Sulfasalazine in Preventing Acute Diarrhea in Patients With Cancer Who Are Undergoing Pelvic Radiation Therapy
Trial Sites
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Basic Trial Information
Trial Description
Summary
Further Trial Information
Eligibility Criteria
Trial Contact Information
| Phase | Type | Status | Age | Sponsor | Protocol IDs |
|---|---|---|---|---|---|
| Phase III | Supportive care, Tissue collection/Repository | Active | 18 and over | NCI, Other | CDR0000684240 NCCTG-N08C9, N08C9, NCT01198145 |
Summary
RATIONALE: Sulfasalazine may relieve diarrhea in patients with cancer who are undergoing pelvic radiation therapy.
PURPOSE: This randomized phase III trial is studying sulfasalazine to see how well it works in preventing acute diarrhea in patients with cancer who are undergoing pelvic radiation therapy.
Further Study Information
OBJECTIVES:
Primary
- To determine whether sulfasalazine is effective in reducing the acute treatment-related diarrhea in patients receiving pelvic radiotherapy as measured by NCI CTC v4.0 in patients receiving pelvic external-beam radiotherapy as adjuvant or primary treatment for malignancy.
Secondary
- To determine whether sulfasalazine can reduce chronic treatment-related bowel dysfunction following completion of therapy.
- To determine whether sulfasalazine causes any toxicity in this situation.
Tertiary
- To bank blood products for future studies, as part of ongoing research for NCCTG studies (Mayo Clinic Rochester only). (Translational)
OUTLINE: This is a multicenter study. Patients are stratified according to history of anterior resection of the rectum (yes vs no); total planned cumulative dosing, including boost fields of external-beam radiotherapy (4500-5350 cGy vs > 5350 cGy); and concurrent radiosensitizing fluorouracil, capecitabine, or oxaliplatin (yes vs no). Patients are randomized to 1 of 2 treatment arms.
- Arm I: Patients receive oral sulfasalazine twice daily during radiotherapy* and for 4 weeks after completion of radiotherapy.
- Arm II: Patients receive oral placebo twice daily during radiotherapy* and for 4 weeks after completion of radiotherapy.
NOTE: *Patients must start study treatment by the third radiotherapy fraction.
Patients may undergo blood sample collection at baseline and then weekly during radiotherapy. All patients complete quality of life and bowel function questionnaires at baseline, weekly during radiotherapy, and at 6 weeks after completion of radiotherapy.
After completion of radiotherapy, patients are followed up at 6 weeks and at 12 and 24 months.
Eligibility Criteria
DISEASE CHARACTERISTICS:
- Diagnosis of cancer that supports the use of radiotherapy to the pelvis
- No current or prior metastases beyond pelvic regional lymph nodes
- Planning to receive a course of continuous definitive or adjuvant external-beam radiotherapy to a minimum dose of 4500 cGy with or without fluorouracil, capecitabine, or oxaliplatin
- Planned course of pelvic radiotherapy must fall within the following parameters:
- Pelvis must be encompassed by the planned radiotherapy fields
- Superior border may not lie superior to the L4-5 interspace and may not be inferior to the most inferior aspect of the sacroiliac joints
- Portions of the rectum may have special blocking, depending upon disease site
- Total planned dose to the central axis midplane (for AP-PA parallel opposed fields) or isocenter (for 3- or 4-field techniques) for the pelvic field must lie between 4500-5300 cGy (inclusive)*
- Subsequent to completion of treatment to the pelvic field, a boost to primary tumor or tumor bed may be planned
- Planned treatment is to be given 4-5 times per week on a one-treatment-per-day basis
- Daily dose (specified at central axis midplane or at isocenter for multi-field techniques) must lie between 170-210 cGy (inclusive) per day*
- NOTE: *For institutions that do not use midplane or isocenter as the point for specification of dose, it will be necessary to determine the dose according to the methods specified above in order to determine patient eligibility.
