Radiation Therapy With or Without Chemotherapy in Patients With Stage I or Stage II Cervical Cancer Who Previously Underwent Surgery
Trial Sites
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Basic Trial Information
Trial Description
Summary
Further Trial Information
Eligibility Criteria
Trial Contact Information
| Phase | Type | Status | Age | Sponsor | Protocol IDs |
|---|---|---|---|---|---|
| Phase III | Tissue collection/Repository, Treatment | Active | 18 and over | NCI, Other | CDR0000670125 GOG-0263, NCT01101451 |
Summary
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether giving radiation therapy together with chemotherapy is more effective than radiation therapy alone in treating patients with cervical cancer.
PURPOSE: This randomized phase III trial is studying giving radiation therapy together with chemotherapy to see how well it works compared to radiation therapy alone in treating patients with stage I or stage II cervical cancer who previously underwent surgery.
Further Study Information
OBJECTIVES:
Primary
- To determine if post-operative adjuvant chemoradiotherapy (CRT) can significantly improve recurrence-free survival (RFS) when compared to radiation therapy (RT) alone in patients with intermediate-risk factors stage I-IIA cervical cancer after treatment with radical hysterectomy.
Secondary
- To compare the overall survival (OS) of patients treated with these regimens.
- To assess differences in incidence and severity of regimen-attributed adverse events in these patients.
- To provide assessment of patient risk vs benefit (positive study only).
- To determine whether post-operative adjuvant CRT improves the health-related quality-of-life compared to RT alone.
- To compare toxicity profiles with particular focus on treatment-related genitourinary, gastrointestinal, neurological, pain, and sexual adverse events in these patients.
Tertiary
- To bank archival tumor tissue for research studies, including studies that evaluate the association between biomarkers, RFS, OS, and clinical-surgical-pathologic characteristics in patients treated with these regimens.
- To bank DNA from whole blood for research studies, including studies that evaluate associations between single nucleotide polymorphisms (SNPs), and measures of clinical outcome, including RFS, OS, and adverse events in patients treated with these regimens.
OUTLINE: This is a multicenter study. Patients are stratified according to capillary-lymphovascular space involvement (positive vs negative), stromal invasion (deep vs middle vs superficial), radiotherapy modality (external-beam radiation therapy [EBRT] vs intensity-modulated radiation therapy [IMRT]), and cooperative group (KGOG vs GOG). Patients are randomized to 1 of 2 treatment arms.
- Arm I: Patients undergo pelvic EBRT or IMRT 5 days a week for 5.5 weeks.
- Arm II: Patients receive cisplatin IV over 1-2 hours on day 1 and undergo radiotherapy as in arm I. Treatment with cisplatin repeats every 7 days for up to 6 weeks in the absence of disease progression or unacceptable toxicity.
Patients complete questionnaires on smoking history, Functional Assessment of Cancer Therapy (FACT-G, Version 4), FACT-Neurotoxicity subscale, and the Brief Pain Inventory (BPI) at baseline and periodically during study.
Tumor tissue and blood samples may be collected and banked for future biomarker and other analysis.
After completion of study therapy, patients are followed up every 3 months for 2 years, and then every 6 months for 3 years.
Eligibility Criteria
DISEASE CHARACTERISTICS:
- Pathologically confirmed primary cervical cancer comprising one of the following cell types:
- Squamous cell carcinoma
- Adenosquamous carcinoma
- Adenocarcinoma
- Stage I-IIA disease
- Initially treated with a standard radical hysterectomy with pelvic lymphadenectomy
- Patients with depth of stromal invasion and lymphovascular space involvement to be pathologically confirmed must meet the following criteria:
- Positive capillary-lymphovascular space involvement and one of the following:
- Deep third penetration
- Middle third penetration, clinical tumor ≥ 2 cm
- Superficial third penetration, clinical tumor ≥ 5 cm
- Negative capillary-lymphatic space involvement
- Middle or deep third penetration, clinical tumor ≥ 4 cm
- No patients with tumor in the parametria, pelvic lymph nodes, or any other extra-uterine site or with positive surgical margins
PATIENT CHARACTERISTICS:
- GOG performance status 0-2
- ANC ≥ 1,500/mm³
- Platelet count ≥ 100,000/mm³
- Creatinine normal OR creatinine clearance ≥ 60 mL/min
- Bilirubin ≤ 1.5 times upper limit of normal (ULN)
- Alkaline phosphate ≤ 3 times ULN
- SGOT ≤ 3 times ULN
- No septicemia or severe infection
- No intestinal obstruction or gastrointestinal bleeding
- No post-operative fistula
- No circumstances that do not permit completion of the study or the required study follow-up
- No renal abnormalities requiring modification of radiation field (e.g., pelvic kidney or renal transplant)
- No prior malignancy within the past 5 years except nonmelanoma skin cancer
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
- At least 3 weeks but ≤ 8 weeks since surgery
