Basic Trial Information
Trial Description
Summary
Further Trial Information
Eligibility Criteria
Trial Contact Information
| Phase | Type | Status | Age | Sponsor | Protocol IDs |
|---|---|---|---|---|---|
| Phase III | Biomarker/Laboratory analysis, Treatment | Active | 3 to 21 | NCI, Other | ACNS0332 NCI-2009-00336, COG-ACNS0332, CDR0000511991, U10CA098543, R01CA114567, NCT00392327 |
Summary
This randomized phase III trial is studying different chemotherapy and radiation therapy regimens to compare how well they work in treating young patients with newly diagnosed, previously untreated, high-risk medulloblastoma or supratentorial primitive neuroectodermal tumor. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Isotretinoin may help chemotherapy work better by making tumor cells more sensitive to the drugs. Radiation therapy uses high-energy x-rays to kill tumor cells. Carboplatin may make tumor cells more sensitive to radiation therapy. It is not yet known which chemotherapy and radiation therapy regimen is more effective in treating brain tumors.
Further Study Information
PRIMARY OBJECTIVES:
I. Determine whether carboplatin radiosensitization increases long-term, event-free survival of pediatric patients with newly diagnosed, previously untreated, high-risk medulloblastoma or supratentorial primitive neuroectodermal tumors.
II. Determine whether isotretinoin increases long-term, event-free survival of these patients.
SECONDARY OBJECTIVES:
I. Compare residual disease response to radiotherapy alone versus radiotherapy and carboplatin in these patients.
II. Identify molecular prognostic indicators suitable for patient stratification in future trials.
OUTLINE: This is a randomized, open-label, factorial-designed, multicenter study. Patients are stratified according to location of disease and dissemination status (M0 medulloblastoma with > 1.5 cm² residual tumor vs M+ medulloblastoma vs M0 supratentorial primitive neuroectodermal tumor [SPNET] with < 1.5 cm² residual tumor vs M0 SPNET with > 1.5 cm² residual tumor vs M+ SPNET vs M0 diffusely anaplastic medulloblastoma). Patients are randomized to 1 of 4 treatment arms.
ARM I (standard chemoradiotherapy and standard maintenance therapy):
CHEMOTHERAPY: Patients undergo radiotherapy once daily on days 1-5, 8-12, 15-19, 22-26, 29-33, and 36-40 and receive vincristine IV over 1 minute on days 1, 8, 15, 22, 29, and 36. Six weeks after completion of chemoradiotherapy, patients proceed to maintenance therapy.
MAINTENANCE THERAPY: Patients receive cisplatin IV over 6 hours on day 1, vincristine IV over 1 minute on days 1 and 8, and cyclophosphamide IV over 1 hour on days 2 and 3. Patients also receive filgrastim (G-CSF) subcutaneously (SC) or IV beginning on day 4 and continuing until blood counts recover (at least 10 days).
Treatment repeats every 28 days for a total of 6 courses in the absence of disease progression or unacceptable toxicity.
ARM II (standard chemoradiotherapy plus carboplatin and standard maintenance therapy):
CHEMORADIOTHERAPY: Patients receive carboplatin IV over 15 minutes once daily on days 1-5, 8-12, 15-19, 22-26, 29-33, and 36-40 and undergo radiotherapy and receive vincristine as in arm I. Six weeks after completion of chemoradiotherapy, patients proceed to maintenance therapy.
MAINTENANCE THERAPY: Patients receive maintenance therapy as in arm I.
ARM III (standard chemoradiotherapy, standard maintenance therapy plus isotretinoin, and continuation therapy with isotretinoin):
CHEMORADIOTHERAPY: Patients undergo chemoradiotherapy as in arm I. Six weeks after completion of chemoradiotherapy, patients proceed to maintenance therapy.
MAINTENANCE THERAPY: Patients receive oral isotretinoin twice daily on day 1 and days 16-28 and cisplatin, vincristine, cyclophosphamide, and G-CSF as in arm I maintenance therapy.
Treatment repeats every 28 days for a total of 6 courses in the absence of disease progression or unacceptable toxicity.
Patients then proceed to continuation therapy.
CONTINUATION THERAPY: Patients receive oral isotretinoin twice daily on days 15-28.
Treatment repeats every 28 days for up to 6 courses in the absence of disease progression or unacceptable toxicity.