- No perineal irradiation planned (e.g., anal cancer patients, patients who have had an abdominal-perineal resection)
- No brachytherapy planned before the completion of all external-beam radiotherapy
- No planned split-course radiotherapy
PATIENT CHARACTERISTICS:
- ECOG performance status 0-2
- Life expectancy ≥ 6 months
- Hemoglobin ≥ 10.0 g/dL
- Leukocytes ≥ 3,500/mm^3
- ANC ≥ 1,500/mm^3
- Platelet count ≥ 100,000/mm^3
- Creatinine ≤ 1.5 times upper limit of normal (ULN)
- AST ≤ 1.5 times ULN
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception
- Willing to provide blood specimens as required by the study (Mayo Clinic Rochester patients only)
- Able to complete questionnaires alone or with assistance
- No history of inflammatory bowel disease
- No history of gastrointestinal or genitourinary obstruction or porphyria
- No history of G6PD deficiency
- No history of irritable bowel syndrome
- No history of blood dyscrasia
- No history of severe allergies or asthma
- No history of hepatic or renal disease
- No diarrhea ≥ grade 3, rectal bleeding, abdominal cramping, or incontinence of stool within the past week
- No medical condition that may interfere with the ability to receive study treatment
- No known allergy to sulfasalazine, sulfa medications, salicylates, or any known component of drug formulation
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
- No prior pelvic radiotherapy
- No prior abdominal-perineal resection, Hartmann procedure, or other surgical procedure leaving the patient without a functioning rectum
- No planned use of leucovorin or cytotoxic chemotherapeutic agents concurrent with radiotherapy (except for fluorouracil, capecitabine, or oxaliplatin)
- No other concurrent sulfasalazine
- No concurrent digoxin
Trial Lead Organizations/Sponsors
North Central Cancer Treatment Group
National Cancer Institute| Robert C. Miller |  | Study Chair |
| James A. Martenson | |
| Charles L. Loprinzi | |
Trial Sites
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| U.S.A. | |||
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| Arizona | |||
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| Phoeniz | |||
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| Mayo Clinic Hospital | |||
| Robert C. Miller | Ph: 507-538-7623 | ||
| Scottsdale | |||
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| Mayo Clinic Scottsdale | |||
| Robert C. Miller | Ph: 507-538-7623 | ||
| Colorado | |||
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| Aurora | |||
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| Medical Center of Aurora - South Campus | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Boulder | |||
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| Boulder Community Hospital | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Colorado Springs | |||
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| Penrose Cancer Center at Penrose Hospital | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Denver | |||
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| Porter Adventist Hospital | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Presbyterian - St. Luke's Medical Center | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Rose Medical Center | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| St. Anthony Central Hospital | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| St. Joseph Hospital | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Englewood | |||
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| Swedish Medical Center | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Greeley | |||
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| North Colorado Medical Center | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Lone Tree | |||
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| Sky Ridge Medical Center | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Longmont | |||
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| Hope Cancer Care Center at Longmont United Hospital | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Loveland | |||
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| McKee Medical Center | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Pueblo | |||
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| St. Mary - Corwin Regional Medical Center | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Thornton | |||
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| North Suburban Medical Center | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Wheat Ridge | |||
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| Exempla Lutheran Medical Center | |||
| Eduardo R. Pajon | Ph: 888-785-6789 | ||
| Connecticut | |||
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| Hartford | |||
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| Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center | |||
| Philip J. Stella | Ph: 734-712-3456 | ||
| Delaware | |||
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| Lewes | |||
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| Tunnell Cancer Center at Beebe Medical Center | |||
| Stephen Scott Grubbs | Ph: 302-733-6227 | ||
| Newark | |||
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| Helen F. Graham Cancer Center at Christiana Hospital | |||
| Stephen Scott Grubbs | Ph: 302-733-6227 | ||
| Georgia | |||
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| Augusta | |||
