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Clinical Trials (PDQ®)

S1202: Duloxetine Hydrochloride to Treat Muscle, Bone, and Joint Pain in Pts W/Early-Stage Breast Cancer Receiving Hormone Therapy

Basic Trial Information
Trial Description
     Summary
     Further Trial Information
     Eligibility Criteria
Trial Contact Information

Basic Trial Information

PhaseTypeStatusAgeSponsorProtocol IDs
Phase IIIBiomarker/Laboratory analysis, Supportive careActiveNot specifiedNCI, OtherS1202
U10CA037429, NCI-2012-01960, SWOG-S1202, NCT01598298

Trial Description

Summary

RATIONALE: Duloxetine hydrochloride may lessen muscle, bone, and joint pain caused by hormone therapy. It is not yet known whether duloxetine hydrochloride is more effective than a placebo in treating patients with muscle, bone, and joint pain caused by hormone therapy.

PURPOSE: This randomized phase III trial studies how well duloxetine hydrochloride works compared to a placebo in treating muscle, bone, and joint pain in patients with early-stage breast cancer receiving hormone therapy.

Further Study Information

OBJECTIVES:

Primary

  • To assess whether daily duloxetine hydrochloride (duloxetine) decreases average joint pain in women with aromatase inhibitor-associated musculoskeletal syndrome (AIMSS), as measured at 12 weeks by the modified Brief Pain Inventory Short Form (BPI-SF).

Secondary

  • To assess whether daily duloxetine decreases worst joint pain in women with AIMSS, as measured at 12 weeks by the modified BPI-SF.
  • To assess whether daily duloxetine decreases pain interference in women with AIMSS, as measured at 12 weeks by the modified BPI-SF.
  • To investigate whether daily duloxetine improves functioning, pain, and stiffness in the knees/hips according to the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) scale. (Exploratory)
  • To investigate whether daily duloxetine improves function, pain, and stiffness in the hands according to the Modified Score for the Assessment and Quantification of Chronic Rheumatoid Affections of the Hands (M-SACRAH). (Exploratory)
  • To investigate whether daily duloxetine improves functional quality of life as measured by the Functional Assessment of Cancer Therapy-Endocrine Scale (FACT-ES). (Exploratory)
  • To investigate whether daily duloxetine improves the proportion of patients reporting changes for the better versus worst as measured by the Global Rating of Change Scale. (Exploratory)
  • To investigate whether daily duloxetine decreases analgesic use.
  • To investigate whether daily duloxetine increases adherence to, and reduces the discontinuation rate for, aromatase inhibitor (AI) therapy. (Exploratory)
  • To assess whether patients receiving duloxetine as compared to placebo have improved depression as measured by the Patient Health Questionnaire (PHQ-9) at Weeks 6 and 12. (Exploratory)
  • To explore the relationship between inherited variants in genes responsible for duloxetine metabolism and activity (COMT, HTR3A, SLC6A2, SLC6A4, CYP1A2, CYP2D6) and aromatase (CYP19A1) and change in pain with 12 weeks of treatment. (Exploratory)
  • To explore the impact of treatment on serum inflammatory cytokine levels with 12 weeks of treatment at baseline and 12 weeks. (Exploratory)
  • To bank blood samples for future correlative analyses. (Exploratory)

OUTLINE: This is a multicenter study. Patients are stratified according to baseline pain score (4-6 vs 7-10), and prior taxane use (yes vs no). Patients are randomized to 1 of 2 treatment arms.

  • Arm I: Patients receive duloxetine hydrochloride orally (PO) once daily (QD) on days 1-7, twice daily (BID) on days 8-84, and then QD on days 85-91.
  • Arm II: Patients receive placebo PO QD on days 1-7, BID on days 8-84, and then QD on days 85-91.

Patients complete the modified Brief Pain Inventory Short Form (BPI-SF) questionnaire at baseline and periodically during study treatment. Patients may also complete the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) scale, the Modified Score for the Assessment and Quantification of Chronic Rheumatoid Affections of the Hands (M-SACRAH), the Functional Assessment of Cancer Therapy-Endocrine Scale (FACT-ES), Global Rating of Change Scale, and the patient Health Questionnaire (PHQ-9).

Patients undergo blood sample collection at baseline and periodically during treatment for correlative studies, including biomarker and genetic studies.

After completion of study treatment, patients are followed up for 168 days.

Eligibility Criteria

DISEASE CHARACTERISTICS:

  • Patients must be women with histologically confirmed estrogen receptor (ER)- and/or progesterone receptor (PgR)-positive invasive carcinoma of the breast with no evidence of metastatic disease (M0)
  • Patients must have completed mastectomy or breast-sparing surgery and must have recovered from all side effects of the surgery
  • Patients must have aromatase inhibitor (AI)-associated musculoskeletal symptoms that began or increased after starting AI therapy; new musculoskeletal pain must not be due specifically to fracture or traumatic injury
  • Patients must have completed the S1202 Brief Pain Inventory-Short Form (BPI-SF) within 7 days prior to registration; patients must have an "average pain" of at least 4 on the BPI-SF

PATIENT CHARACTERISTICS:

  • Patients must be post-menopausal, as defined by at least one of the following:
  • At least 12 months since the last menstrual period
  • Prior bilateral oophorectomy
  • Previous hysterectomy with one or both ovaries left in place (or previous hysterectomy in which documentation of bilateral oophorectomy is unavailable) AND follicle-stimulating hormone (FSH) values consistent with the institutional normal values for the post menopausal state; if patient is under the age of 55, FSH levels must be obtained within 28 days prior to registration
  • Patients must have Zubrod performance status of 0-2
  • Patients must have no known allergy or hypersensitivity to duloxetine or any of the inactive ingredients in the matching placebo
  • Patients must not have any contraindicated concurrent illnesses listed on the duloxetine package insert including:
  • Current primary psychiatric diagnosis (schizophrenia, psychosis) or suicidal ideation, history of bipolar disorder, or seizure disorder
  • History of alcohol or other substance abuse or dependence within 365 days prior to registration
  • Chronic liver disease
  • End-stage renal disease
  • Uncontrolled narrow-angle glaucoma
  • Clinically significant coagulation disorder
  • Creatinine clearance > 30 mL/min
  • Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) both within 3 x upper limit of normal
  • Total bilirubin within the upper limit of normal
  • Patients must be able to complete study questionnaires in English
  • Patients must not have concurrent medical/arthritic disease that could confound or interfere with evaluation of pain or efficacy including: inflammatory arthritis (rheumatoid arthritis, systemic lupus, spondyloarthropathy, psoriatic arthritis, polymyalgia rheumatica), or cancer involving the bone
  • Patients must be willing to submit blood samples for correlative studies; baseline samples must be obtained prior to beginning protocol treatment

PRIOR CONCURRENT THERAPY:

  • See Disease Characteristics
  • If patients were treated with chemotherapy and/or radiation therapy, these treatments must be completed at least 28 days prior to study registration
  • Concurrent bisphosphonate and trastuzumab therapies are allowed
  • Patients should have recovered from all Grade 2 or higher side effects of chemotherapy and/or radiation therapy with the exception of alopecia and peripheral neuropathy
  • Patients must currently be taking one of the following aromatase inhibitor (AI) doses for at least 21 days, but no longer than 12 months, prior to registration and plans to continue for at least an additional 180 days after registration
  • Anastrozole (Arimidex®) 1 mg daily
  • Letrozole (Femara®) 2.5 mg daily
  • Exemestane (Aromasin®) 25 mg daily
  • Patients must not be taking any contraindicated medications listed on the duloxetine package insert including the following: treatment with phenothiazines, propafenone, flecainide, or linezolid; treatment with monoamine oxidase (MAO)-inhibitor within 14 days prior to registration; or current use of anticoagulation medication (e.g., heparin, warfarin)
  • Patients must not require selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephirine reuptake inhibitors (SNRIs), or tricyclic antidepressants during study participation; patients must have been able to taper and discontinue treatment with these medications at least 7 days prior to registration; patients must not have taken duloxetine or milnacipran within 90 days prior to registration
  • Patients who are receiving treatment with narcotics, tramadol, gabapentin, and/or pregabalin must have been taking a stable dose for at least 30 days prior to registration

