|Phase III||Treatment||Closed||18 to 60||Other||LY9|
CAN-NCIC-LY9, ROCHE-CAN-NCIC-LY9, MINT-M39045, CDR0000309053, NCT00064116
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Monoclonal antibodies such as rituximab can locate cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells. It is not yet known whether combination chemotherapy is more effective with or without rituximab in treating patients with non-Hodgkin's lymphoma.
PURPOSE: This randomized phase III trial is studying four different combination chemotherapy regimens and rituximab to see how well they work compared to four different combination chemotherapy regimens alone in treating patients with non-Hodgkin's lymphoma.
Further Study Information
- Compare the time to treatment failure in patients with CD20-positive diffuse large B-cell non-Hodgkin's lymphoma treated with CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone)-like chemotherapy with vs without rituximab.
- Compare the tumor control, progression rate, and complete remission rate in patients treated with these regimens.
- Compare the disease-free and overall survival rate of patients treated with these regimens.
- Compare the toxicity of these regimens in these patients.
OUTLINE: This is a randomized, open-label, multicenter study. Patients are stratified according to participating center, bulky disease (no vs yes), International Prognostic Index score (0 vs 1), and chemotherapy (CHOP vs CHOEP vs PMitCEBO vs MACOP-B). Patients are randomized to 1 of 2 treatment arms.
- Arm I: Patients receive 1 of the following chemotherapy regimens according to participating country:
- CHOP: Patients receive cyclophosphamide IV, doxorubicin IV, and vincristine IV on day 1 and oral prednisone or prednisolone on days 1-5. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity.
- CHOEP-21: Patients receive cyclophosphamide IV, doxorubicin IV, and vincristine IV on day 1; etoposide IV on days 1-3; and oral prednisone on days 1-5. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity.
- PMitCEBO: Patients receive mitoxantrone IV, cyclophosphamide IV, and etoposide IV on day 1; vincristine IV and bleomycin IV on day 8; and oral prednisolone daily during weeks 1-4 and every other day during week 5. Treatment repeats every 14 days for 6 courses in the absence of disease progression or unacceptable toxicity.
- MACOP-B: Patients receive cyclophosphamide IV and doxorubicin IV on days 1, 15, 29, 43, 57, and 71; methotrexate IV and vincristine IV on days 8, 36, and 64; bleomycin IV and vincristine IV on days 22, 50, and 78; and oral or intramuscular prednisone on days 1-84. Treatment continues in the absence of disease progression or unacceptable toxicity.
- Arm II: Patients receive arm I regimens (according to participating country) and rituximab as follows:
- CHOP and rituximab: Patients receive CHOP as in arm I and rituximab IV on day 1.
- CHOEP-21 and rituximab: Patients receive CHOEP-21 as in arm I and rituximab IV on day 1.
- PMitCEBO and rituximab: Patients receive PMitCEBO as in arm I and rituximab IV on day 1 during courses 1 and 4; on day 8 during courses 2 and 5; and on day 1 at 1 and 4 weeks after completion of the last course of PMitCEBO chemotherapy.
- MACOP-B and rituximab: Patients receive MACOP-B as in arm I and rituximab IV on days 1, 22, 43, 64, 85, and 106.
Patients are followed every 3 months for 2 years, every 6 months for 3 years, and then annually thereafter.
PROJECTED ACCRUAL: A total of 820 patients will be accrued for this study within approximately 2 years.
- Histologically confirmed diffuse large B-cell non-Hodgkin's lymphoma according to REAL classification
- Diagnosed within the past 6 weeks
- CD20+ disease
- Ann Arbor stage II, III, or IV disease or stage I bulky disease
- International Prognostic Index (IPI) score of 0 or 1
- Score 0 defined by all of the following:
- Stage I or II disease
- ECOG performance status of 0 or 1
- Lactic dehydrogenase (LDH) no greater than upper limit of normal (ULN)
- Score 1 defined by 1 of the following:
- Stage I or II disease; ECOG performance status of 0 or 1; and LDH greater than ULN
- Stage I or II disease; ECOG performance status 2 or 3; and LDH no greater than ULN
- Stage III or IV disease; ECOG performance status 0 or 1; and LDH no greater than ULN
- Previously untreated disease
- Mediastinal B-cell lymphoma allowed
- No secondary lymphoma after prior chemotherapy or radiotherapy for other malignancies
- No transformed lymphoma
- No primary CNS lymphoma
- No primary gastrointestinal (MALT) lymphoma
- No post-transplant lymphoproliferative disorder
- 18 to 60
- See Disease Characteristics
- ECOG 0-3
- At least 3 months
- Not specified
- Bilirubin no greater than 2.0 mg/dL*
- Transaminases no greater than 3 times normal*
- No active chronic hepatitis B or C infection NOTE: *Unless related to lymphoma
- Creatinine no greater than 2 times normal* NOTE: *Unless related to lymphoma
- No myocardial infarction within the past 6 months
- No uncompensated heart failure
- No dilatative cardiomyopathy
- No coronary heart disease with ST segment depression on ECG
- No severe uncompensated hypertension
- No chronic lung disease with hypoxemia
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception
- HIV negative
- No known allergic reactions against foreign proteins
- No other prior malignancy except basal cell skin cancer or carcinoma in situ of the cervix
- No concurrent disease that would preclude study treatment
- No active infections requiring systemic antibiotics or antiviral medications
- No severe uncompensated diabetes mellitus
- No clinical signs of cerebral dysfunction
- No severe psychiatric disease
PRIOR CONCURRENT THERAPY:
- No prior murine antibodies
- No other concurrent anticancer chemotherapy
- Not specified
- No concurrent response-adapted (slow response or unconfirmed complete response) radiotherapy
- Not specified
- No prior lymphoma-specific treatment
- More than 12 weeks since prior participation in another clinical trial
- No prior participation in this study
- No other concurrent study medication
Trial Lead Organizations/Sponsors
NCIC-Clinical Trials Group
|Kevin Imrie||Study Chair|
Link to the current ClinicalTrials.gov record.
NLM Identifer NCT00064116
ClinicalTrials.gov processed this data on October 17, 2013
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