Basic Trial Information
Trial Description
     Summary
     Further Trial Information
     Eligibility Criteria
Trial Contact Information

Basic Trial Information

Trial Description

Summary

RATIONALE: Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may also stop the growth of non-small cell lung cancer by blocking blood flow to the tumor. Pemetrexed disodium may stop the growth of tumor cells by blocking some enzymes needed for cell growth. It is not yet known whether giving bevacizumab or pemetrexed disodium alone or in combination is more effective in treating non-squamous non-small cell lung cancer.

PURPOSE: This randomized phase III trial is studying bevacizumab and pemetrexed disodium alone or in combination after induction therapy to see how well they work in treating patients with advanced non-squamous non-small cell lung cancer.

Further Study Information

OBJECTIVES:

Primary

• To compare the overall survival (OS) of patients with advanced non-squamous non-small cell lung cancer (NSCLC) treated with maintenance therapy with bevacizumab vs pemetrexed disodium vs bevacizumab and pemetrexed disodium following induction therapy.

Secondary

• To determine the response rate in patients treated with these regimens.

• To evaluate the progression-free survival (PFS) of patients treated with these regimens.

• To define the toxicity of these regimens in these patients.

• To determine the frequency of polymorphisms in VEGF 3578 AA, 1154 AA, ABCB1 G2677TT/AA, and ERCC-118 TT in patients treated with induction therapy comprising paclitaxel, carboplatin and bevacizumab and determine the association between genotypes and response rate.

• To determine the association between bevacizumab and pemetrexed disodium population pharmacokinetics and patient-specific covariate with bevacizumab or pemetrexed disodium toxicity.

• To determine the frequency of TSER*3 polymorphisms in NSCLC and the association between TSER polymorphisms and benefit from pemetrexed disodium.

• To evaluate TS and ERCC1 expression by RT-PCR and MTAP mutations in existing tumor specimens as a predictor of pemetrexed disodium response.

• To evaluate polymorphisms within CYPs 2C8, 3A4, 3A5 and/or the UGT1A1 collectively or monogenically as markers for variation in efficacious and/or toxic response of individuals to treatment with taxanes.

• To explore the association between proteomic profiles and ICAM, VEGF, and FGF-beta with the clinical outcomes of the study (OS, PFS, and response) (Closed as of 04/01/2010).

• To evaluate the ability of FOX03a to predict first-line treatment outcome in non-squamous NSCLC.(Closed as of 04/01/2010)

• To evaluate the ability of ADSS1 to predict outcome of pemetrexed maintenance treatment in non-squamous NSCLC.(Closed as of 04/01/2010)

• To develop proteomic classifiers to identify patient populations that would benefit from bevacizumab or pemetrexed therapy.(Closed as of 04/01/2010)

OUTLINE: This is a randomized, multicenter study. Patients are stratified according to gender (male vs female), stage of disease (IIIB-T4Nx [with nodule in ipsilateral lung lobe and not candidate for combined chemotherapy and radiation] and IV M1a vs IV M1b vs recurrent), best response to first-time therapy (complete response/partial response vs stable disease), and smoking status (never vs smoker).

• Induction therapy: Patients receive paclitaxel IV over 3 hours, carboplatin IV over 15-30 minutes, and bevacizumab IV over 30-90 minutes on day 1. Courses repeat every 21 days for 4 courses in the absence of disease progression or unacceptable toxicity.

• Maintenance Therapy: Patients achieving complete response, partial response or stable disease following induction therapy are randomized to 1 of 3 treatment arms. Treatment begins within 6 weeks of the last day of induction chemotherapy administration.

• Arm I: Patients receive bevacizumab IV over 30-90 minutes on day 1.

• Arm II: Patients receive pemetrexed disodium IV over 10 minutes on day 1.

• Arm III: Patients receive bevacizumab as in arm I and pemetrexed as in arm II. In all arms, courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.

Some patients undergo blood sample collection at baseline and periodically during study for pharmacokinetics, protein biomarkers, proteomic profiling (closed as of 04/01/10), and other analyses.

After completion of study therapy, patients are followed up every 3 months for 2 years and then every 6 months for 2-5 years.

Eligibility Criteria

DISEASE CHARACTERISTICS:

• Cytologically or histologically confirmed non-small cell lung cancer (NSCLC)

• Predominant non-squamous histology

• NSCLC not otherwise specified allowed

• Mixed tumors are categorized by the predominant cell type

• Must meet 1 of the following criteria:

• Stage IV disease including M1a or M1b stages or recurrent disease

• Stage IIIB (T4NX) disease with ipsilateral lung lobe allowed provided patients are not candidates for combined chemotherapy or radiotherapy

• Measurable or non-measurable disease as defined by RECIST criteria

• Patient must have an overall stable or better response after 4 courses of induction therapy

• No cavitary lesions in the lungs

• Patients with brain metastasis must have received local therapy to the brain and have no evidence of progression in the brain for at least 2 weeks from the time of completion of local therapy, prior to registration

PATIENT CHARACTERISTICS:

• ECOG performance status 0-1

• Leukocytes ≥ 3,000/mm^3

• ANC ≥ 1,500/mm^3

• Platelet count ≥ 100,000/mm^3

• Total bilirubin ≤ institutional upper limit of normal (ULN)

• AST and ALT ≤ 3 times ULN

• Creatinine ≤ institutional ULN OR creatinine clearance ≥ 60 mL/min

• Urine protein:urine dipstick ≤ 0-1+ (if > 1+, urine protein creatinine ratio must be < 1)

• Not pregnant or nursing

• Negative pregnancy test

• Fertile patients must agree to abstain from sexual intercourse or to use adequate contraceptive methods during and for at least 6 months after completion of study therapy

• No prior malignancy within the past 3 years except superficial melanoma, basal cell carcinoma, or carcinoma in situ

• No major hemoptysis within the past 4 weeks

• No uncontrolled intercurrent illness including, but not limited to, any of the following:

• Ongoing or active infection

• Symptomatic congestive heart failure

• Unstable angina pectoris

• Serious cardiac arrhythmia

• Psychiatric illness and/or social situations that would limit compliance with study requirements

• Patients with hypertension must be adequately controlled (BP < 150/100 mm Hg) with appropriate anti-hypertensive therapy or diet

• No history of arterial thrombotic events or major bleeding within the past 12 months

• No significant vascular disease (e.g., aortic aneurysm requiring surgical repair or recent peripheral arterial thrombosis) within the past 6 months

• No significant traumatic injury in the past 3 months

• No clinically significant cardiovascular disease

• No abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within the past 6 months

• No history of serious non-healing wounds, ulcers, or bone fractures

PRIOR CONCURRENT THERAPY:

• See Disease Characteristics

• At least 12 months since prior adjuvant chemotherapy

• At least 2 weeks since prior radiotherapy

• Patients must not have had any major surgery such as thoracotomy, laparotomy, craniotomy, or significant traumatic injury within 6 weeks prior to registration

• Biopsy procedures and chest tube insertion are not considered major surgery for the purpose of this protocol

• More than 7 days since a core biopsy

• Concurrent therapeutic anti-coagulation allowed

• No prior systemic chemotherapy for advanced stage lung cancer

• No prior paclitaxel, pemetrexed disodium, or bevacizumab

• Prior carboplatin allowed provided it was given as part of adjuvant chemotherapy