Trial Contact Information

Trial Lead Organizations/Sponsors

Southwest Oncology Group

National Cancer Institute

N. Lynn HenryPrincipal Investigator

Anne F. SchottStudy Chair

Kimberly KaberlePh: 2106148808 Ext.1022
  Email: kkaberle@swog.org

Trial Sites

U.S.A.
Alaska
  Anchorage
 Alaska Breast Care and Surgery LLC
 Kelly S Perlewitz Ph: 503-537-1463
 Anchorage Oncology Centre
 Kelly S Perlewitz Ph: 503-537-1463
 Katmai Oncology Group
 Kelly S Perlewitz Ph: 503-537-1463
 Providence Cancer Center
 Kelly S Perlewitz Ph: 503-537-1463
Arkansas
  Jonesboro
 NEA Medical Clinic - East Matthews
 Carroll Dean Scroggin Ph: 210-614-8808
  Email: protocols@swog.org
California
  Antioch
 Kaiser Permanente - Deer Valley
 Louis Fehrenbacher Ph: 626-564-3455
  Auburn
 Sutter Auburn Faith Hospital
 Ari D Baron Ph: 415-600-1182
  Email: SchmidtJ@cpmcri.org
  Berkeley
 Alta Bates Summit Comprehensive Cancer Center
 Ari D Baron Ph: 415-600-1182
  Email: SchmidtJ@cpmcri.org
  Burlingame
 Peninsula Medical Center
 Ari D Baron Ph: 415-600-1182
  Email: SchmidtJ@cpmcri.org
  Davis
 Sutter Davis Hospital
 Ari D Baron Ph: 415-600-1182
  Email: SchmidtJ@cpmcri.org
  Fremont
 Kaiser Permanente - Fremont
 Louis Fehrenbacher Ph: 626-564-3455
  Fresno
 Kaiser Permanente Fresno Medical Center
 Louis Fehrenbacher Ph: 626-564-3455
  Martinez
 Contra Costa Regional Medical Center
 James H. Feusner Ph: 510-450-7600
  Modesto
 Kaiser Permanente-Modesto
 Louis Fehrenbacher Ph: 626-564-3455
 Memorial Medical Center
 Ari D Baron Ph: 415-600-1182
  Email: SchmidtJ@cpmcri.org
  Mountain View
 Palo Alto Medical Foundation
 Ari D Baron Ph: 415-600-1182
  Email: SchmidtJ@cpmcri.org
 Ari D Baron Ph: 415-600-1182
  Email: SchmidtJ@cpmcri.org
  Novato
 Sutter Health Western Division Cancer Research Group
 Ari D Baron Ph: 415-600-1182
  Email: SchmidtJ@cpmcri.org
  Oakland
 Alta Bates Summit Medical Center - Summit Campus
 James H. Feusner Ph: 510-450-7600
 Bay Area Breast Surgeons, Incorporated
 James H. Feusner Ph: 510-450-7600
 CCOP - Bay Area Tumor Institute
 James H. Feusner Ph: 510-450-7600
 Epic Care - Oakland
 James H. Feusner Ph: 510-450-7600
 Kaiser Permanente-Oakland
 Louis Fehrenbacher Ph: 626-564-3455
 Larry G Strieff MD Medical Corporation
 James H. Feusner Ph: 510-450-7600
  Palo Alto
 Palo Alto Medical Foundation - Palo Alto
 Ari D Baron Ph: 415-600-1182
  Email: SchmidtJ@cpmcri.org
  Pasadena
 Huntington OutPatient Surgery Center
 Jeannie Shen Ph: 626-535-2420
  Redwood City
 Kaiser Permanente Medical Center - Redwood City
 Louis Fehrenbacher Ph: 626-564-3455
  Richmond
 Kaiser Permanente Medical Center - Richmond
 Louis Fehrenbacher Ph: 626-564-3455
  Roseville
 Kaiser Permanente Medical Center - Roseville
 Louis Fehrenbacher Ph: 626-564-3455
 Sutter Cancer Center at Roseville Medical Center
 Ari D Baron Ph: 415-600-1182
  Email: SchmidtJ@cpmcri.org
  Sacramento
 Kaiser Permanente Medical Center - Sacramento
 Louis Fehrenbacher Ph: 626-564-3455
 South Sacramento Kaiser-Permanente Medical Center
 Louis Fehrenbacher Ph: 626-564-3455
 Sutter Cancer Center
 Ari D Baron Ph: 415-600-1182
  Email: SchmidtJ@cpmcri.org
  San Francisco
 California Pacific Medical Center - California Campus
 Ari D Baron Ph: 415-209-2686
  Email: bernicl@sutterhealth.org
 Kaiser Permanente Medical Center - San Francisco Geary Campus
 Louis Fehrenbacher Ph: 626-564-3455
  San Jose
 Kaiser Permanente Medical Center - Santa Teresa
 Louis Fehrenbacher Ph: 626-564-3455
  San Leandro
 Kaiser Permanente Medical Center - Hayward
 Louis Fehrenbacher Ph: 626-564-3455
  San Rafael
 Kaiser Foundation Hospital - San Rafael
 Louis Fehrenbacher Ph: 626-564-3455
  Santa Clara
 Kaiser Permanente Medical Center - Santa Clara Homestead Campus
 Louis Fehrenbacher Ph: 626-564-3455
  Santa Cruz
 Palo Alto Medical Foundation-Santa Cruz
 Ari D Baron Ph: 415-600-1182
  Email: SchmidtJ@cpmcri.org
  Santa Rosa
 Kaiser Permanente Medical Center - Santa Rosa
 Louis Fehrenbacher Ph: 626-564-3455
 Sutter Pacific Medical Foundation
 Ari D Baron Ph: 415-600-1182
  Email: SchmidtJ@cpmcri.org
  South San Francisco
 Kaiser Permanente Medical Center - South San Francisco
 Louis Fehrenbacher Ph: 626-564-3455
  Stockton
 Kaiser Permanente Medical Facility - Stockton
 Louis Fehrenbacher Ph: 626-564-3455
  Sunnyvale
 Palo Atlo Medical Foundation-Sunnyvale
 Ari D Baron Ph: 415-600-1182
  Email: SchmidtJ@cpmcri.org
  Vacaville
 Kaiser Permanente Medical Center - Vacaville
 Louis Fehrenbacher Ph: 626-564-3455
  Vallejo
 Kaiser Permanente Medical Center - Vallejo
 Louis Fehrenbacher Ph: 626-564-3455
 Sutter Solano Medical Center
 Ari D Baron Ph: 415-600-1182
  Email: SchmidtJ@cpmcri.org
  Walnut Creek
 Kaiser Permanente Medical Center - Walnut Creek
 Louis Fehrenbacher Ph: 626-564-3455
  Whittier
 Ruby L. Golleher Cancer Program at Presbyterian Intercommunity Hospital
 Dustin E Stevenson Ph: 562-698-0811
Colorado
  Aurora
 Medical Center of Aurora - South Campus
 Keren Sturtz Ph: 888-785-6789
 Rocky Mountain Cancer Centers - Aurora
 Keren Sturtz Ph: 888-785-6789
  Boulder
 Boulder Community Hospital
 Keren Sturtz Ph: 888-785-6789
 Rocky Mountain Cancer Centers-Boulder
 Keren Sturtz Ph: 888-785-6789
  Colorado Springs
 Penrose Cancer Center at Penrose Hospital
 Keren Sturtz Ph: 888-785-6789
 Rocky Mountain Cancer Centers at the Pavilion
 Keren Sturtz Ph: 888-785-6789
  Denver
 CCOP - Colorado Cancer Research Program
 Keren Sturtz Ph: 888-785-6789
 Colorado Blood Cancer Institute
 Keren Sturtz Ph: 888-785-6789
 Porter Adventist Hospital
 Keren Sturtz Ph: 888-785-6789
 Presbyterian - St. Luke's Medical Center
 Keren Sturtz Ph: 888-785-6789
 Rocky Mountain Cancer Centers - Denver Midtown
 Keren Sturtz Ph: 888-785-6789
 Rocky Mountain Cancer Centers-Rose
 Keren Sturtz Ph: 888-785-6789
 Rose Medical Center
 Keren Sturtz Ph: 888-785-6789
 St. Joseph Hospital
 Keren Sturtz Ph: 888-785-6789
  Durango
 Mercy Medical Center
 Keren Sturtz Ph: 888-785-6789
  Englewood
 Comprehensive Cancer Care and Research Institute of Colorado LLC
 Keren Sturtz Ph: 888-785-6789
 Swedish Medical Center
 Keren Sturtz Ph: 888-785-6789
  Golden
 Mountain Blue Cancer Care Center
 Keren Sturtz Ph: 888-785-6789
  Greeley
 North Colorado Medical Center
 Keren Sturtz Ph: 888-785-6789
  Greenwood Village
 Breast Cancer Care Consultants
 Keren Sturtz Ph: 888-785-6789
  Lakewood
 Rocky Mountain Cancer Centers-Lakewood
 Keren Sturtz Ph: 888-785-6789
 St. Anthony Central Hospital
 Keren Sturtz Ph: 888-785-6789
  Littleton
 Littleton Adventist Hospital
 Keren Sturtz Ph: 888-785-6789
 Rocky Mountain Cancer Centers - Littleton
 Keren Sturtz Ph: 888-785-6789
  Lone Tree
 Rocky Mountain Cancer Centers - Lone Tree
 Keren Sturtz Ph: 888-785-6789
 Sky Ridge Medical Center
 Keren Sturtz Ph: 888-785-6789
  Longmont
 Hope Cancer Care Center at Longmont United Hospital