ARM IV (standard chemoradiotherapy plus carboplatin, standard maintenance therapy plus isotretinoin, and continuation therapy with isotretinoin):
CHEMORADIOTHERAPY: Patients undergo chemoradiotherapy as in arm II. Six weeks after completion of chemoradiotherapy, patients proceed to maintenance therapy.
MAINTENANCE THERAPY: Patients receive maintenance therapy as in arm III. Patients then proceed to continuation therapy.
CONTINUATION THERAPY: Patients receive continuation therapy as in arm III.
After completion of study treatment, patients are followed up periodically for up to 10 years.
Eligibility Criteria
Inclusion Criteria:
- Histologically confirmed diagnosis of medulloblastoma or supratentorial primitive neuroectodermal tumor (PNET)
- Newly diagnosed disease
- Previously untreated disease
- Meets 1 of the following criteria:
- M0 medulloblastoma with > 1.5 cm² residual tumor
- M+ medulloblastoma
- M0 or M+ supratentorial PNET (including pineoblastoma)
- Diffusely anaplastic medulloblastoma with any M-stage or residual tumor
- Must have undergone stereotactic biopsy or attempted neurosurgical resection of the tumor within the past 31 days
- The following procedures are required:
- Pre-operative MRI of the brain with and without contrast
- Post-operative (preferably within 72 hours after surgery) MRI of the brain with and without contrast**
- Spinal MRI with and without contrast within 10 days before surgery or 28 days after surgery
- Lumbar cerebrospinal fluid (CSF) cytological examination obtained pre-operatively or within 31 days after surgery***
- No M4 disease
- Karnofsky performance status (PS) 30-100% (for patients > 16 years of age) OR Lansky PS 30-100% (for patients ≤ 16 years of age)
- Life expectancy > 8 weeks
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use 2 effective forms of contraception
- Creatinine normal OR creatinine clearance or radioisotope glomerular filtration rate ≥ 70 mL/min OR serum creatinine based on age and/or gender as follows:
- 0.4 mg/dL (1 month to < 6 months of age)
- 0.5 mg/dL (6 months to < 1 year of age)
- 0.6 mg/dL (1 to < 2 years of age)
- 0.8 mg/dL (2 to < 6 years of age)
- 1.0 mg/dL (6 to < 10 years of age)
- 1.2 mg/dL (10 to < 13 years of age)
- 1.5 mg/dL (male) or 1.4 mg/dL (female) (13 to < 16 years of age)
- 1.7 mg/dL (male) or 1.4 mg/dL (female) (≥ 16 years of age)
- Bilirubin < 1.5 times upper limit of normal (ULN)
- AST and ALT < 2.5 times ULN (5 times ULN for patients on antiseizure medications)
- Absolute neutrophil count ≥ 1,000/mm³
- Platelet count ≥ 100,000/mm³ (transfusions not allowed)
- Hemoglobin ≥ 8 g/dL (transfusions allowed)
- No concurrent corticosteroids as an antiemetic during chemotherapy
- No prior chemotherapy or radiotherapy
- No other concurrent experimental therapy
- No concurrent isotretinoin for acne treatment
Trial Lead Organizations/Sponsors
Children's Oncology Group
National Cancer Institute| James Olson |  | Principal Investigator |
Trial Sites
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| U.S.A. | |||
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| Alabama | |||
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| Birmingham | |||
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| Children's Hospital of Alabama at University of Alabama at Birmingham | |||
| Alyssa T Reddy | Ph: 205-934-0309 | ||
| UAB Comprehensive Cancer Center | |||
| Alyssa T Reddy | Ph: 205-934-0309 | ||
| Arkansas | |||
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| Little Rock | |||
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| Arkansas Cancer Research Center at University of Arkansas for Medical Sciences | |||
| David L Becton | Ph: 501-364-7373 | ||
| California | |||
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| Arcadia | |||
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| Children's Oncology Group | |||
| James M Olson | Ph: 206-667-7955 | ||
| Email: jolson@fhcrc.org | |||
| Loma Linda | |||
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| Loma Linda University Cancer Institute at Loma Linda University Medical Center | |||
| Antranik A Bedros | Ph: 909-558-3375 | ||
| Long Beach | |||
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| Jonathan Jaques Children's Cancer Center at Miller Children's Hospital | |||
| Shadi Farzin-Gohar | Ph: 909-558-3375 | ||
| Los Angeles | |||
