 Keren Sturtz Ph: 888-785-6789
  Loveland
 McKee Medical Center
 Keren Sturtz Ph: 888-785-6789
  Parker
 Parker Adventist Hospital
 Keren Sturtz Ph: 888-785-6789
  Pueblo
 St. Mary - Corwin Regional Medical Center
 Keren Sturtz Ph: 888-785-6789
  Wheat Ridge
 Exempla Lutheran Medical Center
 Keren Sturtz Ph: 888-785-6789
Connecticut
  Middletown
 Middlesex Hospital Cancer Center
 Susanna Hong Ph: 860-358-2058
District of Columbia
  Washington
 George Washington University Cancer Institute
 Lauren A Mauro Ph: 202-741-2981
 Lombardi Comprehensive Cancer Center at Georgetown University Medical Center
 Claudine Isaacs Ph: 202-444-0381
 Washington Cancer Institute at Washington Hospital Center
 Claudine Isaacs Ph: 202-444-0381
Florida
  Fort Lauderdale
 Broward General Medical Center Cancer Center
 Shazia Zafar Ph: 954-355-5346
  Lakeland
 Lakeland Regional Cancer Center at Lakeland Regional Medical Center
 Madhavi L. Venigalla Ph: 863-904-1900
Georgia
  Augusta
 Medical College of Georgia Cancer Center
 Randall F. Roberts Ph: 706-721-1663
  Email: cancer@georgiahealth.edu
  Gainesville
 Northeast Georgia Medical Center
 Richard J. LoCicero Ph: 770-219-8800
  Email: cancerpatient.navigator@nghs.com
  Savannah
 Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler
 Mark A. Taylor Ph: 912-350-8568
Hawaii
  Honolulu
 OnCare Hawaii, Incorporated - Lusitana
 Maya Guglin Ph: 813-259-0600
  Email: mguglin@health.usf.edu
 Tripler Army Medical Center
 Maya Guglin Ph: 813-259-0600
  Email: mguglin@health.usf.edu
Illinois
  Bloomington
 Illinois CancerCare - Bloomington
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  Canton
 Illinois CancerCare - Canton
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  Carthage
 Illinois CancerCare - Carthage
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  Chicago
 John H. Stroger, Jr. Hospital of Cook County
 Maya Guglin Ph: 813-259-0600
  Email: mguglin@health.usf.edu
 Louis A. Weiss Memorial Hospital
 Keith L. Shulman Ph: 773-564-5044
 Resurrection Medical Center
 Christopher G. Rose Ph: 773-792-5116
  Decatur
 Decatur Memorial Hospital Cancer Care Institute
 James L. Wade Ph: 217-876-4740
  Email: kcheek@dmhhs.org
  Eureka
 Illinois CancerCare - Eureka
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  Galesburg
 Galesburg Clinic, PC
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  Kewanee
 Illinois CancerCare - Kewanee Clinic
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  La Grange
 La Grange Memorial Hospital
 Renee H. Jacobs Ph: 630-856-7526
  Macomb
 Illinois CancerCare - Macomb
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  Oak Lawn
 Advocate Christ Medical Center
 Amar Hamad Ph: 800-323-8622
  Ottawa
 Illinois CancerCare - Ottawa
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  Pekin
 Illinois CancerCare - Pekin
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  Peru
 Illinois CancerCare - Princeton
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  Princeton
 Illinois CancerCare - Princeton
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  River Forest
 West Suburban Center for Cancer Care
 Isoken Koko Ph: 708-488-0882
  Springfield
 Regional Cancer Center at Memorial Medical Center
 James L. Wade Ph: 217-876-4740
  Email: kcheek@dmhhs.org
Indiana
  Beech Grove
 St. Francis Hospital and Health Centers - Beech Grove Campus
 Howard M. Gross Ph: 765-983-3000
  Bloomington
 Bloomington Hospital Regional Cancer Institute
 David Y. Lee Ph: 812-353-2831
  Elkhart
 Elkhart Clinic, LLC
 Robin Zon Ph: 574-234-5123
 Michiana Hematology-Oncology, PC - Elkhart
 Robin Zon Ph: 574-234-5123
  Mishawaka