 Keren Sturtz Ph: 888-785-6789
 Rocky Mountain Cancer Centers - Longmont
 Keren Sturtz Ph: 888-785-6789
  Loveland
 McKee Medical Center
 Keren Sturtz Ph: 888-785-6789
  Parker
 Parker Adventist Hospital
 Keren Sturtz Ph: 888-785-6789
 Rocky Mountain Cancer Centers - Parker
 Keren Sturtz Ph: 888-785-6789
  Pueblo
 Rocky Mountain Cancer Centers - Pueblo
 Keren Sturtz Ph: 888-785-6789
 St. Mary - Corwin Regional Medical Center
 Keren Sturtz Ph: 888-785-6789
  Thornton
 Rocky Mountain Cancer Centers - Thornton
 Keren Sturtz Ph: 888-785-6789
  Wheat Ridge
 Exempla Lutheran Medical Center
 Keren Sturtz Ph: 888-785-6789
Connecticut
  Farmington
 Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center
 Susan H Tannenbaum Ph: 800-579-7822
  Hartford
 Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center
 Tareq Al Baghdadi Ph: 734-712-4673
  Middletown
 Middlesex Hospital Cancer Center
 Susanna Hong Ph: 860-358-2058
District of Columbia
  Washington
 Kaiser Permanente at Capitol Hill Medical Center
 Mahrukh M Hussain Ph: 301-816-7446
Florida
  Lakeland
 Center for Cancer Care and Research at Watson Clinic, LLP
 Galina Vugman Ph: 863-680-7780
  Miami Beach
 CCOP - Mount Sinai Medical Center
 Michael Schwartz Ph: 305-674-2625
  Email: info@msccop.com
  Orlando
 Florida Hospital Cancer Institute at Florida Hospital Orlando
 Lee M. Zehngebot Ph: 407-303-5623
  Pensacola
 Sacred Heart Cancer Center at Sacred Heart Hospital
 James F Watkins Ph: 850-416-4611
 Sacred Heart Medical Oncology Group
 James F Watkins Ph: 850-416-4611
Georgia
  Athens
 Northeast Georgia Cancer Care, LLC - Medical Oncology
 Randall F. Roberts Ph: 706-721-1663
  Email: cancer@georgiahealth.edu
  Augusta
 Medical College of Georgia Cancer Center
 Randall F. Roberts Ph: 706-721-1663
  Email: cancer@georgiahealth.edu
  Savannah
 Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler
 Jennifer Yannucci Ph: 912-350-8568
  Valdosta
 Pearlman Comprehensive Cancer Center at South Georgia Medical Center
 Samuel N Ofori Ph: 229-259-4628
  Email: maryann.heddon@sgmc.org
Hawaii
  Honolulu
 Kaiser Permanente - Moanalua Medical Center and Clinic
 Louis Fehrenbacher Ph: 626-564-3455
 Tripler Army Medical Center
 Jeffrey L. Berenberg Ph: 808-586-2979
Idaho
  Boise
 Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
 Tareq Al Baghdadi Ph: 734-712-4673
  Post Falls
 Kootenai Cancer Center - Post Falls
 Benjamin Thomas Marchello Ph: 800-648-6274
Illinois
  Aurora
 Rush-Copley Cancer Care Center
 Kendrith M. Rowland Ph: 800-446-5532
  Berwyn
 MacNeal Cancer Center at MacNeal Hospital
 Mary Beth Leonard Ph: 773-564-5044
  Bloomington
 Illinois CancerCare - Bloomington
 Nguyet A Le-Lindqwister Ph: 800-793-2262
 St. Joseph Medical Center
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  Canton
 Illinois CancerCare - Canton
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  Carbondale
 Memorial Hospital of Carbondale
 James L. Wade Ph: 217-876-4740
  Email: kcheek@dmhhs.org
  Carthage
 Illinois CancerCare - Carthage
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  Centralia
 Centralia Oncology Clinic
 James L. Wade Ph: 217-876-4740
  Email: kcheek@dmhhs.org
  Chicago
 Louis A. Weiss Memorial Hospital
 Keith L. Shulman Ph: 773-564-5044
 University of Illinois Cancer Center
 Oana C Danciu Ph: 312-355-3046
  Danville
 Carle on Vermilion
 Kendrith M. Rowland Ph: 800-446-5532
  Decatur
 Cancer Care Center of Decatur
 James L. Wade Ph: 217-876-4740
  Email: kcheek@dmhhs.org
 CCOP - Central Illinois
 Norah L Henry Ph: 734-936-4991
  Email: norahh@med.umich.edu
 Decatur Memorial Hospital Cancer Care Institute
 James L. Wade Ph: 217-876-4740
  Email: kcheek@dmhhs.org
  Effingham
 Carle Physician Group-Effingham
 Kendrith M. Rowland Ph: 800-446-5532
 Crossroads Cancer Center
 James L. Wade Ph: 217-876-4740
  Email: kcheek@dmhhs.org
  Eureka
 Illinois CancerCare - Eureka
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  Galesburg
 Galesburg Clinic, PC
 Nguyet A Le-Lindqwister Ph: 800-793-2262
 Medical and Surgical Specialists, LLC
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  Harvey
 Ingalls Cancer Care Center at Ingalls Memorial Hospital
 Mark F. Kozloff Ph: 708-915-4673
  Email: clinicaltrials@ingalls.org
  Hinsdale
 Hinsdale Hematology Oncology Associates
 Elyse Cheryl Schneiderman Ph: 630-654-1790
  Email: info@hhoaltd.com
  Kewanee
 Illinois CancerCare - Kewanee Clinic
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  Macomb
 Illinois CancerCare - Macomb
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  Maywood
 Cardinal Bernardin Cancer Center at Loyola University Medical Center
 Patricia A Robinson Ph: 708-226-4357
  Mount Vernon
 Good Samaritan Regional Health Center
 Jay W Carlson Ph: 800-821-7532
  Ottawa
 Illinois CancerCare - Ottawa
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  Pekin
 Cancer Treatment Center at Pekin Hospital
 Nguyet A Le-Lindqwister Ph: 800-793-2262
 Illinois CancerCare - Pekin
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  Peoria
 Illinois CancerCare - Peoria
 Nguyet A Le-Lindqwister Ph: 800-793-2262
 Methodist Medical Center of Illinois
 Nguyet A Le-Lindqwister Ph: 800-793-2262
 OSF St. Francis Medical Center
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  Peru
 Illinois CancerCare - Princeton
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  Princeton
 Illinois CancerCare - Princeton
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  River Forest
 West Suburban Center for Cancer Care
 Isoken Koko Ph: 708-488-0882
  Springfield
 Regional Cancer Center at Memorial Medical Center
 James L. Wade Ph: 217-876-4740
  Email: kcheek@dmhhs.org
  Urbana
 Carle Cancer Center at Carle Foundation Hospital
 Kendrith M. Rowland Ph: 800-446-5532
 Kendrith M. Rowland Ph: 800-446-5532
  Yorkville
 Rush-Copley Healthcare Center
 Kendrith M. Rowland Ph: 800-446-5532
Indiana
  Elkhart
 Elkhart Clinic, LLC
 Robin Zon Ph: 574-234-5123
 Michiana Hematology-Oncology, PC - Elkhart
 Robin Zon Ph: 574-234-5123
  Indianapolis
 Community Regional Cancer Care at Community Hospital East
 Radhika Walling Ph: 317-621-7104
 Community Regional Cancer Care at Community Hospital North
 Radhika Walling Ph: 317-621-7104
  Merrillville
 Premier Oncology Hematology Associates
 Bharat H. Barai Ph: 219-736-2800
  Michigan City
 Saint Anthony Memorial Health Centers
 Kendrith M. Rowland Ph: 800-446-5532
 Woodland Cancer Care Center
 Kendrith M. Rowland Ph: 800-446-5532
  Mishawaka
 Memorial Regional Cancer Center Day Road
 Thomas Joseph Reid Ph: 800-284-7370
 Michiana Hematology-Oncology, PC - Mishawaka
 Robin Zon Ph: 574-234-5123
 Saint Joseph's Medical Center
 Robin Zon Ph: 574-234-5123
  Plymouth
 Michiana Hematology Oncology PC - Plymouth
 Robin Zon Ph: 574-234-5123
  Richmond
 Reid Hospital & Health Care Services
 Howard M. Gross Ph: 937-775-1350