• No concurrent anti-retroviral therapy in patients with HIV infection

Trial Contact Information

Trial Lead Organizations/Sponsors

Eastern Cooperative Oncology Group

Suresh Ramalingam

Principal Investigator

U.S.A.
Alaska
	Fairbanks
	Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital
		Craig R. Nichols	Ph: 503-215-6412
Arkansas
	Ft. Smith
	Hembree Mercy Cancer Center at St. Edward Mercy Medical Center
		Tony A Flippin	Ph: 800-378-9373
	Jonesboro
	NEA Medical Clinic - East Matthews
		Carroll Dean Scroggin	Ph: 870-972-7235
California
	Fairfield
	North Bay Cancer Center
		Brian G Vikstrom	Ph: 707-646-4016
	Greenbrae
	Marin Cancer Institute at Marin General Hospital
		Peter D. Eisenberg	Ph: 415-925-5000
			Email: info@marinspecialtycare.com
	Long Beach
	Todd Cancer Institute at Long Beach Memorial Medical Center
		Nilesh L Vora	Ph: 562-933-0900
	Monterey
	Community Hospital of the Monterey Peninsula Comprehensive Cancer Center
		John Hausdorff	Ph: 831-625-4753
	Orange
	St. Joseph Hospital Regional Cancer Center - Orange
		Madhavi Mummaneni	Ph: 714-734-6220
	Palo Alto
	Veterans Affairs Medical Center - Palo Alto
		Heather A Wakelee	Ph: 650-498-7061
			Email: ccto-office@stanford.edu
	Paradise
	Feather River Hospital Cancer Center
		Sam Mazj	Ph: 530-876-7995
			Email: haleew@ah.org
	Roseville
	Sutter Cancer Center at Roseville Medical Center
		Deepti Behl	Ph: 916-454-6500
			Email: cancerinfo@sutterhealth.org
	Sacramento
	Sutter Cancer Center
		Deepti Behl	Ph: 916-454-6500
			Email: cancerinfo@sutterhealth.org
	Salinas
	Salinas Valley Memorial Hospital
		Shehzad Aziz	Ph: 831-759-3271
			Email: nvoogd@svmh.com
	Stanford
	Stanford Cancer Center
		Heather A Wakelee	Ph: 650-498-7061
			Email: ccto-office@stanford.edu
Colorado
	Aurora
	Medical Center of Aurora - South Campus
		Eduardo R. Pajon	Ph: 888-785-6789
	Boulder
	Boulder Community Hospital
		Eduardo R. Pajon	Ph: 888-785-6789
	Colorado Springs
	Penrose Cancer Center at Penrose Hospital
		Eduardo R. Pajon	Ph: 888-785-6789
	Denver
	CCOP - Colorado Cancer Research Program
		Eduardo R. Pajon	Ph: 888-785-6789
	Kaiser Permanente of Colorado
		Alexander Menter	Ph: 303-614-1300
	Porter Adventist Hospital
		Eduardo R. Pajon	Ph: 888-785-6789
	Presbyterian - St. Luke's Medical Center
		Eduardo R. Pajon	Ph: 888-785-6789
	Rose Medical Center
		Eduardo R. Pajon	Ph: 888-785-6789
	St. Anthony Central Hospital
		Eduardo R. Pajon	Ph: 888-785-6789
	St. Joseph Hospital
		Eduardo R. Pajon	Ph: 888-785-6789
	Englewood
	Swedish Medical Center
		Eduardo R. Pajon	Ph: 888-785-6789
	Fort Collins
	Front Range Cancer Specialists
		Diana C. Medgyesy	Ph: 970-212-7600
	Poudre Valley Hospital
		Paolo Romero	Ph: 970-495-8226
	Greeley
	North Colorado Medical Center
		Eduardo R. Pajon	Ph: 888-785-6789
	Lafayette
	Kaiser Permanente - Lafayette
		Alexander Menter	Ph: 303-614-1300
	Littleton
	Littleton Adventist Hospital
		Eduardo R. Pajon	Ph: 888-785-6789
	Lone Tree
	Sky Ridge Medical Center
		Eduardo R. Pajon	Ph: 888-785-6789
	Longmont
	Hope Cancer Care Center at Longmont United Hospital
		Eduardo R. Pajon	Ph: 888-785-6789
	Loveland
	McKee Medical Center
		Eduardo R. Pajon	Ph: 888-785-6789
	Parker
	Parker Adventist Hospital
		Eduardo R. Pajon	Ph: 888-785-6789
	Pueblo
	St. Mary - Corwin Regional Medical Center
		Eduardo R. Pajon	Ph: 888-785-6789
	Thornton
	North Suburban Medical Center
		Eduardo R. Pajon	Ph: 888-785-6789
	Wheat Ridge
	Exempla Lutheran Medical Center
		Eduardo R. Pajon	Ph: 888-785-6789
Connecticut
	Bridgeport
	St. Vincent's Medical Center
		Paul E Berard	Ph: 203-576-6329
			Email: twhite@stvincents.org
	Danbury
	Praxair Cancer Center at Danbury Hospital
		Robert B. Cooper	Ph: 203-739-8074
	Hartford
	Helen and Harry Gray Cancer Center at Hartford Hospital
		Todd J Alekshun	Ph: 860-545-5363
	Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center
		Philip J. Stella	Ph: 734-712-3456
	Manchester
	Manchester Memorial Hospital
		Michael A Reale	Ph: 860-533-4000
	Meriden
	MidState Medical Center
		Todd J Alekshun	Ph: 860-545-5363
	Middletown
	Middlesex Hospital Cancer Center
		Susanna Hong	Ph: 860-358-2058
	New Britain
	George Bray Cancer Center at the Hospital of Central Connecticut - New Britain Campus
		Brian J Byrne	Ph: 860-224-5660
District of Columbia
	Washington
	Kaiser Permanente at Capitol Hill Medical Center
		Leon C. Hwang	Ph: 301-816-7446
	Sibley Memorial Hospital
		Frederick Pearson Smith	Ph: 202-243-2373
	Veterans Affairs Medical Center - Washington, DC
		Anthony G Arcenas	Ph: 877-328-2621
Florida
	Deerfield Beach
	North Broward Medical Center
		Douglas E Faig	Ph: 954-941-8300
	Fort Lauderdale
	Broward General Medical Center Cancer Center
		Archana Maini	Ph: 954-355-5346
	Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
		Michael Schwartz	Ph: 305-674-2625
			Email: info@msccop.com
	Hollywood
	Joe DiMaggio Children's Hospital
		Luis E. Raez	Ph: 866-574-5124
			Email: Sylvester@emergingmed.com
	Jupiter
	Ella Milbank Foshay Cancer Center at Jupiter Medical Center
		Michael Schwartz	Ph: 305-674-2625
			Email: info@msccop.com
	Miami Beach
	CCOP - Mount Sinai Medical Center
		Michael Schwartz	Ph: 305-674-2625
			Email: info@msccop.com
	Orlando
	Florida Hospital Cancer Institute at Florida Hospital Orlando
		Lee M. Zehngebot	Ph: 407-303-5623
	Pensacola
	Sacred Heart Cancer Center at Sacred Heart Hospital
		James F Watkins	Ph: 850-416-6316
			Email: ttamayo@shhpens.org
	Sacred Heart Medical Oncology Group
		James F Watkins	Ph: 850-416-6316
			Email: ttamayo@shhpens.org
	Stuart
	Robert and Carol Weissman Cancer Center at Martin Memorial
		Prashant R. Patel	Ph: 772-288-5858ext4
		Prashant R. Patel	Ph: 772-288-5858ext4
		Prashant R. Patel	Ph: 772-288-5858ext4
Georgia
	Albany
	Phoebe Cancer Center at Phoebe Putney Memorial Hospital
		Chirag R Jani	Ph: 229-312-2251
	Atlanta
	Emory Crawford Long Hospital
		Suresh Ramalingam	Ph: 404-778-1868
	Winship Cancer Institute of Emory University
		Suresh Ramalingam	Ph: 404-778-1868
	Columbus
	John B. Amos Cancer Center
		Andrew W. Pippas	Ph: 706-660-6404
	Decatur
	Veterans Affairs Medical Center - Atlanta (Decatur)
		Johann C Brandes	Ph: 404-321-6111ext7632
	Gainesville
