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Clinical Trials (PDQ®)

Higher Per Daily Treatment-Dose Radiation Therapy or Standard Per Daily Treatment Radiation Therapy in Treating Patients With Early-Stage Breast Cancer That Was Removed by Surgery

Basic Trial Information
Trial Description
     Summary
     Further Trial Information
     Eligibility Criteria
Trial Contact Information

Basic Trial Information

PhaseTypeStatusAgeSponsorProtocol IDs
Phase IIITreatmentClosed18 and overNCI, OtherRTOG 1005
NCI-2011-02669, CDR0000700069, NCT01349322

Trial Description

Summary

RATIONALE: It is not yet know whether higher per daily radiation therapy is equally as effective as standard per daily radiation therapy in treating breast cancer.

PURPOSE: This randomized phase III trial studies how well an accelerated course of higher per daily radiation therapy with concomitant boost works compared to standard per daily radiation therapy with a sequential boost in treating patients with early-stage breast cancer that was removed by surgery.

Further Study Information

OBJECTIVES:

Primary

  • To determine whether an accelerated course of hypofractionated whole-breast irradiation (WBI) including a concomitant boost to the tumor bed in 15 fractions following lumpectomy will prove to be non-inferior in local control to a regimen of standard WBI with a sequential boost following lumpectomy for early-stage breast cancer patients.

Secondary

  • To determine whether breast-related symptoms and cosmesis from accelerated WBI that is hypofractionated (in only 3 weeks) with a concomitant boost is non-inferior to standard WBI with sequential boost.
  • To determine whether the risk of late cardiac toxicity in patients with left-sided breast cancer treated with hypofractionation will be non-inferior to conventional fractionated radiation therapy (RT) based upon analysis of radiation dosimetry from CT-based treatment planning and NTCP calculations.
  • To determine whether CT-based conformal methods intensity-modulated radiation therapy (IMRT) and three-dimensional conformal radiotherapy (3D-CRT) for WBI are feasible in a multi-institutional setting following lumpectomy in early-stage breast cancer patients and whether dose-volume analyses can be established to assess treatment adequacy and likelihood of toxicity.
  • To determine that cosmetic results and breast-related symptoms 3 years after hypofractionated breast radiation with concomitant boost will not be inferior to that obtained 3 years after WBI with sequential boost.
  • To determine whether future correlative studies can identify individual gene expressions and biological host factors associated with toxicity and/or local recurrence from standard and hypofractionated WBI.
  • If shown to be non-inferior, to then determine if accelerated course of hypofractionated WBI including a concomitant boost to the tumor bed in 15 fractions following lumpectomy will prove to be superior in local control to a regimen of standard WBI with a sequential boost following lumpectomy for early-stage breast cancer patients.
  • To determine whether treatment costs for hypofractionated WBI with concomitant boost are not higher than WBI with sequential boost.

OUTLINE: This is a multicenter study. Patients are stratified according to age (< 50 vs. ≥ 50 years), prior chemotherapy (yes vs. no), estrogen-receptor status (+ vs. -), and histology grade (1-2 vs. 3). Patients are randomized to 1 of 2 treatment arms. Treatment begins within 9 weeks of last surgery or chemotherapy delivery.

  • Arm I: Patients undergo standard whole-breast radiotherapy (WBI) comprising intensity-modulated radiation therapy (IMRT) or three-dimensional conformal radiotherapy (3D-CRT) 5 days a week for 3-5 weeks followed by a sequential radiotherapy boost to the lumpectomy area 5 days a week for 1-1½ weeks. Treatment continues in the absence of disease progression or unacceptable toxicity.
  • Arm II: Patients undergo accelerated hypofractionated WBI comprising IMRT or 3D-CRT with a concurrent boost to the lumpectomy area 5 days a week for 3 weeks. Treatment continues in the absence of disease progression or unacceptable toxicity.

Patients' tissue samples may be collected for future research studies.

After completion of study therapy, patients are followed at 1 month, at 6 months, and then yearly.

Eligibility Criteria

DISEASE CHARACTERISTICS:

  • Pathologically proven diagnosis of breast cancer resected by lumpectomy and whole-breast irradiation (WBI) with boost without regional nodal irradiation planned
  • Must meet one of the following three criteria:
  • pStage I or II breast cancer AND at least one of the following:
  • Age < 50 years or
  • Positive axillary nodes or
  • Lymphovascular space invasion (LVI) or
  • At least 2 close resection margins (> 0 mm to ≤ 2 mm) or
  • One close resection margin and extensive in-situ component (EIC) or
  • Focally positive resection margins or
  • Non-hormone-sensitive breast cancer (estrogen and progesterone receptor negative (ER- and PR-) or
  • Grade III histology or
  • Oncotype recurrence score > 25 or
  • pStage 0 breast cancer with nuclear grade 3 ductal carcinoma in situ (DCIS) and patient age < 50 years or
  • If multifocal breast cancer, then it must have been resected through a single lumpectomy incision with negative margins
  • Breast-conserving surgery with margins defined as follows:
  • Negative margins defined as no tumor at the resected specimen edge
  • Close resection margins > 0 mm to ≤ 2 mm as follows:
  • One close resection margin and EIC
  • Two or more close resection margins
  • A focally positive resection margin
  • Allowable options for mandatory axillary staging include:
  • Sentinel node biopsy alone (if sentinel node is negative, pN0, pN0[IHC-,+])
  • Sentinel node biopsy alone, OR followed by axillary node dissection, for clinically node-negative patients as described below:
  • Microscopic sentinel node (SN) positive (pN1mic)
  • One or two SNs positive (pN1) without extracapsular extension
  • Negative SN biopsy after neoadjuvant chemotherapy
  • Axillary node dissection is required following SN biopsy with a minimum total of 6 axillary nodes if any of the following exist:
  • For > 2 positive SN
  • Any positive SN biopsy after neoadjuvant chemotherapy
  • For clinically (by either imaging or examination) T3 disease
  • For extracapsular extension
  • Axillary dissection alone (with a minimum of 6 axillary nodes)
  • CT-imaging of the ipsilateral breast within 28 days of study entry for the radiation treatment planning.
  • Must be able to delineate on CT scan the extent of the target lumpectomy cavity for boost (placement of surgical clips to assist in treatment planning of the boost is strongly recommended)
  • No clinical evidence for distant metastases, based upon the following minimum diagnostic workup:
  • History/physical examination, including breast exam (inspection and palpation of the breasts) and documentation of weight and Zubrod Performance Status of 0-2 within 28 days prior to study entry
  • A mammogram of both right and left breast within only 1 time point of 90 days of the diagnostic biopsy establishing the diagnosis
  • No prior invasive or in-situ carcinoma of the breast (prior LCIS is eligible)
  • No American Joint Committee on Cancer (AJCC) pathologic T4, N2 or N3, or M1 breast cancer
  • Must not have two or more breast cancers that are not resectable through a single lumpectomy incision
  • Must not be DCIS and ≥ 50 years old
  • Must not be DCIS only (without an invasive component), nuclear grade 1 or 2 and < 50 years old
  • No suspicious unresected microcalcification, densities, or palpable abnormalities (in the ipsilateral or contralateral breast) unless biopsied and found to be benign
  • No non-epithelial breast malignancies such as sarcoma or lymphoma
  • No Paget disease of the nipple
  • No male breast cancer
  • Breast implants allowed