  South Bend
 CCOP - Northern Indiana CR Consortium
 Robin Zon Ph: 574-234-5123
 Memorial Hospital of South Bend
 Thomas Joseph Reid Ph: 800-284-7370
 Michiana Hematology-Oncology, PC - South Bend
 Robin Zon Ph: 574-234-5123
  Westville
 Michiana Hematology Oncology-PC Westville
 Robin Zon Ph: 574-234-5123
Iowa
  Ames
 McFarland Clinic, PC
 Joseph James Merchant Ph: 515-239-2621
 William R. Bliss Cancer Center at Mary Greeley Medical Center
 Joseph James Merchant Ph: 515-239-2621
  Boone
 McFarland Clinic PC-Boone
 Joseph James Merchant Ph: 515-239-2621
  Cedar Rapids
 Cedar Rapids Oncology Associates
 Deborah W Wilbur Ph: 319-363-2690
 Mercy Regional Cancer Center at Mercy Medical Center
 Deborah W Wilbur Ph: 319-363-2690
  Clive
 Medical Oncology and Hematology Associates-West Des Moines
 Robert J Behrens Ph: 888-244-6061
  Email: sherrijr@iora.org
  Des Moines
 CCOP - Iowa Oncology Research Association
 Robert J Behrens Ph: 888-244-6061
  Email: sherrijr@iora.org
 John Stoddard Cancer Center at Iowa Lutheran Hospital
 Robert J Behrens Ph: 888-244-6061
  Email: sherrijr@iora.org
 John Stoddard Cancer Center at Iowa Methodist Medical Center
 Robert J Behrens Ph: 888-244-6061
  Email: sherrijr@iora.org
 Medical Oncology and Hematology Associates at John Stoddard Cancer Center
 Robert J Behrens Ph: 888-244-6061
  Email: sherrijr@iora.org
 Medical Oncology and Hematology Associates at Mercy Cancer Center
 Robert J Behrens Ph: 888-244-6061
  Email: sherrijr@iora.org
  Fort Dodge
 Trinity Regional Medical Center
 Joseph James Merchant Ph: 515-239-2621
  Jefferson
 McFarland Clinic PC-Jefferson
 Joseph James Merchant Ph: 515-239-2621
  Marshalltown
 McFarland Clinic PC-Marshalltown
 Joseph James Merchant Ph: 515-239-2621
  Mason City
 Mercy Cancer Center at Mercy Medical Center - North Iowa
 Arvind Y Vemula Ph: 800-433-3883
  Sioux City
 Siouxland Hematology-Oncology Associates, LLP
 Donald Bruce Wender Ph: 712-252-0088
  West Des Moines
 Methodist West Hospital
 Robert J Behrens Ph: 888-244-6061
  Email: sherrijr@iora.org
Kansas
  Chanute
 Cancer Center of Kansas, PA - Chanute
 Shaker R. Dakhil Ph: 316-262-4467
  Dodge City
 Cancer Center of Kansas, PA - Dodge City
 Shaker R. Dakhil Ph: 316-262-4467
  El Dorado
 Cancer Center of Kansas, PA - El Dorado
 Shaker R. Dakhil Ph: 316-262-4467
  Fort Scott
 Cancer Center of Kansas - Fort Scott
 Shaker R. Dakhil Ph: 316-262-4467
  Independence
 Cancer Center of Kansas-Independence
 Shaker R. Dakhil Ph: 316-262-4467
  Kingman
 Cancer Center of Kansas, PA - Kingman
 Shaker R. Dakhil Ph: 316-262-4467
  Lawrence
 Lawrence Memorial Hospital
 Shaker R. Dakhil Ph: 316-262-4467
  Liberal
 Cancer Center of Kansas, PA - Liberal
 Shaker R. Dakhil Ph: 316-262-4467
  Newton
 Cancer Center of Kansas, PA - Newton
 Shaker R. Dakhil Ph: 316-262-4467
  Parsons
 Cancer Center of Kansas, PA - Parsons
 Shaker R. Dakhil Ph: 316-262-4467
  Pratt
 Cancer Center of Kansas, PA - Pratt
 Shaker R. Dakhil Ph: 316-262-4467
  Salina
 Cancer Center of Kansas, PA - Salina
 Shaker R. Dakhil Ph: 316-262-4467
  Topeka
 Cotton-O'Neil Cancer Center
 Mehmood H Hashmi Ph: 785-270-4963
  Wellington
 Cancer Center of Kansas, PA - Wellington
 Shaker R. Dakhil Ph: 316-262-4467
  Wichita
 Associates in Women's Health, PA - North Hillside
 Shaker R. Dakhil Ph: 316-262-4467
 Cancer Center of Kansas, PA - Medical Arts Tower
 Shaker R. Dakhil Ph: 316-262-4467
 Cancer Center of Kansas, PA - Wichita
 Shaker R. Dakhil Ph: 316-262-4467
 Via Christi Cancer Center at Via Christi Regional Medical Center
 Shaker R. Dakhil Ph: 316-262-4467
  Winfield
 Cancer Center of Kansas, PA - Winfield
 Shaker R. Dakhil Ph: 316-262-4467
Kentucky
  Corbin
 Baptist Regional Medical Center
 Arvinda Padmanabhan Ph: 859-260-6425
  Crestview Hills
 Oncology Hematology Care, Incorporated - Crestview Hills
 Howard M. Gross Ph: 937-775-1350
  Elizabethtown
 Hardin Memorial Hospital
 Arvinda Padmanabhan Ph: 859-260-6425
  Lexington
 Central Baptist Hospital
 Arvinda Padmanabhan Ph: 859-260-6425
  Owensboro
 Mitchell Memorial Cancer Center at Owensboro Medical Health System
 Kevin P Ridenhour Ph: 270-688-3691
  Email: shawns@omhs.org
Louisiana
  Alexandria
 Cabrini Center for Cancer Care at Christus St. Frances Cabrini Hospital
 Steven J Saccaro Ph: 504-988-6121
  Monroe
 Louisiana State University Health Sciences Center - Monroe
 Gary V Burton Ph: 318-813-1412
  Shreveport
 Feist-Weiller Cancer Center at Louisiana State University Health Sciences
 Gary V Burton Ph: 318-813-1412
Maine
  Augusta
 Harold Alfond Center for Cancer Care
 Thomas Henry Openshaw Ph: 207-973-4274
  Bangor
 CancerCare of Maine at Eastern Maine Medical Center
 Thomas Henry Openshaw Ph: 207-973-4274
  Lewiston
 Central Maine Comprehensive Cancer Center at Central Maine Medical Center
 Nicholette Erickson Ph: 207-795-8250
  Email: benderli@cmhc.org
  Rockport
 Penobscot Bay Medical Center Cancer Care Center
 Thomas Henry Openshaw Ph: 207-973-4274
Maryland
  Baltimore
 Kaiser Permanente at Woodlawn Medical Center
 Mahrukh M Hussain Ph: 301-816-7446
  Bethesda
 Suburban Hospital
 Carolyn Bennett Hendricks Ph: 301-896-2719
  Email: Bsquiller@suburbanhospital.org
  Frederick
 Frederick Memorial Hospital Regional Cancer Therapy Center
 Brian M. O'Connor Ph: 240-566-3584
  Email: clinicaltrials@fmh.org
  Gaithersburg
 Kaiser Permanente - Gaithersburg Medical Center
 Mahrukh M Hussain Ph: 301-816-7446
  Largo
 Kaiser Permanente Mid-Atlantic Medical Group-Largo Medical Facility
 Mahrukh M Hussain Ph: 301-816-7446
Massachusetts
  Boston
 Boston University Cancer Research Center
 Rita Ann Blanchard Ph: 617-638-8265
  Fall River
 Hudner Oncology Center at Saint Anne's Hospital - Fall River
 John L Yang Ph: 508-674-5600
  Newton
 Newton-Wellesley Hospital
 Caroline C Block Ph: 888-823-5923
  Email: ctsucontact@westat.com
  Norwood
 Caritas Norwood Hospital
 Rita Ann Blanchard Ph: 617-638-8265
  Springfield
 Baystate Medical Center
 Grace Makari-Judson Ph: 413-794-3565
  Email: tamara.wrenn@baystatehealth.org
Michigan
  Adrian
 Hickman Cancer Center at Bixby Medical Center
 Rex B Mowat Ph: 517-265-0116
 Rex B Mowat Ph: 517-265-0116
  Ann Arbor
 Saint Joseph Mercy Cancer Center
 Tareq Al Baghdadi Ph: 734-712-4673
 University of Michigan Comprehensive Cancer Center
 Norah L Henry Ph: 800-865-1125
  Battle Creek
 Battle Creek Health System Cancer Care Center
 Gilbert D Padula Ph: 616-685-5225
  Bay City
 Bay Regional Medical Center
 Justin F Klamerus Ph: 800-248-6777
  Clarkston
 Great Lakes Cancer Institute
 Justin F Klamerus Ph: 800-248-6777
  Dearborn
 Oakwood Cancer Center at Oakwood Hospital and Medical Center
 Tareq Al Baghdadi Ph: 734-712-4673
  Detroit
 Van Elslander Cancer Center at St. John Hospital and Medical Center
 Tareq Al Baghdadi Ph: 734-712-4673
 Wayne State University
 Sayeh M Lavasani Ph: 313-576-9363