	Northeast Georgia Medical Center
		Richard J. LoCicero	Ph: 770-219-8800
			Email: cancerpatient.navigator@nghs.com
	Savannah
	Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler
		O. George Negrea	Ph: 912-350-8568
	Valdosta
	Pearlman Comprehensive Cancer Center at South Georgia Medical Center
		Jeffrey M. Hoy	Ph: 229-259-4628
			Email: maryann.heddon@sgmc.org
Idaho
	Boise
	Mountain States Tumor Institute at St. Luke's Regional Medical Center
		Theodore A. Walters	Ph: 800-845-4624
	Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
		Philip J. Stella	Ph: 734-712-3456
	Fruitland
	Saint Luke's Mountain States Tumor Institute - Fruitland
		Theodore A. Walters	Ph: 800-845-4624
	Lewiston
	St. Joseph Regional Medical Center
		Yoshio Inoue	Ph: 253-403-2394
	Meridian
	Mountain States Tumor Institute - Meridian
		Theodore A. Walters	Ph: 800-845-4624
	Nampa
	Saint Luke's Mountain States Tumor Institute
		Theodore A. Walters	Ph: 800-845-4624
	Twin Falls
	Mountain States Tumor Institute at St. Luke's
		Paul G. Montgomery	Ph: 800-845-4624
Illinois
	Aurora
	Rush-Copley Cancer Care Center
		Vamsi K Vasireddy	Ph: 800-446-5532
	Chicago
	Louis A. Weiss Memorial Hospital
		Keith L. Shulman	Ph: 773-564-5044
	Mount Sinai Hospital Medical Center
		Pam G. Khosla	Ph: 773-257-5960
			Email: suhi@sinai.org
	Resurrection Medical Center
		Prashant K Joshi	Ph: 773-792-5116
	Robert H. Lurie Comprehensive Cancer Center at Northwestern University
		Melissa L Johnson	Ph: 312-695-1301
			Email: cancer@northwestern.edu
	Saint Joseph Hospital
		Ira Oliff	Ph: 312-695-1301
			Email: cancer@northwestern.edu
	University of Illinois Cancer Center
		Irene Q Ma	Ph: 708-488-0882
	Veterans Affairs Medical Center - Chicago Westside Hospital
		Lawrence Eric Feldman	Ph: 312-355-3046
	Elmhurst
	Elmhurst Memorial Hospital
		Robert M Eisner	Ph: 630-352-5300
	Freeport
	Leonard C. Ferguson Cancer Center
		Arshad R Shaikh	Ph: 815-599-7000
	Geneva
	Delnor Hospital - Geneva
		Perry J Menini	Ph: 630-232-0610
	Highland Park
	Hematology Oncology Associates of Illinois-Highland Park
		Melissa L Johnson	Ph: 312-695-1301
			Email: cancer@northwestern.edu
	Hinsdale
	Hinsdale Hematology Oncology Associates
		Elyse Cheryl Schneiderman	Ph: 630-654-1790
			Email: info@hhoaltd.com
	Joliet
	Joliet Oncology-Hematology Associates, Limited - West
		Kulumani M Sivarajan	Ph: 815-730-3098
			Email: maureenc@jolietoncology.com
	Kankakee
	Provena St. Mary's Regional Cancer Center - Kankakee
		Melissa L Johnson	Ph: 312-695-1301
			Email: cancer@northwestern.edu
	La Grange
	La Grange Memorial Hospital
		Renee H. Jacobs	Ph: 630-856-7526
	Libertyville
	North Shore Oncology and Hematology Associates, Limited - Libertyville
		Melissa L Johnson	Ph: 312-695-1301
			Email: cancer@northwestern.edu
	Niles
	Cancer Care and Hematology Specialists of Chicagoland - Niles
		Melissa L Johnson	Ph: 312-695-1301
			Email: cancer@northwestern.edu
	River Forest
	West Suburban Center for Cancer Care
		Isoken Koko	Ph: 708-488-0882
	Rockford
	Swedish-American Regional Cancer Center
		Harvey Eric Einhorn	Ph: 815-489-4413
	Skokie
	Hematology Oncology Associates - Skokie
		Melissa L Johnson	Ph: 312-695-1301
			Email: cancer@northwestern.edu
	Urbana
	Carle Cancer Center at Carle Foundation Hospital
		Vamsi K Vasireddy	Ph: 800-446-5532
	Warrenville
	Central Dupage Cancer Center
		Linda L Ferris	Ph: 630-352-5300
Indiana
	Beech Grove
	St. Francis Hospital and Health Centers - Beech Grove Campus
		Howard M. Gross	Ph: 765-983-3000
	Indianapolis
	Indiana University Melvin and Bren Simon Cancer Center
		Lawrence H. Einhorn	Ph: 317-274-2552
	St. Francis Hospital Cancer Care Services
		Howard M. Gross	Ph: 765-983-3000
	Veterans Affairs Medical Center - Indianapolis
		Lawrence H. Einhorn	Ph: 317-274-2552
	William N. Wishard Memorial Hospital
		Lawrence H. Einhorn	Ph: 317-274-2552
	Lafayette
	Clarian Arnett Cancer Care
		Thomas Isaac Jones	Ph: 800-899-8448ext7431
			Email: sstidham@clarianarnett.com
	Merrillville
	Premier Oncology Hematology Associates
		Bharat H. Barai	Ph: 219-736-2800
	Michigan City
	Saint Anthony Memorial Health Centers
		Vamsi K Vasireddy	Ph: 800-446-5532
	Richmond
	Reid Hospital & Health Care Services
		Howard M. Gross	Ph: 317-783-8918
Iowa
	Ames
	McFarland Clinic, PC
		Joseph James Merchant	Ph: 515-239-2621
	Bettendorf
	Hematology Oncology Associates of the Quad Cities
		Shobha R. Chitneni	Ph: 563-355-7733
			Email: kedaprile@rccqc.com
	Cedar Rapids
	Cedar Rapids Oncology Associates
		Deborah W Wilbur	Ph: 319-363-2690
		Deborah W Wilbur	Ph: 319-363-2690
	Iowa Blood and Cancer Care
		David O. Zenk	Ph: 319-297-2900
			Email: cetscheidt@pcofiowa.com
	Mercy Regional Cancer Center at Mercy Medical Center
		David O. Zenk	Ph: 319-297-2900
			Email: cetscheidt@pcofiowa.com
	St. Luke's Hospital
		David O. Zenk	Ph: 319-297-2900
			Email: cetscheidt@pcofiowa.com
	Clive
	Medical Oncology and Hematology Associates-West Des Moines
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Mercy Cancer Center - West Lakes
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Davenport
	Genesis Regional Cancer Center at Genesis Medical Center
		George Kovach	Ph: 800-446-6088
			Email: werners@genesishealth.com
	Des Moines
	CCOP - Iowa Oncology Research Association
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	John Stoddard Cancer Center at Iowa Lutheran Hospital
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	John Stoddard Cancer Center at Iowa Methodist Medical Center
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Medical Oncology and Hematology Associates at John Stoddard Cancer Center
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Medical Oncology and Hematology Associates at Mercy Cancer Center
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Mercy Cancer Center at Mercy Medical Center - Des Moines
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Iowa City
	Holden Comprehensive Cancer Center at University of Iowa
		Daniel A Vaena	Ph: 800-237-1225
	Mason City
	Mercy Cancer Center at Mercy Medical Center - North Iowa
		Arvind Y Vemula	Ph: 800-433-3883
	Ottumwa
	South Iowa Radiation Oncology Center at Ottumwa Regional Health Center