PATIENT CHARACTERISTICS:

  • ANC ≥ 1,800/mm³
  • Platelet count ≥ 75,000/mm³
  • Hemoglobin ≥ 8.0 g/dL (transfusion or other intervention to achieve Hgb ≥ 8.0 g/dL is acceptable)
  • Negative urine or serum pregnancy test within 14 days of study entry
  • Women of childbearing potential must not be pregnant or nursing and willing to use medically acceptable form of contraception during radiotherapy
  • No prior invasive non-breast malignancy (except non-melanomatous skin cancer or carcinoma in situ of the cervix) unless disease free for a minimum of 5 years prior to study entry
  • No severely active co-morbidity, defined as follows:
  • Unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months
  • Transmural myocardial infarction within the past 6 months
  • Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration
  • Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy within 30 days before registration
  • Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects; note, however, that laboratory tests for liver function and coagulation parameters are not required for entry into this protocol
  • Acquired Immune-Deficiency Syndrome (AIDS) based upon current CDC definition
  • HIV testing is not required for entry into this protocol
  • No active systemic lupus, erythematosus, or any history of scleroderma or dermatomyositis with active rash
  • Medical, psychiatric, or other condition that would prevent the patient from receiving the protocol therapy or providing informed consent

PRIOR CONCURRENT THERAPY:

  • See Disease Characteristics
  • Study entry must be within 50 days of last breast/axillary surgery and/or last chemotherapy
  • No treatment plan that includes regional-node radiotherapy
  • No prior radiotherapy to the breast or prior radiation to the region of the ipsilateral breast that would result in overlap of radiation therapy fields
  • No intention to administer concurrent chemotherapy for current breast cancer

