Basic Trial Information
Trial Description
     Summary
     Further Trial Information
     Eligibility Criteria
Trial Contact Information

Basic Trial Information

Trial Description

Summary

RATIONALE: Breast-conserving surgery is a less invasive type of surgery for breast cancer and may have fewer side effects and improve recovery. Radiation therapy uses high-energy x rays to kill tumor cells. Giving radiation therapy after surgery may kill any tumor cells that remain after surgery.

PURPOSE: This phase II trial studies how well breast-conserving surgery and radiation therapy work in treating patients with multiple ipsilateral breast cancer

Further Study Information

OBJECTIVES:

Primary

• To assess the local recurrence (LR) rate with breast-conservation in patients with multiple ipsilateral primary breast cancer (MIBC).

Secondary

• To examine the conversion rate to mastectomy secondary to persistent positive margins; poor cosmesis within the first year of attempting breast-conservation surgery (BCS) or inability to satisfy the radiation dose constraints on the boost to the lumpectomy bed of each site of disease.

• To assess patient's perception of cosmesis and incidence of breast lymphedema.

• To examine the type and severity of adverse effects of BCS and radiation for women with MIBC.

• To examine the radiation-related side effects of whole-breast radiation with a boost to 1 large or > 1 lumpectomy site.

• To evaluate protein and gene expression patterns in tissue taken from each breast lesion and to evaluate the concordance of the findings between these lesions.

• To compare the extent of disease described on imaging (mammography, bilateral breast magnetic resonance imaging [MRI] and other adjunctive imaging modalities) with surgical findings.

OUTLINE: This is a multicenter study.

Patients undergo breast-conserving surgery (BCS) with all lesions resected to negative margins using 1 lumpectomy or 2-3 separate lumpectomy incisions at the discretion of the surgeon. Patients receive adjuvant chemotherapy and/or endocrine therapy at the discretion of the treating medical oncologist based on tumor characteristics.

Within 6-10 weeks after surgery or 8 weeks after completion of cytotoxic chemotherapy, patients undergo adjuvant whole-breast irradiation (WBI) with a boost to the lumpectomy bed of each site of disease 5 days a week for approximately 6 weeks.

Patients complete the Breast-Conserving Therapy Module (BREAST-Q© subscales) questionnaire 5-30 days after surgery and every 6 months for the first 2 years and the yearly for the next 3 years after WBI. Patients' surgeons also complete the questionnaire 5-30 days after performing final surgery to assess cosmetic outcomes.

Formalin-fixed paraffin-embedded (FFPE) tissue block from each site of disease are collected during BCS for protein and gene expression pattern studies. Blood samples may be also collected at baseline and during BCS.

After completion of study treatment, patients are followed up every 6 months for 2 years and then yearly for years 3-5.

Eligibility Criteria

DISEASE CHARACTERISTICS:

• Upon clinical exam and pre-operative imaging by MRI and mammogram both, two or three foci of biopsy-proven breast cancer separated by ≥ 3 cm of normal breast tissue on clinical exam and preoperative imaging; foci must include at least one focus of invasive breast carcinoma with another focus of either invasive breast carcinoma or ductal carcinoma in situ (DCIS); no more than 2 quadrants with biopsy-positive breast cancer

• Ultrasound cannot be used to determine patient eligibility; eligibility to be determined by bilateral mammogram and MRI only

• Bilateral mammogram ≤ 60 days prior to registration

• Bilateral breast MRI ≤ 45 days prior to registration

• cN0 or cN1 disease

• No cNX, cN2, or cN3 disease

• Willing to provide tissue samples for correlative research purposes

• Largest single focus of disease > 5 cm by either mammogram or MRI or both (measurement of the largest single focus should include any satellite lesions within 1 cm of the index lesion)

• No clinical or radiographic evidence of metastatic disease

• No prior or current lobular carcinoma in situ (LCIS), DCIS, or invasive breast cancer in the opposite breast (i.e., bilateral disease is not allowed)