 Michiana Hematology-Oncology, PC - Mishawaka
 Robin Zon Ph: 574-234-5123
 Saint Joseph's Medical Center
 Robin Zon Ph: 574-234-5123
  Plymouth
 Michiana Hematology Oncology PC - Plymouth
 Robin Zon Ph: 574-234-5123
  South Bend
 CCOP - Northern Indiana CR Consortium
 Robin Zon Ph: 574-234-5123
 Memorial Hospital of South Bend
 Robin Zon Ph: 574-234-5123
 Michiana Hematology-Oncology, PC - South Bend
 Robin Zon Ph: 574-234-5123
  Westville
 Michiana Hematology Oncology-PC Westville
 Robin Zon Ph: 574-234-5123
Iowa
  Cedar Rapids
 Cedar Rapids Oncology Associates
 Deborah W Wilbur Ph: 319-363-2690
  Clive
 Medical Oncology and Hematology Associates-West Des Moines
 Robert J Behrens Ph: 888-244-6061
  Email: sherrijr@iora.org
  Des Moines
 CCOP - Iowa Oncology Research Association
 Robert J Behrens Ph: 888-244-6061
  Email: sherrijr@iora.org
 Medical Oncology and Hematology Associates at John Stoddard Cancer Center
 Robert J Behrens Ph: 888-244-6061
  Email: sherrijr@iora.org
 Medical Oncology and Hematology Associates at Mercy Cancer Center
 Robert J Behrens Ph: 888-244-6061
  Email: sherrijr@iora.org
  Mason City
 Mercy Cancer Center at Mercy Medical Center - North Iowa
 Arvind Y Vemula Ph: 800-433-3883
  Waterloo
 Covenant Cancer Treatment Center
 Mohammed T. Masri Ph: 319-272-2070
Kentucky
  Lexington
 University of Kentucky Chandler Medical Center
 Suleiman A Massarweh Ph: 859-257-3379
Maine
  Portland
 Mercy Hospital
 Roger C. Inhorn Ph: 207-553-6866
Maryland
  Baltimore
 Alvin and Lois Lapidus Cancer Institute at Sinai Hospital
 Mayer Gorbaty Ph: 410-601-6120
  Email: pridgely@lifebridgehealth.org
 Mercy Medical Center
 David A. Riseberg Ph: 410-951-7950
  Email: prc@mdmercy.com
  Bethesda
 Suburban Hospital
 Carolyn Bennett Hendricks Ph: 301-896-2719
  Email: Bsquiller@suburbanhospital.org
  Easton
 Shore Regional Cancer Center at Memorial Hospital - Easton
 Mary S. DeShields Ph: 410-820-6800ext108
  Email: srichter@shorehealth.org
Massachusetts
  Plymouth
 Jordan Hospital Club Cancer Center
 James M Koomey Ph: 508-830-2390
  Email: cancerinfo@jordanhospital.org
Michigan
  Battle Creek
 Battle Creek Health System Cancer Care Center
 Gilbert D Padula Ph: 616-685-5225
  Bay City
 Bay Regional Medical Center
 Justin F Klamerus Ph: 800-248-6777
  Clarkston
 Great Lakes Cancer Institute
 Justin F Klamerus Ph: 800-248-6777
  Detroit
 Wayne State University
 Lawrence E. Flaherty Ph: 313-576-9363
  Flint
 Singh and Arora Hematology Oncology, PC
 Justin F Klamerus Ph: 800-248-6777
  Grand Blanc
 Genesys Regional Medical Center
 Maya Guglin Ph: 813-259-0600
  Email: mguglin@health.usf.edu
  Grand Rapids
 Butterworth Hospital at Spectrum Health
 Gilbert D Padula Ph: 616-685-5225
 Lacks Cancer Center at Saint Mary's Health Care
 Gilbert D Padula Ph: 616-685-5225
  Kalamazoo
 West Michigan Cancer Center
 Raymond Sterling Lord Ph: 269-373-7458
  Lapeer
 Great Lakes Cancer Institute - Lapeer Campus
 Justin F Klamerus Ph: 800-248-6777
  Marquette
 Upper Michigan Cancer Center at Marquette General Hospital
 Amy Weise Ph: 313-576-9363
  Mount Clemens
 Clemens Regional Medical Center
 Justin F Klamerus Ph: 800-248-6777
  Mount Pleasant
 Norval K. Morey Cancer Center at Central Michigan Community Hospital
 Justin F Klamerus Ph: 800-248-6777
  Muskegon
 Mercy General Health Partners
 Gilbert D Padula Ph: 616-685-5225
  Niles
 Michiana Hematology Oncology PC - Niles
 Robin Zon Ph: 574-234-5123
  Petoskey
 Northern Michigan Hospital
 Justin F Klamerus Ph: 800-248-6777
  Royal Oak
 William Beaumont Hospital - Royal Oak Campus
 Maya Guglin Ph: 813-259-0600
  Email: mguglin@health.usf.edu
  Saint Joseph
 Lakeside Cancer Specialists, PLLC