Trial Contact Information

Trial Lead Organizations/Sponsors

Radiation Therapy Oncology Group

National Cancer Institute

NRG Oncology

Frank A. Vicini, MD, FACRPrincipal Investigator

Gary M. Freedman, MDStudy Chair

Julia R. White, MDStudy Chair

Douglas W. ArthurStudy Chair

Trial Sites

U.S.A.
Alabama
  Birmingham
 Kirklin Clinic at Acton Road
 Jennifer F De Los Santos Ph: 205-934-0309
 UAB Comprehensive Cancer Center
 Ruby F. Meredith Ph: 205-934-0309
Arizona
  Scottsdale
 21st Century Oncology - Scottsdale
 Steven E Finkelstein Ph: 888-823-5923
  Email: ctsucontact@westat.com
 Mayo Clinic Scottsdale
 Ivy A. Petersen Ph: 507-538-7623
  Tucson
 Arizona Cancer Center at University of Arizona Health Sciences Center
 Victor J Gonzalez Ph: 520-626-9008
 Arizona Oncology - Tucson
 Vivek S Kavadi Ph: 281-277-5200
Arkansas
  Little Rock
 Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
 V. Suzanne Klimberg Ph: 501-686-8274
California
  Auburn
 Auburn Radiation Oncology
 Christopher Jones Ph: 916-454-6500
  Email: cancerinfo@sutterhealth.org
  Cameron Park
 Radiation Oncology Centers - Cameron Park
 Christopher Jones Ph: 916-454-6500
  Email: cancerinfo@sutterhealth.org
  Carmichael
 Mercy Cancer Center at Mercy San Juan Medical Center
 Christopher Jones Ph: 916-454-6500
  Email: cancerinfo@sutterhealth.org
  Chico
 Enloe Cancer Center at Enloe Medical Center
 Grace E Yuh Ph: 530-332-3808
  Duarte
 City of Hope Comprehensive Cancer Center
 Nayana L. Vora Ph: 800-826-4673
  Email: becomingapatient@coh.org
  Dublin
 Epic Care-Dublin
 James H. Feusner Ph: 510-450-7600
  LA Jolla
 Rebecca and John Moores UCSD Cancer Center
 Loren K Mell Ph: 858-822-5354
  Email: cancercto@ucsd.edu
  Los Angeles
 Jonsson Comprehensive Cancer Center at UCLA
 Susan A McCloskey Ph: 888-798-0719
 Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center
 Christiane M Burnison Ph: 310-423-8965
 USC/Norris Comprehensive Cancer Center and Hospital
 Eugene I Chung Ph: 323-865-0451
 Eugene I Chung Ph: 323-865-0451
  Oakland
 Kaiser Permanente-Oakland
 Samantha A Seaward Ph: 626-564-3455
  Rancho Cardova
 Kaiser Permanente Medical Center - Rancho Cordova
 Samantha A Seaward Ph: 626-564-3455
  Rohnert Park
 Rohnert Park Cancer Center
 Samantha A Seaward Ph: 626-564-3455
  Roseville
 Radiation Oncology Center - Roseville
 Christopher Jones Ph: 916-454-6500
  Email: cancerinfo@sutterhealth.org
 The Permanente Medical Group-Roseville Radiation Oncology
 Samantha A Seaward Ph: 626-564-3455
  Sacramento
 South Sacramento Cancer Center
 Samantha A Seaward Ph: 626-564-3455
 Sutter Cancer Center
 Christopher Jones Ph: 916-454-6500
  Email: cancerinfo@sutterhealth.org
 University of California Davis Cancer Center
 Jyoti S Mayadev Ph: 916-734-3089
  Santa Clara
 Kaiser Permanente Medical Center - Santa Clara Homestead Campus
 Samantha A Seaward Ph: 626-564-3455
 Louis Fehrenbacher Ph: 626-564-3455
  South Pasadena
 City of Hope Medical Group, Incorporated
 Nayana L. Vora Ph: 800-826-4673
  Email: becomingapatient@coh.org
  South San Francisco
 Kaiser Permanente Cancer Treatment Center
 Samantha A Seaward Ph: 626-564-3455
  Vacaville
 Solano Radiation Oncology Center
 Christopher Jones Ph: 916-454-6500
  Email: cancerinfo@sutterhealth.org
Colorado
  Aurora
 University of Colorado Cancer Center at UC Health Sciences Center
 Rachel A. Rabinovitch Ph: 720-848-0650
  Colorado Springs
 Penrose Cancer Center at Penrose Hospital
 Alan T Monroe Ph: 888-785-6789
  Denver
 Porter Adventist Hospital
 Keren Sturtz Ph: 888-785-6789
  Loveland
 McKee Medical Center
 Keren Sturtz Ph: 888-785-6789
Connecticut
  Hartford
 Helen and Harry Gray Cancer Center at Hartford Hospital
 Helaine F Bertsch Ph: 860-545-5363
District of Columbia
  Washington
 Washington Cancer Institute at Washington Hospital Center
 Pamela Randolph Ph: 202-877-8839
Florida
  Atlantis
 JFK Medical Center
 Georges F Hatoum Ph: 866-574-5124
  Email: Sylvester@emergingmed.com
  Daytona Beach
 Florida Hospital Memorial Medical Center
 Ronald J Krochak Ph: 386-676-6025
  Deerfield Beach
 University of Miami/Deerfield Beach
 Cristiane Takita Ph: 866-574-5124
  Email: Sylvester@emergingmed.com
  Gainesville
 UF Health Cancer Center
 R. Charles Nichols Ph: 877-686-6009
  Jacksonville
 Baptist Cancer Institute - Jacksonville
 Cynthia S Anderson Ph: 904-202-7051
 University of Florida Health Science Center - Jacksonville
 R. Charles Nichols Ph: 877-686-6009
  Jascksonville
 Integrated Community Oncology Network - Baptist South
 Cynthia S Anderson Ph: 904-202-7051
  Miami
 Jackson Memorial Hospital
 Cristiane Takita Ph: 866-574-5124
  Email: Sylvester@emergingmed.com
 University of Miami Sylvester Comprehensive Cancer Center - Miami
 Cristiane Takita Ph: 866-574-5124
  Email: Sylvester@emergingmed.com
  Orange Park
 Integrated Community Oncology Network - Orange Park
 Cynthia S Anderson Ph: 904-202-7051
  Orlando
 M.D. Anderson Cancer Center at Orlando
 Tomas Dvorak Ph: 321-841-7246
  Palatka
 Cancer Specialists of North Florida-Putnam
 Cynthia S Anderson Ph: 904-202-7051
  Saint Augustine
 Integrated Community Oncology Network at St. Augustine Cancer Center
 Cynthia S Anderson Ph: 904-202-7051
  Tampa
 H. Lee Moffitt Cancer Center and Research Institute at University of South Florida
 Eleanor E.R. Harris Ph: 252-744-2391
  Email: canceranswers@moffitt.org
  The Villages
 The Villages Regional Hospital
 Jorge E Freire Ph: 352-751-8185
Georgia
  Atlanta
 Georgia Cancer Center for Excellence at Grady Memorial Hospital
 Mylin A Torres Ph: 404-778-1868
 Northside Hospital Cancer Center
 Sahar E Rosenbaum Ph: 404-303-3355
 Piedmont Hospital
 Adam W Nowlan Ph: 404-425-7943
  Email: phri@piedmont.org
 Saint Joseph's Hospital of Atlanta
 Mylin A Torres Ph: 404-778-1868
 Winship Cancer Institute of Emory University
 Mylin A Torres Ph: 404-778-1868
  Cumming
 Northside Hospital-Forsyth
 Sahar E Rosenbaum Ph: 404-303-3355