• No patients with known BRCA mutations

PATIENT CHARACTERISTICS:

• Life expectancy of at least 5 years, excluding diagnosis of breast cancer (comorbid conditions should be taken into consideration, but breast cancer diagnosis is not a consideration)

• Men are excluded from this study

• Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0, 1, or 2

• Hemoglobin (Hgb) ≥ 8 g/dL

• Peripheral platelet count (PLT) ≥ 50,000/mm³

• Ability to complete questionnaire(s) by themselves or with assistance

• Willing to return to enrolling institution for follow-up during the Active Monitoring Phase (the active treatment and observation portions) of the study

• Negative serum or urine pregnancy test done ≤ 7 days prior to registration, for women of childbearing potential only

• None of the following:

• Pregnant women

• Nursing women

• Women of childbearing potential who are unwilling to employ adequate contraception (as determined by the treating physician)

• No co-morbid systemic illnesses or other severe concurrent disease which, in the judgment of the investigator, would interfere significantly with whole-breast irradiation (such as connective tissue disorders, lupus, or scleroderma)

• No uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements

• No other active malignancy ≤ 5 years prior to registration; EXCEPTIONS: non-melanotic skin cancer or carcinoma-in-situ of the cervix

• If there is a history of prior malignancy, they must not be receiving other specific treatment for their cancer

PRIOR CONCURRENT THERAPY:

• No surgical axillary staging procedure prior to study entry

• Fine-needle aspiration (FNA) or core-needle biopsy of axillary node is permitted

• No breast implants at time of diagnosis

• Patients who have had implants previously removed prior to diagnosis are eligible

• No treatment including radiation therapy, chemotherapy, biotherapy, or hormonal therapy for this cancer prior to registration