- No prior radiotherapy or chemotherapy for cancer of the cervix
- No prior cancer treatment that contraindicates this protocol therapy
- No concurrent brachytherapy boost
Trial Lead Organizations/Sponsors
Gynecologic Oncology Group
National Cancer Institute| Sang Young Ryu |  | Principal Investigator |
| Wui-jin Koh | |
Trial Sites
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| U.S.A. | |||
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| Arizona | |||
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| Phoenix | |||
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| St. Joseph's Hospital and Medical Center | |||
| Ivor Benjamin | Ph: 623-773-2873 | ||
| California | |||
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| Burbank | |||
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| Roy and Patricia Disney Family Cancer Center at Providence Saint Joseph Medical Center | |||
| Richard Friedman | Ph: 818-847-3220 | ||
| Concord | |||
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| Cancer Care Center at John Muir Health - Concord Campus | |||
| Babak Edraki | Ph: 925-674-2580 | ||
| Los Angeles | |||
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| Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center | |||
| Bobbie J Rimel | Ph: 310-423-8965 | ||
| Email: info@ccadmin.wustl.edu | |||
| Mountain View | |||
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| Palo Alto Medical Foundation | |||
| Albert L Pisani | Ph: 650-934-7000 | ||
| Pomona | |||
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| Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical Center | |||
| Alberto A Mendivil | Ph: 949-642-5165 | ||
| Sylmar | |||
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| Olive View - UCLA Medical Center Foundation | |||
| Christine Holschneider | Ph: 888-798-0719 | ||
| Walnut Creek | |||
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| John Muir/Mt. Diablo Comprehensive Cancer Center | |||
| Babak Edraki | Ph: 925-674-2580 | ||
| Colorado | |||
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| Aurora | |||
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| Medical Center of Aurora - South Campus | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Boulder | |||
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| Boulder Community Hospital | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Colorado Springs | |||
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| Penrose Cancer Center at Penrose Hospital | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Denver | |||
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| CCOP - Colorado Cancer Research Program | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Porter Adventist Hospital | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Presbyterian - St. Luke's Medical Center | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Rose Medical Center | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| St. Anthony Central Hospital | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| St. Joseph Hospital | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Englewood | |||
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| Swedish Medical Center | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Greeley | |||
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| North Colorado Medical Center | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Littleton | |||
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| Littleton Adventist Hospital | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Lone Tree | |||
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| Sky Ridge Medical Center | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Longmont | |||
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| Hope Cancer Care Center at Longmont United Hospital | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Loveland | |||
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| McKee Medical Center | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Parker | |||
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| Parker Adventist Hospital | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Pueblo | |||
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| St. Mary - Corwin Regional Medical Center | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Wheat Ridge | |||
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| Exempla Lutheran Medical Center | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Connecticut | |||
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| Hartford | |||
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| Helen and Harry Gray Cancer Center at Hartford Hospital | |||
| James S. Hoffman | Ph: 860-224-5660 | ||
| Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center | |||
| Philip J. Stella | Ph: 734-712-3456 | ||
| New Britain | |||
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| George Bray Cancer Center at the Hospital of Central Connecticut - New Britain Campus | |||
| James S. Hoffman | Ph: 860-224-5660 | ||
| District of Columbia | |||
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| Washington | |||
