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Clinical Trials (PDQ®)

Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma

Basic Trial Information
Trial Description
     Summary
     Further Trial Information
     Eligibility Criteria
Trial Contact Information

Basic Trial Information

PhaseTypeStatusAgeSponsorProtocol IDs
Phase II, Phase IBiomarker/Laboratory analysis, TreatmentActive12 to 21NCINCI-2012-03173
CDR667932, PBTC-029B, PBTC-029, UM1CA081457, U01CA081457, NCT01089101

Trial Description

Summary

This phase I/II trial studies the side effects and the best dose of selumetinib and how well it works in treating or re-treating young patients with low grade glioma that has come back or does not respond to treatment. Selumetinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Further Study Information

PRIMARY OBJECTIVES:

I. To estimate the maximum tolerated dose (MTD) or recommend a Phase II dose of AZD6244 (selumetinib) in children with recurrent or refractory low-grade glioma. (Phase I, completed as of April 29, 2013) II. To describe the toxicity profile and define the dose limiting toxicity of AZD6244 in children with recurrent or refractory low-grade glioma. (Phase I) III. To study the safety of the maximum tolerated dose (MTD) or recommended a Phase II dose (RP2D) of AZD6244 as determined based on safety data from children >= 12 years of age in children < 12 years of age; if the MTD/RP2D of the older children is too toxic for the younger children, we will de-escalate to one dose level below and study the safety of that dose in the younger age cohort. (Phase I) IV. To assess the sustained response rate of AZD6244 administered at 25 mg/m^2/dose twice daily (BID), in a single arm Phase II setting in patients assigned to strata based on neurofibromatosis (NF)-1 status and presence or absence of v-raf murine sarcoma viral oncogene homolog B (BRAF) aberrations, specifically BRAF V600E mutations and/or BRAF KIAA1549 fusion identified by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH), respectively. (Phase II) V. To estimate the sustained response rate and prolonged disease stabilization rate (defined as lack of disease progression for >= 12 courses) associated with AZD6244 in patients with recurrent and/or progressive low-grade gliomas who previously received treatment on PBTC-029 or PBTC-029B for a minimum of 12 courses, with at least stable disease or patients who had a sustained response but remained on treatment < 12 courses. (Re-treatment Study)

SECONDARY OBJECTIVES:

I. To characterize the inter- and intra-patient variability in AZD6244 pharmacokinetics administered on this schedule and to assess the influence of patient specific covariates (including concomitant drug therapy) on AZD6244 pharmacokinetics. (Phase I) II. To evaluate the feasibility of collecting pre-trial tumor samples and the feasibility of using in situ hybridization assay to identify BRAF aberrations in available tumor specimens. (Phase I) III. To determine if pre-trial tumor samples show the biochemical signature that indicates activation of the mitogen-activated protein kinase (MAPK) pathway. (Phase I) IV. To describe magnetic resonance imaging (MRI) characteristics of the tumors before and after treatment and to explore the diffusion changes in the tumors before and after treatment to determine if there is an early diffusion indicator of response. (Phase I) V. Within the constraints of a Phase I trial, to document antitumor activity of treatment with AZD6244, as measured by objective responses and progression-free survival (PFS). (Phase I) VI. To explore the pharmacogenetic polymorphisms in AZD6244 metabolizing enzymes and transporters and relate these polymorphisms to AZD6244 pharmacokinetics. (Phase I) VII. To estimate the PFS distributions associated with AZD6244 treatment separately in patients assigned to the six strata as well as for various other subsets e.g. histology and tumor grade across strata. (Phase II) VIII. To explore correlations between BRAF aberrations and treatment response and PFS in patients for whom relevant biology data are available. (Phase II) IX. To assess MAPK aberrations by a combination of whole-exome and ribonucleic acid (RNA) sequencing. (Phase II) X. To characterize the inter- and intra-patient variability in AZD6244 pharmacokinetics administered on this schedule at the MTD/RP2D. (Phase II) XI. To determine progression-free survival following re-treatment with AZD6244 for progressive, recurrent low-grade gliomas and to evaluate the impact of variables such as previous response, interval treatment regimens, BRAF status and previous dose of AZD6244. (Re-treatment Study) XII. To evaluate the toxicity profile of re-treatment with AZD6244 and correlate with toxicities seen during initial treatment. (Re-treatment Study) XIII. To evaluate the toxicity profile of re-treatment with AZD6244 beyond 2 years for those patients who continue to show benefit from the drug, i.e. at least stable disease (SD). (Re-treatment Study)

OUTLINE: This is a phase I dose-escalation study (completed as of April 29, 2013) followed by a phase II study.

Patients receive selumetinib orally (PO) twice daily (BID) on days 1-28. Courses repeat every 28 days for up to 26 courses in the absence of disease progression or unacceptable toxicity. Patients who experience a sustained objective response from selumetinib on the phase I or phase II portions of the trial, and who have completed 2 years of treatment and stopped study drug may be enrolled on the re-treatment study after progression/recurrence. Patients in the re-treatment study may continue treatment indefinitely in the absence of disease progression or unacceptable toxicities.