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Sioux City
	Mercy Medical Center - Sioux City
		Donald Bruce Wender	Ph: 712-252-0088
	Siouxland Hematology-Oncology Associates, LLP
		Donald Bruce Wender	Ph: 712-252-0088
	St. Luke's Regional Medical Center
		Donald Bruce Wender	Ph: 712-252-0088
	Waterloo
	Covenant Cancer Treatment Center
		Mohammed T. Masri	Ph: 319-272-2070
	West Des Moines
	Methodist West Hospital
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
Kansas
	Kansas City
	Providence Medical Center
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Overland Park
	Menorah Medical Center
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Saint Luke's Hospital - South
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Prairie Village
	CCOP - Kansas City
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
Kentucky
	Owensboro
	Mitchell Memorial Cancer Center at Owensboro Medical Health System
		Jewraj G Maheshwari	Ph: 270-688-3691
			Email: shawns@omhs.org
Louisiana
	Baton Rouge
	Mary Bird Perkins Cancer Center - Baton Rouge
		Robert W Veith	Ph: 504-568-3410
			Email: aconne1@lsuhsc.edu
	Ochsner Health Center - Bluebonnet
		Suma P Satti	Ph: 888-562-4763
	Covington
	Ochsner Health Center - Covington
		Suma P Satti	Ph: 888-562-4763
	Monroe
	Louisiana State University Health Sciences Center - Monroe
		Colette A Salm-Schmid	Ph: 920-433-8889
	New Orleans
	CCOP - Ochsner
		Suma P Satti	Ph: 888-562-4763
	Medical Center of Louisiana - New Orleans
		Robert W Veith	Ph: 504-568-3410
			Email: aconne1@lsuhsc.edu
	New Orleans Cancer Institute at Memorial Medical Center
		Suma P Satti	Ph: 888-562-4763
	Ochsner Cancer Institute at Ochsner Clinic Foundation
		Suma P Satti	Ph: 888-562-4763
	Stanley S. Scott Cancer Center at Louisiana State University Medical Center - New Orleans
		Robert W Veith	Ph: 504-568-3410
			Email: aconne1@lsuhsc.edu
	Shreveport
	Feist-Weiller Cancer Center at Louisiana State University Health Sciences
		Colette A Salm-Schmid	Ph: 920-433-8889
Maine
	Augusta
	Harold Alfond Center for Cancer Care
		Thomas Henry Openshaw	Ph: 207-973-4274
	Bangor
	CancerCare of Maine at Eastern Maine Medical Center
		Thomas Henry Openshaw	Ph: 207-973-4274
Maryland
	Baltimore
	Alvin and Lois Lapidus Cancer Institute at Sinai Hospital
		Roberto F Martinez	Ph: 410-601-6120
			Email: pridgely@lifebridgehealth.org
	Kaiser Permanente at Woodlawn Medical Center
		Leon C. Hwang	Ph: 301-816-7446
	Frederick
	Frederick Memorial Hospital Regional Cancer Therapy Center
		Elhamy Eskander	Ph: 240-566-3584
			Email: clinicaltrials@fmh.org
	Gaithersburg
	Kaiser Permanente - Gaithersburg Medical Center
		Leon C. Hwang	Ph: 301-816-7446
	Largo
	Kaiser Permanente Mid-Atlantic Medical Group-Largo Medical Facility
		Leon C. Hwang	Ph: 301-816-7446
	Rockville
	Kaiser Permanente Capital Area Medical Group - Shady Grove Facility
		Leon C. Hwang	Ph: 301-816-7446
	Salisbury
	Peninsula Regional Medical Center
		Paul E Zorsky	Ph: 410-543-7017
			Email: sandra.heineken@peninsula.org
	Silver Spring
	Holy Cross Hospital
		Kashif A Firozvi	Ph: 310-754-7552
Massachusetts
	Attleboro
	Sturdy Memorial Hospital
		Colleen K Yavarow	Ph: 508-236-7059
	Beverly
	Beverly Hospital
		Angus P. McIntyre	Ph: 978-283-4000ext559
	Cambridge
	Mount Auburn Hospital
		Thomas D Caughey
			Email: ecog.ctrp-contact@jimmy.harvard.edu
	Gloucester
	Addison Gilbert Hospital
		Angus P. McIntyre	Ph: 978-283-4000ext559
	Pittsfield
	Berkshire Hematology Oncology, PC
		Harvey Zimbler	Ph: 413-496-8205
			Email: Gloria.Gero@berkshirehemonc.com
	Plymouth
	Jordan Hospital Club Cancer Center
		James M Koomey	Ph: 508-830-2390
			Email: cancerinfo@jordanhospital.org
	Springfield
	Baystate Medical Center
		John McCann	Ph: 413-794-3565
			Email: tamara.wrenn@baystatehealth.org
	Worcester
	UMASS Memorial Cancer Center - University Campus
		William V. Walsh	Ph: 508-856-2464
			Email: laura.lefko@umassmed.edu
Michigan
	Adrian
	Hickman Cancer Center at Bixby Medical Center
		Rex B Mowat	Ph: 517-265-0116
		Rex B Mowat	Ph: 517-265-0116
	Ann Arbor
	CCOP - Michigan Cancer Research Consortium
		Philip J. Stella	Ph: 734-712-3456
	Saint Joseph Mercy Cancer Center
		Philip J. Stella	Ph: 734-712-3456
	University of Michigan Comprehensive Cancer Center
		Gregory P. Kalemkerian	Ph: 800-865-1125
	Dearborn
	Oakwood Cancer Center at Oakwood Hospital and Medical Center
		Philip J. Stella	Ph: 734-712-3456
	Detroit
	Van Elslander Cancer Center at St. John Hospital and Medical Center
		Philip J. Stella	Ph: 734-712-3456
	Escanaba
	Green Bay Oncology, Limited - Escanaba
		Gerald K. Bayer	Ph: 800-432-6049
	Flint
	Genesys Hurley Cancer Institute
		Philip J. Stella	Ph: 734-712-3456
		Philip J. Stella	Ph: 734-712-3456
	Hurley Medical Center
		Philip J. Stella	Ph: 734-712-3456
	Iron Mountain
	Green Bay Oncology - Iron Mountain
		Gerald K. Bayer	Ph: 800-432-6049
	Jackson
	Gayle M. Jacob Cancer Center at Allegiance Health
		Philip J. Stella	Ph: 734-712-3456
	Kalamazoo
	Borgess Medical Center
		Raymond Sterling Lord	Ph: 269-373-7458
	Bronson Methodist Hospital
		Raymond Sterling Lord	Ph: 269-373-7458
	West Michigan Cancer Center
		Raymond Sterling Lord	Ph: 269-373-7458
	Lansing
	Sparrow Regional Cancer Center
		Philip J. Stella	Ph: 734-712-3456
	Livonia
	St. Mary Mercy Hospital
		Philip J. Stella	Ph: 734-712-3456
	Marquette
	Upper Michigan Cancer Center at Marquette General Hospital
		Amy Weise	Ph: 313-576-9363
	Monroe
	Community Cancer Center of Monroe
		Rex B Mowat	Ph: 517-265-0116
	Mercy Memorial Hospital - Monroe
		Rex B Mowat	Ph: 517-265-0116
	Pontiac
	St. Joseph Mercy Oakland
		Philip J. Stella	Ph: 734-712-3456
	Port Huron
	Mercy Regional Cancer Center at Mercy Hospital
		Philip J. Stella	Ph: 734-712-3456
	Saginaw
	Seton Cancer Institute at Saint Mary's - Saginaw
		Philip J. Stella	Ph: 734-712-3456
	Warren
	St. John Macomb Hospital
		Philip J. Stella	Ph: 734-712-3456
Minnesota
	Bemidji
	MeritCare Bemidji
		Preston D. Steen	Ph: 701-234-6161
	Brainerd
	St. Joseph's Medical Center
		Daniel Nikcevich	Ph: 888-203-7267
	Burnsville
	Fairview Ridges Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Coon Rapids
	Mercy and Unity Cancer Center at Mercy Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Duluth