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| Medical College of Georgia Cancer Center | |||
| Randall F. Roberts | Ph: 706-721-1663 | ||
| Email: cancer@georgiahealth.edu | |||
| Columbus | |||
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| John B. Amos Cancer Center | |||
| Andrew W. Pippas | Ph: 706-660-6404 | ||
| Hawaii | |||
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| Aiea | |||
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| Kapiolani Medical Center at Pali Momi | |||
| William S. Loui | Ph: 808-586-2979 | ||
| Email: dorothy@crch.hawaii.edu | |||
| Honolulu | |||
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| Cancer Research Center of Hawaii | |||
| William S. Loui | Ph: 808-586-2979 | ||
| Email: dorothy@crch.hawaii.edu | |||
| Hawaii Medical Center - East | |||
| William S. Loui | Ph: 808-586-2979 | ||
| Email: dorothy@crch.hawaii.edu | |||
| Kapiolani Medical Center for Women and Children | |||
| William S. Loui | Ph: 808-586-2979 | ||
| Email: dorothy@crch.hawaii.edu | |||
| OnCare Hawaii, Incorporated - Kuakini | |||
| William S. Loui | Ph: 808-586-2979 | ||
| Email: dorothy@crch.hawaii.edu | |||
| OnCare Hawaii, Incorporated - Lusitana | |||
| William S. Loui | Ph: 808-586-2979 | ||
| Email: dorothy@crch.hawaii.edu | |||
| Queen's Cancer Institute at Queen's Medical Center | |||
| William S. Loui | Ph: 808-586-2979 | ||
| Email: dorothy@crch.hawaii.edu | |||
| Straub Clinic and Hospital, Incorporated | |||
| William S. Loui | Ph: 808-586-2979 | ||
| Email: dorothy@crch.hawaii.edu | |||
| Tripler Army Medical Center | |||
| Jeffrey L. Berenberg | Ph: 808-586-2979 | ||
| Idaho | |||
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| Boise | |||
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| Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center | |||
| Philip J. Stella | Ph: 734-712-3456 | ||
| Illinois | |||
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| Aurora | |||
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| Rush-Copley Cancer Care Center | |||
| Ronald A Sapiente | Ph: 800-446-5532 | ||
| Chicago | |||
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| Louis A. Weiss Memorial Hospital | |||
| Keith L. Shulman | Ph: 773-564-5044 | ||
| Harvey | |||
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| Ingalls Cancer Care Center at Ingalls Memorial Hospital | |||
| Mark F. Kozloff | Ph: 708-915-4673 | ||
| Email: clinicaltrials@ingalls.org | |||
| Moline | |||
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| Garneau, Stewart C MD (UIA Investigator) | |||
| Costas L. Constantinou | Ph: 319-363-2690 | ||
| Porubcin, Michael MD (UIA Investigator) | |||
| Costas L. Constantinou | Ph: 319-363-2690 | ||
| Spector, David MD (UIA Investigator) | |||
| Costas L. Constantinou | Ph: 319-363-2690 | ||
| Trinity Cancer Center at Trinity Medical Center - 7th Street Campus | |||
| Costas L. Constantinou | Ph: 319-363-2690 | ||
| Urbana | |||
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| Carle Cancer Center at Carle Foundation Hospital | |||
| Ronald A Sapiente | Ph: 800-446-5532 | ||
| Indiana | |||
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| Elkhart | |||
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| Elkhart Clinic, LLC | |||
| Michael W. Method | Ph: 574-237-1328 | ||
| Elkhart General Hospital | |||
| Michael W. Method | Ph: 574-237-1328 | ||
| Michiana Hematology-Oncology, PC - Elkhart | |||
| Michael W. Method | Ph: 574-237-1328 | ||
| Indianapolis | |||
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| St. Francis Hospital Cancer Care Services | |||
| Howard M. Gross | Ph: 765-983-3000 | ||
| Kokomo | |||
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| Community Cancer Care at Howard Regional Health System | |||
| Michael W. Method | Ph: 574-237-1328 | ||
| Mishawaka | |||
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| Michiana Hematology-Oncology, PC - Mishawaka | |||
| Michael W. Method | Ph: 574-237-1328 | ||
| Saint Joseph's Medical Center | |||
| Michael W. Method | Ph: 574-237-1328 | ||
| Plymouth | |||
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| Michiana Hematology Oncology PC - Plymouth | |||
| Michael W. Method | Ph: 574-237-1328 | ||
| Richmond | |||
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| Reid Hospital & Health Care Services | |||
| Howard M. Gross | Ph: 317-783-8918 | ||
| South Bend | |||
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| CCOP - Northern Indiana CR Consortium | |||
| Michael W. Method | Ph: 574-237-1328 | ||
| Memorial Hospital of South Bend | |||
| Michael W. Method | Ph: 574-237-1328 | ||
| Michiana Hematology-Oncology, PC - South Bend | |||
| Michael W. Method | Ph: 574-237-1328 | ||
| Westville | |||
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| Michiana Hematology Oncology-PC Westville | |||
| Michael W. Method | Ph: 574-237-1328 | ||
| Iowa | |||
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| Bettendorf | |||
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| Constantinou, Costas L MD (UIA Investigator) | |||
| Costas L. Constantinou | Ph: 319-363-2690 | ||
| Cedar Rapids | |||
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| Cedar Rapids Oncology Associates | |||
| Deborah W Wilbur | Ph: 319-363-2690 | ||
| Deborah W Wilbur | Ph: 319-363-2690 | ||
| Mercy Regional Cancer Center at Mercy Medical Center | |||
| Deborah W Wilbur | Ph: 319-363-2690 | ||