  Savannah
 Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler
 John A Pablo Ph: 912-819-5704
Hawaii
  Honolulu
 Queen's Cancer Institute at Queen's Medical Center
 Paul A. DeMare Ph: 808-545-8548
Idaho
  Boise
 Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
 Samir Narayan Ph: 734-712-3456
Illinois
  Chicago
 Creticos Cancer Center at Advocate Illinois Masonic Medical Center
 Paige L Dorn Ph: 773-296-5360
 Robert H. Lurie Comprehensive Cancer Center at Northwestern University
 John P Hayes Ph: 312-695-1301
  Email: cancer@northwestern.edu
 University of Chicago Cancer Research Center
 Steven J Chmura Ph: 773-834-7424
  Decatur
 Decatur Memorial Hospital Cancer Care Institute
 James L. Wade Ph: 217-876-4740
  Email: kcheek@dmhhs.org
  Freeport
 Leonard C. Ferguson Cancer Center
 Lauren Q Shapiro Ph: 877-405-6866
  Maywood
 Cardinal Bernardin Cancer Center at Loyola University Medical Center
 Tarita O Thomas Ph: 708-226-4357
  Normal
 Community Cancer Center
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  Park Ridge
 Advocate Lutheran General Cancer Care Center
 James E Ruffer Ph: 847-842-4847
  Peoria
 OSF Saint Francis Medical Center Radiation Oncology Service at the Central Illinois Comprehensive CC
 Nguyet A Le-Lindqwister Ph: 800-793-2262
 OSF St. Francis Medical Center
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  Rockford
 Advanced Care and Treatment Medical Group, PC
 Harvey Eric Einhorn Ph: 779-696-9400
  Email: cancercare@swedishamerican.org
  Springfield
 Cancer Institute at St. John's Hospital
 Cathy L. Clausen Ph: 217-525-5666
  Email: diana.weyhenmeyer@st-johns.org
  Warrenville
 Central Dupage Cancer Center
 Christy M Kesslering Ph: 630-352-5300
Indiana
  Anderson
 Saint John's Health System
 Alexander M. Yeh Ph: 765-646-8358
  Avon
 Clarian West Medical Center
 Peter A. Johnstone Ph: 317-274-2552
  Goshen
 Center for Cancer Care at Goshen General Hospital
 James A. Wheeler Ph: 574-535-2858
  Indianapolis
 Community Regional Cancer Care at Community Hospital East
 Shih J Wei Ph: 317-621-7104
 Community Regional Cancer Care at Community Hospital North
 Shih J Wei Ph: 317-621-7104
 Indiana University Melvin and Bren Simon Cancer Center
 Peter A. Johnstone Ph: 317-274-2552
  Mishawaka
 Michiana Hematology-Oncology, PC - Mishawaka
 David A. Hornback Ph: 800-284-7370
  Muncie
 Cancer Center at Ball Memorial Hospital
 Yunjie X Lin Ph: 765-751-5850
  Email: alpatterson@medicalconsultantspc.com
Iowa
  Clive
 Mercy Cancer Center - West Lakes
 Robert J Behrens Ph: 888-244-6061
  Email: sherrijr@iora.org
  Des Moines
 John Stoddard Cancer Center at Iowa Methodist Medical Center
 Robert J Behrens Ph: 888-244-6061
  Email: sherrijr@iora.org
 Mercy Cancer Center at Mercy Medical Center - Des Moines
 Robert J Behrens Ph: 888-244-6061
  Email: sherrijr@iora.org
  Dubuque
 Wendt Regional Cancer Center at Finley Hospital
 Nagendra (Bobby) S Koneru Ph: 800-397-2467
  Email: cancer@northwestern.edu
Kansas
  Kansas City
 Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center
 Parvesh Kumar Ph: 913-588-4709
  Lawrence
 Lawrence Memorial Hospital
 Shaker R. Dakhil Ph: 316-262-4467
  Overland Park
 Kansas City Cancer Centers - Southwest
 Parvesh Kumar Ph: 913-588-4709
  Prairie Village
 CCOP - Kansas City
 Rakesh Gaur Ph: 913-948-5588
  Email: aroland@kccop.org
  Wichita
 CCOP - Wichita
 Shaker R. Dakhil Ph: 316-262-4467
 Via Christi Cancer Center at Via Christi Regional Medical Center
 Shaker R. Dakhil Ph: 316-262-4467
Kentucky
  Lexington
 University of Kentucky Chandler Medical Center
 Jonathan M Feddock Ph: 859-257-3379
  Owensboro
 Mitchell Memorial Cancer Center at Owensboro Medical Health System
 Samuel R Faught Ph: 270-688-3691
  Email: shawns@omhs.org
Louisiana
  New Orleans
 Tulane Cancer Center at Tulane University Hospital and Clinic
 William R. Robinson Ph: 504-988-6121
Maryland
  Annapolis
 DeCesaris Cancer Institute at Anne Arundel Medical Center
 Mary E Young Ph: 443-481-1320
  Email: kbodenhorn@aahs.org
  Baltimore
 Greater Baltimore Medical Center Cancer Center
 Geoffrey A Neuner Ph: 443-849-3706
 Greenebaum Cancer Center at University of Maryland Medical Center
 Steven Feigenberg Ph: 800-888-8823
 St. Agnes Hospital Cancer Center
 Richard S. Hudes Ph: 410-368-2910
  Bethesda
 National Naval Medical Center
 John J O'Connell Ph: 301-319-2100
  Columbia
 Central Maryland Oncology Center
 Steven Feigenberg Ph: 800-888-8823
  Glen Burnie
 Tate Cancer Center at Baltimore Washington Medical Center
 Steven Feigenberg Ph: 800-888-8823
  Salisbury
 Peninsula Regional Medical Center
 Matthew L Snyder Ph: 866-922-6237
Massachusetts
  Boston
 Boston University Cancer Research Center
 Lisa A. Kachnic Ph: 617-638-8265
 Massachusetts General Hospital
 Alphonse G Taghian Ph: 877-726-5130
  Lowell
 Lowell General Hospital
 Matthew S Katz Ph: 978-788-7084
  Email: ghincks@lowellgeneral.org
  Newton
 Newton-Wellesley Hospital
 Alphonse G Taghian Ph: 877-726-5130
  Peabody
 NSMC Cancer Center - Peabody
 Alphonse G Taghian Ph: 877-726-5130
Michigan
  Ann Arbor
 University of Michigan Comprehensive Cancer Center
 Reshma Jagsi Ph: 800-865-1125
  Clarkston
 21st Century Oncology-Clarkston
 Jeffrey D. Forman Ph: 248-858-6215
  Clinton Township
 Henry Ford Macomb Hospital
 Eleanor M. Walker Ph: 313-916-1784
  Detroit
 Josephine Ford Cancer Center at Henry Ford Hospital
 Eleanor M. Walker Ph: 313-916-1784
 Van Elslander Cancer Center at St. John Hospital and Medical Center
 Samir Narayan Ph: 734-712-3456
 Wayne State University
 Steven R. Miller Ph: 313-576-9363
  Farmington
 Botsford Oncology Practice at Botsford General Hospital
 John M. Robertson Ph: 248-551-7695
  Farmington Hills
 21st Century Oncology-Farmington Hills
 Jeffrey D. Forman Ph: 248-858-6215
 Weisberg Cancer Treatment Center
 Steven R. Miller Ph: 313-576-9363
  Flint
 McLaren Cancer Institute
 Hesham E. Gayar Ph: 810-342-4071
  Grand Rapids