	CCOP - Duluth
		Daniel Nikcevich	Ph: 888-203-7267
	Essentia Health - Duluth Clinic
		Daniel Nikcevich	Ph: 888-203-7267
	Miller - Dwan Medical Center
		Daniel Nikcevich	Ph: 888-203-7267
	Edina
	Fairview Southdale Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Fridley
	Mercy and Unity Cancer Center at Unity Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Hutchinson
	Hutchinson Area Health Care
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Mankato
	Immanuel St. Joseph's
		Mohmmad J Ranginwala	Ph: 507-385-2929
	Maplewood
	HealthEast Cancer Care at St. John's Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Minnesota Oncology - Maplewood
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Minneapolis
	Hennepin County Medical Center - Minneapolis
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	New Ulm
	New Ulm Medical Center
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Robbinsdale
	Humphrey Cancer Center at North Memorial Outpatient Center
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Saint Louis Park
	CCOP - Metro-Minnesota
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Park Nicollet Cancer Center
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Saint Paul
	Regions Hospital Cancer Care Center
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	United Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Shakopee
	St. Francis Cancer Center at St. Francis Medical Center
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Stillwater
	Lakeview Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Waconia
	Ridgeview Medical Center
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Willmar
	Willmar Cancer Center at Rice Memorial Hospital
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Woodbury
	Minnesota Oncology - Woodbury
		Patrick J. Flynn	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
Mississippi
	Pascagoula
	Regional Cancer Center at Singing River Hospital
		James E. Clarkson	Ph: 228-809-5292
Missouri
	Bolivar
	Central Care Cancer Center at Carrie J. Babb Cancer Center
		Robert L Carolla	Ph: 417-269-4520
	Branson
	Skaggs Cancer Center at Skaggs Regional Medical Center
		Robert L Carolla	Ph: 417-269-4520
	Cape Girardeau
	Southeast Cancer Center
		Alan Philip Lyss	Ph: 800-392-0936
	Chesterfield
	Saint Luke's Hospital
		Donald F. Busiek	Ph: 314-205-6936
	Jefferson City
	Goldschmidt Cancer Center
		Alan Philip Lyss	Ph: 800-392-0936
	Joplin
	Freeman Cancer Institute at Freeman Health System
		John H Vu	Ph: 417-347-4030
	St. John's Regional Medical Center
		Mark Joseph Skelley	Ph: 417-625-2488
	Kansas City
	Heartland Hematology Oncology Associates, Incorporated
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	North Kansas City Hospital
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Research Medical Center
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Saint Luke's Hospital
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Lee's Summit
	Saint Luke's East - Lee's Summit
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Liberty
	Parvin Radiation Oncology
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Rolla
	Mercy Clinic Cancer and Hematology - Rolla
		Robert L Carolla	Ph: 417-269-4520
	Phelps County Regional Medical Center
		Robert L Carolla	Ph: 417-269-4520
	Saint Joseph
	Heartland Regional Medical Center
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Saint Joseph Oncology, Incorporated
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Saint Louis
	Missouri Baptist Cancer Center
		Alan Philip Lyss	Ph: 800-392-0936
	Springfield
	Cancer Research for the Ozarks
		Robert L Carolla	Ph: 417-269-4520
	Hulston Cancer Center at Cox Medical Center South
		Robert L Carolla	Ph: 417-269-4520
	St. John's Regional Health Center
		Robert L Carolla	Ph: 417-269-4520
Montana
	Billings
	Billings Clinic Cancer Center - 801 N 29th Street
		Benjamin Thomas Marchello	Ph: 800-648-6274
	CCOP - Montana Cancer Consortium
		Benjamin Thomas Marchello	Ph: 800-648-6274
	Hematology-Oncology Centers of the Northern Rockies - Billings
		Benjamin Thomas Marchello	Ph: 800-648-6274
	St. Vincent Healthcare Cancer Care Services
		Benjamin Thomas Marchello	Ph: 800-648-6274
	Bozeman
	Bozeman Deaconess Cancer Center
		Benjamin Thomas Marchello	Ph: 800-648-6274
		Benjamin Thomas Marchello	Ph: 800-648-6274
	Butte
	St. James Healthcare Cancer Care
		Benjamin Thomas Marchello	Ph: 800-648-6274
	Great Falls
	Benefis Sletten Cancer Institute
		Benjamin Thomas Marchello	Ph: 800-648-6274
	Great Falls Clinic - Main Facility
		Benjamin Thomas Marchello	Ph: 800-648-6274
	Helena
	St. Peter's Hospital
		Benjamin Thomas Marchello	Ph: 800-648-6274
	Kalispell
	Kalispell Regional Medical Center
		Benjamin Thomas Marchello	Ph: 800-648-6274
	Missoula
	Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
		Benjamin Thomas Marchello	Ph: 800-648-6274
	Montana Cancer Specialists at Montana Cancer Center
		Benjamin Thomas Marchello	Ph: 800-648-6274
Nebraska
	Kearney
	Good Samaritan Cancer Center at Good Samaritan Hospital
		George K. Bascom	Ph: 308-865-7963
	Lincoln
	Cancer Resource Center - Lincoln
		Gamini S. Soori	Ph: 800-253-4368
	Omaha
	Alegant Health Cancer Center at Bergan Mercy Medical Center
		Gamini S. Soori	Ph: 800-253-4368
	CCOP - Missouri Valley Cancer Consortium
		Gamini S. Soori	Ph: 800-253-4368
	Creighton University Medical Center
		Gamini S. Soori	Ph: 800-253-4368
	Immanuel Medical Center
		Gamini S. Soori	Ph: 800-253-4368
	Lakeside Hospital
		Gamini S. Soori	Ph: 800-253-4368
Nevada
	Reno
	Renown Institute for Cancer at Renown Regional Medical Center
		John R Caton	Ph: 775-982-4400
New Hampshire
	Dover
	Seacoast Cancer Center at Wentworth - Douglass Hospital
		Taylor M Ortiz	Ph: 603-740-2150
	Nashua
	Oncology Center at St. Joseph Hospital
		Mary Ann Voltz	Ph: 603-880-3408
			Email: carcieri@sjh-nh.org
New Jersey
	East Orange
	Veterans Affairs Medical Center - East Orange
		Basil S. Kasimis	Ph: 800-475-2336
			Email: patricia.goyer@med.va.gov
	Flemington
	Hunterdon Regional Cancer Center at Hunterdon Medical Center
		Kenneth B. Blankstein	Ph: 888-788-1260
	Long Branch