| Clive | |||
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| Medical Oncology and Hematology Associates-West Des Moines | |||
| Robert J Behrens | Ph: 888-244-6061 | ||
| Email: sherrijr@iora.org | |||
| Mercy Cancer Center - West Lakes | |||
| Robert J Behrens | Ph: 888-244-6061 | ||
| Email: sherrijr@iora.org | |||
| Des Moines | |||
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| CCOP - Iowa Oncology Research Association | |||
| Robert J Behrens | Ph: 888-244-6061 | ||
| Email: sherrijr@iora.org | |||
| John Stoddard Cancer Center at Iowa Lutheran Hospital | |||
| Robert J Behrens | Ph: 888-244-6061 | ||
| Email: sherrijr@iora.org | |||
| John Stoddard Cancer Center at Iowa Methodist Medical Center | |||
| Robert J Behrens | Ph: 888-244-6061 | ||
| Email: sherrijr@iora.org | |||
| Medical Oncology and Hematology Associates at John Stoddard Cancer Center | |||
| Robert J Behrens | Ph: 888-244-6061 | ||
| Email: sherrijr@iora.org | |||
| Medical Oncology and Hematology Associates at Mercy Cancer Center | |||
| Robert J Behrens | Ph: 888-244-6061 | ||
| Email: sherrijr@iora.org | |||
| Mercy Cancer Center at Mercy Medical Center - Des Moines | |||
| Robert J Behrens | Ph: 888-244-6061 | ||
| Email: sherrijr@iora.org | |||
| Sioux City | |||
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| Mercy Medical Center - Sioux City | |||
| Donald Bruce Wender | Ph: 712-252-0088 | ||
| Siouxland Hematology-Oncology Associates, LLP | |||
| Donald Bruce Wender | Ph: 712-252-0088 | ||
| St. Luke's Regional Medical Center | |||
| Donald Bruce Wender | Ph: 712-252-0088 | ||
| West Des Moines | |||
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| Methodist West Hospital | |||
| Robert J Behrens | Ph: 888-244-6061 | ||
| Email: sherrijr@iora.org | |||
| Robert J Behrens | Ph: 888-244-6061 | ||
| Email: sherrijr@iora.org | |||
| Kansas | |||
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| Chanute | |||
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| Cancer Center of Kansas, PA - Chanute | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| Dodge City | |||
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| Cancer Center of Kansas, PA - Dodge City | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| El Dorado | |||
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| Cancer Center of Kansas, PA - El Dorado | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| Fort Scott | |||
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| Cancer Center of Kansas - Fort Scott | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| Independence | |||
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| Cancer Center of Kansas-Independence | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| Kingman | |||
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| Cancer Center of Kansas, PA - Kingman | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| Lawrence | |||
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| Lawrence Memorial Hospital | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| Liberal | |||
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| Cancer Center of Kansas, PA - Liberal | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| Newton | |||
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| Cancer Center of Kansas, PA - Newton | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| Parsons | |||
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| Cancer Center of Kansas, PA - Parsons | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| Pratt | |||
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| Cancer Center of Kansas, PA - Pratt | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| Salina | |||
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| Cancer Center of Kansas, PA - Salina | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| Wellington | |||
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| Cancer Center of Kansas, PA - Wellington | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| Wichita | |||
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| Associates in Women's Health, PA - North Hillside | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| Cancer Center of Kansas, PA - Medical Arts Tower | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| Cancer Center of Kansas, PA - Wichita | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| CCOP - Wichita | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| Via Christi Cancer Center at Via Christi Regional Medical Center | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| Winfield | |||
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| Cancer Center of Kansas, PA - Winfield | |||
| Shaker R. Dakhil | Ph: 316-262-4467 | ||
| Louisiana | |||
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| New Orleans | |||
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| Ochsner Cancer Institute at Ochsner Clinic Foundation | |||
| Jyotsna Fuloria | Ph: 888-562-4763 | ||
| Maryland | |||
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| Elkton MD | |||
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| Union Hospital of Cecil County | |||
| Stephen Scott Grubbs | Ph: 302-733-6227 | ||
| Massachusetts | |||
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| Boston | |||
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| Boston University Cancer Research Center | |||
| Ariel E Hirsch | Ph: 617-638-8265 | ||