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| Sibley Memorial Hospital | |||
| Mildred Rodriguez Chernofsky | Ph: 202-243-2373 | ||
| Florida | |||
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| Miami | |||
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| University of Miami Sylvester Comprehensive Cancer Center - Miami | |||
| Nagy Elsayyad | Ph: 866-574-5124 | ||
| Email: Sylvester@emergingmed.com | |||
| Orlando | |||
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| Florida Hospital Cancer Institute at Florida Hospital Orlando | |||
| James E Kendrick | Ph: 407-303-5623 | ||
| Georgia | |||
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| Atlanta | |||
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| Northside Hospital Cancer Center | |||
| Guilherme C. Cantuaria | Ph: 404-303-3355 | ||
| Email: clinicaltrials@northside.com | |||
| Piedmont Hospital | |||
| Adam W Nowlan | Ph: 404-425-7943 | ||
| Email: phri@piedmont.org | |||
| Saint Joseph's Hospital of Atlanta | |||
| Thomas E. Seay | Ph: 404-303-3355 | ||
| Columbus | |||
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| John B. Amos Cancer Center | |||
| John L Currie | Ph: 860-545-5363 | ||
| Decatur | |||
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| Charles B. Eberhart Cancer Center at DeKalb Medical Center | |||
| Thomas E. Seay | Ph: 404-303-3355 | ||
| Gainesville | |||
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| Northeast Georgia Medical Center | |||
| Andrew E Green | Ph: 770-219-8800 | ||
| Email: cancerpatient.navigator@nghs.com | |||
| Marietta | |||
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| Kennestone Cancer Center at Wellstar Kennestone Hospital | |||
| Thomas E. Seay | Ph: 404-303-3355 | ||
| Riverdale | |||
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| Southern Regional Medical Center | |||
| Thomas E. Seay | Ph: 404-303-3355 | ||
| Savannah | |||
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| Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center | |||
| James J Burke | Ph: 912-350-8568 | ||
| Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler | |||
| William Edward Richards | Ph: 800-622-6877 | ||
| Email: uchealthnews@uc.edu | |||
| Hawaii | |||
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| Honolulu | |||
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| Cancer Research Center of Hawaii | |||
| Michael E. Carney | Ph: 808-983-6090 | ||
| MBCCOP - Hawaii | |||
| Michael E. Carney | Ph: 808-983-6090 | ||
| Queen's Cancer Institute at Queen's Medical Center | |||
| Michael E. Carney | Ph: 808-983-6090 | ||
| Idaho | |||
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| Boise | |||
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| Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center | |||
| Philip J. Stella | Ph: 734-712-3456 | ||
| Illinois | |||
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| Chicago | |||
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| University of Illinois Cancer Center | |||
| Rajul Kothari | Ph: 312-355-3046 | ||
| Hinsdale | |||
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| Gynecologic Oncology | |||
| Sudarshan K. Sharma | Ph: 630-856-6757 | ||
| Maywood | |||
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| Cardinal Bernardin Cancer Center at Loyola University Medical Center | |||
| Ronald Keith Potkul | Ph: 708-226-4357 | ||
| Mt. Vernon | |||
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| Good Samaritan Regional Health Center | |||
| Robert L Carolla | Ph: 417-269-4520 | ||
| Indiana | |||
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| Fort Wayne | |||
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| Parkview Regional Cancer Center at Parkview Health | |||
| Brian K Chang | Ph: 260-373-8888 | ||
| Email: parkviewresearch@parkview.com | |||
| Radiation Oncology Associates Southwest | |||
| Brian K Chang | Ph: 260-373-8888 | ||
| Email: parkviewresearch@parkview.com | |||
| Indianapolis | |||
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| Indiana University Melvin and Bren Simon Cancer Center | |||
| Jeanne M Schilder | Ph: 317-274-2552 | ||
| St. Vincent Oncology Center | |||
| Gregory P. Sutton | Ph: 317-338-2194 | ||
| Iowa | |||
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| Ames | |||
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| McFarland Clinic, PC | |||
| Joseph James Merchant | Ph: 515-239-2621 | ||
| Clive | |||
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| Medical Oncology and Hematology Associates-West Des Moines | |||
| Robert J Behrens | Ph: 888-244-6061 | ||
| Email: sherrijr@iora.org | |||
| Mercy Cancer Center - West Lakes | |||
| Robert J Behrens | Ph: 888-244-6061 | ||
| Email: sherrijr@iora.org | |||
| Des Moines | |||
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| CCOP - Iowa Oncology Research Association | |||
| Robert J Behrens | Ph: 888-244-6061 | ||
| Email: sherrijr@iora.org | |||
| John Stoddard Cancer Center at Iowa Lutheran Hospital | |||
| Robert J Behrens | Ph: 888-244-6061 | ||
| Email: sherrijr@iora.org | |||