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| Childrens Hospital Los Angeles | |||
| Leo Mascarenhas | Ph: 323-361-4110 | ||
| Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center | |||
| Carole H Hurvitz | Ph: 310-423-8965 | ||
| Madera | |||
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| Children's Hospital Central California | |||
| Vonda L Crouse | Ph: 866-353-5437 | ||
| Oakland | |||
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| Children's Hospital and Research Center Oakland | |||
| Joseph C Torkildson | Ph: 510-450-7600 | ||
| Kaiser Permanente-Oakland | |||
| Vincent A Kiley | Ph: 626-564-3455 | ||
| Orange | |||
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| Children's Hospital of Orange County | |||
| Violet Shen | Ph: 714-997-3000 | ||
| Palo Alto | |||
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| Lucile Packard Children's Hospital at Stanford University Medical Center | |||
| Neyssa M Marina | Ph: 650-498-7061 | ||
| Email: clinicaltrials@med.stanford.edu | |||
| Sacramento | |||
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| University of California Davis Cancer Center | |||
| Jay Michael S Balagtas | Ph: 916-734-3089 | ||
| San Diego | |||
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| Rady Children's Hospital - San Diego | |||
| William D Roberts | Ph: 858-966-5934 | ||
| San Francisco | |||
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| UCSF Helen Diller Family Comprehensive Cancer Center | |||
| Anuradha Banerjee | Ph: 877-827-3222 | ||
| Connecticut | |||
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| Hartford | |||
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| Connecticut Children's Medical Center | |||
| Michael S Isakoff | Ph: 860-545-9981 | ||
| New Haven | |||
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| Yale Cancer Center | |||
| Nina S Kadan-Lottick | Ph: 203-785-5702 | ||
| Delaware | |||
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| Wilmington | |||
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| Alfred I. duPont Hospital for Children | |||
| Christopher N Frantz | Ph: 302-651-5755 | ||
| District of Columbia | |||
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| Washington | |||
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| Children's National Medical Center | |||
| Jeffrey S Dome | Ph: 202-884-2549 | ||
| Florida | |||
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| Fort Myers | |||
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| Lee Cancer Care of Lee Memorial Health System | |||
| Emad K Salman | Ph: 239-343-5333 | ||
| Hollywood | |||
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| Joe DiMaggio Children's Hospital | |||
| Iftikhar Hanif | Ph: 954-265-2234 | ||
| Jacksonville | |||
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| Nemours Children's Clinic | |||
| Eric S Sandler | Ph: 904-697-3529 | ||
| Miami | |||
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| University of Miami Sylvester Comprehensive Cancer Center - Miami | |||
| Julio C Barredo | Ph: 866-574-5124 | ||
| Email: Sylvester@emergingmed.com | |||
| Orlando | |||
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| Florida Hospital Cancer Institute at Florida Hospital Orlando | |||
| Clifford A Selsky | Ph: 407-303-5623 | ||
| M.D. Anderson Cancer Center at Orlando | |||
| Vincent F Giusti | Ph: 321-841-7246 | ||
| Nemours Children's Clinic - Orlando | |||
| Ramamoorthy Nagasubramanian | Ph: 407-650-7150 | ||
| Pensacola | |||
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| Nemours Children's Clinic - Pensacola | |||
| Jeffrey H Schwartz | Ph: 904-697-3529 | ||
| Saint Petersburg | |||
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| All Children's Hospital | |||
| Gregory A Hale | Ph: 727-767-2423 | ||
| Email: HamblinF@allkids.org | |||
| Tampa | |||
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| St. Joseph's Children's Hospital of Tampa | |||
| Hardeo K Panchoosingh | Ph: 800-882-4123 | ||
| West Palm Beach | |||
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| Kaplan Cancer Center at St. Mary's Medical Center | |||
| Narayana Gowda | Ph: 888-823-5923 | ||
| Email: ctsucontact@westat.com | |||
| Georgia | |||
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| Atlanta | |||