  Escanaba
 Green Bay Oncology, Limited - Escanaba
 Matthew L Ryan Ph: 800-432-6049
  Flint
 Genesys Hurley Cancer Institute
 Tareq Al Baghdadi Ph: 734-712-4673
 Hurley Medical Center
 Tareq Al Baghdadi Ph: 734-712-4673
 Singh and Arora Hematology Oncology, PC
 Justin F Klamerus Ph: 800-248-6777
  Grand Rapids
 Butterworth Hospital at Spectrum Health
 Gilbert D Padula Ph: 616-685-5225
 Lacks Cancer Center at Saint Mary's Health Care
 Gilbert D Padula Ph: 616-685-5225
  Iron Mountain
 Green Bay Oncology - Iron Mountain
 Matthew L Ryan Ph: 800-432-6049
  Jackson
 Gayle M. Jacob Cancer Center at Allegiance Health
 Tareq Al Baghdadi Ph: 734-712-4673
  Kalamazoo
 Borgess Medical Center
 Raymond Sterling Lord Ph: 269-373-7458
 Bronson Methodist Hospital
 Raymond Sterling Lord Ph: 269-373-7458
 West Michigan Cancer Center
 Raymond Sterling Lord Ph: 269-373-7458
  Lansing
 Breslin Cancer Center at Ingham Regional Medical Center
 Justin F Klamerus Ph: 800-248-6777
 Sparrow Regional Cancer Center
 Tareq Al Baghdadi Ph: 734-712-4673
  Livonia
 St. Mary Mercy Hospital
 Tareq Al Baghdadi Ph: 734-712-4673
  Midland
 MidMichigan Medical Center - Midland
 Michel R. Hurtubise Ph: 989-839-3377
  Monroe
 Community Cancer Center of Monroe
 Rex B Mowat Ph: 517-265-0116
  Mount Clemens
 Clemens Regional Medical Center
 Justin F Klamerus Ph: 800-248-6777
  Mount Pleasant
 Norval K. Morey Cancer Center at Central Michigan Community Hospital
 Justin F Klamerus Ph: 800-248-6777
  Muskegon
 Mercy General Health Partners
 Gilbert D Padula Ph: 616-685-5225
  Niles
 Lakeland Hospital - Niles
 Gilbert D Padula Ph: 616-685-5225
  Petoskey
 Northern Michigan Hospital
 Justin F Klamerus Ph: 800-248-6777
  Pontiac
 St. Joseph Mercy Oakland
 Tareq Al Baghdadi Ph: 734-712-4673
  Port Huron
 Mercy Regional Cancer Center at Mercy Hospital
 Tareq Al Baghdadi Ph: 734-712-4673
  Reed City
 Spectrum Health Reed City Hospital
 Gilbert D Padula Ph: 616-685-5225
  Royal Oak
 William Beaumont Hospital - Royal Oak Campus
 Michael J. Stender Ph: 248-551-7695
  Saginaw
 Seton Cancer Institute at Saint Mary's - Saginaw
 Tareq Al Baghdadi Ph: 734-712-4673
  Saint Joseph
 Lakeside Cancer Specialists, PLLC
 Gilbert D Padula Ph: 616-685-5225
  Southfield
 Providence Hospital - Southfield
 Andrew A Muskovitz Ph: 248-849-5337
  Email: jaswinder.grewal@stjohn.org
  St. Joseph
 Lakeland Regional Cancer Care Center - St. Joseph
 Gilbert D Padula Ph: 616-685-5225
  Traverse City
 Munson Medical Center
 Gilbert D Padula Ph: 616-685-5225
  Troy
 William Beaumont Hospital - Troy Campus
 Michael J. Stender Ph: 248-551-7695
  Warren
 St. John Macomb Hospital
 Tareq Al Baghdadi Ph: 734-712-4673
Minnesota
  Bemidji
 MeritCare Bemidji
 Preston D. Steen Ph: 701-234-6161
  Brainerd
 St. Joseph's Medical Center
 Bret E Friday Ph: 888-203-7267
  Burnsville
 Fairview Ridges Hospital
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Coon Rapids
 Mercy and Unity Cancer Center at Mercy Hospital
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Duluth
 CCOP - Duluth
 Bret E Friday Ph: 888-203-7267
 Essentia Health - Duluth Clinic
 Bret E Friday Ph: 888-203-7267
 Miller - Dwan Medical Center
 Bret E Friday Ph: 888-203-7267
  Edina
 Fairview Southdale Hospital
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Fergus Falls
 Lake Region Healthcare Corporation-Cancer Care
 Bret E Friday Ph: 888-203-7267
  Fridley
 Mercy and Unity Cancer Center at Unity Hospital
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Hutchinson
 Hutchinson Area Health Care
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Maplewood
 HealthEast Cancer Care at St. John's Hospital
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
 Minnesota Oncology - Maplewood
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Minneapolis
 Health Partners Inc
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
 Hennepin County Medical Center - Minneapolis
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
 Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  New Ulm
 New Ulm Medical Center
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Robbinsdale
 Humphrey Cancer Center at North Memorial Outpatient Center
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Saint Louis Park
 Park Nicollet Cancer Center
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Saint Paul
 Regions Hospital Cancer Care Center
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
 United Hospital
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Shakopee
 St. Francis Cancer Center at St. Francis Medical Center
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Stillwater
 Lakeview Hospital
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Waconia
 Ridgeview Medical Center
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Willmar
 Willmar Cancer Center at Rice Memorial Hospital
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Woodbury
 Minnesota Oncology - Woodbury
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
Mississippi
  Jackson
 University of Mississippi Cancer Clinic
 Barbara S Craft Ph: 601-815-6700
  Oxford
 Family Cancer Center, PLLC - Oxford
 Raymond U Osarogiagbon Ph: 901-448-3303
  Southaven
 Family Cancer Center, PLLC - Southaven
 Raymond U Osarogiagbon Ph: 901-448-3303
  Southhaven
 Baptist Memorial Hospital-Desoto
 Raymond U Osarogiagbon Ph: 901-448-3303
Missouri
  Cape Girardeau
 Saint Francis Medical Center
 James L. Wade Ph: 217-876-4740
  Email: kcheek@dmhhs.org
 Southeast Cancer Center
 Bryan A Faller Ph: 800-392-0936
  Jefferson City
 Goldschmidt Cancer Center
 Bryan A Faller Ph: 800-392-0936
  Joplin
 St. John's Regional Medical Center
 Jay W Carlson Ph: 800-821-7532
  Rolla
 Mercy Clinic Cancer and Hematology - Rolla
 Jay W Carlson Ph: 800-821-7532
 Phelps County Regional Medical Center
 Jay W Carlson Ph: 800-821-7532
  Saint Louis
 David C. Pratt Cancer Center at St. John's Mercy
 Jay W Carlson Ph: 800-821-7532
 Mercy Clinic St. Louis Cancer and Breast Institute
 Jay W Carlson Ph: 800-821-7532
 Missouri Baptist Cancer Center
 Bryan A Faller Ph: 800-392-0936
  Springfield
 Hulston Cancer Center at Cox Medical Center South
 Jay W Carlson Ph: 800-821-7532
 St. John's Regional Health Center
 Jay W Carlson Ph: 800-821-7532
Montana
  Billings
 Billings Clinic Cancer Center - 801 N 29th Street
 Benjamin Thomas Marchello Ph: 800-648-6274
 CCOP - Montana Cancer Consortium
 Benjamin Thomas Marchello Ph: 800-648-6274
 St. Vincent Healthcare Cancer Care Services
 Benjamin Thomas Marchello Ph: 800-648-6274
  Bozeman
 Bozeman Deaconess Cancer Center
 Benjamin Thomas Marchello Ph: 800-648-6274
  Butte
 St. James Healthcare Cancer Care
 Benjamin Thomas Marchello Ph: 800-648-6274
  Great Falls
 Benefis Sletten Cancer Institute
 Benjamin Thomas Marchello Ph: 800-648-6274
  Helena
 St. Peter's Hospital