| Michigan | |||
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| Adrian | |||
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| Hickman Cancer Center at Bixby Medical Center | |||
| Rex B Mowat | Ph: 517-265-0116 | ||
| Rex B Mowat | Ph: 517-265-0116 | ||
| Ann Arbor | |||
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| CCOP - Michigan Cancer Research Consortium | |||
| Philip J. Stella | Ph: 734-712-3456 | ||
| Saint Joseph Mercy Cancer Center | |||
| Philip J. Stella | Ph: 734-712-3456 | ||
| Dearborn | |||
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| Oakwood Cancer Center at Oakwood Hospital and Medical Center | |||
| Philip J. Stella | Ph: 734-712-3456 | ||
| Detroit | |||
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| Van Elslander Cancer Center at St. John Hospital and Medical Center | |||
| Philip J. Stella | Ph: 734-712-3456 | ||
| Flint | |||
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| Genesys Hurley Cancer Institute | |||
| Philip J. Stella | Ph: 734-712-3456 | ||
| Hurley Medical Center | |||
| Philip J. Stella | Ph: 734-712-3456 | ||
| Jackson | |||
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| Gayle M. Jacob Cancer Center at Allegiance Health | |||
| Philip J. Stella | Ph: 734-712-3456 | ||
| Lansing | |||
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| Sparrow Regional Cancer Center | |||
| Philip J. Stella | Ph: 734-712-3456 | ||
| Livonia | |||
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| St. Mary Mercy Hospital | |||
| Philip J. Stella | Ph: 734-712-3456 | ||
| Monroe | |||
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| Community Cancer Center of Monroe | |||
| Rex B Mowat | Ph: 517-265-0116 | ||
| Mercy Memorial Hospital - Monroe | |||
| Rex B Mowat | Ph: 517-265-0116 | ||
| Pontiac | |||
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| St. Joseph Mercy Oakland | |||
| Philip J. Stella | Ph: 734-712-3456 | ||
| Port Huron | |||
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| Mercy Regional Cancer Center at Mercy Hospital | |||
| Philip J. Stella | Ph: 734-712-3456 | ||
| Saginaw | |||
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| Seton Cancer Institute at Saint Mary's - Saginaw | |||
| Philip J. Stella | Ph: 734-712-3456 | ||
| Saint Joseph | |||
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| Lakeside Cancer Specialists, PLLC | |||
| Michael W. Method | Ph: 574-237-1328 | ||
| St. Joseph | |||
|
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| Lakeland Regional Cancer Care Center - St. Joseph | |||
| Michael W. Method | Ph: 574-237-1328 | ||
| Warren | |||
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| St. John Macomb Hospital | |||
| Philip J. Stella | Ph: 734-712-3456 | ||
| Minnesota | |||
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| Bemidji | |||
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| MeritCare Bemidji | |||
| Preston D. Steen | Ph: 701-234-6161 | ||
| Brainerd | |||
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| St. Joseph's Medical Center | |||
| Daniel Nikcevich | Ph: 888-203-7267 | ||
| Burnsville | |||
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| Fairview Ridges Hospital | |||
| Daniel M Anderson | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Coon Rapids | |||
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| Mercy and Unity Cancer Center at Mercy Hospital | |||
| Daniel M Anderson | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Duluth | |||
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| CCOP - Duluth | |||
| Daniel Nikcevich | Ph: 888-203-7267 | ||
| Essentia Health - Duluth Clinic | |||
| Daniel Nikcevich | Ph: 888-203-7267 | ||
| Miller - Dwan Medical Center | |||
| Daniel Nikcevich | Ph: 888-203-7267 | ||
| Edina | |||
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| Fairview Southdale Hospital | |||
| Daniel M Anderson | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Fridley | |||
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| Mercy and Unity Cancer Center at Unity Hospital | |||
| Daniel M Anderson | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Hutchinson | |||
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| Hutchinson Area Health Care | |||
| Daniel M Anderson | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Mankato | |||
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| Immanuel St. Joseph's | |||
| Mohmmad J Ranginwala | Ph: 507-385-2929 | ||
| Maplewood | |||
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| HealthEast Cancer Care at St. John's Hospital | |||
| Daniel M Anderson | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Minnesota Oncology - Maplewood | |||
| Daniel M Anderson | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Minneapolis | |||
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| Hennepin County Medical Center - Minneapolis | |||
| Daniel M Anderson | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Virginia Piper Cancer Institute at Abbott - Northwestern Hospital | |||
| Daniel M Anderson | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Robbinsdale | |||
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| Humphrey Cancer Center at North Memorial Outpatient Center | |||
| Daniel M Anderson | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Rochester | |||
|
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| Mayo Clinic Cancer Center | |||