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| AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Egleston Campus | |||
| Howard M Katzenstein | Ph: 888-785-1112 | ||
| Savannah | |||
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| Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center | |||
| J. Martin Johnston | Ph: 912-350-8568 | ||
| Hawaii | |||
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| Honolulu | |||
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| Cancer Research Center of Hawaii | |||
| Robert W Wilkinson | Ph: 808-983-6090 | ||
| Idaho | |||
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| Boise | |||
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| Mountain States Tumor Institute at St. Luke's Regional Medical Center | |||
| Eugenia Chang | Ph: 800-845-4624 | ||
| Illinois | |||
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| Chicago | |||
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| Ann and Robert H. Lurie Children's Hospital of Chicago | |||
| David O Walterhouse | Ph: 773-880-4562 | ||
| University of Chicago Cancer Research Center | |||
| Susan L Cohn | Ph: 773-834-7424 | ||
| University of Illinois Cancer Center | |||
| Mary L Schmidt | Ph: 312-355-3046 | ||
| Maywood | |||
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| Cardinal Bernardin Cancer Center at Loyola University Medical Center | |||
| Ricarchito B Manera | Ph: 708-226-4357 | ||
| Oak Lawn | |||
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| Keyser Family Cancer Center at Advocate Hope Children's Hospital | |||
| Sharad N Salvi | Ph: 847-723-7570 | ||
| Park Ridge | |||
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| Advocate Lutheran General Cancer Care Center | |||
| Jong H Kwon | Ph: 847-384-3621 | ||
| Peoria | |||
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| Saint Jude Midwest Affiliate | |||
| Pedro A De Alarcon | Ph: 309-655-3258 | ||
| Springfield | |||
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| Simmons Cooper Cancer Institute | |||
| Gregory P Brandt | Ph: 217-545-7929 | ||
| Indiana | |||
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| Indianapolis | |||
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| Riley's Children Cancer Center at Riley Hospital for Children | |||
| Robert J Fallon | Ph: 317-274-2552 | ||
| St. Vincent Indianapolis Hospital | |||
| Bassem I Razzouk | Ph: 317-338-2194 | ||
| Iowa | |||
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| Des Moines | |||
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| Blank Children's Hospital | |||
| Wendy L Woods-Swafford | Ph: 888-823-5923 | ||
| Email: ctsucontact@westat.com | |||
| Iowa City | |||
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| Holden Comprehensive Cancer Center at University of Iowa | |||
| Ayman A El-Sheikh | Ph: 800-237-1225 | ||
| Kentucky | |||
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| Lexington | |||
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| University of Kentucky Chandler Medical Center | |||
| Martha F Greenwood | Ph: 859-257-3379 | ||
| Louisville | |||
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| Kosair Children's Hospital | |||
| Salvatore J Bertolone | Ph: 866-530-5516 | ||
| Louisiana | |||
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| New Orleans | |||
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| Children's Hospital of New Orleans | |||
| Lolie C Yu | Ph: 504-894-5377 | ||
| Tulane Cancer Center at Tulane University Hospital and Clinic | |||
| Tammuella C Singleton | Ph: 504-988-6121 | ||
| Maryland | |||
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| Baltimore | |||
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| Greenebaum Cancer Center at University of Maryland Medical Center | |||
| Teresa A York | Ph: 800-888-8823 | ||
| Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | |||
| Kenneth J Cohen | Ph: 410-955-8804 | ||
| Email: jhcccro@jhmi.edu | |||
| Bethesda | |||
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| National Naval Medical Center | |||
| Anne B Warwick | Ph: 301-319-2100 | ||
| Massachusetts | |||
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| Boston | |||
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| Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute | |||
| Carlos Rodriguez-Galindo | Ph: 866-790-4500 | ||
| Floating Hospital for Children at Tufts - New England Medical Center | |||