| John Stoddard Cancer Center at Iowa Methodist Medical Center | |||
| Robert J Behrens | Ph: 888-244-6061 | ||
| Email: sherrijr@iora.org | |||
| Medical Oncology and Hematology Associates at John Stoddard Cancer Center | |||
| Robert J Behrens | Ph: 888-244-6061 | ||
| Email: sherrijr@iora.org | |||
| Medical Oncology and Hematology Associates at Mercy Cancer Center | |||
| Robert J Behrens | Ph: 888-244-6061 | ||
| Email: sherrijr@iora.org | |||
| Mercy Cancer Center at Mercy Medical Center - Des Moines | |||
| Robert J Behrens | Ph: 888-244-6061 | ||
| Email: sherrijr@iora.org | |||
| Iowa City | |||
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| Holden Comprehensive Cancer Center at University of Iowa | |||
| Koen De Geest | Ph: 800-237-1225 | ||
| Sioux City | |||
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| Mercy Medical Center - Sioux City | |||
| Donald Bruce Wender | Ph: 712-252-0088 | ||
| Siouxland Hematology-Oncology Associates, LLP | |||
| Donald Bruce Wender | Ph: 712-252-0088 | ||
| St. Luke's Regional Medical Center | |||
| Donald Bruce Wender | Ph: 712-252-0088 | ||
| West Des Moines | |||
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| Methodist West Hospital | |||
| Robert J Behrens | Ph: 888-244-6061 | ||
| Email: sherrijr@iora.org | |||
| Robert J Behrens | Ph: 888-244-6061 | ||
| Email: sherrijr@iora.org | |||
| Kansas | |||
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| Kansas City | |||
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| Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center | |||
| Julia A. Chapman | Ph: 913-588-4709 | ||
| Kentucky | |||
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| Lexington | |||
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| University of Kentucky Chandler Medical Center | |||
| Frederick Ueland | Ph: 859-257-3379 | ||
| Pikeville | |||
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| Leonard Lawson Cancer Center at Pikeville Medical Center | |||
| Holly H. Gallion | Ph: 888-823-5923 | ||
| Email: ctsucontact@westat.com | |||
| Louisiana | |||
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| Baton Rouge | |||
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| Woman's Hospital | |||
| Giles Fort | Ph: 225-215-1353 | ||
| Email: clinicalreserach@marybird.com | |||
| Maine | |||
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| Portland | |||
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| Maine Medical Center - Bramhall Campus | |||
| Ian J Bristol | Ph: 207-396-8090 | ||
| Email: wrighd@mmc.org | |||
| Scarborough | |||
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| Maine Medical Center- Scarborough Campus | |||
| Ian J Bristol | Ph: 207-396-8090 | ||
| Email: wrighd@mmc.org | |||
| Maryland | |||
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| Baltimore | |||
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| Greater Baltimore Medical Center Cancer Center | |||
| Paul Celano | Ph: 443-849-3706 | ||
| Bethesda | |||
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| National Naval Medical Center | |||
| Michael P Stany | Ph: 301-319-2100 | ||
| Silver Spring | |||
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| Holy Cross Hospital | |||
| Sheela D Modin | Ph: 310-754-7552 | ||
| Michigan | |||
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| Ann Arbor | |||
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| CCOP - Michigan Cancer Research Consortium | |||
| Philip J. Stella | Ph: 734-712-3456 | ||
| Saint Joseph Mercy Cancer Center | |||
| Philip J. Stella | Ph: 734-712-3456 | ||
| Dearborn | |||
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| Oakwood Cancer Center at Oakwood Hospital and Medical Center | |||
| Philip J. Stella | Ph: 734-712-3456 | ||
| Detroit | |||
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| Van Elslander Cancer Center at St. John Hospital and Medical Center | |||
| Philip J. Stella | Ph: 734-712-3456 | ||
| Wayne State University | |||
| Robert T. Morris | Ph: 313-576-9363 | ||
| Flint | |||
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| Genesys Hurley Cancer Institute | |||
| Philip J. Stella | Ph: 734-712-3456 | ||
| Hurley Medical Center | |||
| Philip J. Stella | Ph: 734-712-3456 | ||
| Grand Blanc | |||
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| Genesys Regional Medical Center | |||
| Philip J. Stella | Ph: 734-712-3456 | ||
| Jackson | |||
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| Gayle M. Jacob Cancer Center at Allegiance Health | |||
| Philip J. Stella | Ph: 734-712-3456 | ||
| Kalamazoo | |||
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| Borgess Medical Center | |||
| Raymond Sterling Lord | Ph: 269-373-7458 | ||
| Bronson Methodist Hospital | |||
| Raymond Sterling Lord | Ph: 269-373-7458 | ||
| West Michigan Cancer Center | |||
| Raymond Sterling Lord | Ph: 269-373-7458 | ||
| Lansing | |||
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| Sparrow Regional Cancer Center | |||
| Philip J. Stella | Ph: 734-712-3456 | ||
| Livonia | |||
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| St. Mary Mercy Hospital | |||