After completion of study treatment, patients are followed up for 30 days.

Eligibility Criteria

Inclusion Criteria:

  • Participant is willing to sign a screening consent and provide pre-trial tumor material for BRAF testing (both for BRAF V^600E mutation and BRAF KIAA1549 fusion assessments)
  • All patients who are candidates for enrollment in stratum 5 based on their tumor histology must be pre-screened
  • Screening may be applied to potential stratum 1 and 2 patients when patient accrual is close to pre-specified interim analysis or final sample size thresholds in either stratum; the Operations and Biostatistics Data Management Center (OBDMC) will notify sites when it becomes necessary to screen patients for BRAF aberrations for stratum 1 and 2
  • Patients whose prior BRAF testing was performed at another lab (Clinical Laboratory Improvement Amendments [CLIA]/College of American Pathologist [CAP] certified or otherwise) must send additional tumor material to Brigham and Women's Hospital (BWH) for confirmation; however, to preserve available tumor material, patients whose tumor material has previously undergone BRAF analysis at the Lindeman and Ligon Labs at Brigham and Women's Hospital using the same procedures as described in this protocol, will not be required to submit additional tumor material for analysis; these patients must have both the BRAFV600E mutation and BRAF KIAA1549 fusion assessments done and if only one test was previously conducted; additional tissue will be required for the second test
  • Patient must have one of the following:
  • For stratum 5: non NF-1 associated low grade glioma (LGG) (other than pilocytic astrocytoma or optic pathway glioma)
  • For stratum 1 or 2: non NF-1, non-optic pathway pilocytic astrocytoma; note: all patients with non NF-1 associated optic pathway glioma with or without tissue must be enrolled on stratum 4
  • Imaging evaluations necessary to establish eligibility for study entry must be done within three (3) weeks prior to registration
  • All other evaluations necessary to establish eligibility for study entry must be done within two (2) weeks prior to registration
  • Patients must start therapy within 7 calendar days of registration and may begin treatment prior to stratification
  • Laboratory values must be no older than seven (7) days prior to the start of therapy; if a test that is repeated after registration and prior to therapy is outside the limits for eligibility, it must be rechecked within 48 hours prior to the start of therapy; if laboratory values still fail to meet eligibility criteria, the patient may not receive protocol therapy
  • All patients must meet the following inclusion and exclusion criteria; NO EXCEPTIONS WILL BE GIVEN
  • Patients with sporadic (non NF-1 associated), histologically diagnosed progressive, recurrent or refractory non-optic pathway pilocytic astrocytoma who have pre- treatment tumor tissue available for BRAF analysis
  • NF-1 patients with radiographic evidence of a progressive, recurrent or refractory low grade glioma, with or without pre-treatment tumor tissue
  • Patients with progressive, recurrent or refractory optic pathway glioma, with or without pre-treatment tumor tissue
  • Patients with histologically diagnosed progressive, recurrent or refractory non NF-1 associated LGG (other than pilocytic astrocytoma or optic pathway glioma); these patients must have BRAF aberrations as documented by the Lindeman and Ligon Labs at Brigham and Women's Hospital using the same procedures
  • Patients will be assigned to one of 6 strata following enrollment; all BRAF assessments used for stratification below must be done at the Lindeman and Ligon Labs at Brigham and Women's Hospital using the same procedures as described in this protocol; assessments for both BRAF V^600E mutation and BRAF KIAA1549 fusion are required for patients who will enroll on strata 1, 2 and 5
  • Stratum 1: patients with non NF-1 associated progressive, recurrent or refractory pilocytic astrocytoma with pre-trial tumor material available and with a BRAF aberration i.e. BRAFV^600E mutation and/or BRAF KIAA1549 fusion as determined by IHC and FISH, respectively; patients with optic pathway glioma are excluded
  • Stratum 2: patients with non NF-1 associated progressive, recurrent or refractory pilocytic astrocytoma with pre-trial tumor material available and without a BRAF aberration i.e. BRAF^V600E mutation and/or BRAF KIAA1549 fusion as determined by IHC and FISH, respectively; patients with optic pathway glioma are excluded
  • Stratum 3: patients with neuro-fibromatosis 1 (NF-1) associated progressive, recurrent or refractory low grade glioma (World Health Organization [WHO] grade I & II), with or without tissue
  • Stratum 4: patients with non-NF1 associated progressive, recurrent or refractory optic pathway glioma with or without tissue available for BRAF evaluation
  • Stratum 5: patients with non NF-1 associated progressive, recurrent or refractory low grade glioma other than pilocytic astrocytoma or optic pathway glioma with a documented BRAF aberration identified in pre-trial tumor material
  • Stratum 6: patients with non-NF-1 associated progressive, recurrent or refractory low grade glioma (other than optic pathway glioma [OPG]) with tissue available for BRAF analyses who cannot be classified into stratum 1, 2 or 5 due to inadequate tissue quality, assay failure, etc