| Johannes E Wolff | Ph: 617-636-5000 | ||
| Email: ContactUsCancerCenter@TuftsMedicalCenter.org | |||
| Massachusetts General Hospital | |||
| Howard J Weinstein | Ph: 877-726-5130 | ||
| Michigan | |||
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| Ann Arbor | |||
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| C.S. Mott Children's Hospital at University of Michigan Medical Center | |||
| Patricia L Robertson | Ph: 800-865-1125 | ||
| Detroit | |||
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| Van Elslander Cancer Center at St. John Hospital and Medical Center | |||
| Hadi Sawaf | Ph: 313-343-3166 | ||
| Wayne State University | |||
| Kanta Bhambhani | Ph: 313-576-9363 | ||
| Grand Rapids | |||
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| Helen DeVos Children's Hospital at Spectrum Health | |||
| David S Dickens | Ph: 616-267-1925 | ||
| Kalamazoo | |||
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| Bronson Methodist Hospital | |||
| Jeffrey S Lobel | Ph: 800-227-2345 | ||
| Western Michigan University School of Medicine Clinics | |||
| Jeffrey S Lobel | Ph: 800-227-2345 | ||
| Minnesota | |||
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| Minneapolis | |||
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| Children's Hospitals and Clinics of Minnesota - Minneapolis | |||
| Bruce C Bostrom | Ph: 612-813-5193 | ||
| Masonic Cancer Center at University of Minnesota | |||
| Christopher L Moertel | Ph: 612-624-2620 | ||
| Rochester | |||
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| Mayo Clinic Cancer Center | |||
| Carola A. S. Arndt | Ph: 507-538-7623 | ||
| Mississippi | |||
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| Jackson | |||
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| University of Mississippi Cancer Clinic | |||
| Betty L Herrington | Ph: 601-815-6700 | ||
| Missouri | |||
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| Kansas City | |||
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| Children's Mercy Hospital | |||
| Maxine L Hetherington | Ph: 816-234-3265 | ||
| Saint Louis | |||
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| Cardinal Glennon Children's Hospital | |||
| William S Ferguson | Ph: 314-268-4000 | ||
| David C. Pratt Cancer Center at St. John's Mercy | |||
| Bethany G. Sleckman | Ph: 913-948-5588 | ||
| Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis | |||
| Joshua B Rubin | Ph: 800-600-3606 | ||
| Email: info@siteman.wustl.edu | |||
| Nebraska | |||
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| Omaha | |||
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| Children's Hospital | |||
| Minnie Abromowitch | Ph: 402-955-3949 | ||
| Nevada | |||
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| Las Vegas | |||
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| CCOP - Nevada Cancer Research Foundation | |||
| Jonathan Bernstein | Ph: 702-384-0013 | ||
| New Hampshire | |||
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| Lebanon | |||
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| Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center | |||
| Sara Chaffee | Ph: 800-639-6918 | ||
| Email: cancer.research.nurse@dartmouth.edu | |||
| New Jersey | |||
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| Hackensack | |||
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| Hackensack University Medical Center Cancer Center | |||
| Burton E Appel | Ph: 201-996-2879 | ||
| Livingston | |||
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| St. Barnabas Medical Center Cancer Center | |||
| Stacey Rifkin-Zenenberg | Ph: 973-926-7230 | ||
| Morristown | |||
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| Carol G. Simon Cancer Center at Morristown Memorial Hospital | |||
| Steven L Halpern | Ph: 973-971-5900 | ||
| New Brunswick | |||
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| Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School | |||
| Richard A Drachtman | Ph: 732-235-8675 | ||
| Saint Peter's University Hospital | |||
| Stanley Calderwood | Ph: 732-745-8600ext6163 | ||
| Email: kcovert@saintpetersuh.com | |||
| Newark | |||
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| Newark Beth Israel Medical Center | |||
| Peri Kamalakar | Ph: 973-926-7230 | ||
| Paterson | |||