 Robin Zon Ph: 574-234-5123
  Southfield
 Providence Hospital - Southfield
 Anibal Drelichman Ph: 248-849-5337
  Email: jaswinder.grewal@stjohn.org
  St. Joseph
 Lakeland Regional Cancer Care Center - St. Joseph
 Robin Zon Ph: 574-234-5123
  Traverse City
 Munson Medical Center
 Gilbert D Padula Ph: 616-685-5225
  Troy
 William Beaumont Hospital - Troy Campus
 Maya Guglin Ph: 813-259-0600
  Email: mguglin@health.usf.edu
Minnesota
  Brainerd
 St. Joseph's Medical Center
 Daniel Nikcevich Ph: 888-203-7267
  Burnsville
 Fairview Ridges Hospital
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Coon Rapids
 Mercy and Unity Cancer Center at Mercy Hospital
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Duluth
 CCOP - Duluth
 Daniel Nikcevich Ph: 888-203-7267
  Edina
 Fairview Southdale Hospital
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Fridley
 Mercy and Unity Cancer Center at Unity Hospital
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Hutchinson
 Hutchinson Area Health Care
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Maplewood
 HealthEast Cancer Care at St. John's Hospital
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Minneapolis
 Hennepin County Medical Center - Minneapolis
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
 Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Robbinsdale
 Humphrey Cancer Center at North Memorial Outpatient Center
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Saint Louis Park
 CCOP - Metro-Minnesota
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
 Park Nicollet Cancer Center
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Saint Paul
 Regions Hospital Cancer Care Center
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
 United Hospital
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Shakopee
 St. Francis Cancer Center at St. Francis Medical Center
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Stillwater
 Lakeview Hospital
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Waconia
 Ridgeview Medical Center
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Woodbury
 Minnesota Oncology - Woodbury
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
Mississippi
  Pascagoula
 Regional Cancer Center at Singing River Hospital
 James E. Clarkson Ph: 228-809-5292
Missouri
  Cape Girardeau
 Southeast Cancer Center
 Bryan A Faller Ph: 800-392-0936
  Jefferson City
 Goldschmidt Cancer Center
 Bryan A Faller Ph: 800-392-0936
  Rolla
 Mercy Clinic Cancer and Hematology - Rolla
 Maya Guglin Ph: 813-259-0600
  Email: mguglin@health.usf.edu
  Saint Louis
 Missouri Baptist Cancer Center
 Bryan A Faller Ph: 800-392-0936
  Springfield
 Hulston Cancer Center at Cox Medical Center South
 Maya Guglin Ph: 813-259-0600
  Email: mguglin@health.usf.edu
 St. John's Regional Health Center
 Maya Guglin Ph: 813-259-0600
  Email: mguglin@health.usf.edu
Montana
  Billings
 Billings Clinic Cancer Center - 801 N 29th Street
 Benjamin Thomas Marchello Ph: 800-648-6274
 CCOP - Montana Cancer Consortium
 Benjamin Thomas Marchello Ph: 800-648-6274
 St. Vincent Healthcare Cancer Care Services
 Benjamin Thomas Marchello Ph: 800-648-6274
  Bozeman
 Bozeman Deaconess Cancer Center
 Benjamin Thomas Marchello Ph: 800-648-6274
  Butte
 St. James Healthcare Cancer Care
 Benjamin Thomas Marchello Ph: 800-648-6274
  Great Falls
 Benefis Sletten Cancer Institute
 Grant William Harrer Ph: 406-731-8217
  Helena
 St. Peter's Hospital
 Benjamin Thomas Marchello Ph: 800-648-6274
  Kalispell
 Kalispell Regional Medical Center
 Benjamin Thomas Marchello Ph: 800-648-6274
  Missoula
 Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