• No neoadjuvant endocrine therapy or neoadjuvant hormonal therapy

• No planned partial-breast radiation

• No administration of any investigational agent ≤ 30 days prior to registration

Trial Contact Information

Trial Lead Organizations/Sponsors

American College of Surgeons

Judy Boughey

Study Chair

U.S.A.
California
	Castro Valley
	East Bay Radiation Oncology Center
		James H. Feusner	Ph: 510-450-7600
	LA Jolla
	Rebecca and John Moores UCSD Cancer Center
		Sarah L Blair	Ph: 858-822-5354
			Email: cancercto@ucsd.edu
	Los Angeles
	Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center
		Armando E Giuliano	Ph: 310-423-8965
	Martinez
	Contra Costa Regional Medical Center
		James H. Feusner	Ph: 510-450-7600
	Mountain View
	El Camino Hospital Cancer Center
		James H. Feusner	Ph: 510-450-7600
	Oakland
	Alta Bates Summit Medical Center - Summit Campus
		James H. Feusner	Ph: 510-450-7600
	Bay Area Breast Surgeons, Incorporated
		James H. Feusner	Ph: 510-450-7600
	CCOP - Bay Area Tumor Institute
		James H. Feusner	Ph: 510-450-7600
	Larry G Strieff MD Medical Corporation
		James H. Feusner	Ph: 510-450-7600
	Tom K Lee, Incorporated
		James H. Feusner	Ph: 510-450-7600
	San Diego
	Sharp Memorial Hospital Cancer Center
		Robert M. Barone	Ph: 858-939-5015
	San Pablo
	Doctors Medical Center - San Pablo Campus
		James H. Feusner	Ph: 510-450-7600
	Stanford
	Stanford Cancer Center
		Frederick M Dirbas	Ph: 650-498-7061
			Email: ccto-office@stanford.edu
Colorado
	Aurora
	University of Colorado Cancer Center at UC Health Sciences Center
		Nicole Kounalakis	Ph: 720-848-0650
Connecticut
	Bridgeport
	St. Vincent's Medical Center
		Anthy Demestihas	Ph: 888-823-5923
			Email: ctsucontact@westat.com
Delaware
	Lewes
	Tunnell Cancer Center at Beebe Medical Center
		Diana Dickson-Witmer	Ph: 302-733-6227
	Newark
	Helen F. Graham Cancer Center at Christiana Hospital
		Diana Dickson-Witmer	Ph: 302-733-6227
Florida
	Clearwater
	Morton Plant Hospital
		Peter William Blumencranz	Ph: 727-461-8519
	Fort Lauderdale
	Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
		Michael Schwartz	Ph: 305-674-2625
			Email: info@msccop.com
	Jupiter
	Ella Milbank Foshay Cancer Center at Jupiter Medical Center
		Michael Schwartz	Ph: 305-674-2625
			Email: info@msccop.com
	Miami Beach
	CCOP - Mount Sinai Medical Center
		Michael Schwartz	Ph: 305-674-2625
			Email: info@msccop.com
Georgia
	Decatur
	Charles B. Eberhart Cancer Center at DeKalb Medical Center
		John S. Kennedy	Ph: 404-501-3279
Hawaii
	Aiea
	Kapiolani Medical Center at Pali Momi
		Jeffrey L. Berenberg	Ph: 808-586-2979
		Jeffrey L. Berenberg	Ph: 808-586-2979
	Honolulu
	Cancer Research Center of Hawaii
		Jeffrey L. Berenberg	Ph: 808-586-2979
	Kapiolani Medical Center for Women and Children
		Jeffrey L. Berenberg	Ph: 808-586-2979
	OnCare Hawaii, Incorporated - Kuakini
		Jeffrey L. Berenberg	Ph: 808-586-2979
		Jeffrey L. Berenberg	Ph: 808-586-2979
	OnCare Hawaii, Incorporated - Lusitana
		Jeffrey L. Berenberg	Ph: 808-586-2979
	Queen's Cancer Institute at Queen's Medical Center
		Jeffrey L. Berenberg	Ph: 808-586-2979
	Straub Clinic and Hospital, Incorporated
		Jeffrey L. Berenberg	Ph: 808-586-2979
	Kailua
	Castle Medical Center
		Jeffrey L. Berenberg	Ph: 808-586-2979
	Lihue
	Kauai Medical Clinic
		Jeffrey L. Berenberg	Ph: 808-586-2979
Idaho
	Boise
	Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
		Tari S Stull	Ph: 734-712-3456
Illinois
	Chicago
	Resurrection Medical Center
		Rabia Z Bhatti	Ph: 773-792-5116
	Elmhurst
	Elmhurst Memorial Hospital
		Lucio Di Nunno	Ph: 630-782-7900
	Harvey
	Ingalls Cancer Care Center at Ingalls Memorial Hospital