 Benjamin Thomas Marchello Ph: 800-648-6274
  Kalispell
 Kalispell Regional Medical Center
 Benjamin Thomas Marchello Ph: 800-648-6274
  Missoula
 Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
 Benjamin Thomas Marchello Ph: 800-648-6274
Nebraska
  Kearney
 Good Samaritan Cancer Center at Good Samaritan Hospital
 George K. Bascom Ph: 308-865-7963
  Lincoln
 Cancer Resource Center - Lincoln
 Gamini S. Soori Ph: 800-253-4368
 Nebraska Hematology and Oncology
 Gamini S. Soori Ph: 402-991-8070ext202
  Email: mwilwerding@mvcc.cc
  Norfolk
 Carson Cancer Center at Faith Regional Hospital
 Gamini S. Soori Ph: 402-991-8070ext202
  Email: mwilwerding@mvcc.cc
  North Platte
 Callahan Cancer Center at Great Plains Regional Medical Center
 Gamini S. Soori Ph: 402-991-8070ext202
  Email: mwilwerding@mvcc.cc
  Omaha
 Alegant Health Cancer Center at Bergan Mercy Medical Center
 Gamini S. Soori Ph: 800-253-4368
 CCOP - Missouri Valley Cancer Consortium
 Gamini S. Soori Ph: 402-398-6060
 Creighton University Medical Center
 Gamini S. Soori Ph: 402-991-8070ext202
  Email: mwilwerding@mvcc.cc
 Immanuel Medical Center
 Gamini S. Soori Ph: 800-253-4368
 Lakeside Hospital
 Gamini S. Soori Ph: 800-253-4368
 Oncology Hematology West PC
 Gamini S. Soori Ph: 402-991-8070ext202
  Email: mwilwerding@mvcc.cc
 Oncology Hematology West, PC - Omaha Bergan
 Gamini S. Soori Ph: 402-991-8070ext202
  Email: mwilwerding@mvcc.cc
  Scottsbluff
 Cancer Treatment Center at Regional West Medical Center
 Gamini S. Soori Ph: 402-991-8070ext202
  Email: mwilwerding@mvcc.cc
Nevada
  Henderson
 21st Century Oncology - Henderson
 John Allan Ellerton Ph: 702-384-0013
 Cancer and Blood Specialists-Henderson
 John Allan Ellerton Ph: 702-384-0013
 Comprehensive Cancer Centers of Nevada - Henderson
 John Allan Ellerton Ph: 702-384-0013
 Comprehensive Cancer Centers of Nevada-Southeast Henderson
 John Allan Ellerton Ph: 702-384-0013
 Las Vegas Cancer Center - Henderson
 John Allan Ellerton Ph: 702-384-0013
  Las Vegas
 21st Century Oncology - Fort Apache
 John Allan Ellerton Ph: 702-384-0013
 21st Century Oncology - Vegas Sunrise
 John Allan Ellerton Ph: 702-384-0013
 21st Century Oncology - Vegas Tenaya
 John Allan Ellerton Ph: 702-384-0013
 Cancer and Blood Specialists-Fort Apache
 John Allan Ellerton Ph: 702-384-0013
 Cancer and Blood Specialists-Shadow
 John Allan Ellerton Ph: 702-384-0013
 Cancer and Blood Specialists-Tenaya
 John Allan Ellerton Ph: 702-384-0013
 Cancer Institute of Nevada at Summerlin Hospital Medical Center
 John Allan Ellerton Ph: 702-384-0013
 Cancer Therapy and Integrative Medicine
 John Allan Ellerton Ph: 702-384-0013
 CCOP - Nevada Cancer Research Foundation
 John Allan Ellerton Ph: 702-384-0013
 Comprehensive Cancer Centers of Nevada - Central Valley
 John Allan Ellerton Ph: 702-384-0013
 Comprehensive Cancer Centers of Nevada - Northwest
 John Allan Ellerton Ph: 702-384-0013
 Comprehensive Cancer Centers of Nevada - Southwest
 John Allan Ellerton Ph: 702-384-0013
 HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
 John Allan Ellerton Ph: 702-384-0013
 HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
 John Allan Ellerton Ph: 702-384-0013
 HealthCare Partners Medical Group Oncology/Hematology-San Martin
 John Allan Ellerton Ph: 702-384-0013
 HealthCare Partners Medical Group Oncology/Hematology-Tenaya
 John Allan Ellerton Ph: 702-384-0013
 Las Vegas Cancer Center-Medical Center
 John Allan Ellerton Ph: 702-384-0013
 Radiation Oncology Centers of Las Vegas - Downtown Location
 John Allan Ellerton Ph: 702-384-0013
 Radiation Oncology Centers of Las Vegas - Eastern Location
 John Allan Ellerton Ph: 702-384-0013
 University Medical Center of Southern Nevada
 John Allan Ellerton Ph: 702-384-0013
  Reno
 Abrass and Conrath Hematology - Oncology
 Vodur S Reddy Ph: 775-770-3854
 Alpine Hematology-Oncology
 Vodur S Reddy Ph: 775-770-3854
 Saint Mary's Regional Medical Center
 Vodur S Reddy Ph: 775-770-3854
New Hampshire
  Dover
 Seacoast Cancer Center at Wentworth - Douglass Hospital
 Barbara Shea Ph: 603-740-2150
  Portsmouth
 Portsmouth Regional Hospital
 Christine Wasilewski Ph: 603-433-5226
New Jersey
  Egg Harbor Township
 AtlantiCare Surgery Center
 Vijay K Sandilya Ph: 609-748-7200
  New Brunswick
 Saint Peter's University Hospital
 Sameer P Desai Ph: 888-823-5923
  Email: ctsucontact@westat.com
  Newark
 Newark Beth Israel Medical Center
 Lori Schleicher Ph: 973-926-7230
  Pennington
 Capital Health Medical Center-Hopewell
 Bernard Grossman Ph: 800-255-3440
  Vineland
 Frank and Edith Scarpa Regional Cancer Pavillion at South Jersey Healthcare
 Tami L Bach Ph: 856-641-7933
New York
  Auburn
 Hematology Oncology Associates of Central New York-Auburn
 Jeffrey J. Kirshner Ph: 315-472-7504
  Bronx
 Lincoln Medical and Mental Health Center
 Niyati Bhagwati Ph: 718-579-5000
  Buffalo
 Roswell Park Cancer Institute
 Ellis G. Levine Ph: 877-275-7724
  Cooperstown
 Bassett Healthcare Regional Cancer Program at Mary Imogene Bassett Hospital
 Eric Bravin Ph: 607-547-3073
  Email: diana.crean@bassett.org
  East Syracuse
 CCOP - Hematology-Oncology Associates of Central New York
 Jeffrey J. Kirshner Ph: 315-472-7504
  Elmhurst
 Elmhurst Hospital Center
 Mary Margaret Kemeny Ph: 718-883-3000
  Elmira
 Falck Cancer Center at Arnot Ogden Medical Center
 Jonathan W Friedberg Ph: 585-275-5830
  Jamaica
 Queens Cancer Center of Queens Hospital
 Mary Margaret Kemeny Ph: 718-883-3000
  New York
 Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center
 Norah L Henry Ph: 734-936-4991
  Email: norahh@med.umich.edu
  Rochester
 James P. Wilmot Cancer Center at University of Rochester Medical Center
 Jonathan W Friedberg Ph: 585-275-5830
  Staten Island
 Nalitt Cancer Institute at Staten Island University Hospital
 Meekoo Dhar Ph: 718-226-8888
  Syracuse
 Hematology Oncology Associates of Central New York-Onondaga Hill
 Jeffrey J. Kirshner Ph: 315-472-7504
  White Plains
 Dickstein Cancer Treatment Center at White Plains Hospital Center
 Karen B Green Ph: 914-681-2290
North Carolina
  Asheboro
 Randolph Hospital
 James M Granfortuna Ph: 336-832-0821
  Asheville
 Mission Hospitals - Memorial Campus
 Christopher H Chay Ph: 828-213-4150
  Clinton
 Southeastern Medical Oncology Center-Clinton
 James N. Atkins Ph: 919-580-0000
  Goldsboro
 Southeastern Medical Oncology Center - Goldsboro
 James N. Atkins Ph: 919-580-0000
 Wayne Memorial Hospital, Incorporated
 James N. Atkins Ph: 919-580-0000
  Greensboro
 Moses Cone Regional Cancer Center at Wesley Long Community Hospital
 James M Granfortuna Ph: 336-832-0821
  Hendersonville
 Comprehensive Cancer Center at Pardee Hospital
 James E. Radford Ph: 828-696-4716
 Hendersonville Hematology and Oncology
 James E. Radford Ph: 828-696-4716
 Park Ridge Hospital Breast Health Center
 James Dewitt Bearden Ph: 800-486-5941
  Jacksonville