	Monmouth Medical Center
		Seth D Cohen	Ph: 732-923-7689
	Morristown
	Carol G. Simon Cancer Center at Morristown Memorial Hospital
		Dennis A Lowenthal	Ph: 908-522-2043
	Mount Holly
	Virtua Fox Chase Health Cancer Program at Virtua Memorial Hospital Burlington County
		Michael S. Entmacher	Ph: 888-847-8823
	Newark
	Newark Beth Israel Medical Center
		Lori Schleicher	Ph: 973-926-7230
	UMDNJ University Hospital
		Lillian F. Pliner	Ph: 732-235-8675
	Sparta
	Frederick R. and Betty M. Smith Cancer Treatment Center
		Rita Susan Axelrod	Ph: 215-955-6084
	Summit
	Overlook Hospital
		Dennis A Lowenthal	Ph: 908-522-2043
	Vineland
	Frank and Edith Scarpa Regional Cancer Pavillion at South Jersey Healthcare
		Ramakrishna Sudhindra	Ph: 856-641-7933
	Voorhees
	Fox Chase Virtua Health Cancer Program at Virtua West Jersey
		Michael S. Entmacher	Ph: 888-847-8823
New York
	Bronx
	Jack D. Weiler Hospital at Montefiore Medical Center - East Campus
		Bilal Piperdi	Ph: 718-904-2730
			Email: aecc@aecom.yu.edu
	Montefiore Medical Center
		Bilal Piperdi	Ph: 718-904-2730
			Email: aecc@aecom.yu.edu
	Brooklyn
	Maimonides Cancer Center at Maimonides Medical Center
		Kevin Becker	Ph: 203-785-5702
	Veterans Affairs Medical Center - Brooklyn
		Andrea Nadine Wiesel Leaf	Ph: 800-877-6976
	Cooperstown
	Bassett Healthcare Regional Cancer Program at Mary Imogene Bassett Hospital
		Eric Bravin	Ph: 607-547-6965
			Email: jennifer.victory@bassett.org
	Glens Falls
	Charles R. Wood Cancer Center at Glens Falls Hospital
		John P Stoutenburg	Ph: 518-926-6700
	Middletown
	Tucker Center for Cancer Care at Orange Regional Medical Center
		Jeffrey M. Stewart	Ph: 845-342-7609
	Staten Island
	Nalitt Cancer Institute at Staten Island University Hospital
		Philip Friscia	Ph: 718-226-8888
	Stony Brook
	Stony Brook University Cancer Center
		Roger S. Keresztes	Ph: 800-862-2215
	White Plains
	Dickstein Cancer Treatment Center at White Plains Hospital Center
		Dan Costin	Ph: 914-681-2290
North Carolina
	Asheboro
	Randolph Hospital
		Peter Rubin	Ph: 336-832-0821
	Burlington
	Alamance Cancer Center at Alamance Regional Medical Center
		Janak K. Choksi	Ph: 336-538-7725
	Chapel Hill
	Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
		Thomas E. Stinchcombe	Ph: 877-668-0683
	Charlotte
	Presbyterian Cancer Center at Presbyterian Hospital
		Justin P Favaro	Ph: 704-384-5369
	Goldsboro
	Wayne Memorial Hospital, Incorporated
		James N. Atkins	Ph: 919-580-0000
	Greensboro
	Moses Cone Regional Cancer Center at Wesley Long Community Hospital
		Peter Rubin	Ph: 336-832-0821
	Hendersonville
	Comprehensive Cancer Center at Pardee Hospital
		James E. Radford	Ph: 828-696-4716
	Park Ridge Hospital Breast Health Center
		Charles E Bowers	Ph: 800-486-5941
	Kinston
	Kinston Medical Specialists
		Peter R. Watson	Ph: 252-559-2200
	Reidsville
	Annie Penn Cancer Center
		Peter Rubin	Ph: 336-832-0821
	Rutherfordton
	Rutherford Hospital
		Charles E Bowers	Ph: 800-486-5941
	Statesville
	Iredell Memorial Hospital
		Ruby A. Grimm	Ph: 704-873-5661
North Dakota
	Bismarck
	Bismarck Cancer Center
		John T Reynolds	Ph: 701-323-5760
			Email: tfischer@mohs.org
	Medcenter One Hospital Cancer Care Center
		John T Reynolds	Ph: 701-323-5760
			Email: tfischer@mohs.org
	Mid Dakota Clinic, PC
		John T Reynolds	Ph: 701-323-5760
			Email: tfischer@mohs.org
	St. Alexius Medical Center Cancer Center
		John T Reynolds	Ph: 701-323-5760
			Email: tfischer@mohs.org
	Fargo
	Dakota Cancer Institute at Dakota Clinic - South University
		Daniel Nikcevich	Ph: 888-203-7267
	Roger Maris Cancer Center at MeritCare Hospital
		Preston D. Steen	Ph: 701-234-6161
		Preston D. Steen	Ph: 701-234-6161
	Sanford Clinic North-Fargo
		Preston D. Steen	Ph: 701-234-6161
	Grand Forks
	Altru Cancer Center at Altru Hospital
		Grant R Seeger	Ph: 701-780-6520
	Minot
	Trinity CancerCare Center
		Patanit Watanaboonyakhet	Ph: 800-862-0005
Ohio
	Beachwood
	Cleveland Clinic Taussig Cancer Center
		Anjali S Advani	Ph: 866-223-8100
	Bowling Green
	Wood County Oncology Center
		Rex B Mowat	Ph: 517-265-0116
	Canton
	Aultman Cancer Center at Aultman Hospital
		Kisa E Weeman	Ph: 330-363-6891
	Mercy Cancer Center at Mercy Medical Center
		Mitchell Haut	Ph: 888-293-4673
	Cleveland
	Case Comprehensive Cancer Center
		Afshin Dowlati	Ph: 800-641-2422
	Cleveland Clinic Cancer Center at Fairview Hospital
		Anjali S Advani	Ph: 866-223-8100
	Cleveland Clinic Taussig Cancer Center
		Anjali S Advani	Ph: 866-223-8100
	MetroHealth Cancer Care Center at MetroHealth Medical Center
		Bruce J. Averbook	Ph: 216-778-8526
			Email: kbauchens@metrohealth.org
	Columbus
	Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center
		Gregory A. Otterson	Ph: 866-627-7616
			Email: osu@emergingmed.com
	Dayton
	CCOP - Dayton
		Howard M. Gross	Ph: 317-783-8918
	David L. Rike Cancer Center at Miami Valley Hospital
		Howard M. Gross	Ph: 765-983-3000
	Good Samaritan Hospital
		Howard M. Gross	Ph: 317-783-8918
	Grandview Hospital
		Howard M. Gross	Ph: 317-783-8918
	Samaritan North Cancer Care Center
		Howard M. Gross	Ph: 317-783-8918
	Elyria
	Hematology Oncology Center
		Rex B Mowat	Ph: 517-265-0116
	Mercy Cancer Center - Elyria
		Rex B Mowat	Ph: 517-265-0116
	Findlay
	Blanchard Valley Regional Cancer Center
		Howard M. Gross	Ph: 317-783-8918
	Franklin
	Atrium Medical Center
		Howard M. Gross	Ph: 317-783-8918
	Greenville
	Wayne Hospital
		Howard M. Gross	Ph: 317-783-8918
	Independence
	Cleveland Clinic Taussig Cancer Center
		Anjali S Advani	Ph: 866-223-8100
	Kettering
	Charles F. Kettering Memorial Hospital
		Howard M. Gross	Ph: 317-783-8918
	Lima
	Lima Memorial Hospital
		Rex B Mowat	Ph: 517-265-0116
	St. Rita's Medical Center
		Henry Gerad	Ph: 419-226-9617
	Maumee
	Northwest Ohio Oncology Center
		Rex B Mowat	Ph: 517-265-0116
		Rex B Mowat	Ph: 517-265-0116
	Mayfield Heights
	Hillcrest Cancer Center at Hillcrest Hospital
		Anjali S Advani	Ph: 866-223-8100
	Oregon
	St. Charles Mercy Hospital
		Rex B Mowat	Ph: 517-265-0116
	Toledo Clinic - Oregon
		Rex B Mowat	Ph: 517-265-0116
	Parma
	Parma Community General Hospital
		Anjali S Advani	Ph: 866-223-8100
	Sandusky
	North Coast Cancer Care, Incorporated
		Anjali S Advani	Ph: 866-223-8100