		Mark F. Kozloff	Ph: 708-915-4673
			Email: clinicaltrials@ingalls.org
Indiana
	Avon
	Clarian West Medical Center
		Linda K Han	Ph: 317-274-2552
	Carmel
	IU Health North Hospital
		Linda K Han	Ph: 317-274-2552
	Elkhart
	Elkhart Clinic, LLC
		Robin Zon	Ph: 574-234-5123
	Elkhart General Hospital
		Robin Zon	Ph: 574-234-5123
	Michiana Hematology-Oncology, PC - Elkhart
		Robin Zon	Ph: 574-234-5123
	Indianapolis
	Indiana University Melvin and Bren Simon Cancer Center
		Linda K Han	Ph: 317-274-2552
	Methodist Cancer Center at Methodist Hospital
		Linda K Han	Ph: 317-274-2552
	William N. Wishard Memorial Hospital
		Linda K Han	Ph: 317-274-2552
	Kokomo
	Community Cancer Care at Howard Regional Health System
		Robin Zon	Ph: 574-234-5123
	La Porte
	Center for Cancer Therapy at LaPorte Hospital and Health Services
		Robin Zon	Ph: 574-234-5123
	Mishawaka
	Michiana Hematology-Oncology, PC - Mishawaka
		Robin Zon	Ph: 574-234-5123
	Saint Joseph's Medical Center
		Robin Zon	Ph: 574-234-5123
	Plymouth
	Michiana Hematology Oncology PC - Plymouth
		Robin Zon	Ph: 574-234-5123
	South Bend
	CCOP - Northern Indiana CR Consortium
		Robin Zon	Ph: 574-234-5123
	Memorial Hospital of South Bend
		Robin Zon	Ph: 574-234-5123
	Michiana Hematology-Oncology, PC - South Bend
		Robin Zon	Ph: 574-234-5123
	Westville
	Michiana Hematology Oncology-PC Westville
		Robin Zon	Ph: 574-234-5123
Iowa
	Ames
	McFarland Clinic, PC
		Joseph James Merchant	Ph: 515-239-2621
	Clive
	Medical Oncology and Hematology Associates-West Des Moines
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Mercy Cancer Center - West Lakes
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Des Moines
	CCOP - Iowa Oncology Research Association
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	John Stoddard Cancer Center at Iowa Lutheran Hospital
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	John Stoddard Cancer Center at Iowa Methodist Medical Center
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Medical Oncology and Hematology Associates at John Stoddard Cancer Center
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Medical Oncology and Hematology Associates at Mercy Cancer Center
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	Mercy Cancer Center at Mercy Medical Center - Des Moines
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
	West Des Moines
	Methodist West Hospital
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
		Robert J Behrens	Ph: 888-244-6061
			Email: sherrijr@iora.org
Kansas
	Overland Park
	Menorah Medical Center
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Saint Luke's Hospital - South
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Prairie Village
	CCOP - Kansas City
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
Kentucky
	Edgewood
	St. Elizabeth Medical Center
		Joseph Michael Guenther	Ph: 859-301-5473
			Email: darla.hehman@stelizabeth.com
Maryland
	Elkton MD
	Union Hospital of Cecil County
		Diana Dickson-Witmer	Ph: 302-733-6227
Michigan
	Ann Arbor
	CCOP - Michigan Cancer Research Consortium
		Tari S Stull	Ph: 734-712-3456
	Saint Joseph Mercy Cancer Center
		Tari S Stull	Ph: 734-712-3456
	Dearborn
	Oakwood Cancer Center at Oakwood Hospital and Medical Center
		Tari S Stull	Ph: 734-712-3456
	Detroit
	Van Elslander Cancer Center at St. John Hospital and Medical Center
		Tari S Stull	Ph: 734-712-3456
	Flint
	Hurley Medical Center
		Tari S Stull	Ph: 734-712-3456
	Jackson
	Gayle M. Jacob Cancer Center at Allegiance Health
		Tari S Stull	Ph: 734-712-3456
	Lansing
	Sparrow Regional Cancer Center