| Philip J. Stella | Ph: 734-712-3456 | ||
| Pontiac | |||
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| St. Joseph Mercy Oakland | |||
| Philip J. Stella | Ph: 734-712-3456 | ||
| Port Huron | |||
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| Mercy Regional Cancer Center at Mercy Hospital | |||
| Philip J. Stella | Ph: 734-712-3456 | ||
| Saginaw | |||
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| Seton Cancer Institute at Saint Mary's - Saginaw | |||
| Philip J. Stella | Ph: 734-712-3456 | ||
| Southfield | |||
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| Providence Hospital - Southfield | |||
| Anibal Drelichman | Ph: 248-849-5337 | ||
| Email: jaswinder.grewal@stjohn.org | |||
| Warren | |||
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| St. John Macomb Hospital | |||
| Philip J. Stella | Ph: 734-712-3456 | ||
| Minnesota | |||
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| Burnsville | |||
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| Fairview Ridges Hospital | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Coon Rapids | |||
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| Mercy and Unity Cancer Center at Mercy Hospital | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Edina | |||
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| Fairview Southdale Hospital | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Fridley | |||
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| Mercy and Unity Cancer Center at Unity Hospital | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Hutchinson | |||
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| Hutchinson Area Health Care | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Maplewood | |||
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| HealthEast Cancer Care at St. John's Hospital | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Minnesota Oncology - Maplewood | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Minneapolis | |||
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| Hennepin County Medical Center - Minneapolis | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Virginia Piper Cancer Institute at Abbott - Northwestern Hospital | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| New Ulm | |||
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| New Ulm Medical Center | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Robbinsdale | |||
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| Humphrey Cancer Center at North Memorial Outpatient Center | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Rochester | |||
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| Mayo Clinic Cancer Center | |||
| Harry J. Long | Ph: 507-538-7623 | ||
| Saint Louis Park | |||
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| CCOP - Metro-Minnesota | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Park Nicollet Cancer Center | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Saint Paul | |||
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| Regions Hospital Cancer Care Center | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| United Hospital | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Shakopee | |||
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| St. Francis Cancer Center at St. Francis Medical Center | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Stillwater | |||
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| Lakeview Hospital | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Waconia | |||
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| Ridgeview Medical Center | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Willmar | |||
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| Willmar Cancer Center at Rice Memorial Hospital | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Woodbury | |||
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| Minnesota Oncology - Woodbury | |||
| Patrick J. Flynn | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Mississippi | |||
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| Jackson | |||
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| University of Mississippi Cancer Clinic | |||
| James Tate Thigpen | Ph: 601-815-6700 | ||
| Pascagoula | |||
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| Regional Cancer Center at Singing River Hospital | |||
| James E. Clarkson | Ph: 228-809-5292 | ||
| Missouri | |||
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| Cape Girardeau | |||
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| Saint Francis Medical Center | |||
| Bethany G. Sleckman | Ph: 913-948-5588 | ||
| Columbia | |||
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| Ellis Fischel Cancer Center at University of Missouri - Columbia | |||
| Mark I Hunter | Ph: 573-882-7440 | ||
| Rolla | |||
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| Mercy Clinic Cancer and Hematology - Rolla | |||
| Robert L Carolla | Ph: 417-269-4520 | ||
| Saint Louis | |||
|
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| CCOP - St. Louis-Cape Girardeau | |||
| Bethany G. Sleckman | Ph: 913-948-5588 | ||