 Butterworth Hospital at Spectrum Health
 Gilbert D Padula Ph: 616-685-5225
 Lacks Cancer Center at Saint Mary's Health Care
 Gilbert D Padula Ph: 616-685-5225
  Kalamazoo
 West Michigan Cancer Center
 Raymond Sterling Lord Ph: 269-373-7458
  Monroe
 KCC Radiation Oncology at Monroe Cancer Center
 Steven R. Miller Ph: 313-576-9363
  Petoskey
 Northern Michigan Hospital
 Peter S Armstrong Ph: 800-248-6777
  Pontiac
 St. Joseph Mercy Oakland
 Samir Narayan Ph: 734-712-3456
  Royal Oak
 William Beaumont Hospital - Royal Oak Campus
 John M. Robertson Ph: 248-551-7695
  Troy
 21st Century Oncology-Troy
 Jeffrey D. Forman Ph: 248-858-6215
 William Beaumont Hospital - Troy Campus
 John M. Robertson Ph: 248-551-7695
  Warren
 St. John Macomb Hospital
 Samir Narayan Ph: 734-712-3456
Minnesota
  Rochester
 Mayo Clinic Cancer Center
 Ivy A. Petersen Ph: 507-538-7623
  Saint Cloud
 CentraCare Clinic - Women and Children
 Barbi L. Kaplan-Frenkel Ph: 877-229-4907
  Email: coborncancercenter@centracare.com
Mississippi
  Pascagoula
 Regional Cancer Center at Singing River Hospital
 James E. Clarkson Ph: 228-809-5292
Missouri
  Chesterfield
 Saint Luke's Hospital
 Donald F. Busiek Ph: 314-205-6936
  Kansas City
 Kansas City Cancer Centers - North
 Parvesh Kumar Ph: 913-588-4709
 Kansas City Cancer Centers - South
 Parvesh Kumar Ph: 913-588-4709
  Lee's Summit
 Kansas City Cancer Centers - East
 Parvesh Kumar Ph: 913-588-4709
  Liberty
 Parvin Radiation Oncology
 Rakesh Gaur Ph: 913-948-5588
  Email: aroland@kccop.org
  Saint Louis
 Barnes-Jewish West County Hospital
 Imran Zoberi Ph: 800-600-3606
  Email: info@ccadmin.wustl.edu
 Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
 Imran Zoberi Ph: 800-600-3606
  Email: info@ccadmin.wustl.edu
 Imran Zoberi Ph: 800-600-3606
  Email: info@ccadmin.wustl.edu
  Saint Peters
 Siteman Cancer Center at Barnes-Jewish St. Peters Hospital - St. Peters
 Imran Zoberi Ph: 800-600-3606
  Email: info@ccadmin.wustl.edu
Montana
  Billings
 Billings Clinic Cancer Center - 801 N 29th Street
 Benjamin Thomas Marchello Ph: 800-648-6274
  Great Falls
 Benefis Sletten Cancer Institute
 Benjamin Thomas Marchello Ph: 800-648-6274
  Kalispell
 Kalispell Regional Medical Center
 Benjamin Thomas Marchello Ph: 800-648-6274
Nebraska
  Omaha
 Fred and Pamela Buffett Cancer Center
 Andrew O Wahl Ph: 800-999-5465
 Methodist Estabrook Cancer Center
 Tien-Shew W Huang Ph: 402-354-5144
Nevada
  Las Vegas
 Radiation Oncology Centers of Las Vegas - Downtown Location
 Raul T Meoz Ph: 702-731-8274
  Reno
 Renown Institute for Cancer at Renown Regional Medical Center
 Michael C Hardacre Ph: 775-982-4400
 Saint Mary's Regional Medical Center
 Kathleen (Katie) B Legarza Ph: 775-770-7410
New Hampshire
  Lebanon
 Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
 Alan C. Hartford Ph: 800-639-6918
  Email: cancer.research.nurse@dartmouth.edu
New Jersey
  Basking Ridge
 Memorial Sloan-Kettering Cancer Center - Basking Ridge
 Preeti K Parhar Ph: 212-639-5007
  Brick
 Ocean Medical Center at Meridian Health
 Douglas A Miller Ph: 732-206-8384
  Long Branch
 Monmouth Medical Center
 Mitchell F Weiss Ph: 732-923-7689
  Morristown
 Carol G. Simon Cancer Center at Morristown Memorial Hospital
 Mona Karim Ph: 973-971-5900
  Mount Holly
 Virtua Fox Chase Health Cancer Program at Virtua Memorial Hospital Burlington County
 Lemuel S. Ariaratnam Ph: 888-847-8823
  Neptune
 Jersey Shore Cancer Center at Jersey Shore University Medical Center
 Douglas A Miller Ph: 732-206-8384
  New Brunswick
 Saint Peter's University Hospital
 Gopal R Desai Ph: 732-745-8600ext6163
  Email: kcovert@saintpetersuh.com
  Red Bank
 Booker Cancer Center at Riverview Medical Center
 Douglas A Miller Ph: 732-206-8384
  Sparta
 Frederick R. and Betty M. Smith Cancer Treatment Center
 Pramila Rani Anne Ph: 215-955-6084
  Toms River
 J. Phillip Citta Regional Cancer Center at Community Medical Center
 David J D'Ambrosio Ph: 732-818-3882
  Voorhees
 Fox Chase Virtua Health Cancer Program at Virtua West Jersey
 Lemuel S. Ariaratnam Ph: 888-847-8823
New Mexico
  Albuquerque
 University of New Mexico Cancer Center
 Thomas M Schroeder Ph: 505-272-6972
  Las Cruces
 Memorial Medical Center
 Thomas M Schroeder Ph: 505-272-6972
New York
  Albany
 New York Oncology Hematology, PC - Albany
 Vivek S Kavadi Ph: 281-277-5200
  Bronx
 Montefiore Medical Center
 Jana L Fox Ph: 718-904-2730
  Email: aecc@aecom.yu.edu
  Buffalo
 Roswell Park Cancer Institute
 Kilian S May Ph: 877-275-7724
  Canandiaqua
 Sands Cancer Center
 Yuhchyau Chen Ph: 585-275-5830
  Commack
 Memorial Sloan-Kettering Cancer Center
 Preeti K Parhar Ph: 212-639-5007
  Cooperstown
 Bassett Healthcare Regional Cancer Program at Mary Imogene Bassett Hospital
 Joy E Anderson Ph: 607-547-3073
  Email: diana.crean@bassett.org
  East Syracuse
 CCOP - Hematology-Oncology Associates of Central New York
 Dennis Jay Kotlove Ph: 315-472-7504
  New Hyde Park
 Long Island Jewish Medical Center
 Lucille N Lee Ph: 516-562-3467
  New York
 Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center
 Daniela Gidea-Addeo Ph: 212-305-8615
 Memorial Sloan-Kettering Cancer Center
 Preeti K Parhar Ph: 212-639-5007
  Poughkeepsie
 Hudson Valley Oncology Associates
 Pramila Rani Anne Ph: 215-955-6084
  Rochester
 Daisy Marquis Jones Radiation Oncology Center at Highland Hospital of Rochester
 Yuhchyau Chen Ph: 585-275-5830
 James P. Wilmot Cancer Center at University of Rochester Medical Center
 Yuhchyau Chen Ph: 585-275-5830
 University Radiation Oncology at Parkridge Hospital
 Yuhchyau Chen Ph: 585-275-5830
  Rockville Centre
 Memorial Sloan-Kettering Cancer Center - Rockville Centre
 Preeti K Parhar Ph: 212-639-5007
  Sleepy Hollow
 Memorial Sloan-Kettering Cancer Center at Phelps Memorial Hospital Center
 Preeti K Parhar Ph: 212-639-5007
  White Plains
 Dickstein Cancer Treatment Center at White Plains Hospital Center