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| St. Joseph's Hospital and Medical Center | |||
| Mary A Bonilla | Ph: 973-754-2909 | ||
| Summit | |||
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| Overlook Hospital | |||
| Steven L Halpern | Ph: 973-971-5900 | ||
| New Mexico | |||
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| Albuquerque | |||
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| University of New Mexico Cancer Center | |||
| Koh B Boayue | Ph: 505-272-6972 | ||
| New York | |||
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| Albany | |||
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| Albany Medical Center Hospital | |||
| Vikramjit S Kanwar | Ph: 518-262-3368 | ||
| Bronx | |||
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| Montefiore Medical Center | |||
| Rosanna J Ricafort | Ph: 718-904-2730 | ||
| Email: aecc@aecom.yu.edu | |||
| Buffalo | |||
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| Roswell Park Cancer Institute | |||
| Martin L Brecher | Ph: 877-275-7724 | ||
| Mineola | |||
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| Winthrop University Hospital | |||
| Mark E Weinblatt | Ph: 866-946-8476 | ||
| New York | |||
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| Memorial Sloan-Kettering Cancer Center | |||
| Peter G Steinherz | Ph: 212-639-7202 | ||
| New York University Medical Center | |||
| Jeffrey C Allen | Ph: 212-263-4434 | ||
| Email: prmc.coordinator@nyumc.org | |||
| Rochester | |||
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| James P. Wilmot Cancer Center at University of Rochester Medical Center | |||
| Lisa R Hackney | Ph: 585-275-5830 | ||
| Stony Brook | |||
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| Stony Brook University Cancer Center | |||
| Robert I Parker | Ph: 800-862-2215 | ||
| Syracuse | |||
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| SUNY Upstate Medical University Hospital | |||
| Karol H Kerr | Ph: 315-464-5476 | ||
| Valhalla | |||
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| New York Medical College | |||
| Mehmet F Ozkaynak | Ph: 914-594-3794 | ||
| North Carolina | |||
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| Chapel Hill | |||
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| Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill | |||
| Stuart H Gold | Ph: 877-668-0683 | ||
| Charlotte | |||
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| Blumenthal Cancer Center at Carolinas Medical Center | |||
| Joel A Kaplan | Ph: 704-355-2884 | ||
| Presbyterian Cancer Center at Presbyterian Hospital | |||
| Paulette C Bryant | Ph: 704-384-5369 | ||
| Durham | |||
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| Duke Cancer Institute | |||
| Susan G Kreissman | Ph: 888-275-3853 | ||
| Winston-Salem | |||
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| Wake Forest University Comprehensive Cancer Center | |||
| Thomas W McLean | Ph: 336-713-6771 | ||
| North Dakota | |||
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| Fargo | |||
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| Roger Maris Cancer Center at MeritCare Hospital | |||
| Nathan L Kobrinsky | Ph: 701-234-6161 | ||
| Ohio | |||
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| Akron | |||
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| Akron Children's Hospital | |||
| Steven J Kuerbitz | Ph: 330-543-3193 | ||
| Cincinnati | |||
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| Cincinnati Children's Hospital Medical Center | |||
| John P Perentesis | Ph: 513-636-2799 | ||
| Cleveland | |||
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| Cleveland Clinic Taussig Cancer Center | |||
| Tanya M Tekautz | Ph: 866-223-8100 | ||
| Seidman Cancer Center at University Hospitals/Case Medical Center | |||
| Yousif (Joe) H Matloub | Ph: 216-844-5437 | ||
| Columbus | |||
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| Nationwide Children's Hospital | |||
| Mark A Ranalli | Ph: 614-722-2708 | ||
| Dayton | |||
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| Dayton Children's - Dayton | |||
| Emmett H Broxson | Ph: 800-228-4055 | ||
| Toledo | |||
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| Mercy Children's Hospital | |||
| Rama Jasty | Ph: 419-251-8210 | ||
| Toledo Hospital | |||
| Dagmar T Stein | Ph: 419-824-1842 | ||