 Benjamin Thomas Marchello Ph: 800-648-6274
Nebraska
  Kearney
 Good Samaritan Cancer Center at Good Samaritan Hospital
 George K. Bascom Ph: 308-865-7963
New Hampshire
  Concord
 New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care
 Douglas Jay Weckstein Ph: 603-224-2556
  Hooksett
 New Hampshire Oncology - Hematology, PA - Hooksett
 Douglas Jay Weckstein Ph: 603-224-2556
  Laconia
 Lakes Region General Hospital
 Douglas Jay Weckstein Ph: 603-224-2556
  Lebanon
 Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
 Gary N Schwartz Ph: 800-639-6918
  Email: cancer.research.nurse@dartmouth.edu
  Nashua
 Oncology Center at St. Joseph Hospital
 Mary Ann Voltz Ph: 603-880-3408
  Email: carcieri@sjh-nh.org
New Jersey
  Englewood
 Dizzy Gillespie Cancer Institute at Englewood Hospital and Medical Center
 Jill S Morrison Ph: 201-894-3456
  Long Branch
 Monmouth Medical Center
 Seth D Cohen Ph: 732-923-7689
  Newark
 UMDNJ University Hospital
 Robert Wieder Ph: 732-235-8675
  Vineland
 Frank and Edith Scarpa Regional Cancer Pavillion at South Jersey Healthcare
 Shailja Roy Ph: 856-641-7933
New Mexico
  Albuquerque
 Presbyterian Cancer Treatment Center at Presbyterian Kaseman Hospital
 Zoneddy R Dayao Ph: 505-272-6972
 University of New Mexico Cancer Center
 Zoneddy R Dayao Ph: 505-272-6972
New York
  Cooperstown
 Bassett Healthcare Regional Cancer Program at Mary Imogene Bassett Hospital
 Eric Bravin Ph: 607-547-3073
  Email: diana.crean@bassett.org
  New Hyde Park
 Long Island Jewish Medical Center
 Kit L Cheng Ph: 516-562-3467
 Monter Cancer Center of the North Shore-LIJ Health System
 Kit L Cheng Ph: 516-562-3467
  Staten Island
 Nalitt Cancer Institute at Staten Island University Hospital
 Qun Dai Ph: 718-226-8888
North Carolina
  Asheville
 Mission Hospitals - Memorial Campus
 Maya Guglin Ph: 813-259-0600
  Email: mguglin@health.usf.edu
  Cary
 Waverly Hematology Oncology
 Maya Guglin Ph: 813-259-0600
  Email: mguglin@health.usf.edu
  Charlotte
 Presbyterian Cancer Center at Presbyterian Hospital
 Maya Guglin Ph: 813-259-0600
  Email: mguglin@health.usf.edu
  Goldsboro
 Southeastern Medical Oncology Center - Goldsboro
 Maya Guglin Ph: 813-259-0600
  Email: mguglin@health.usf.edu
  Hendersonville
 Park Ridge Hospital Breast Health Center
 Maya Guglin Ph: 813-259-0600
  Email: mguglin@health.usf.edu
  Winston-Salem
 Forsyth Regional Cancer Center at Forsyth Medical Center
 Maya Guglin Ph: 813-259-0600
  Email: mguglin@health.usf.edu
Ohio
  Akron
 McDowell Cancer Center at Akron General Medical Center
 Esther H. Rehmus Ph: 330-344-6348
 Summa Center for Cancer Care at Akron City Hospital
 Jennifer E Payne Ph: 330-375-6101
  Canton
 Aultman Cancer Center at Aultman Hospital
 Kisa E Weeman Ph: 330-363-6891
  Columbus
 Doctors Hospital at Ohio Health
 Maya Guglin Ph: 813-259-0600
  Email: mguglin@health.usf.edu
 Grant Medical Center Cancer Care
 Maya Guglin Ph: 813-259-0600
  Email: mguglin@health.usf.edu
 Riverside Methodist Hospital Cancer Care
 Maya Guglin Ph: 813-259-0600
  Email: mguglin@health.usf.edu
  Lima
 St. Rita's Medical Center
 Henry Gerad Ph: 419-226-9617
  Newark
 Licking Memorial Cancer Care Program at Licking Memorial Hospital
 Maya Guglin Ph: 813-259-0600
  Email: mguglin@health.usf.edu
  Springfield
 Community Hospital of Springfield and Clark County
 Maya Guglin Ph: 813-259-0600
  Email: mguglin@health.usf.edu
  Wilmington
 Clinton Memorial Hospital
 Howard M. Gross Ph: 317-783-8918
Oklahoma
  Norman
 Cancer Care Associates - Norman
 Vikki Ann Canfield Ph: 405-271-4272
  Email: julie-traylor@ouhsc.edu
  Oklahoma City
 Cancer Care Associates - Mercy Campus