| David C. Pratt Cancer Center at St. John's Mercy | |||
| Robert L Carolla | Ph: 417-269-4520 | ||
| Springfield | |||
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| Cancer Research for the Ozarks | |||
| Robert L Carolla | Ph: 417-269-4520 | ||
| Hulston Cancer Center at Cox Medical Center South | |||
| Robert L Carolla | Ph: 417-269-4520 | ||
| St. John's Regional Health Center | |||
| Robert L Carolla | Ph: 417-269-4520 | ||
| Nebraska | |||
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| Omaha | |||
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| Methodist Estabrook Cancer Center | |||
| Peter C. Morris | Ph: 402-354-7939 | ||
| Email: kathryn.bartz@nmhs.org | |||
| Nevada | |||
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| Las Vegas | |||
|
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| Women's Cancer Center - La Canada | |||
| Nick M. Spirtos | Ph: 702-851-4672 | ||
| Reno | |||
|
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| Renown Institute for Cancer at Renown Regional Medical Center | |||
| Peter C Lim | Ph: 866-513-8227 | ||
| Peter C Lim | Ph: 866-513-8227 | ||
| New Hampshire | |||
|
|||
| Lebanon | |||
|
|||
| Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center | |||
| Leslie R. DeMars | Ph: 800-639-6918 | ||
| Email: cancer.research.nurse@dartmouth.edu | |||
| New Jersey | |||
|
|||
| Long Branch | |||
|
|||
| Monmouth Medical Center | |||
| Mitchell F Weiss | Ph: 732-923-7689 | ||
| Mount Holly | |||
|
|||
| Virtua Fox Chase Health Cancer Program at Virtua Memorial Hospital Burlington County | |||
| Randolph B Deger | Ph: 888-847-8823 | ||
| Phillipsburg | |||
|
|||
| Women’s Institute for Gynecologic Cancer and Special Pelvic Surgery | |||
| David Foster Silver | Ph: 718-765-2500 | ||
| Ridgewood | |||
|
|||
| Valley Hospital - Ridgewood | |||
| William M. Burke | Ph: 201-634-5792 | ||
| Toms River | |||
|
|||
| J. Phillip Citta Regional Cancer Center at Community Medical Center | |||
| David J D'Ambrosio | Ph: 732-818-3882 | ||
| Vineland | |||
|
|||
| Frank and Edith Scarpa Regional Cancer Pavillion at South Jersey Healthcare | |||
| Ramakrishna Sudhindra | Ph: 856-641-7933 | ||
| Voorhees | |||
|
|||
| Fox Chase Virtua Health Cancer Program at Virtua West Jersey | |||
| Randolph B Deger | Ph: 888-847-8823 | ||
| New Mexico | |||
|
|||
| Albuquerque | |||
|
|||
| Southwest Gynecologic Oncology Associates, Incorporated | |||
| Carolyn Y. Muller | Ph: 505-272-6972 | ||
| University of New Mexico Cancer Center | |||
| Carolyn Y. Muller | Ph: 505-272-6972 | ||
| Las Cruces | |||
|
|||
| Memorial Medical Center | |||
| Teresa L Rutledge | Ph: 505-272-6972 | ||
| New York | |||
|
|||
| Albany | |||
|
|||
| Women's Cancer Care Associates | |||
| Thomas P Morrissey | Ph: 518-458-1390 | ||
| Bronx | |||
|
|||
| Albert Einstein Cancer Center at Albert Einstein College of Medicine | |||
| Mark H. Einstein | Ph: 718-904-2730 | ||
| Email: aecc@aecom.yu.edu | |||
| New York | |||
|
|||
| Memorial Sloan-Kettering Cancer Center | |||
| Mario M Leitao | Ph: 212-639-7202 | ||
| Stony Brook | |||
|
|||
| Stony Brook University Cancer Center | |||
| Michael L. Pearl | Ph: 800-862-2215 | ||
| North Carolina | |||
|
|||
| Chapel Hill | |||
|
|||
| Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill | |||
| Linda Van Le | Ph: 877-668-0683 | ||
| Charlotte | |||
|
|||
| Blumenthal Cancer Center at Carolinas Medical Center | |||
| Robert Victor Higgins | Ph: 704-355-2884 | ||
| Goldsboro | |||
|
|||
| Wayne Memorial Hospital, Incorporated | |||
| James N. Atkins | Ph: 919-580-0000 | ||
| Winston-Salem | |||
|
|||
| Wake Forest University Comprehensive Cancer Center | |||
| Samuel S. Lentz | Ph: 336-713-6771 | ||
| North Dakota | |||
|
|||
| Bismarck | |||
|
|||
| Bismarck Cancer Center | |||
| Edward J. Wos | Ph: 701-323-5760 | ||
| Email: tfischer@mohs.org | |||
| Medcenter One Hospital Cancer Care Center | |||
| Edward J. Wos | Ph: 701-323-5760 | ||
| Email: tfischer@mohs.org | |||
| Mid Dakota Clinic, PC | |||
| Edward J. Wos | Ph: 701-323-5760 | ||
| Email: tfischer@mohs.org | |||
| St. Alexius Medical Center Cancer Center | |||
| Edward J. Wos | Ph: 701-323-5760 | ||
| Email: tfischer@mohs.org | |||
| Ohio | |||
|
|||
| Akron | |||
|
|||
| McDowell Cancer Center at Akron General Medical Center | |||
| Esther H. Rehmus | Ph: 330-344-6348 | ||
| Summa Center for Cancer Care at Akron City Hospital | |||
| Vivian von Gruenigen | Ph: 330-375-6101 | ||
| Chillicothe | |||
|
|||
| Adena Regional Medical Center | |||
| J. Philip Kuebler | Ph: 614-566-3275 | ||
| Cincinnati | |||
|
|||
| University of Cincinnati | |||
| Thomas J. Reid | Ph: 937-298-3399 | ||
| Email: uchealthnews@uc.edu | |||
| Cleveland | |||
|
|||
| Case Comprehensive Cancer Center | |||
| Steven E. Waggoner | Ph: 800-641-2422 | ||
| Cleveland Clinic Cancer Center at Fairview Hospital | |||
| Peter Graham Rose | Ph: 866-223-8100 | ||
| Cleveland Clinic Taussig Cancer Center | |||
| Peter Graham Rose | Ph: 866-223-8100 | ||
| Columbus | |||
|
|||
| CCOP - Columbus | |||
| J. Philip Kuebler | Ph: 502-361-8496 | ||
| Doctors Hospital at Ohio Health | |||
| J. Philip Kuebler | Ph: 502-361-8496 | ||