 Southeastern Medical Oncology Center-Jacksonville
 James N. Atkins Ph: 919-580-0000
  Kernersville
 Novant Health Oncology Specialists-Kernersville
 Judith Owen Hopkins Ph: 336-277-8887
  Kinston
 Kinston Medical Specialists
 Peter R. Watson Ph: 252-559-2200
  Lexington
 Novant Health Oncology Specialists-Davidson County
 Judith Owen Hopkins Ph: 336-277-8887
  Mount Airy
 Novant Health Oncology Specialists-Mount Airy
 Judith Owen Hopkins Ph: 336-277-8887
  Pinehurst
 FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center
 Charles S Kuzma Ph: 910-715-2200
  Reidsville
 Annie Penn Cancer Center
 James M Granfortuna Ph: 336-832-0821
  Statesville
 Iredell Memorial Hospital
 Ruby A. Grimm Ph: 704-873-5661
  Stateville
 Novant Health Oncology Specialists-Statesville
 Judith Owen Hopkins Ph: 336-277-8887
  Wilkesboro
 Novant Health Oncology Specialists-Wilkesboro
 Judith Owen Hopkins Ph: 336-277-8887
  Wilson
 Southeastern Medical Oncology Center - Wilson
 James N. Atkins Ph: 919-580-0000
  Winston-Salem
 Forsyth Regional Cancer Center at Forsyth Medical Center
 Judith Owen Hopkins Ph: 336-277-8887
 Piedmont Hematology-Oncology Associates
 Judith Owen Hopkins Ph: 336-277-8887
 Winston-Salem Health Care
 Judith Owen Hopkins Ph: 336-277-8887
North Dakota
  Bismarck
 Medcenter One Hospital Cancer Care Center
 Preston D. Steen Ph: 701-234-6161
  Fargo
 Dakota Cancer Institute at Dakota Clinic - South University
 Bret E Friday Ph: 888-203-7267
 Roger Maris Cancer Center at MeritCare Hospital
 Preston D. Steen Ph: 701-234-6161
 Preston D. Steen Ph: 701-234-6161
 Sanford Clinic North-Fargo
 Preston D. Steen Ph: 701-234-6161
  Grand Forks
 Altru Cancer Center at Altru Hospital
 Grant R Seeger Ph: 701-780-6520
  Minot
 Trinity CancerCare Center
 Patanit Watanaboonyakhet Ph: 800-862-0005
Ohio
  Akron
 McDowell Cancer Center at Akron General Medical Center
 Esther H. Rehmus Ph: 330-344-6348
  Belpre
 Strecker Cancer Center-Belpre
 J. Philip Kuebler Ph: 614-566-3275
  Chillicothe
 Adena Regional Medical Center
 J. Philip Kuebler Ph: 614-566-3275
  Cincinnati
 Oncology Hematology Care Inc - Western Hills
 Howard M. Gross Ph: 937-775-1350
 Oncology Hematology Care, Incorporated - Anderson
 Howard M. Gross Ph: 937-775-1350
 Oncology Hematology Care, Incorporated - Blue Ash
 Howard M. Gross Ph: 937-775-1350
 Oncology Hematology Care, Incorporated - Kenwood
 Howard M. Gross Ph: 937-775-1350
 Oncology Hematology Care, Incorporated - Mt. Auburn/Taft Road
 Howard M. Gross Ph: 937-775-1350
  Columbus
 Columbus Oncology Associates, Incorporated
 J. Philip Kuebler Ph: 614-566-3275
 Doctors Hospital at Ohio Health
 J. Philip Kuebler Ph: 614-566-3275
 Grant Medical Center Cancer Care
 J. Philip Kuebler Ph: 614-566-3275
 Mount Carmel Health - West Hospital
 J. Philip Kuebler Ph: 614-566-3275
 Riverside Methodist Hospital Cancer Care
 J. Philip Kuebler Ph: 614-566-3275
 Zangmeister Center
 J. Philip Kuebler Ph: 614-566-3275
  Dayton
 David L. Rike Cancer Center at Miami Valley Hospital
 Howard M. Gross Ph: 937-775-1350
 Good Samaritan Hospital
 Howard M. Gross Ph: 937-775-1350
 Samaritan North Cancer Care Center
 Howard M. Gross Ph: 937-775-1350
  Delaware
 Delaware Health Center
 J. Philip Kuebler Ph: 614-566-3275
 Delaware Radiation Oncology
 J. Philip Kuebler Ph: 614-566-3275
 Grady Memorial Hospital
 J. Philip Kuebler Ph: 614-566-3275
  Fairfield
 Oncology Hematology Care, Incorporated - Fairfield Healthplex
 Howard M. Gross Ph: 937-775-1350
  Findlay
 Blanchard Valley Regional Cancer Center
 Howard M. Gross Ph: 937-775-1350
  Franklin
 Atrium Medical Center
 Howard M. Gross Ph: 937-775-1350
  Greenville
 Wayne Hospital
 Howard M. Gross Ph: 937-775-1350
  Kettering
 Charles F. Kettering Memorial Hospital
 Howard M. Gross Ph: 937-775-1350
  Lancaster
 Fairfield Medical Center
 J. Philip Kuebler Ph: 614-566-3275
  Lima
 St. Rita's Medical Center
 Henry Gerad Ph: 419-226-9617
  Marietta
 Strecker Cancer Center at Marietta Memorial Hospital
 J. Philip Kuebler Ph: 614-566-3275
  Maumee
 Northwest Ohio Oncology Center
 Rex B Mowat Ph: 517-265-0116
 Rex B Mowat Ph: 517-265-0116
  Mount Vernon
 Knox Community Hospital
 J. Philip Kuebler Ph: 614-566-3275
  Newark
 Licking Memorial Cancer Care Program at Licking Memorial Hospital
 J. Philip Kuebler Ph: 614-566-3275
 Newark Radiation Oncology
 J. Philip Kuebler Ph: 614-566-3275
  Oregon
 St. Charles Mercy Hospital
 Rex B Mowat Ph: 517-265-0116
  Portsmouth
 Southern Ohio Medical Center Cancer Center
 J. Philip Kuebler Ph: 614-566-3275
  Springfield
 Community Hospital of Springfield and Clark County
 J. Philip Kuebler Ph: 614-566-3275
  Sylvania
 Flower Hospital Cancer Center
 Rex B Mowat Ph: 517-265-0116
  Toledo
 St. Anne Mercy Hospital
 Rex B Mowat Ph: 517-265-0116
 Toledo Clinic, Incorporated - Main Clinic
 Rex B Mowat Ph: 517-265-0116
 University of Toledo Medical Center
 Rex B Mowat Ph: 517-265-0116
  Troy
 UVMC Cancer Care Center at Upper Valley Medical Center
 Howard M. Gross Ph: 937-775-1350
  Westerville
 Mount Carmel St. Ann's Cancer Center
 J. Philip Kuebler Ph: 614-566-3275
  Zanesville
 Genesis - Good Samaritan Hospital
 J. Philip Kuebler Ph: 614-566-3275
Oregon
  Clackamas
 Clackamas Radiation Oncology Center
 Kelly S Perlewitz Ph: 503-537-1463
  Corvallis
 Good Samaritan Hospital
 David M Hufnagel Ph: 888-823-5923
  Email: ctsucontact@westat.com
  Newberg
 Providence Newberg Medical Center
 Kelly S Perlewitz Ph: 503-537-1463
  Oregon City
 Willamette Falls Hospital
 Kelly S Perlewitz Ph: 503-537-1463
  Portland
 Knight Cancer Institute at Oregon Health and Science University
 Kathleen A. Kemmer Ph: 503-494-1080
  Email: trials@ohsu.edu
 Providence Cancer Center at Providence Portland Medical Center
 Kelly S Perlewitz Ph: 503-537-1463
 Providence St. Vincent Medical Center
 Kelly S Perlewitz Ph: 503-537-1463
Pennsylvania
  Allentown
 Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest
 Eliot Lawrence Friedman Ph: 610-402-2273
  Danville
 Geisinger Cancer Institute at Geisinger Health
 Victor Gerald Vogel Ph: 570-271-5251
  Doylestown
 Doylestown Hospital Cancer Center
 Mitchell Alden Ph: 215-345-2378
  Email: lheacock@dh.org
  Easton
 Easton Regional Cancer Center at Easton Hospital
 Sonyo Shin Ph: 610-250-4000
  Hazleton
 Geisinger Hazleton Cancer Center
 Victor Gerald Vogel Ph: 570-271-5251
  Lewisburg
 Geisinger Medical Oncology at Evangelical Community Hospital
 Victor Gerald Vogel Ph: 570-271-5251
  Lewistown
 Lewistown Hospital
 Victor Gerald Vogel Ph: 570-271-5251
  Phoenixville
 Cancer Center at Phoenixville Hospital
 Carl W. Sharer Ph: 610-983-1908
  Pottstown
 Pottstown Memorial Regional Cancer Center
 Wei Song Ph: 610-327-7544
  Pottsville
 Geisinger Medical Oncology-Pottsville
 Victor Gerald Vogel Ph: 570-271-5251
  State College
 Geisinger Medical Group - Scenery Park
 Victor Gerald Vogel Ph: 570-271-5251