		Tari S Stull	Ph: 734-712-3456
	Livonia
	St. Mary Mercy Hospital
		Tari S Stull	Ph: 734-712-3456
	Pontiac
	St. Joseph Mercy Oakland
		Tari S Stull	Ph: 734-712-3456
	Saginaw
	Seton Cancer Institute at Saint Mary's - Saginaw
		Tari S Stull	Ph: 734-712-3456
	Saint Joseph
	Lakeside Cancer Specialists, PLLC
		Robin Zon	Ph: 574-234-5123
	St. Joseph
	Lakeland Regional Cancer Care Center - St. Joseph
		Robin Zon	Ph: 574-234-5123
	Warren
	St. John Macomb Hospital
		Tari S Stull	Ph: 734-712-3456
Minnesota
	Bemidji
	MeritCare Bemidji
		Preston D. Steen	Ph: 701-234-6161
	Burnsville
	Fairview Ridges Hospital
		Daniel M Anderson	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Coon Rapids
	Mercy and Unity Cancer Center at Mercy Hospital
		Daniel M Anderson	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Duluth
	CCOP - Duluth
		Daniel Nikcevich	Ph: 888-203-7267
	Essentia Health - Duluth Clinic
		Daniel Nikcevich	Ph: 888-203-7267
	Miller - Dwan Medical Center
		Daniel Nikcevich	Ph: 888-203-7267
	Edina
	Fairview Southdale Hospital
		Daniel M Anderson	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Fridley
	Mercy and Unity Cancer Center at Unity Hospital
		Daniel M Anderson	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Maplewood
	HealthEast Cancer Care at St. John's Hospital
		Daniel M Anderson	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Minnesota Oncology - Maplewood
		Daniel M Anderson	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Minneapolis
	Hennepin County Medical Center - Minneapolis
		Daniel M Anderson	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
		Daniel M Anderson	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Robbinsdale
	Humphrey Cancer Center at North Memorial Outpatient Center
		Daniel M Anderson	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Rochester
	Mayo Clinic Cancer Center
		Judy C Boughey	Ph: 507-538-7623
	Saint Cloud
	CentraCare Clinic - Women and Children
		Donald J Jurgens	Ph: 877-229-4907
			Email: coborncancercenter@centracare.com
	Coborn Cancer Center
		Donald J Jurgens	Ph: 877-229-4907
			Email: coborncancercenter@centracare.com
	Saint Louis Park
	CCOP - Metro-Minnesota
		Daniel M Anderson	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Park Nicollet Cancer Center
		Daniel M Anderson	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Saint Paul
	Regions Hospital Cancer Care Center
		Daniel M Anderson	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	United Hospital
		Daniel M Anderson	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Shakopee
	St. Francis Cancer Center at St. Francis Medical Center
		Daniel M Anderson	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Waconia
	Ridgeview Medical Center
		Daniel M Anderson	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Willmar
	Willmar Cancer Center at Rice Memorial Hospital
		Daniel M Anderson	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
	Woodbury
	Minnesota Oncology - Woodbury
		Daniel M Anderson	Ph: 952-993-1517
			Email: MMCCOP@parknicollet.com
Missouri
	Cape Girardeau
	Southeast Cancer Center
		Alan Philip Lyss	Ph: 800-392-0936
	Jefferson City
	Goldschmidt Cancer Center
		Alan Philip Lyss	Ph: 800-392-0936
	Kansas City
	Heartland Hematology Oncology Associates, Incorporated
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	North Kansas City Hospital
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Research Medical Center
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Saint Luke's Hospital
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Lee's Summit
	Saint Luke's East - Lee's Summit