| Grant Medical Center Cancer Care | |||
| J. Philip Kuebler | Ph: 502-361-8496 | ||
| Mount Carmel Health - West Hospital | |||
| J. Philip Kuebler | Ph: 614-566-3275 | ||
| Riverside Methodist Hospital Cancer Care | |||
| J. Philip Kuebler | Ph: 502-361-8496 | ||
| Zangmeister Center | |||
| J. Philip Kuebler | Ph: 502-361-8496 | ||
| Delaware | |||
|
|||
| Grady Memorial Hospital | |||
| J. Philip Kuebler | Ph: 614-566-3275 | ||
| Kettering | |||
|
|||
| Charles F. Kettering Memorial Hospital | |||
| Heather S Pulaski | Ph: 937-298-3399 | ||
| Marietta | |||
|
|||
| Strecker Cancer Center at Marietta Memorial Hospital | |||
| J. Philip Kuebler | Ph: 614-566-3275 | ||
| Mayfield Heights | |||
|
|||
| Hillcrest Cancer Center at Hillcrest Hospital | |||
| Peter Graham Rose | Ph: 866-223-8100 | ||
| Mentor | |||
|
|||
| Lake/University Ireland Cancer Center | |||
| Steven E. Waggoner | Ph: 800-641-2422 | ||
| Newark | |||
|
|||
| Licking Memorial Cancer Care Program at Licking Memorial Hospital | |||
| J. Philip Kuebler | Ph: 614-566-3275 | ||
| Portsmouth | |||
|
|||
| Southern Ohio Medical Center Cancer Center | |||
| J. Philip Kuebler | Ph: 502-361-8496 | ||
| Springfield | |||
|
|||
| Community Hospital of Springfield and Clark County | |||
| J. Philip Kuebler | Ph: 614-566-3275 | ||
| Westerville | |||
|
|||
| Mount Carmel St. Ann's Cancer Center | |||
| J. Philip Kuebler | Ph: 614-566-3275 | ||
| Zanesville | |||
|
|||
| Genesis - Good Samaritan Hospital | |||
| J. Philip Kuebler | Ph: 502-361-8496 | ||
| Oklahoma | |||
|
|||
| Oklahoma City | |||
|
|||
| Oklahoma University Cancer Institute | |||
| Robert S. Mannel | Ph: 405-271-4272 | ||
| Email: julie-traylor@ouhsc.edu | |||
| Tulsa | |||
|
|||
| Cancer Care Associates-Yale | |||
| Robert S. Mannel | Ph: 405-271-4272 | ||
| Email: julie-traylor@ouhsc.edu | |||
| Oregon | |||
|
|||
| Portland | |||
|
|||
| Legacy Good Samaritan Hospital & Comprehensive Cancer Center | |||
| William E Winter | Ph: 800-220-4937 | ||
| Email: cancer@lhs.org | |||
| Northwest Cancer Specialists at Rose Quarter Cancer Center | |||
| William E Winter | Ph: 503-413-1742 | ||
| Pennsylvania | |||
|
|||
| Abington | |||
|
|||
| Rosenfeld Cancer Center at Abington Memorial Hospital | |||
| Parviz Hanjani | Ph: 215-481-2402 | ||
| Bethlehem | |||
|
|||
| St. Luke's Cancer Network at St. Luke's Hospital | |||
| Sanjiv S. Agarwala | Ph: 610-954-3582 | ||
| Email: infolink@slhn.org | |||
| Philadelphia | |||
|
|||
| Fox Chase Cancer Center - Philadelphia | |||
| Mark A. Morgan | Ph: 215-728-4790 | ||
| Temple Cancer Center at Temple University Hospital | |||
| Enrique Hernandez | Ph: 215-728-2983 | ||
| Rhode Island | |||
|
|||
| Providence | |||
|
|||
| Women and Infants Hospital of Rhode Island | |||
| Carolyn K McCourt | Ph: 401-274-1122 | ||
| South Dakota | |||
|
|||
| Rapid City | |||
|
|||
| Black Hills Obstetrics & Gynecology LLP | |||
| Helen L. Frederickson | Ph: 605-343-9224 | ||
| Sioux Falls | |||
|
|||
| Avera Cancer Institute | |||
| Luis A Rojas-Espaillat | Ph: 800-657-4377 | ||
| Email: Jan.Healy@avera.org | |||
| Texas | |||
|
|||
| Dallas | |||
|
|||
| Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas | |||
| David Scott Miller | Ph: 214-648-7097 | ||
| Galveston | |||
|
|||
| University of Texas Medical Branch | |||
| Lyuba Levine | Ph: 409-772-1950 | ||
| Email: clinical.research@utmb.edu | |||
| Houston | |||
|
|||
| Methodist Hospital | |||
| Aparna A Kamat | Ph: 281-277-5200 | ||
| Utah | |||
|
|||
| Cedar City | |||
|
|||
| Sandra L. Maxwell Cancer Center | |||
| Ross E. Morgan | Ph: 801-581-4477 | ||
| Email: clinical.trials@hci.utah.edu | |||
| Murray | |||
|
|||
| Jon and Karen Huntsman Cancer Center at Intermountain Medical Center | |||
| Ross E. Morgan | Ph: 801-581-4477 | ||
| Email: clinical.trials@hci.utah.edu | |||
| Ogden | |||
|
|||
| Val and Ann Browning Cancer Center at McKay-Dee Hospital Center | |||
| Ross E. Morgan | Ph: 801-581-4477 | ||
| Email: clinical.trials@hci.utah.edu | |||
| Provo | |||
|
|||
| Utah Valley Regional Medical Center - Provo | |||
| Ross E. Morgan | Ph: 801-581-4477 | ||
| Email: clinical.trials@hci.utah.edu | |||
| Saint George | |||
|
|||
| Dixie Regional Medical Center - East Campus | |||
| Ross E. Morgan | Ph: 801-581-4477 | ||
| Email: clinical.trials@hci.utah.edu | |||
| Salt Lake City | |||
|
|||
| Huntsman Cancer Institute at University of Utah | |||
| Matthew M Poppe | Ph: 801-581-4477 | ||
| Email: clinical.trials@hci.utah.edu | |||
| LDS Hospital | |||
| Ross E. Morgan | Ph: 801-581-4477 | ||
| Email: clinical.trials@hci.utah.edu | |||
| Utah Cancer Specialists at UCS Cancer Center | |||
| Ross E. Morgan | Ph: 801-581-4477 | ||
| Email: clinical.trials@hci.utah.edu | |||
| Virginia | |||
|
|||
| Portsmouth | |||
|
|||
| Naval Medical Center - Portsmouth | |||
| Edward F Miles | Ph: 757-953-5939 | ||
| Washington | |||
|
|||
| Bellingham | |||
|
|||
| PeaceHealth Medical Group, PC at St. Joseph Hospital | |||
| Benjamin E. Greer | Ph: 206-616-8289 | ||
| Bremerton | |||
|
|||
| Harrison Medical Center | |||
| Benjamin E. Greer | Ph: 206-616-8289 | ||
| Olympic Hematology and Oncology | |||