 Vikki Ann Canfield Ph: 405-271-4272
  Email: julie-traylor@ouhsc.edu
Oregon
  Salem
 Salem Hospital Regional Cancer Care Services
 John Strother Ph: 503-561-2618
Pennsylvania
  Danville
 Geisinger Cancer Institute at Geisinger Health
 Harsh Gandhi Ph: 570-459-2901
  Hazleton
 Geisinger Hazleton Cancer Center
 Harsh Gandhi Ph: 570-459-2901
  Phoenixville
 Cancer Center at Phoenixville Hospital
 Carl W. Sharer Ph: 610-983-1908
  Sayre
 Guthrie Cancer Center at Guthrie Clinic Sayre
 Cynthia A Lynch Ph: 800-836-0388
  State College
 Geisinger Medical Group - Scenery Park
 Harsh Gandhi Ph: 570-459-2901
  Wilkes-Barre
 Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
 Harsh Gandhi Ph: 570-459-2901
PR
  San Juan
 San Juan City Hospital
 Maya Guglin Ph: 813-259-0600
  Email: mguglin@health.usf.edu
South Carolina
  Anderson
 AnMed Cancer Center
 Maya Guglin Ph: 813-259-0600
  Email: mguglin@health.usf.edu
  Beaufort
 Keyserling Cancer Center at Beaufort Memorial Hospital
 Majd Chahin Ph: 843-522-7819
  Greenville
 CCOP - Greenville
 Jeffrey Kent Giguere Ph: 864-241-6251
  Spartanburg
 Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
 Maya Guglin Ph: 813-259-0600
  Email: mguglin@health.usf.edu
Texas
  Austin
 University Medical Center Brackenridge
 Om N Pandey Ph: 512-324-7991
  Laredo
 Doctor's Hospital of Laredo
 Gary W. Unzeitig Ph: 888-823-5923
  Email: ctsucontact@westat.com
  Temple
 Scott and White Cancer Institute
 Maya Guglin Ph: 813-259-0600
  Email: mguglin@health.usf.edu
Virginia
  Charlottesville
 Martha Jefferson Hospital Cancer Care Center
 Robert S. Pritchard Ph: 434-654-8400
  Martinsville
 Ravenel Oncology Center at Memorial Hospital of Martinsville and Henry County
 Maya Guglin Ph: 813-259-0600
  Email: mguglin@health.usf.edu
Washington
  Everett
 Providence Regional Cancer Partnership
 Maya Guglin Ph: 813-259-0600
  Email: mguglin@health.usf.edu
  Tacoma
 MultiCare Regional Cancer Center at Tacoma General Hospital
 Maya Guglin Ph: 813-259-0600
  Email: mguglin@health.usf.edu
Wisconsin
  Fond Du Lac
 Central Wisconsin Cancer Program at Agnesian HealthCare
 Michael W Jones Ph: 800-494-2927
  Janesville
 Mercy Regional Cancer Center
 Robert Delaune Ph: 800-928-1103
  La Crosse
 Gundersen Lutheran Center for Cancer and Blood
 Kurt Oettel Ph: 608-775-2385
  Email: cancerctr@gundluth.org
  Madison
 University of Wisconsin Paul P. Carbone Comprehensive Cancer Center
 Mark E Burkard Ph: 877-405-6866
  Mukwonago
 D.N. Greenwald Center
 Timothy R Wassenaar Ph: 262-928-7878
  New Richmond
 Cancer Center of Western Wisconsin
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Oconomowoc
 Regional Cancer Center at Oconomowoc Memorial Hospital
 Timothy R Wassenaar Ph: 262-928-7878
  Waukesha
 Waukesha Memorial Hospital Regional Cancer Center
 Timothy R Wassenaar Ph: 262-928-7878
Wyoming
  Sheridan
 Welch Cancer Center at Sheridan Memorial Hospital
 Benjamin Thomas Marchello Ph: 800-648-6274

Link to the current ClinicalTrials.gov record.
NLM Identifer NCT01009918
ClinicalTrials.gov processed this data on September 16, 2014

Note: Information about this trial is from the ClinicalTrials.gov database. The versions designated for health professionals and patients contain the same text. Minor changes may be made to the ClinicalTrials.gov record to standardize the names of study sponsors, sites, and contacts. Cancer.gov only lists sites that are recruiting patients for active trials, whereas ClinicalTrials.gov lists all sites for all trials. Questions and comments regarding the presented information should be directed to ClinicalTrials.gov.

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