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Saint Joseph
	Heartland Regional Medical Center
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Saint Joseph Oncology, Incorporated
		Rakesh Gaur	Ph: 913-948-5588
			Email: amy.krushelniski@hcahealthcare.com
	Saint Louis
	Missouri Baptist Cancer Center
		Alan Philip Lyss	Ph: 800-392-0936
	Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
		Julie A Margenthaler	Ph: 800-600-3606
			Email: info@siteman.wustl.edu
Montana
	Billings
	Billings Clinic Cancer Center - 801 N 29th Street
		Benjamin Thomas Marchello	Ph: 800-648-6274
	CCOP - Montana Cancer Consortium
		Benjamin Thomas Marchello	Ph: 800-648-6274
	Great Falls
	Benefis Sletten Cancer Institute
		Benjamin Thomas Marchello	Ph: 800-648-6274
New Hampshire
	Lebanon
	Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
		Kari M Rosenkranz	Ph: 800-639-6918
			Email: cancer.research.nurse@dartmouth.edu
New Jersey
	Camden
	Cancer Institute of New Jersey at Cooper University Hospital - Camden
		Diana Dickson-Witmer	Ph: 302-733-6227
	New Brunswick
	Saint Peter's University Hospital
		Susan A McManus	Ph: 732-745-8600ext6163
			Email: kcovert@saintpetersuh.com
New York
	New York
	Memorial Sloan-Kettering Cancer Center
		Kimberly J Van Zee	Ph: 212-639-7202
	Poughkeepsie
	Dyson Center for Cancer Care at Vassar Brothers Medical Center
		Gregory J Zanieski	Ph: 845-483-6483
North Carolina
	Chapel Hill
	Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
		Keith D Amos	Ph: 877-668-0683
	Charlotte
	Blumenthal Cancer Center at Carolinas Medical Center
		Richard L. White	Ph: 704-355-2884
	Presbyterian Cancer Center at Presbyterian Hospital
		Justin P Favaro	Ph: 704-384-5369
	Winston-Salem
	Wake Forest University Comprehensive Cancer Center
		Edward A. Levine	Ph: 336-713-6771
North Dakota
	Fargo
	Roger Maris Cancer Center at MeritCare Hospital
		Preston D. Steen	Ph: 701-234-6161
		Preston D. Steen	Ph: 701-234-6161
	Sanford Clinic North-Fargo
		Preston D. Steen	Ph: 701-234-6161
Ohio
	Chillicothe
	Adena Regional Medical Center
		J. Philip Kuebler	Ph: 614-566-3275
	Columbus
	CCOP - Columbus
		J. Philip Kuebler	Ph: 614-566-3275
	Doctors Hospital at Ohio Health
		J. Philip Kuebler	Ph: 614-566-3275
	Grant Medical Center Cancer Care
		J. Philip Kuebler	Ph: 614-566-3275
	Mount Carmel Health - West Hospital
		J. Philip Kuebler	Ph: 614-566-3275
	Riverside Methodist Hospital Cancer Care
		J. Philip Kuebler	Ph: 614-566-3275
	Zangmeister Center
		J. Philip Kuebler	Ph: 614-566-3275
	Delaware
	Grady Memorial Hospital
		J. Philip Kuebler	Ph: 614-566-3275
	Marietta
	Strecker Cancer Center at Marietta Memorial Hospital
		J. Philip Kuebler	Ph: 614-566-3275
	Newark
	Licking Memorial Cancer Care Program at Licking Memorial Hospital
		J. Philip Kuebler	Ph: 614-566-3275
	Portsmouth
	Southern Ohio Medical Center Cancer Center
		J. Philip Kuebler	Ph: 614-566-3275
	Springfield
	Community Hospital of Springfield and Clark County
		J. Philip Kuebler	Ph: 614-566-3275
	Westerville
	Mount Carmel St. Ann's Cancer Center
		J. Philip Kuebler	Ph: 614-566-3275
	Zanesville
	Genesis - Good Samaritan Hospital
		J. Philip Kuebler	Ph: 614-566-3275
Oklahoma
	Oklahoma City
	Mercy Health Center
		Alan B Hollingsworth	Ph: 405-752-3388
	Oklahoma University Cancer Institute
		William C Dooley	Ph: 405-271-4272
			Email: julie-traylor@ouhsc.edu
Oregon
	Portland
	Knight Cancer Institute at Oregon Health and Science University
		Charlotte D Kubicky	Ph: 503-494-1080
			Email: trials@ohsu.edu
Pennsylvania
	Allentown
	Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest
		Lori C Alfonse	Ph: 610-402-2273