| Benjamin E. Greer | Ph: 206-616-8289 | ||
| Everett | |||
|
|||
| Providence Regional Cancer Partnership | |||
| Benjamin E. Greer | Ph: 206-616-8289 | ||
| Mount Vernon | |||
|
|||
| Skagit Valley Hospital Cancer Care Center | |||
| Benjamin E. Greer | Ph: 206-616-8289 | ||
| Poulsbo | |||
|
|||
| Harrison Poulsbo Hematology and Onocology | |||
| Benjamin E. Greer | Ph: 206-616-8289 | ||
| Seattle | |||
|
|||
| Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium | |||
| Benjamin E. Greer | Ph: 206-616-8289 | ||
| Group Health Central Hospital | |||
| Benjamin E. Greer | Ph: 206-616-8289 | ||
| Pacific Gynecology Specialists | |||
| Benjamin E. Greer | Ph: 206-616-8289 | ||
| Seattle Cancer Care Alliance | |||
| Benjamin E. Greer | Ph: 206-616-8289 | ||
| Swedish Cancer Institute at Swedish Medical Center - First Hill Campus | |||
| Benjamin E. Greer | Ph: 206-616-8289 | ||
| Swedish Cancer Institute at Northwest Hospital & Medical Center | |||
| Benjamin E. Greer | Ph: 206-616-8289 | ||
| University Cancer Center at University of Washington Medical Center | |||
| Benjamin E. Greer | Ph: 206-616-8289 | ||
| Sequim | |||
|
|||
| Olympic Medical Cancer Center | |||
| Benjamin E. Greer | Ph: 206-616-8289 | ||
| Spokane | |||
|
|||
| Cancer Care Northwest - Spokane South | |||
| Benjamin E. Greer | Ph: 206-616-8289 | ||
| Rockwood Clinic Cancer Treatment Center | |||
| Benjamin E. Greer | Ph: 206-616-8289 | ||
| Tacoma | |||
|
|||
| Franciscan Cancer Center at St. Joseph Medical Center | |||
| Benjamin E. Greer | Ph: 206-616-8289 | ||
| MultiCare Regional Cancer Center at Tacoma General Hospital | |||
| Benjamin E. Greer | Ph: 206-616-8289 | ||
| Walla Walla | |||
|
|||
| St. Mary Regional Cancer Center at St. Mary Medical Center | |||
| Benjamin E. Greer | Ph: 206-616-8289 | ||
| Wenatchee | |||
|
|||
| Wenatchee Valley Medical Center | |||
| Benjamin E. Greer | Ph: 206-616-8289 | ||
| Wisconsin | |||
|
|||
| La Crosse | |||
|
|||
| Gundersen Lutheran Center for Cancer and Blood | |||
| Kurt Oettel | Ph: 608-775-2385 | ||
| Email: cancerctr@gundluth.org | |||
| Madison | |||
|
|||
| University of Wisconsin Paul P. Carbone Comprehensive Cancer Center | |||
| David M Kushner | Ph: 877-405-6866 | ||
| Milwaukee | |||
|
|||
| Froedtert Hospital and Medical College of Wisconsin | |||
| William H Bradley | Ph: 414-805-4380 | ||
| Vince Lombardi Cancer Clinic at Aurora St. Luke's Medical Center | |||
| Scott A Kamelle | Ph: 414-649-7200 | ||
| New Richmond | |||
|
|||
| Cancer Center of Western Wisconsin | |||
| David H. Irwin | Ph: 510-204-3428 | ||
| West Allis | |||
|
|||
| Aurora Women's Pavilion of West Allis Memorial Hospital | |||
| Peter Johnson | Ph: 800-252-2990 | ||
| Japan | |||
|
|||
| Kagoshima City, Kagoshima | |||
|
|||
| Kagoshima City Hospital | |||
| Masayuki Hatae | Ph: 011 81 099 224 2101 | ||
| Matsuyama | |||
|
|||
| Shikoku Cancer Center | |||
| Dina K Rooney | Ph: (888) 293-4673 | ||
| Aoba-ku | |||
|
|||
| Sendai | |||
|
|||
| Tohoku University Graduate School of Medicine | |||
| Nobuo Yaegashi | |||
| Email: med-som@bureau.tohoku.ac.jp | |||
| Hiroshima | |||
|
|||
| Kure | |||
|
|||
| National Hospital Organization - Medical Center of Kure | |||
| Hiroko Nakamura | Ph: (0823) 22-3111 | ||
| Iwate | |||
|
|||
| Morioka | |||
|
|||
| Iwate Medical University Hospital | |||
| Toru Sugiyama | Ph: 019-651-5111 | ||
| Niigata | |||
|
|||
| Niigata City | |||
|
|||
| Niigata University Medical and Dental Hospital | |||
| Kenichi Tanaka | Ph: 81-025-223-6161 | ||
| Republic of Korea | |||
|
|||
| Seoul | |||
|
|||
| Asan Medical Center - University of Ulsan College of Medicine | |||
| Young-Tak Kim | Ph: irbksh@amc.seoul.kr | ||
| Gangnam Severance Hospital | |||
| Jae-Hoon Kim | |||
| Email: clinical.trial@bms.com | |||
| Korea Cancer Center Hospital | |||
| Beob-Jong Kim | Ph: 011-82-02-9702-114 | ||
| Seoul National University Hospital | |||
| Soon-Beom Kang | Ph: 011-82-760-2384 | ||
| Daegu | |||
|
|||
| Jung-Ku | |||
|
|||
| Dongsan Medical Center of Keimyung University | |||
| Chi-Heum Cho | |||
| Email: ho@dsmc.or.kr | |||
| Incheon | |||
|
|||
| Jung-gu | |||
|
|||
| Inha University Hospital | |||
| Eun-Seop Song | Ph: 011-82-760-2384 | ||
| KOREA | |||
|
|||
| Seoul | |||
|
|||
| Samsung Medical Center | |||
| Duk-Soo Bae | Ph: 011-82-1599-3114 | ||
| Kyeonggi-do | |||
|
|||
| Seongnam City | |||
|
|||
| Seoul National University Bundang Hospital | |||
| Kidong Kim | Ph: 011-82-02-9702-114 | ||
Link to the current ClinicalTrials.gov record.
NLM Identifer NCT01101451
Information obtained from ClinicalTrials.gov on November 20, 2012
Note: Information about this trial is from the ClinicalTrials.gov database. The versions designated for health professionals and patients contain
the same text. Minor
changes may be made to the ClinicalTrials.gov record to standardize the names of study sponsors, sites, and
contacts. Cancer.gov only lists sites that are recruiting patients for active trials, whereas ClinicalTrials.gov lists all sites for all trials. Questions and comments regarding the presented information should
be directed to ClinicalTrials.gov.
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