 Randy E Stevens Ph: 914-681-2290
North Carolina
  Durham
 Duke Cancer Institute
 Janet K Horton Ph: 888-275-3853
  Greenville
 Leo W. Jenkins Cancer Center at ECU Medical School
 Eleanor E.R. Harris Ph: 252-744-2391
  Email: canceranswers@moffitt.org
  Morehead City
 Coleman Radiation Oncology Center at Carter General Hospital
 Michael A Papagikos Ph: 910-251-1839
  New Bern
 CarolinaEast Cancer Care
 Michael A Papagikos Ph: 910-251-1839
  Pinehurst
 FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center
 Charles S Kuzma Ph: 910-715-2200
  Statesville
 Iredell Memorial Hospital
 Ruby A. Grimm Ph: 704-873-5661
  Supply
 South Atlantic Radiation Oncology, LLC
 Michael A Papagikos Ph: 910-251-1839
  Wilmington
 Coastal Carolina Radiation Oncology Center
 Michael A Papagikos Ph: 910-251-1839
 Zimmer Cancer Center at New Hanover Regional Medical Center
 Michael A Papagikos Ph: 910-251-1839
North Dakota
  Bismarck
 Medcenter One Hospital Cancer Care Center
 Preston D. Steen Ph: 701-234-6161
  Grand Forks
 Altru Cancer Center at Altru Hospital
 Grant R Seeger Ph: 701-780-6520
Ohio
  Akron
 McDowell Cancer Center at Akron General Medical Center
 Mitchell Lee Fromm Ph: 330-344-6348
 Summa Center for Cancer Care at Akron City Hospital
 Charles A Kunos Ph: 330-375-6101
  Barberton
 Barberton Citizens Hospital
 Charles A Kunos Ph: 330-375-6101
  Chardon
 Geauga Regional Hospital
 Janice Lyons Ph: 800-641-2422
  Chillicothe
 Adena Regional Medical Center
 Mark J Becker Ph: 614-566-4475
  Cincinnati
 Christ Hospital Cancer Center
 Cornelia M McCluskey Ph: 513-585-2859
 University of Cincinnati
 Kevin P. Redmond Ph: 513-558-4553
  Email: uchealthnews@uc.edu
  Cleveland
 Case Comprehensive Cancer Center
 Janice Lyons Ph: 800-641-2422
 Cleveland Clinic Cancer Center at Fairview Hospital
 Rahul D Tendulkar Ph: 866-223-8100
 Cleveland Clinic Taussig Cancer Center
 Rahul D Tendulkar Ph: 866-223-8100
  Columbus
 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center
 Julia R. White Ph: 866-627-7616
  Email: osu@emergingmed.com
  Independence
 Cleveland Clinic Taussig Cancer Center
 Rahul D Tendulkar Ph: 866-223-8100
  Mayfield Heights
 Hillcrest Cancer Center at Hillcrest Hospital
 Rahul D Tendulkar Ph: 866-223-8100
  Medina
 Summa Health Center at Lake Medina
 Charles A Kunos Ph: 330-375-6101
  Mentor
 Lake/University Ireland Cancer Center
 Janice Lyons Ph: 800-641-2422
  Middleburg Heights
 Southwest General Health Center
 Janice Lyons Ph: 800-641-2422
  Orange Village
 UHHS Chagrin Highlands Medical Center
 Janice Lyons Ph: 800-641-2422
  Ravenna
 Robinson Radiation Oncology
 Mitchell Lee Fromm Ph: 330-344-6348
  Sandusky
 North Coast Cancer Care, Incorporated
 Rahul D Tendulkar Ph: 866-223-8100
  Strongsville
 Cleveland Clinic Foundation - Strongsville
 Rahul D Tendulkar Ph: 866-223-8100
  Westlake
 UHHS Westlake Medical Center
 Janice Lyons Ph: 800-641-2422
Oklahoma
  Oklahoma City
 Oklahoma University Cancer Institute
 Terence S. Herman Ph: 405-271-4272
  Email: julie-traylor@ouhsc.edu
  Tulsa
 Natalie Warren Bryant Cancer Center at St. Francis Hospital
 Charles E Stewart Ph: 918-494-2200
Oregon
  Clackamas
 Clackamas Radiation Oncology Center
 Matthew C Solhjem Ph: 503-215-6412
  Eugene
 Willamette Valley Cancer Center - Eugene
 Vivek S Kavadi Ph: 281-277-5200
  Grants Pass
 Three Rivers Community Hospital
 Gordon L. Metz Ph: 541-789-6176
  Medford
 Dubs Cancer Center at Rogue Valley Medical Center
 Gordon L. Metz Ph: 541-789-6176
 Providence Cancer Center at PMCC
 Gordon L. Metz Ph: 541-789-6176
  Portland
 Providence Cancer Center at Providence Portland Medical Center
 Matthew C Solhjem Ph: 503-215-6412
Pennsylvania
  Abington
 Rosenfeld Cancer Center at Abington Memorial Hospital
 Wayne H Pinover Ph: 215-481-2402
  Beaver
 UPMC Cancer Center at Beaver Medical Center
 Sushil Beriwal Ph: 412-647-2811
  Bryn Mawr
 Bryn Mawr Hospital
 Albert S DeNittis Ph: 866-225-5654
  Clairton
 UPMC Cancer Center at Jefferson Regional Medical Center
 Sushil Beriwal Ph: 412-647-2811
  Danville
 Geisinger Cancer Institute at Geisinger Health
 Thomas J Gergel Ph: 570-271-5251
  Drexel Hill
 Delaware County Regional Cancer Center at Delaware County Memorial Hospital
 Rachelle M. Lanciano Ph: 610-284-8237
  Email: jolene.garney@crozer.org
  Dunmore
 Northeast Radiation Oncology Center
 Pramila Rani Anne Ph: 215-955-6084
  East Stroudsburg
 Dale and Frances Hughes Cancer Center at Pocono Medical Center
 Pramila Rani Anne Ph: 215-955-6084
  Erie
 Regional Cancer Center - Erie
 Andrew T Figura Ph: 814-838-0448
  Email: mhaynes@trcc.org
  Gettysburg
 Adams Cancer Center
 Amit B. Shah Ph: 877-441-7957
  Greensburg
 UPMC Cancer Center - Arnold Palmer Pavilion
 Sushil Beriwal Ph: 412-647-2811
  Hanover
 Cherry Tree Cancer Center
 Amit B. Shah Ph: 877-441-7957
  Hershey
 Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center
 Henry Wagner Ph: 717-531-3779
  Email: CTO@hmc.psu.edu
  Johnstown
 UPMC Cancer Center at the John P. Murtha Pavilion
 Sushil Beriwal Ph: 412-647-2811
  Lancaster
 Lancaster General Hospital
 Jeffery S Eshleman Ph: 717-544-5511
  Langhorne
 St. Mary Regional Cancer Center
 Robert C. Reilly Ph: 215-710-4585
  McKeesport
 UPMC Cancer Center at UPMC McKeesport
 Sushil Beriwal Ph: 412-647-2811
  Meadowbrook
 Charles A. & Betty Bott Cancer Center at Holy Redeemer Hospital
 Pallav Mehta Ph: 215-938-3551
  Media
 Riddle Memorial Hospital Cancer Center
 Pramila Rani Anne Ph: 215-955-6084
  Monroeville
 Intercommunity Cancer Center
 David S. Parda Ph: 877-284-2000
  Moon Township
 UPMC - Moon
 Sushil Beriwal Ph: 412-647-2811
  Natrona Heights
 Alle-Kiski Medical Center
 David S. Parda Ph: 877-284-2000
  New Castle
 Jameson Memorial Hospital - North Campus
 Sushil Beriwal Ph: 412-647-2811
  Paoli
 Cancer Center of Paoli Memorial Hospital
 Albert S DeNittis Ph: 866-225-5654
  Philadelphia
 Fox Chase Cancer Center - Philadelphia