	Bryn Mawr
	Bryn Mawr Hospital
		Ned Z. Carp	Ph: 866-225-5654
			Email: wellenbachj@mlhs.org
	Gettysburg
	Adams Cancer Center
		Thomas L. Bauer	Ph: 877-441-7957
	Hanover
	Cherry Tree Cancer Center
		Thomas L. Bauer	Ph: 877-441-7957
	Lancaster
	Lancaster General Hospital
		Daleela G Dodge	Ph: 717-544-5511
	Pittsburgh
	UPMC Cancer Centers
		Gretchen M. Ahrendt	Ph: 412-647-2811
	Wynnewood
	Lankenau Cancer Center at Lankenau Hospital
		Ned Z. Carp	Ph: 866-225-5654
			Email: wellenbachj@mlhs.org
	York
	WellSpan Health
		Thomas L. Bauer	Ph: 877-441-7957
Rhode Island
	Providence
	Roger Williams Medical Center
		R. James Koness	Ph: 401-456-2268
			Email: rdavies@rwmc.org
South Carolina
	Charleston
	Hollings Cancer Center at Medical University of South Carolina
		Megan K Baker Ruppel	Ph: 843-792-9321
	Hilton Head Island
	Hilton Head Regional Medical Center
		Megan K Baker Ruppel	Ph: 843-792-9321
	West Columbia
	Lexington Medical Center
		Lynn M Tucker	Ph: 803-936-8050
South Dakota
	Sioux Falls
	Avera Cancer Institute
		Wade E Dosch	Ph: 605-328-1367
	Sanford Cancer Center at Sanford USD Medical Center
		Miroslaw A Mazurczak	Ph: 605-328-1367
		Miroslaw A Mazurczak	Ph: 605-328-1367
Tennessee
	Nashville
	MBCCOP - Meharry Medical College - Nashville
		Kevin T Palka	Ph: 615-327-5724
			Email: jmurray@mmc.edu
	Nashville Breast Center
		Kevin T Palka	Ph: 615-327-5724
			Email: jmurray@mmc.edu
Texas
	Dallas
	Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas
		Ann Marilyn Leitch	Ph: 214-648-7097
	Houston
	Univeristy of Texas M.D. Anderson Cancer Center
		Elizabeth A Mittendorf	Ph: 713-792-3245
	Laredo
	Doctor's Hospital of Laredo
		Gary W. Unzeitig
			Email: calgbco@calgb.org
Vermont
	Berlin
	Mountainview Medical
		Michelle Sowden	Ph: 802-656-8990
	Burlington
	Vermont Cancer Center at University of Vermont
		Michelle Sowden	Ph: 802-656-8990
Wisconsin
	Appleton
	Fox Valley Surgical Associates at Appleton Medical Center
		Honnie R Bermas	Ph: 800-574-3872
		Honnie R Bermas	Ph: 800-574-3872
	Green Bay
	Green Bay Oncology, Limited at St. Mary's Hospital
		Anthony J. Jaslowski	Ph: 800-432-6049
	Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center
		Anthony J. Jaslowski	Ph: 800-432-6049
	St. Mary's Hospital Medical Center - Green Bay
		Anthony J. Jaslowski	Ph: 800-432-6049
	St. Vincent Hospital Regional Cancer Center
		Anthony J. Jaslowski	Ph: 800-432-6049
	Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center
		William L Owens	Ph: 800-252-2990
	La Crosse
	Gundersen Lutheran Center for Cancer and Blood
		Jeanne M Johnson	Ph: 608-775-2385
			Email: cancerctr@gundluth.org
	Madison
	University of Wisconsin Paul P. Carbone Comprehensive Cancer Center
		Lee G Wilke	Ph: 877-405-6866
	Mequon
	Columbia Saint Mary's Hospital - Ozaukee
		Charles H. I. Tiber	Ph: 414-326-2675
			Email: clinicaltrials@columbia-stmarys.org
	Milwaukee
	Aurora Sinai Medical Center
		Judy A Tjoe	Ph: 800-252-2990
	Columbia-Saint Mary's Cancer Care Center
		Charles H. I. Tiber	Ph: 414-326-2675
			Email: clinicaltrials@columbia-stmarys.org
	Vince Lombardi Cancer Clinic at Aurora St. Luke's Medical Center
		Judy A Tjoe	Ph: 800-252-2990
	Oshkosh
	Vince Lombardi Cancer Clinic - Oshkosh
		William L Owens	Ph: 800-252-2990
	Summit
	Aurora Medical Center
		William L Owens	Ph: 800-252-2990
	West Allis
	Aurora Women's Pavilion of West Allis Memorial Hospital
		Judy A Tjoe	Ph: 800-252-2990

Link to the current ClinicalTrials.gov record.
NLM Identifer NCT01556243
Information obtained from ClinicalTrials.gov on April 04, 2013

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