| Oklahoma | |||
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| Oklahoma City | |||
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| Oklahoma University Cancer Institute | |||
| Rene Y McNall-Knapp | Ph: 405-271-4272 | ||
| Email: julie-traylor@ouhsc.edu | |||
| Oregon | |||
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| Portland | |||
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| Knight Cancer Institute at Oregon Health and Science University | |||
| Kellie J Nazemi | Ph: 503-494-1080 | ||
| Email: trials@ohsu.edu | |||
| Legacy Emanuel Children's Hospital | |||
| Janice F Olson | Ph: 503-413-2560 | ||
| Legacy Emanuel Hospital and Health Center and Children's Hospital | |||
| Janice F Olson | Ph: 503-413-2560 | ||
| Pennsylvania | |||
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| Bethlehem | |||
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| Lehigh Valley Hospital - Muhlenberg | |||
| Philip M Monteleone | Ph: 484-884-2201 | ||
| Danville | |||
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| Geisinger Cancer Institute at Geisinger Health | |||
| Jeffrey S Taylor | Ph: 570-271-5251 | ||
| Hershey | |||
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| Penn State Children's Hospital | |||
| John F Kuttesch | Ph: 505-272-6972 | ||
| Email: CTO@hmc.psu.edu | |||
| Philadelphia | |||
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| Children's Hospital of Philadelphia | |||
| Michael J Fisher | Ph: 215-590-2810 | ||
| St. Christopher's Hospital for Children | |||
| Gregory E Halligan | Ph: 215-427-8991 | ||
| Pittsburgh | |||
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| Children's Hospital of Pittsburgh of UPMC | |||
| Arthur K Ritchey | Ph: 412-692-5573 | ||
| PR | |||
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| Santurce | |||
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| San Jorge Children's Hospital | |||
| Luis A Clavell | Ph: 888-823-5923 | ||
| Email: ctsucontact@westat.com | |||
| South Carolina | |||
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| Charleston | |||
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| Hollings Cancer Center at Medical University of South Carolina | |||
| Jacqueline M Kraveka | Ph: 843-792-9321 | ||
| Columbia | |||
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| Palmetto Health South Carolina Cancer Center | |||
| Ronnie W. Neuberg | Ph: 803-434-3680 | ||
| Greenville | |||
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| BI-LO Charities Children's Cancer Center | |||
| Nichole L Bryant | Ph: 864-241-6251 | ||
| Cancer Centers of the Carolinas - Faris Road | |||
| Nichole L Bryant | Ph: 864-241-6251 | ||
| South Dakota | |||
|
|||
| Sioux Falls | |||
|
|||
| Sanford Cancer Center at Sanford USD Medical Center | |||
| Kayelyn J Wagner | Ph: 605-328-1367 | ||
| Tennessee | |||
|
|||
| Knoxville | |||
|
|||
| East Tennessee Children's Hospital | |||
| Ray C Pais | Ph: 865-541-8266 | ||
| Nashville | |||
|
|||
| Vanderbilt-Ingram Cancer Center | |||
| Haydar A Frangoul | Ph: 800-811-8480 | ||
| Texas | |||
|
|||
| Amarillo | |||
|
|||
| Texas Tech University Health Sciences Center School of Medicine - Amarillo | |||
| Osvaldo Regueira | Ph: 806-354-5411 | ||
| Austin | |||
|
|||
| Dell Children's Medical Center of Central Texas | |||
| Sharon K Lockhart | Ph: 512-324-8022 | ||
| Corpus Christi | |||
|
|||
| Driscoll Children's Hospital | |||
| M. C Johnson | Ph: 361-694-5311 | ||
| Dallas | |||
|
|||
| Medical City Dallas Hospital | |||
| Carl Lenarsky | Ph: 972-566-5588 | ||
| Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas | |||
| Naomi J Winick | Ph: 214-648-7097 | ||
| Fort Worth | |||
|
|||
| Cook Children's Medical Center - Fort Worth | |||
| Mary Meaghan P Granger | Ph: 682-885-2103 | ||
| Houston | |||
|
|||
| Dan L. Duncan Cancer Center at Baylor College of Medicine | |||
| Lisa R Bomgaars | Ph: 713-798-1354 | ||
| Email: burton@bcm.edu | |||
| Univeristy of Texas M.D. Anderson Cancer Center | |||
| Soumen Khatua | Ph: 713-792-3245 | ||
| Lubbock | |||
|
|||
| Covenant Children's Hospital | |||
| Latha Prasannan | Ph: 806-725-8000 | ||
| Email: jaccresearch@covhs.org | |||
| San Antonio | |||
|
|||
| Methodist Children's Hospital of South Texas | |||
| Jaime Estrada | Ph: 210-575-7000 | ||
| University of Texas Health Science Center at San Antonio | |||