 Penny R Anderson Ph: 215-728-4790
 Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
 Pramila Rani Anne Ph: 215-955-6084
  Pittsburgh
 Allegheny Cancer Center at Allegheny General Hospital
 David S. Parda Ph: 877-284-2000
 St. Clair Memorial Hospital Cancer Center
 Sushil Beriwal Ph: 412-647-2811
 UPMC - Shadyside
 Sushil Beriwal Ph: 412-647-2811
 UPMC Cancer Center at Magee-Womens Hospital
 Sushil Beriwal Ph: 412-647-2811
 UPMC Cancer Center at UPMC Passavant
 Sushil Beriwal Ph: 412-647-2811
 UPMC Cancer Center at UPMC St. Margaret
 Sushil Beriwal Ph: 412-647-2811
  Reading
 St. Joseph Medical Center
 Leonard C Tuanquin Ph: 610-378-2336
  Email: danielward2@catholichealth.net
  Sellersville
 Grand View Hospital
 Martin C Hightower Ph: 215-453-4162
  Email: PParsons@gvh.org
  State College
 Mount Nittany Medical Center
 Jerome Derdel Ph: 814-231-7813
  Email: smoyer@mountnittany.org
  Washington
 Washington Hospital Cancer Center
 Sushil Beriwal Ph: 412-647-2811
  West Reading
 McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center
 Albert Yuen Ph: 610-988-9323
  Wynnewood
 Lankenau Cancer Center at Lankenau Hospital
 Albert S DeNittis Ph: 866-225-5654
  York
 WellSpan Health
 Amit B. Shah Ph: 877-441-7957
South Carolina
  Charleston
 Hollings Cancer Center at Medical University of South Carolina
 Jennifer L Harper Ph: 843-792-9321
  Greenville
 Cancer Centers of the Carolinas - Faris Road
 David L Grisell Ph: 864-241-6251
 CCOP - Greenville
 David L Grisell Ph: 864-241-6251
  Greer
 Cancer Centers of the Carolinas - Greer Radiation Oncology
 David L Grisell Ph: 864-241-6251
 Gibbs Cancer Center-Pelham
 Patricia C Griffin Ph: 800-486-5941
  Seneca
 Cancer Centers of the Carolinas - Seneca
 David L Grisell Ph: 864-241-6251
  Spartanburg
 Cancer Centers of the Carolinas - Spartanburg
 David L Grisell Ph: 864-241-6251
 Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
 Patricia C Griffin Ph: 800-486-5941
  West Columbia
 Lexington Medical Center
 Quillin G Davis Ph: 803-936-8050
South Dakota
  Rapid City
 Rapid City Regional Hospital
 Michael J Swartz Ph: 605-716-3982
  Email: research@rcrh.org
  Sioux Falls
 Avera Cancer Institute
 James H Simon Ph: 800-657-4377
  Email: Jan.Healy@avera.org
Texas
  Arlington
 Texas Oncology, PA at Texas Cancer Center - Arlington South
 Vivek S Kavadi Ph: 281-277-5200
  Austin
 Texas Oncology - Midtown Austin
 Vivek S Kavadi Ph: 281-277-5200
 Texas Oncology, PA at South Austin Cancer Center
 Vivek S Kavadi Ph: 281-277-5200
  Bedford
 Texas Oncology, PA at Harris Center HEB
 Vivek S Kavadi Ph: 281-277-5200
  Dallas
 Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas
 Asal S Rahimi Ph: 214-648-7097
  Denton
 Texas Oncology, PA at Texas Cancer Center - Denton South
 Vivek S Kavadi Ph: 281-277-5200
  Fort Worth
 Klabzuba Cancer Center at Harris Methodist Fort Worth Hospital
 Vivek S Kavadi Ph: 281-277-5200
  Houston
 Memorial Hermann Hospital - Memorial City
 Vivek S Kavadi Ph: 281-277-5200
  Irving
 Baylor Medical Center at Irving
 Barry N Wilcox Ph: 800-422-9567
  Plano
 Texas Oncology - Plano West Cancer Center
 Vivek S Kavadi Ph: 281-277-5200
  Round Rock
 Texas Oncology, PA - Seton Williamson
 Vivek S Kavadi Ph: 281-277-5200
 Texas Oncology, PA at Texas Cancer Center Round Rock
 Vivek S Kavadi Ph: 281-277-5200
  San Antonio
 University of Texas Health Science Center at San Antonio
 Richard L Crownover Ph: 210-567-0653
  Email: che@uthscsa.edu
  Sherman
 Texas Oncology, PA at Texas Cancer Center - Sherman
 Vivek S Kavadi Ph: 281-277-5200
  Sugar Land
 Texas Oncology, PA at Texas Oncology Cancer Center Sugar Land
 Vivek S Kavadi Ph: 281-277-5200
Utah
  Logan
 Logan Regional Hospital
 Vilija N Avizonis Ph: 801-507-3950
  Murray
 Jon and Karen Huntsman Cancer Center at Intermountain Medical Center
 Vilija N Avizonis Ph: 801-507-3950
  Ogden
 Val and Ann Browning Cancer Center at McKay-Dee Hospital Center
 Vilija N Avizonis Ph: 801-507-3950
  Saint George
 Dixie Regional Medical Center - East Campus
 Vilija N Avizonis Ph: 801-507-3950
  Salt Lake City
 Huntsman Cancer Institute at University of Utah
 Matthew M Poppe Ph: 801-581-4477
  Email: clinical.trials@hci.utah.edu
 Utah Cancer Specialists at UCS Cancer Center
 Vilija N Avizonis Ph: 801-507-3950
Vermont
  Saint Johnsbury
 Norris Cotton Cancer Center - North
 Alan C. Hartford Ph: 800-639-6918
  Email: cancer.research.nurse@dartmouth.edu
Virginia
  Charlottesville
 University of Virginia Cancer Center
 Timothy N Showalter Ph: 434-243-6143
  Falls Church
 Inova Fairfax Hospital
 Samir P Kanani Ph: 703-208-6650
  Hampton
 Sentara Cancer Institute at Sentara CarePlex Hospital
 Scott S Williams Ph: 757-388-2406
  Norfolk
 Sentara Cancer Institute at Sentara Norfolk General Hospital
 Scott S Williams Ph: 757-388-2406
  Portsmouth
 Naval Medical Center - Portsmouth
 Edward F Miles Ph: 757-953-5939
  Richmond
 Virginia Commonwealth University Massey Cancer Center
 Harry D. Bear Ph: 804-628-1939
  Virginia Beach
 Coastal Cancer Center at Sentara Virginia Beach General Hospital
 Scott S Williams Ph: 757-388-2406
Washington
  Federal Way
 St. Francis Hospital
 Huong T. Pham Ph: 800-354-9527
  Mount Vernon
 Skagit Valley Hospital Cancer Care Center
 George E. Laramore Ph: 206-616-8289
  Seattle
 CCOP - Virginia Mason Research Center
 Huong T. Pham Ph: 800-354-9527
 Seattle Cancer Care Alliance
 George E. Laramore Ph: 206-616-8289
  Sequim
 Olympic Medical Cancer Center
 George E. Laramore Ph: 206-616-8289
  Spokane
 Cancer Care Northwest - North
 Vivek S Kavadi Ph: 281-277-5200
 Cancer Care Northwest - Spokane South
 Vivek S Kavadi Ph: 281-277-5200
  Wenatchee
 Confluence Health - Wenatchee Valley Medical Center
 George E. Laramore Ph: 206-616-8289
West Virginia
  Huntington
 Edwards Comprehensive Cancer Center at Cabell Huntington Hospital
 Maria-Rosalia B. Tria Tirona Ph: 304-399-6617
  Morgantown
 Mary Babb Randolph Cancer Center at West Virginia University Hospitals