| Robert C. Miller | Ph: 507-538-7623 | ||
| Saint Louis Park | |||
|
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| CCOP - Metro-Minnesota | |||
| Daniel M Anderson | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Park Nicollet Cancer Center | |||
| Daniel M Anderson | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Saint Paul | |||
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| Regions Hospital Cancer Care Center | |||
| Daniel M Anderson | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| United Hospital | |||
| Daniel M Anderson | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Shakopee | |||
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| St. Francis Cancer Center at St. Francis Medical Center | |||
| Daniel M Anderson | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Stillwater | |||
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| Lakeview Hospital | |||
| Daniel M Anderson | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Waconia | |||
|
|||
| Ridgeview Medical Center | |||
| Daniel M Anderson | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Willmar | |||
|
|||
| Willmar Cancer Center at Rice Memorial Hospital | |||
| Daniel M Anderson | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Woodbury | |||
|
|||
| Minnesota Oncology - Woodbury | |||
| Daniel M Anderson | Ph: 952-993-1517 | ||
| Email: MMCCOP@parknicollet.com | |||
| Missouri | |||
|
|||
| Bolivar | |||
|
|||
| Central Care Cancer Center at Carrie J. Babb Cancer Center | |||
| Robert L Carolla | Ph: 417-269-4520 | ||
| Cape Girardeau | |||
|
|||
| Southeast Cancer Center | |||
| Bryan A Faller | Ph: 800-392-0936 | ||
| Jefferson City | |||
|
|||
| Goldschmidt Cancer Center | |||
| Bryan A Faller | Ph: 800-392-0936 | ||
| Saint Louis | |||
|
|||
| Missouri Baptist Cancer Center | |||
| Bryan A Faller | Ph: 800-392-0936 | ||
| Springfield | |||
|
|||
| Cancer Research for the Ozarks | |||
| Robert L Carolla | Ph: 417-269-4520 | ||
| Hulston Cancer Center at Cox Medical Center South | |||
| Robert L Carolla | Ph: 417-269-4520 | ||
| Montana | |||
|
|||
| Billings | |||
|
|||
| Billings Clinic Cancer Center - 801 N 29th Street | |||
| Benjamin Thomas Marchello | Ph: 800-648-6274 | ||
| CCOP - Montana Cancer Consortium | |||
| Benjamin Thomas Marchello | Ph: 800-648-6274 | ||
| Hematology-Oncology Centers of the Northern Rockies - Billings | |||
| Benjamin Thomas Marchello | Ph: 800-648-6274 | ||
| St. Vincent Healthcare Cancer Care Services | |||
| Benjamin Thomas Marchello | Ph: 800-648-6274 | ||
| Bozeman | |||
|
|||
| Bozeman Deaconess Cancer Center | |||
| Benjamin Thomas Marchello | Ph: 800-648-6274 | ||
| Butte | |||
|
|||
| St. James Healthcare Cancer Care | |||
| Benjamin Thomas Marchello | Ph: 800-648-6274 | ||
| Great Falls | |||
|
|||
| Benefis Sletten Cancer Institute | |||
| Benjamin Thomas Marchello | Ph: 800-648-6274 | ||
| Helena | |||
|
|||
| St. Peter's Hospital | |||
| Benjamin Thomas Marchello | Ph: 800-648-6274 | ||
| Kalispell | |||
|
|||
| Kalispell Regional Medical Center | |||
| Benjamin Thomas Marchello | Ph: 800-648-6274 | ||
| Missoula | |||
|
|||
| Montana Cancer Center at St. Patrick Hospital and Health Sciences Center | |||
| Benjamin Thomas Marchello | Ph: 800-648-6274 | ||
| Montana Cancer Specialists at Montana Cancer Center | |||
| Benjamin Thomas Marchello | Ph: 800-648-6274 | ||
| Nebraska | |||
|
|||
| Lincoln | |||
|
|||
| Cancer Resource Center - Lincoln | |||
| Gamini S. Soori | Ph: 800-253-4368 | ||
| Omaha | |||
|
|||
| Alegant Health Cancer Center at Bergan Mercy Medical Center | |||
| Gamini S. Soori | Ph: 800-253-4368 | ||
| CCOP - Missouri Valley Cancer Consortium | |||
| Gamini S. Soori | Ph: 800-253-4368 | ||
| Creighton University Medical Center | |||
| Gamini S. Soori | Ph: 800-253-4368 | ||
| Immanuel Medical Center | |||
| Gamini S. Soori | Ph: 800-253-4368 | ||
| Lakeside Hospital | |||
| Gamini S. Soori | Ph: 800-253-4368 | ||
| New Hampshire | |||
|
|||
| Concord | |||
|
|||
| New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care | |||
| Douglas Jay Weckstein | Ph: 603-224-2556 | ||
| Hooksett | |||
|
|||
| New Hampshire Oncology - Hematology, PA - Hooksett | |||
| Douglas Jay Weckstein | Ph: 603-224-2556 | ||
| Laconia | |||
|
|||
| Lakes Region General Hospital | |||
| Douglas Jay Weckstein | Ph: 603-224-2556 | ||
| New Jersey | |||
|
|||
| Camden | |||
|
|||
| Cancer Institute of New Jersey at Cooper University Hospital - Camden | |||
| Stephen Scott Grubbs | Ph: 302-733-6227 | ||
| New Mexico | |||
|
|||
| Albuquerque | |||
|
|||
| University of New Mexico Cancer Center | |||
| Benny J. Liem | Ph: 505-272-6972 | ||
| Las Cruces | |||
|
|||
| Memorial Medical Center | |||
| Benny J. Liem | Ph: 505-272-6972 | ||
| New York | |||
|
|||
| Mount Kisco | |||
|
|||
| Northern Westchester Hospital | |||
| Alfred Tinger | Ph: 888-823-5923 | ||
| Email: ctsucontact@westat.com | |||
| North Carolina | |||
|
|||
| Asheboro | |||
|
|||
| Randolph Hospital | |||
| Peter Rubin | Ph: 336-832-0821 | ||
| Charlotte | |||
|
|||
| Presbyterian Cancer Center at Presbyterian Hospital | |||
| Justin P Favaro | Ph: 704-384-5369 | ||
| Gastonia | |||
|
|||
| CaroMont Cancer Center at Gaston Memorial Hospital | |||
| Charles J. Meakin | Ph: 704-834-2932 | ||
| Goldsboro | |||
|
|||
| Wayne Memorial Hospital, Incorporated | |||
| James N. Atkins | Ph: 919-580-0000 | ||
| Greensboro | |||
|
|||