  West Reading
 McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center
 Terrence P. Cescon Ph: 610-988-9323
  Wilkes-Barre
 Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
 Victor Gerald Vogel Ph: 570-271-5251
  Williamsport
 Susquehanna Cancer Center at Divine Providence Hospital
 Warren L Robinson Ph: 800-598-4282
South Carolina
  Anderson
 AnMed Cancer Center
 James Dewitt Bearden Ph: 800-486-5941
  Beaufort
 Keyserling Cancer Center at Beaufort Memorial Hospital
 Majd Chahin Ph: 843-522-7819
  Charleston
 Charleston Hematology Oncology Associates PA-St. Francis
 James Michael Orcutt Ph: 843-720-8386
  Email: elizabeth.strojny@roperstfrancis.com
 Charleston Hematology Oncology Associates, PA
 James Michael Orcutt Ph: 843-720-8386
  Email: elizabeth.strojny@roperstfrancis.com
 Lowcountry Hematology Oncology PA-Charleston
 James Michael Orcutt Ph: 843-720-8386
  Email: elizabeth.strojny@roperstfrancis.com
 Lowcountry Hematology Oncology PA-West Ashley
 James Michael Orcutt Ph: 843-720-8386
  Email: elizabeth.strojny@roperstfrancis.com
 Roper St. Francis Cancer Center at Roper Hospital
 James Michael Orcutt Ph: 843-720-8386
  Email: elizabeth.strojny@roperstfrancis.com
  Florence
 McLeod Regional Medical Center
 Rajesh Bajaj Ph: 843-679-7256
  Greenville
 Bon Secours St. Francis Health System
 James Dewitt Bearden Ph: 800-486-5941
 Cancer Centers of the Carolinas - Faris Road
 Jeffrey Kent Giguere Ph: 864-241-6251
 Cancer Centers of the Carolinas - Grove Commons
 Jeffrey Kent Giguere Ph: 864-241-6251
 CCOP - Greenville
 Jeffrey Kent Giguere Ph: 864-241-6251
 Greenville Memorial Hospital
 Jeffrey Kent Giguere Ph: 864-241-6251
  Greenwood
 Self Regional Cancer Center at Self Regional Medical Center
 Joanna K Metzner-Sadurski Ph: 864-725-4771
  Greer
 Cancer Centers of the Carolinas - Greer Radiation Oncology
 Jeffrey Kent Giguere Ph: 864-241-6251
  Mount Pleasant
 Lowcountry Hematology and Oncology, PA
 James Michael Orcutt Ph: 843-720-8386
  Email: elizabeth.strojny@roperstfrancis.com
  Seneca
 Cancer Centers of the Carolinas - Seneca
 Jeffrey Kent Giguere Ph: 864-241-6251
  Spartanburg
 Cancer Centers of the Carolinas - Spartanburg
 Jeffrey Kent Giguere Ph: 864-241-6251
 Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
 James Dewitt Bearden Ph: 800-486-5941
South Dakota
  Rapid City
 Rapid City Regional Hospital
 Mark T Schroeder Ph: 605-716-3982
  Email: research@rcrh.org
  Sioux Falls
 Sanford Cancer Center at Sanford USD Medical Center
 Preston D. Steen Ph: 701-234-6161
 Preston D. Steen Ph: 701-234-6161
Tennessee
  Bartlett
 Boston Baskin Cancer Center-Bartlett
 Raymond U Osarogiagbon Ph: 901-448-3303
  Memphis
 Baptist Centers for Cancer Care
 Raymond U Osarogiagbon Ph: 901-448-3303
 Family Cancer Center-Memphis
 Raymond U Osarogiagbon Ph: 901-448-3303
Texas
  Amarillo
 Harrington Cancer Center
 Brian T. Pruitt Ph: 806-359-4673
  Email: ryokubaitis@harringtoncc.org
  Laredo
 Doctor's Hospital of Laredo
 Gary W. Unzeitig Ph: 888-823-5923
  Email: ctsucontact@westat.com
Virginia
  Burke
 Kaiser Permanente at Burke Medical Center
 Mahrukh M Hussain Ph: 301-816-7446
  Charlottesville
 Martha Jefferson Hospital Cancer Care Center
 Erika J Struble Ph: 434-654-8400
  Fairfax
 Medical Oncology and Hematology Associates of North Virginia - Fairfax
 Mary J Wilkinson Ph: 703-720-5210ext1044
  McLean
 Kaiser Permanente Tysons Corner Medical Center
 Mahrukh M Hussain Ph: 301-816-7446
  Midlothian
 Bon Secours Cancer Institute - Virginia Breast Center
 William J Irvin Ph: 804-594-4900
  Richmond
 Bon Secours Cancer Institute at St. Mary's Hospital
 William J Irvin Ph: 804-594-4900
Washington
  Longview
 Lower Columbia Regional Cancer Center at PeaceHealth-St. John Medical Center
 Kelly S Perlewitz Ph: 503-537-1463
  Vancouver
 Northwest Cancer Specialists at Vancouver Cancer Center
 Kelly S Perlewitz Ph: 503-537-1463
 Southwest Washington Medical Center Cancer Center
 Kelly S Perlewitz Ph: 503-537-1463
Wisconsin
  Antigo
 Langlade Memorial Hospital
 Christopher G Peterson Ph: 877-405-6866
  Chippewa Falls
 Marshfield Clinic - Chippewa Center
 Rezwan Islam Ph: 715-393-1400
  Eau Claire
 Marshfield Clinic Cancer Care at Regional Cancer Center
 Rezwan Islam Ph: 715-393-1400
  Green Bay
 Green Bay Oncology, Limited at St. Mary's Hospital
 Matthew L Ryan Ph: 800-432-6049
 Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center
 Matthew L Ryan Ph: 800-432-6049
 St. Mary's Hospital Medical Center - Green Bay
 Matthew L Ryan Ph: 800-432-6049
 St. Vincent Hospital Regional Cancer Center
 Matthew L Ryan Ph: 800-432-6049
  Janesville
 Mercy Regional Cancer Center
 Robert Delaune Ph: 800-928-1103
  Manitowoc
 Holy Family Memorial Medical Center Cancer Care Center
 Matthew L Ryan Ph: 800-432-6049
  Marinette
 Bay Area Cancer Care Center at Bay Area Medical Center
 Matthew L Ryan Ph: 800-432-6049
  Marshfield
 Marshfield Clinic - Marshfield Center
 Rezwan Islam Ph: 715-393-1400
  Minocqua
 Marshfield Clinic - Lakeland Center
 Rezwan Islam Ph: 715-393-1400
  New Richmond
 Cancer Center of Western Wisconsin
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Oconto Falls
 Green Bay Oncology, Limited - Oconto Falls
 Matthew L Ryan Ph: 800-432-6049
  Rhinelander
 Ministry Medical Group at Saint Mary's Hospital
 Rezwan Islam Ph: 715-393-1400
  Rice Lake
 Marshfield Clinic - Indianhead Center
 Rezwan Islam Ph: 715-393-1400
  Sheboygan
 Saint Nicholas Hospital
 Matthew L Ryan Ph: 800-432-6049
  Stevens Point
 Marshfield Clinic at Saint Michael's Hospital
 Rezwan Islam Ph: 715-393-1400
  Sturgeon Bay
 Green Bay Oncology, Limited - Sturgeon Bay
 Matthew L Ryan Ph: 800-432-6049
  Wausau
 Marshfield Clinic - Wausau Center
 Rezwan Islam Ph: 715-393-1400
 University of Wisconcin Cancer Center at Aspirus Wausau Hospital
 Christopher G Peterson Ph: 877-405-6866
  Weston
 Marshfield Clinic - Weston Center
 Rezwan Islam Ph: 715-393-1400
  Wisconsin Rapids
 Marshfield Clinic - Wisconsin Rapids Center
 Rezwan Islam Ph: 715-393-1400
Wyoming
  Sheridan
 Welch Cancer Center at Sheridan Memorial Hospital
 Benjamin Thomas Marchello Ph: 800-648-6274

Link to the current ClinicalTrials.gov record.
NLM Identifer NCT01598298
ClinicalTrials.gov processed this data on November 12, 2014

Note: Information about this trial is from the ClinicalTrials.gov database. The versions designated for health professionals and patients contain the same text. Minor changes may be made to the ClinicalTrials.gov record to standardize the names of study sponsors, sites, and contacts. Cancer.gov only lists sites that are recruiting patients for active trials, whereas ClinicalTrials.gov lists all sites for all trials. Questions and comments regarding the presented information should be directed to ClinicalTrials.gov.

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