 Geraldine M Jacobson Ph: 304-293-2745
  Email: sfilburn@hsc.wvu.edu
  Wheeling
 Schiffler Cancer Center at Wheeling Hospital
 Jon David Pollock Ph: 304-243-6442
Wisconsin
  Antigo
 Langlade Memorial Hospital
 Darryl R. Barton Ph: 877-405-6866
  Appleton
 Fox Valley Surgical Associates at Appleton Medical Center
 Michael E Ray Ph: 920-380-1500
  Beloit
 Beloit Memorial Hospital
 Bethany M Anderson Ph: 877-405-6866
  Eau Claire
 Luther Midlelfort Hospital
 Larry R Past Ph: 715-838-6072
  Fond Du Lac
 Central Wisconsin Cancer Program at Agnesian HealthCare
 Timothy P Korytko Ph: 800-494-2927
  Green Bay
 Bellin Memorial Hospital
 Charlie C Pan Ph: 800-865-1125
 St. Mary's Hospital Medical Center - Green Bay
 James L Leenstra Ph: 920-433-8889
 St. Vincent Hospital Regional Cancer Center
 James L Leenstra Ph: 920-433-8889
 Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center
 Mitchell H. Pincus Ph: 800-252-2990
  Johnson Creek
 UW Cancer Center Johnson Creek
 Bethany M Anderson Ph: 877-405-6866
  La Crosse
 Franciscan Skemp Healthcare - La Crosse Campus
 David J Schwartz Ph: 608-392-9462
  Email: MMCCOP@parknicollet.com
 Gundersen Lutheran Center for Cancer and Blood
 Collin D Driscoll Ph: 608-775-2385
  Email: cancerctr@gundluth.org
  Madison
 University of Wisconsin Paul P. Carbone Comprehensive Cancer Center
 Bethany M Anderson Ph: 877-405-6866
  Marinette
 Bay Area Cancer Care Center at Bay Area Medical Center
 James L Leenstra Ph: 920-433-8889
  Menomonee Falls
 Community Memorial Hospital Cancer Care Center
 Adam D Currey Ph: 414-805-4380
  Mequon
 Columbia Saint Mary's Hospital - Ozaukee
 Erika L Swanson Ph: 414-326-2675
  Email: clinicaltrials@columbia-stmarys.org
  Milwaukee
 Columbia-Saint Mary's Cancer Care Center
 Erika L Swanson Ph: 414-326-2675
  Email: clinicaltrials@columbia-stmarys.org
 Froedtert Hospital and Medical College of Wisconsin
 Adam D Currey Ph: 414-805-4380
 Vince Lombardi Cancer Clinic at Aurora St. Luke's Medical Center
 Mitchell H. Pincus Ph: 800-252-2990
  Racine
 All Saints Cancer Center at Wheaton Franciscan Healthcare
 James H. Taylor Ph: 414-874-4541
  Email: Kelli.holton@wfhc.org
  Sheboygan
 Vince Lombardi Cancer Clinic - Sheboygan
 Mitchell H. Pincus Ph: 800-252-2990
  Sturgeon Bay
 Door County Cancer Center at Door County Memorial Hospital
 James L Leenstra Ph: 920-433-8889
  Summit
 Aurora Medical Center
 Mitchell H. Pincus Ph: 800-252-2990
  Two Rivers
 Vince Lombardi Cancer Clinic - Two Rivers
 Mitchell H. Pincus Ph: 800-252-2990
  Waukesha
 Waukesha Memorial Hospital Regional Cancer Center
 Wingate F. Clapper Ph: 262-928-7632
  Wausau
 University of Wisconcin Cancer Center at Aspirus Wausau Hospital
 Darryl R. Barton Ph: 877-405-6866
  West Allis
 Aurora Women's Pavilion of West Allis Memorial Hospital
 Mitchell H. Pincus Ph: 800-252-2990
Canada
Alberta
  Edmonton
 Cross Cancer Institute at University of Alberta
 Zsolt Gabos Ph: 780-432-8500
British Columbia
  Vancouver
 British Columbia Cancer Agency - Vancouver Cancer Centre
 Lorna M Weir Ph: 888-939-3333
Manitoba
  Winnipeg
 CancerCare Manitoba
 Maged Nashed Ph: 866-561-1026
  Email: CIO_Web@cancercare.mb.ca
New Brunswick
  Saint John
 Saint John Regional Hospital
 Farah Naz Ph: 506-648-6890
Ontario
  Kitchener
 Grand River Regional Cancer Centre at Grand River Hospital
 Darindra D Gopaul Ph: 519-749-4300ext2307
  London
 London Regional Cancer Program at London Health Sciences Centre
 Tracy L Sexton Ph: 519-685-8600
  Ottawa
 Irving Greenberg Family Cancer Centre at Queensway-Carleton Hospital
 Samy El-Sayed Ph: 613-761-4395
  Email: info@ohri.ca
 Ottawa Hospital Regional Cancer Centre - General Campus
 Samy El-Sayed Ph: 613-761-4395
  Email: info@ohri.ca
  Windsor
 Windsor Regional Cancer Centre at Windsor Regional Hospital
 Khalid J Hirmiz Ph: 519-253-5253
Quebec
  Laval
 Cite de la Sante de Laval
 Sebastien Clavel Ph: 450-975-5359
  Email: sylvie.beaudoin.chum@ssss.gouv.qc.ca
  Montreal
 Hopital Notre-Dame du CHUM
 Sophie Lavertu Ph: 514-890-8000ext23611
  Email: sylvie.beaudoin.chum@ssss.gouv.qc.ca
 Maisonneuve-Rosemont Hospital
 Michael Yassa Ph: 514-252-3400ext3329
 McGill Cancer Centre at McGill University
 Tarek Hijal Ph: 514-934-1934ext42953
  Email: evelyn.ortega@muhc.mcgill.ca
  Sherbrooke
 CHUS-Hopital Fleurimont
 Sawyna Provencher Ph: 819-820-6480
  Email: crcinformation.chus@ssss.gouv.qc.ca
Saskatchewan
  Regina
 Allan Blair Cancer Centre at Pasqua Hospital
 Asim Amjad Ph: 306-766-2213
Hong Kong
  Chai Wan
 Pamela Youde Nethersole Eastern Hospital
 Foon-Yiu Cheung Ph: 888-823-5923
  Email: ctsucontact@westat.com
Israel
  Petach Tikva
 Rabin Medical Center - Beilinson Campus
 Aaron M Allen Ph: (866) 790-4500
  Tel Hashomer
 Chaim Sheba Medical Center
 Merav Akiva Ben-David Ph:  972 3 530-5943
Republic of Korea
  Seoul
 Severance Hospital
 Yong Bae Kim Ph: 215-574-3173
Gyeonggi-do
  Goyang-si
 National Cancer Center - Korea
 Kwan H Cho Ph: 888-823-5923
  Email: ctsucontact@westat.com
Republic of Singapore
  Singapore
 Cancer Institute at National University Hospital
 Ihsiung J Tang Ph: 215-574-3173
Switzerland
  Aarau
 Kantonsspital Aarau
 Stephan B Bodis Ph: 215-574-3173

Link to the current ClinicalTrials.gov record.
NLM Identifer NCT01349322
ClinicalTrials.gov processed this data on November 12, 2014

Note: Information about this trial is from the ClinicalTrials.gov database. The versions designated for health professionals and patients contain the same text. Minor changes may be made to the ClinicalTrials.gov record to standardize the names of study sponsors, sites, and contacts. Cancer.gov only lists sites that are recruiting patients for active trials, whereas ClinicalTrials.gov lists all sites for all trials. Questions and comments regarding the presented information should be directed to ClinicalTrials.gov.

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