| Moses Cone Regional Cancer Center at Wesley Long Community Hospital | |||
| Peter Rubin | Ph: 336-832-0821 | ||
| Hendersonville | |||
|
|||
| Park Ridge Hospital Breast Health Center | |||
| Patricia C Griffin | Ph: 800-486-5941 | ||
| High Point | |||
|
|||
| High Point Regional Hospital | |||
| Kulbir Kolby Sidhu | Ph: 336-878-6107 | ||
| Reidsville | |||
|
|||
| Annie Penn Cancer Center | |||
| Peter Rubin | Ph: 336-832-0821 | ||
| Statesville | |||
|
|||
| Iredell Memorial Hospital | |||
| Ruby A. Grimm | Ph: 704-873-5661 | ||
| North Dakota | |||
|
|||
| Bismarck | |||
|
|||
| Medcenter One Hospital Cancer Care Center | |||
| John T Reynolds | Ph: 701-323-5760 | ||
| Email: tfischer@mohs.org | |||
| Mid Dakota Clinic, PC | |||
| John T Reynolds | Ph: 701-323-5760 | ||
| Email: tfischer@mohs.org | |||
| St. Alexius Medical Center Cancer Center | |||
| John T Reynolds | Ph: 701-323-5760 | ||
| Email: tfischer@mohs.org | |||
| Fargo | |||
|
|||
| Sanford Clinic North-Fargo | |||
| Preston D. Steen | Ph: 701-234-6161 | ||
| Grand Forks | |||
|
|||
| Altru Cancer Center at Altru Hospital | |||
| Grant R Seeger | Ph: 701-780-6520 | ||
| Ohio | |||
|
|||
| Bowling Green | |||
|
|||
| Wood County Oncology Center | |||
| Rex B Mowat | Ph: 517-265-0116 | ||
| Chillicothe | |||
|
|||
| Adena Regional Medical Center | |||
| J. Philip Kuebler | Ph: 502-361-8496 | ||
| Columbus | |||
|
|||
| Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center | |||
| Evan J Wuthrick | Ph: 866-627-7616 | ||
| Email: osu@emergingmed.com | |||
| CCOP - Columbus | |||
| J. Philip Kuebler | Ph: 502-361-8496 | ||
| Doctors Hospital at Ohio Health | |||
| J. Philip Kuebler | Ph: 502-361-8496 | ||
| Grant Medical Center Cancer Care | |||
| J. Philip Kuebler | Ph: 502-361-8496 | ||
| Mount Carmel Health - West Hospital | |||
| J. Philip Kuebler | Ph: 502-361-8496 | ||
| Riverside Methodist Hospital Cancer Care | |||
| J. Philip Kuebler | Ph: 502-361-8496 | ||
| Dayton | |||
|
|||
| CCOP - Dayton | |||
| Howard M. Gross | Ph: 317-783-8918 | ||
| David L. Rike Cancer Center at Miami Valley Hospital | |||
| Howard M. Gross | Ph: 317-783-8918 | ||
| Good Samaritan Hospital | |||
| Howard M. Gross | Ph: 317-783-8918 | ||
| Grandview Hospital | |||
| Howard M. Gross | Ph: 317-783-8918 | ||
| Samaritan North Cancer Care Center | |||
| Howard M. Gross | Ph: 317-783-8918 | ||
| Delaware | |||
|
|||
| Grady Memorial Hospital | |||
| J. Philip Kuebler | Ph: 614-566-3275 | ||
| Elyria | |||
|
|||
| Hematology Oncology Center | |||
| Rex B Mowat | Ph: 517-265-0116 | ||
| Mercy Cancer Center - Elyria | |||
| Rex B Mowat | Ph: 517-265-0116 | ||
| Findlay | |||
|
|||
| Blanchard Valley Regional Cancer Center | |||
| Howard M. Gross | Ph: 317-783-8918 | ||
| Franklin | |||
|
|||
| Atrium Medical Center | |||
| Howard M. Gross | Ph: 317-783-8918 | ||
| Greenville | |||
|
|||
| Wayne Hospital | |||
| Howard M. Gross | Ph: 317-783-8918 | ||
| Kettering | |||
|
|||
| Charles F. Kettering Memorial Hospital | |||
| Howard M. Gross | Ph: 317-783-8918 | ||
| Lancaster | |||
|
|||
| Fairfield Medical Center | |||
| J. Philip Kuebler | Ph: 502-361-8496 | ||
| Lima | |||
|
|||
| Lima Memorial Hospital | |||
| Rex B Mowat | Ph: 517-265-0116 | ||
| Marietta | |||
|
|||
| Strecker Cancer Center at Marietta Memorial Hospital | |||
| J. Philip Kuebler | Ph: 502-361-8496 | ||
| Maumee | |||
|
|||
| Northwest Ohio Oncology Center | |||
| Rex B Mowat | Ph: 517-265-0116 | ||
| Rex B Mowat | Ph: 517-265-0116 | ||
| Mount Vernon | |||
|
|||
| Knox Community Hospital | |||
| J. Philip Kuebler | Ph: 502-361-8496 | ||
| Newark | |||
|
|||
| Licking Memorial Cancer Care Program at Licking Memorial Hospital | |||
| J. Philip Kuebler | Ph: 502-361-8496 | ||
| Oregon | |||
|
|||
| St. Charles Mercy Hospital | |||
| Rex B Mowat | Ph: 517-265-0116 | ||
| Toledo Clinic - Oregon | |||
| Rex B Mowat | Ph: 517-265-0116 | ||
| Springfield | |||
|
|||
| Community Hospital of Springfield and Clark County | |||
| J. Philip Kuebler | Ph: 502-361-8496 | ||
| Sylvania | |||
|
|||
| Flower Hospital Cancer Center | |||
| Rex B Mowat | Ph: 517-265-0116 | ||
| Tiffin | |||
|
|||
| Mercy Hospital of Tiffin | |||
| Rex B Mowat | Ph: 517-265-0116 | ||
| Toledo | |||
|
|||
| St. Anne Mercy Hospital | |||
| Rex B Mowat | Ph: 517-265-0116 | ||
| St. Vincent Mercy Medical Center | |||
| Rex B Mowat | Ph: 517-265-0116 | ||
| Toledo Clinic, Incorporated - Main Clinic | |||
| Rex B Mowat | Ph: 517-265-0116 | ||
| Toledo Hospital | |||
| Rex B Mowat | Ph: 517-265-0116 | ||
| University of Toledo Medical Center | |||
| Rex B Mowat | Ph: 517-265-0116 | ||
| Troy | |||
|
|||
| UVMC Cancer Care Center at Upper Valley Medical Center | |||
| Howard M. Gross | Ph: 317-783-8918 | ||
| Wauseon | |||
|
|||
| Fulton County Health Center | |||
| Rex B Mowat | Ph: 517-265-0116 | ||
| Westerville | |||
|
|||
| Mount Carmel St. Ann's Cancer Center | |||
| J. Philip Kuebler | Ph: 502-361-8496 | ||
| Xenia | |||
|
|||
| Ruth G. McMillan Cancer Center at Greene Memorial Hospital | |||
| Howard M. Gross | Ph: 317-783-8918 | ||
| Zanesville | |||
|
|||
| Genesis - Good Samaritan Hospital | |||
| J. Philip Kuebler | Ph: 502-361-8496 | ||
| Oregon | |||
|
|||
| Glesham | |||
|
|||
| Legacy Mount Hood Medical Center | |||
| Regan M Look | Ph: 503-413-1742 | ||
| Portland | |||
|
|||
| Legacy Good Samaritan Hospital & Comprehensive Cancer Center | |||
| Regan M Look | Ph: 503-413-1742 | ||
| Tualatin | |||
|
|||