| Anne-Marie R Langevin | Ph: 210-567-0653 | ||
| Email: che@uthscsa.edu | |||
| Temple | |||
|
|||
| Scott and White Cancer Institute | |||
| Guy H Grayson | Ph: 254-724-5407 | ||
| Utah | |||
|
|||
| Salt Lake City | |||
|
|||
| Primary Children's Medical Center | |||
| Phillip E Barnette | Ph: 801-585-5270 | ||
| Vermont | |||
|
|||
| Burlington | |||
|
|||
| Vermont Cancer Center at University of Vermont | |||
| Alan C Homans | Ph: 802-656-8990 | ||
| Virginia | |||
|
|||
| Falls Church | |||
|
|||
| Inova Fairfax Hospital | |||
| Marshall A Schorin | Ph: 703-208-6650 | ||
| Norfolk | |||
|
|||
| Children's Hospital of The King's Daughters | |||
| Eric J Lowe | Ph: 757-668-7243 | ||
| Richmond | |||
|
|||
| Virginia Commonwealth University Massey Cancer Center | |||
| Asadullah Khan | Ph: 804-628-1939 | ||
| Roanoke | |||
|
|||
| Carilion Medical Center for Children at Roanoke Community Hospital | |||
| Mandy M Atkinson | Ph: 540-981-7376 | ||
| Washington | |||
|
|||
| Seattle | |||
|
|||
| Children's Hospital and Regional Medical Center - Seattle | |||
| James M Olson | Ph: 866-987-2000 | ||
| Spokane | |||
|
|||
| Providence Cancer Center at Sacred Heart Medical Center | |||
| James M Olson | Ph: 866-987-2000 | ||
| Tacoma | |||
|
|||
| Mary Bridge Children's Hospital and Health Center - Tacoma | |||
| Robert G Irwin | Ph: 888-823-5923 | ||
| Email: ctsucontact@westat.com | |||
| West Virginia | |||
|
|||
| Charleston | |||
|
|||
| West Virginia University Medical School - Charleston | |||
| Allen R Chauvenet | Ph: 304-388-9944 | ||
| Wisconsin | |||
|
|||
| Green Bay | |||
|
|||
| St. Vincent Hospital Regional Cancer Center | |||
| John R Hill | Ph: 920-433-8889 | ||
| Marshfield | |||
|
|||
| Marshfield Clinic - Marshfield Center | |||
| Michael J McManus | Ph: 715-389-4457 | ||
| Milwaukee | |||
|
|||
| Midwest Children's Cancer Center at Children's Hospital of Wisconsin | |||
| Michael E Kelly | Ph: 414-805-4380 | ||
| Australia | |||
|
|||
| South Australia | |||
|
|||
| North Adelaide | |||
|
|||
| Women's and Children's Hospital | |||
| Maria L Kirby | Ph: (08) 8161 7327 | ||
| Email: cywhs.oncsec@health.sa.gov.au | |||
| Western Australia | |||
|
|||
| Perth | |||
|
|||
| Princess Margaret Hospital for Children | |||
| Catherine H Cole | Ph: (08) 9340 8330 | ||
| Email: admin@childcancerresearch.com.au | |||
| Canada | |||
|
|||
| Alberta | |||
|
|||
| Edmonton | |||
|
|||
| University of Alberta Hospital | |||
| Sunil Jayantilal` S Desai | Ph: 780-407-6615 | ||
| Email: val.taylor@albertahealthservices.ca | |||
| British Columbia | |||
|
|||
| Vancouver | |||
|
|||
| Children's and Women's Hospital of British Columbia | |||
| Caron Strahlendorf | Ph: 604-875-2345ext6477 | ||
| Manitoba | |||
|
|||
| Winnipeg | |||
|
|||
| CancerCare Manitoba | |||
| Rochelle A Yanofsky | Ph: 866-561-1026 | ||
| Email: CIO_Web@cancercare.mb.ca | |||
| Nova Scotia | |||
|
|||
| Halifax | |||
|
|||
| IWK Health Centre | |||
| Margaret C Yhap | Ph: 902-470-8394 | ||
| Ontario | |||
|
|||
| Hamilton | |||
|
|||
| McMaster Children's Hospital at Hamilton Health Sciences | |||
| Carol Portwine | Ph: 905-521-2100ext74595 | ||
| Carol Portwine | Ph: 905-521-2100ext74595 | ||
| Ottawa | |||
|
|||
| Children's Hospital of Eastern Ontario | |||
| Jacqueline M Halton | Ph: 613-738-3931 | ||
| Toronto | |||
|
|||
| Hospital for Sick Children | |||
| Eric Bouffet | Ph: 416-813-7654ext2027 | ||
| Email: jason.mcguire@sickkids.ca | |||
| Quebec | |||
|
|||
| Montreal | |||
|
|||
| Hopital Sainte Justine | |||
| Yvan Samson | Ph: 514-345-4931 | ||
| Montreal Children's Hospital at McGill University Health Center | |||
| Sharon B Abish | Ph: 514-412-4445 | ||
| Email: info@thechildren.com | |||
| Ste-Foy | |||
|
|||
| Centre de Recherche du Centre Hospitalier de l'Universite Laval | |||
| Bruno Michon | Ph: 418-525-4444 | ||
| Saskatchewan | |||
|
|||
| Saskatoon | |||
|
|||
| Saskatoon Cancer Centre at the University of Saskatchewan | |||
| Christopher Mpofu | Ph: 306-655-2914 | ||
| Netherlands | |||
|
|||
| Den Haag | |||
|
|||
| Dutch Childhood Oncology Group | |||
| Cornelia E Gidding | Ph: 888-823-5923 | ||
| Email: ctsucontact@westat.com | |||
Link to the current ClinicalTrials.gov record.
NLM Identifer NCT00392327
Information obtained from ClinicalTrials.gov on June 10, 2013
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