	Strongsville
	Cleveland Clinic Foundation - Strongsville
		Anjali S Advani	Ph: 866-223-8100
	Sylvania
	Flower Hospital Cancer Center
		Rex B Mowat	Ph: 517-265-0116
	Tiffin
	Mercy Hospital of Tiffin
		Rex B Mowat	Ph: 517-265-0116
	Toledo
	CCOP - Toledo Community Hospital
		Rex B Mowat	Ph: 517-265-0116
	St. Anne Mercy Hospital
		Rex B Mowat	Ph: 517-265-0116
	St. Vincent Mercy Medical Center
		Rex B Mowat	Ph: 517-265-0116
	Toledo Clinic, Incorporated - Main Clinic
		Rex B Mowat	Ph: 517-265-0116
	Toledo Hospital
		Rex B Mowat	Ph: 517-265-0116
	University of Toledo Medical Center
		Rex B Mowat	Ph: 517-265-0116
	Troy
	UVMC Cancer Care Center at Upper Valley Medical Center
		Howard M. Gross	Ph: 317-783-8918
	Wauseon
	Fulton County Health Center
		Rex B Mowat	Ph: 517-265-0116
	Wooster
	Cleveland Clinic - Wooster
		Anjali S Advani	Ph: 866-223-8100
	Wright-Patterson Afb
	United States Air Force Medical Center - Wright-Patterson
		Brandon J Cutler	Ph: 937-257-1398
	Xenia
	Ruth G. McMillan Cancer Center at Greene Memorial Hospital
		Howard M. Gross	Ph: 317-783-8918
Oklahoma
	Norman
	Cancer Care Associates - Norman
		Vikki Ann Canfield	Ph: 888-823-5923
			Email: ctsucontact@westat.com
	Oklahoma City
	Cancer Care Associates - Mercy Campus
		Vikki Ann Canfield	Ph: 888-823-5923
			Email: ctsucontact@westat.com
	INTEGRIS Cancer Institute of Oklahoma - Proton Campus
		Romeo A Mandanas	Ph: 405-949-3870
	Oklahoma University Cancer Institute
		Carla Kurkjian	Ph: 405-271-4272
			Email: julie-traylor@ouhsc.edu
	Tulsa
	Natalie Warren Bryant Cancer Center at St. Francis Hospital
		Joseph P. Lynch	Ph: 918-494-2200
Pennsylvania
	Allentown
	Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest
		Eliot Lawrence Friedman	Ph: 610-402-2273
	Bryn Mawr
	Bryn Mawr Hospital
		Paul B. Gilman	Ph: 484-476-2649
			Email: wellenbachj@mlhs.org
	Danville
	Geisinger Cancer Institute at Geisinger Health
		Rajiv Panikkar	Ph: 570-271-5251
	Darby
	Mercy Fitzgerald Hospital
		Rita Susan Axelrod	Ph: 215-955-6084
	Ephrata
	Ephrata Cancer Center at Ephrata Community Hospital
		Rita Susan Axelrod	Ph: 215-955-6084
	Erie
	Regional Cancer Center - Erie
		Jan M. Rothman	Ph: 814-838-0448
			Email: mhaynes@trcc.org
	Gettysburg
	Adams Cancer Center
		Amir Tabatabai	Ph: 877-441-7957
	Hanover
	Cherry Tree Cancer Center
		Amir Tabatabai	Ph: 877-441-7957
	Harrisburg
	PinnacleHealth Regional Cancer Center at Polyclinic Hospital
		Alan N Gordon	Ph: 478-633-6090
	Hazleton
	Geisinger Hazleton Cancer Center
		Rajiv Panikkar	Ph: 570-271-5251
	Hershey
	Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center
		Chandra Prakash Belani	Ph: 717-531-3779
			Email: CTO@hmc.psu.edu
	Lancaster
	Lancaster General Hospital
		Randall A Oyer	Ph: 717-544-5511
	Lewistown
	Lewistown Hospital
		Chandra Prakash Belani	Ph: 717-531-3779
			Email: CTO@hmc.psu.edu
	Media
	Riddle Memorial Hospital Cancer Center
		Rita Susan Axelrod	Ph: 215-955-6084
	Paoli
	Cancer Center of Paoli Memorial Hospital
		Paul B. Gilman	Ph: 484-476-2649
			Email: wellenbachj@mlhs.org
	Philadelphia
	Albert Einstein Cancer Center
		William J. Tester	Ph: 215-456-3880
	Fox Chase Cancer Center - Philadelphia
		Hossein Borghaei	Ph: 215-728-4790
	Frankford Hospital Cancer Center - Torresdale Campus
		Allen Lord Terzian	Ph: 215-612-5296
	Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
		Rita Susan Axelrod	Ph: 215-955-6084
	Phoenixville
	Cancer Center at Phoenixville Hospital
		Carl W. Sharer	Ph: 610-983-1908
	Reading
	St. Joseph Medical Center
		Marc Rovito	Ph: 610-378-2336
			Email: kevinkeller@catholichealth.net
	Sayre
	Guthrie Cancer Center at Guthrie Clinic Sayre
		Edward T. O'Brien	Ph: 800-836-0388
	Scranton
	Hematology and Oncology Associates of North East Pennsylvania
		Rita Susan Axelrod	Ph: 215-955-6084
	Mercy Hospital Cancer Center - Scranton
		Martin B. Hyzinski	Ph: 570-558-3020
	Scranton Hematology Oncology
		Martin B. Hyzinski	Ph: 570-558-3020
	Sellersville
	Grand View Hospital
		Anthony J Magdalinski	Ph: 215-453-4162
			Email: PParsons@gvh.org
	State College
	Geisinger Medical Group - Scenery Park
		Rajiv Panikkar	Ph: 570-271-5251
	Mount Nittany Medical Center
		Chandra Prakash Belani	Ph: 717-531-3779
			Email: CTO@hmc.psu.edu
	West Chester
	Cancer Center of Chester County
		William E. Luginbuhl	Ph: 610-431-5297
	West Reading
	McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center
		Terrence P. Cescon	Ph: 610-988-9323
	Wilkes-Barre
	Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
		Rajiv Panikkar	Ph: 570-271-5251
	Williamsport
	Susquehanna Cancer Center at Divine Providence Hospital
		Warren L Robinson	Ph: 800-598-4282
	Wynnewood
	CCOP - Main Line Health
		Paul B. Gilman	Ph: 484-476-2649
			Email: wellenbachj@mlhs.org
	Lankenau Cancer Center at Lankenau Hospital
		Paul B. Gilman	Ph: 484-476-2649
			Email: wellenbachj@mlhs.org
	York
	WellSpan Health
		Amir Tabatabai	Ph: 877-441-7957
South Carolina
	Anderson
	AnMed Cancer Center
		David Griffin	Ph: 864-512-1000
		Charles E Bowers	Ph: 800-486-5941
	Easley
	Cancer Centers of the Carolinas - Easley
		Jeffrey Kent Giguere	Ph: 864-241-6251
	Florence
	McLeod Regional Medical Center
		Rajesh Bajaj	Ph: 843-679-7256
	Georgetown
	Georgetown Memorial Hospital
		David L Milling	Ph: 843-792-9321
	Greenville
	Bon Secours St. Francis Health System
		Charles E Bowers	Ph: 800-486-5941
	Cancer Centers of the Carolinas - Faris Road
		Jeffrey Kent Giguere	Ph: 864-241-6251
	Cancer Centers of the Carolinas - Grove Commons
		Jeffrey Kent Giguere	Ph: 864-241-6251
	CCOP - Greenville
		Jeffrey Kent Giguere	Ph: 864-241-6251
	Greenville Memorial Hospital
		Jeffrey Kent Giguere	Ph: 864-241-6251
	Greer
	Cancer Centers of the Carolinas - Greer Medical Oncology
		Jeffrey Kent Giguere	Ph: 864-241-6251
	Seneca
	Cancer Centers of the Carolinas - Seneca
		Jeffrey Kent Giguere	Ph: 864-241-6251
	Spartanburg
	Cancer Centers of the Carolinas - Spartanburg
		Jeffrey Kent Giguere	Ph: 864-241-6251
	CCOP - Upstate Carolina
		Charles E Bowers	Ph: 800-486-5941
	Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
		Charles E Bowers	Ph: 800-486-5941
South Dakota
	Aberdeen
	Conklin Regional Cancer Center
		Richard J. Conklin	Ph: 605-622-5613