| Legacy Meridian Park Hospital | |||
| Regan M Look | Ph: 503-413-1742 | ||
| South Carolina | |||
|
|||
| Anderson | |||
|
|||
| AnMed Cancer Center | |||
| Patricia C Griffin | Ph: 800-486-5941 | ||
| Greenville | |||
|
|||
| Bon Secours St. Francis Health System | |||
| Patricia C Griffin | Ph: 800-486-5941 | ||
| Cancer Centers of the Carolinas - Faris Road | |||
| David L Grisell | Ph: 864-241-6251 | ||
| CCOP - Greenville | |||
| David L Grisell | Ph: 864-241-6251 | ||
| Greenville Memorial Hospital | |||
| David L Grisell | Ph: 864-241-6251 | ||
| Greer | |||
|
|||
| Cancer Centers of the Carolinas - Greer Radiation Oncology | |||
| David L Grisell | Ph: 864-241-6251 | ||
| Seneca | |||
|
|||
| Cancer Centers of the Carolinas - Seneca | |||
| David L Grisell | Ph: 864-241-6251 | ||
| Spartanburg | |||
|
|||
| Cancer Centers of the Carolinas - Spartanburg | |||
| David L Grisell | Ph: 864-241-6251 | ||
| CCOP - Upstate Carolina | |||
| Patricia C Griffin | Ph: 800-486-5941 | ||
| Gibbs Regional Cancer Center at Spartanburg Regional Medical Center | |||
| Patricia C Griffin | Ph: 800-486-5941 | ||
| South Dakota | |||
|
|||
| Rapid City | |||
|
|||
| Rapid City Regional Hospital | |||
| Mark T Schroeder | Ph: 605-716-3982 | ||
| Email: research@rcrh.org | |||
| Sioux Falls | |||
|
|||
| Avera Cancer Institute | |||
| Addison R Tolentino | Ph: 800-657-4377 | ||
| Email: Jan.Healy@avera.org | |||
| Sanford Cancer Center at Sanford USD Medical Center | |||
| Miroslaw A Mazurczak | Ph: 605-328-1367 | ||
| Miroslaw A Mazurczak | Ph: 605-328-1367 | ||
| Tennessee | |||
|
|||
| Kingsport | |||
|
|||
| Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center | |||
| Asheesh Shipstone | Ph: 423-578-8538 | ||
| Virginia | |||
|
|||
| Fredericksburg | |||
|
|||
| Fredericksburg Oncology Inc | |||
| Rex B Mowat | Ph: 517-265-0116 | ||
| Martinsville | |||
|
|||
| Ravenel Oncology Center at Memorial Hospital of Martinsville and Henry County | |||
| Sreedhar Katragadda | Ph: 276-666-7827 | ||
| Washington | |||
|
|||
| Vancouver | |||
|
|||
| Legacy Salmon Creek Medical Center | |||
| Regan M Look | Ph: 503-413-1742 | ||
| West Virginia | |||
|
|||
| Huntington | |||
|
|||
| Edwards Comprehensive Cancer Center at Cabell Huntington Hospital | |||
| Maria-Rosalia B. Tria Tirona | Ph: 304-399-6617 | ||
| Wisconsin | |||
|
|||
| Eau Claire | |||
|
|||
| Center for Cancer Treatment & Prevention at Sacred Heart Hospital | |||
| Matthias Weiss | Ph: 800-347-0673 | ||
| Marshfield Clinic Cancer Care at Regional Cancer Center | |||
| Matthias Weiss | Ph: 800-347-0673 | ||
| Fond Du Lac | |||
|
|||
| Central Wisconsin Cancer Program at Agnesian HealthCare | |||
| Timothy P Korytko | Ph: 800-494-2927 | ||
| Green Bay | |||
|
|||
| Green Bay Oncology, Limited at St. Mary's Hospital | |||
| Anthony J. Jaslowski | Ph: 800-432-6049 | ||
| Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center | |||
| Anthony J. Jaslowski | Ph: 800-432-6049 | ||
| St. Mary's Hospital Medical Center - Green Bay | |||
| Anthony J. Jaslowski | Ph: 800-432-6049 | ||
| St. Vincent Hospital Regional Cancer Center | |||
| Anthony J. Jaslowski | Ph: 800-432-6049 | ||
| La Crosse | |||
|
|||
| Gundersen Lutheran Center for Cancer and Blood | |||
| Kurt Oettel | Ph: 608-775-2385 | ||
| Email: cancerctr@gundluth.org | |||
| Manitowoc | |||
|
|||
| Holy Family Memorial Medical Center Cancer Care Center | |||
| Anthony J. Jaslowski | Ph: 800-432-6049 | ||
| Marinette | |||
|
|||
| Bay Area Cancer Care Center at Bay Area Medical Center | |||
| Anthony J. Jaslowski | Ph: 800-432-6049 | ||
| Marshfield | |||
|
|||
| Marshfield Clinic - Marshfield Center | |||
| Matthias Weiss | Ph: 800-347-0673 | ||
| Saint Joseph's Hospital | |||
| Matthias Weiss | Ph: 800-347-0673 | ||
| Minocqua | |||
|
|||
| Marshfield Clinic - Lakeland Center | |||
| Matthias Weiss | Ph: 800-347-0673 | ||
| Rhinelander | |||
|
|||
| Ministry Medical Group at Saint Mary's Hospital | |||
| Matthias Weiss | Ph: 800-347-0673 | ||
| Rice Lake | |||
|
|||
| Marshfield Clinic - Indianhead Center | |||
| Matthias Weiss | Ph: 800-347-0673 | ||
| Sheboygan | |||
|
|||
| Saint Nicholas Hospital | |||
| Anthony J. Jaslowski | Ph: 800-432-6049 | ||
| Stevens Point | |||
|
|||
| Marshfield Clinic at Saint Michael's Hospital | |||
| Matthias Weiss | Ph: 800-347-0673 | ||
| Saint Michael's Hospital Cancer Center | |||
| Matthias Weiss | Ph: 800-347-0673 | ||
| Sturgeon Bay | |||
|
|||
| Door County Cancer Center at Door County Memorial Hospital | |||
| Anthony J. Jaslowski | Ph: 800-432-6049 | ||
| Weston | |||
|
|||
| Marshfield Clinic - Weston Center | |||
| Matthias Weiss | Ph: 800-347-0673 | ||
| Ministry Saint Clare's Hospital | |||
| Matthias Weiss | Ph: 800-347-0673 | ||
Link to the current ClinicalTrials.gov record.
NLM Identifer NCT01198145
Information obtained from ClinicalTrials.gov on February 21, 2013
Note: Information about this trial is from the ClinicalTrials.gov database. The versions designated for health professionals and patients contain
the same text. Minor
changes may be made to the ClinicalTrials.gov record to standardize the names of study sponsors, sites, and
contacts. Cancer.gov only lists sites that are recruiting patients for active trials, whereas ClinicalTrials.gov lists all sites for all trials. Questions and comments regarding the presented information should
be directed to ClinicalTrials.gov.
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