	Rapid City
	Rapid City Regional Hospital
		Mark T Schroeder	Ph: 605-716-3982
			Email: research@rcrh.org
	Sioux Falls
	Avera Cancer Institute
		Addison R Tolentino	Ph: 800-657-4377
			Email: Jan.Healy@avera.org
	Sanford Cancer Center at Sanford USD Medical Center
		Miroslaw A Mazurczak	Ph: 605-328-1367
		Miroslaw A Mazurczak	Ph: 605-328-1367
Tennessee
	Jackson
	West Tennessee Cancer Center at Jackson-Madison County General Hospital
		Salomon Asmar	Ph: 731-425-6865
	Kingsport
	Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center
		Asheesh Shipstone	Ph: 423-578-8538
	Knoxville
	Center for Biomedical Research
		Tracy William Dobbs	Ph: 865-244-3209
	Nashville
	MBCCOP - Meharry Medical College - Nashville
		John J Murray	Ph: 615-327-5724
			Email: jmurray@mmc.edu
	Vanderbilt-Ingram Cancer Center
		Leora Horn	Ph: 800-811-8480
Texas
	Abilene
	Hendrick Cancer Center
		Jose A Vega Dulanto
			Email: ecog.ctrp-contact@jimmy.harvard.edu
	Amarillo
	Harrington Cancer Center
		Stewart Allen Sharp	Ph: 806-359-4673
			Email: ryokubaitis@harringtoncc.org
	Houston
	Univeristy of Texas M.D. Anderson Cancer Center
		Ahmed Eid	Ph: 713-792-3245
			Email: burton@bcm.edu
Virginia
	Burke
	Kaiser Permanente at Burke Medical Center
		Leon C. Hwang	Ph: 301-816-7446
	Fredericksburg
	Fredericksburg Oncology Inc
		Rex B Mowat	Ph: 517-265-0116
	Hematology Oncology Associates of Fredericksburg Inc
		Christopher N Vaughn	Ph: 540-371-0079
	Hampton
	Virginia Oncology Associates - Hampton
		Paul R. Conkling	Ph: 757-873-9400
	McLean
	Kaiser Permanente Tysons Corner Medical Center
		Leon C. Hwang	Ph: 301-816-7446
	Norton
	Southwest Virginia Regional Cancer Center at Wellmonth Health
		Asheesh Shipstone	Ph: 423-578-8538
	Richmond
	Virginia Commonwealth University Massey Cancer Center
		Sherman Baker	Ph: 804-628-1939
	South Hill
	Community Memorial Health Center
		Sherman Baker	Ph: 804-628-1939
Washington
	Auburn
	Auburn Regional Center for Cancer Care
		Yoshio Inoue	Ph: 253-403-2394
	Bellevue
	Overlake Cancer Center at Overlake Hospital Medical Center
		Yoshio Inoue	Ph: 253-403-2394
	Centralia
	Providence Centralia Hospital
		Yoshio Inoue	Ph: 253-403-2394
	Everett
	Providence Regional Cancer Partnership
		Yoshio Inoue	Ph: 253-403-2394
	Federal Way
	St. Francis Hospital
		Yoshio Inoue	Ph: 253-403-2394
	Olympia
	Providence St. Peter Hospital Regional Cancer Center
		Yoshio Inoue	Ph: 253-403-2394
	Puyallup
	Good Samaritan Cancer Center
		Yoshio Inoue	Ph: 253-403-2394
	Seattle
	CCOP - Virginia Mason Research Center
		Craig R. Nichols	Ph: 503-215-6412
	Pacific Medical Center
		Craig R. Nichols	Ph: 503-215-6412
	Virginia Mason Medical Center
		Craig R. Nichols	Ph: 503-215-6412
	Spokane
	Rockwood Clinic Cancer Treatment Center
		Jay L. Wittenkeller	Ph: 509-838-2531
	Tacoma
	Allenmore Hospital
		Yoshio Inoue	Ph: 253-403-2394
	CCOP - Northwest
		Yoshio Inoue	Ph: 253-403-2394
	Franciscan Cancer Center at St. Joseph Medical Center
		Yoshio Inoue	Ph: 253-403-2394
	MultiCare Regional Cancer Center at Tacoma General Hospital
		Yoshio Inoue	Ph: 253-403-2394
	St. Clare Hospital
		Yoshio Inoue	Ph: 253-403-2394
West Virginia
	Charleston
	West Virginia University Medical School - Charleston
		Steven J. Jubelirer	Ph: 304-388-9944
	Morgantown
	Mary Babb Randolph Cancer Center at West Virginia University Hospitals
		Mohammed Almubarak	Ph: 304-293-2745
			Email: sfilburn@hsc.wvu.edu
Wisconsin
	Antigo
	Langlade Memorial Hospital
		Hamied R. Rezazadeh	Ph: 877-405-6866
	Eau Claire
	Luther Midlelfort Hospital
		Daniel Burns	Ph: 715-838-6072
	Midelfort Clinic - Luther
		Daniel Burns	Ph: 715-838-6072
	Green Bay
	Bellin Memorial Hospital
		Patrick J Mansky	Ph: 920-435-8326
	Green Bay Oncology, Limited at St. Mary's Hospital
		Gerald K. Bayer	Ph: 800-432-6049
	Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center
		Gerald K. Bayer	Ph: 800-432-6049
	St. Mary's Hospital Medical Center - Green Bay
		Gerald K. Bayer	Ph: 800-432-6049
	St. Vincent Hospital Regional Cancer Center
		Gerald K. Bayer	Ph: 800-432-6049
	Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center
		Dhimant R. Patel	Ph: 800-252-2990
	Janesville
	Mercy Regional Cancer Center
		Robert Delaune	Ph: 800-928-1103
	La Crosse
	Gundersen Lutheran Center for Cancer and Blood
		Kurt Oettel	Ph: 608-775-2385
			Email: cancerctr@gundluth.org
	Manitowoc
	Holy Family Memorial Medical Center Cancer Care Center
		Gerald K. Bayer	Ph: 800-432-6049
	Marinette
	Bay Area Cancer Care Center at Bay Area Medical Center
		Gerald K. Bayer	Ph: 800-432-6049
	Vince Lombardi Cancer Clinic - Marinette
		Dhimant R. Patel	Ph: 800-252-2990
	Milwaukee
	Wheaton Franciscan Cancer Care - St. Joseph
		Francis J Cuevas	Ph: 414-874-4541
	Mukwonago
	D.N. Greenwald Center
		Michael A Thompson	Ph: 262-928-7632
	New Richmond
	Cancer Center of Western Wisconsin
		Joseph W Leach	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Oconomowoc
	Regional Cancer Center at Oconomowoc Memorial Hospital
		Michael A Thompson	Ph: 262-928-7632
	Oconto Falls
	Green Bay Oncology, Limited - Oconto Falls
		Gerald K. Bayer	Ph: 800-432-6049
	Oshkosh
	Vince Lombardi Cancer Clinic - Oshkosh
		Dhimant R. Patel	Ph: 800-252-2990
	Sheboygan
	Saint Nicholas Hospital
		Gerald K. Bayer	Ph: 800-432-6049
	Vince Lombardi Cancer Clinic - Sheboygan
		Dhimant R. Patel	Ph: 800-252-2990
	Sturgeon Bay
	Green Bay Oncology, Limited - Sturgeon Bay
		Gerald K. Bayer	Ph: 800-432-6049
	Summit
	Aurora Medical Center
		Dhimant R. Patel	Ph: 800-252-2990
	Two Rivers
	Vince Lombardi Cancer Clinic - Two Rivers
		Dhimant R. Patel	Ph: 800-252-2990
	Waukesha
	Waukesha Memorial Hospital Regional Cancer Center
		Michael A Thompson	Ph: 262-928-7632
	Wausau
	University of Wisconcin Cancer Center at Aspirus Wausau Hospital
		Hamied R. Rezazadeh	Ph: 877-405-6866
	Wauwatosa
	Oncology Alliance, SC - Milwaukee - West
		Rubina Qamar	Ph: 888-709-2080
	Wisconsin Rapids
	Riverview UW Cancer Center at Riverview Hospital
		Ron James Kirschling	Ph: 877-405-6866
Wyoming
	Casper
	Rocky Mountain Oncology
		Benjamin Thomas Marchello	Ph: 800-648-6274
	Sheridan
	Welch Cancer Center at Sheridan Memorial Hospital
		Benjamin Thomas Marchello	Ph: 800-648-6274