  • Patients must have bi-dimensionally measurable disease defined as at least one lesion that can be accurately measured in at least two planes in order to be eligible for this study
  • Patients must have received prior therapy other than surgery and must have fully recovered from the acute toxic effects of all prior chemotherapy, immunotherapy, biologic therapy or radiotherapy prior to study entry
  • Patients must have received their last dose of known myelosuppressive anticancer chemotherapy at least three weeks prior to study registration or at least six weeks if nitrosourea
  • Patient must have received their last dose of the biologic agent >= 7 days prior to study registration
  • For biologic agents that have a prolonged half-life, at least three half-lives must have elapsed prior to registration
  • Monoclonal antibody treatment: at least three half-lives must have elapsed prior to registration
  • Radiation: patients must have:
  • Had their last fraction of local irradiation to primary tumor >= 12 months prior to registration; investigators are reminded to review potentially eligible cases to avoid confusion with pseudo-progression
  • Had their last fraction of craniospinal irradiation (> 24 Gy) > 3 months prior to registration
  • Corticosteroids: patients who are receiving dexamethasone must be on a stable or decreasing dose for at least 1 week prior to registration
  • Patients must be off all colony-forming growth factor(s) for at least 1 week prior to registration (filgrastim, sargramostim, erythropoietin) and at least 2 weeks for long-acting formulations
  • Patients must have a body surface area (BSA) >= 0.55 m^2
  • Patients with neurological deficits should have deficits that are stable for a minimum of 1 week prior to registration
  • Patients must be able to swallow capsules
  • Karnofsky performance scale (KPS for > 16 years [yrs.] of age) or Lansky performance score (LPS for =< 16 years of age) >= 60 assessed within two weeks prior to registration
  • Absolute neutrophil count >= 1,000/uL (unsupported)
  • Platelets >= 100,000/L (unsupported)
  • Hemoglobin >= 8 g/dL (may be supported)
  • Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 X institutional upper limit of normal for age
  • Total bilirubin < 1.5 times upper limit of normal for age
  • Albumin >= 3 g/dL
  • Serum sodium and potassium within the institutional limits of normal
  • Serum calcium and magnesium above the institutional lower limit of normal
  • Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73m^2 or a serum creatinine based on age as follows:
  • =< 5 years: 0.8 mg/dL
  • > 5 years but =< 10 years: 1 mg/dL
  • > 10 years but =< 15 years: 1.2 mg/dL
  • > 15 years: 1.5 mg/dL
  • Left ventricular ejection fraction (LVEF) >= 55%
  • Corrected QT (QTc) interval =< 450 msecs
  • Hypertension:
  • Patients, 3-17 years of age must have a blood pressure that is =< 95th percentile for age, height and gender at the time of registration
  • The normal blood pressure by height, age and gender tables can be accessed in the Generic Forms section of the Pediatric Brain Tumor Consortium (PBTC) members' webpage
  • Patients who are >= 18 years of age must have a blood pressure that is < 140/90 mm of Hg at the time of registration
  • Note: if a blood pressure (BP) reading prior to registration is above the 95th percentile for age, height and gender it must be rechecked and documented to be =< the 95th percentile for age, height and gender prior to patient registration
  • Female patients of childbearing potential must not be pregnant or breast-feeding; female patients of childbearing potential must have a negative serum or urine pregnancy test
  • Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation, and for four weeks after dosing with AZD6244 ceases; women of child-bearing potential must have a negative pregnancy test prior to entry; should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately; please note that the AZD6244 manufacturer recommends that adequate contraception for male patients should be used for 16 weeks post-last dose due to sperm life cycle
  • Ability to understand and the willingness to sign a written informed consent document according to institutional guidelines
  • ELIGIBILITY CRITERIA FOR ENROLLMENT ON THE RE-TREATMENT STUDY
  • Patients must have recurrence or progression of their low-grade glioma after coming off treatment with AZD6244 on PBTC-029 or PBTC-029B, with or without having received additional anti-tumor therapy following discontinuation of AZD6244; the progression must be unequivocal and sufficient to warrant re-treatment in the opinion of the investigator
  • Patients must have received treatment on PBTC-029 or PBTC-029B for a minimum of 12 courses with at least stable disease, or had a sustained response (partial response [PR]/ complete response [CR]) but remained on treatment < 12 courses
  • Patients must have bi-dimensionally measureable disease defined as at least one lesion that can be accurately measured in at least two planes
  • Patients must have fully recovered from the acute toxic effects of all prior chemotherapy, immunotherapy, biologic therapy or radiotherapy prior to study entry
  • Myelosuppressive chemotherapy: Patients must have received their last dose of known myelosuppressive anticancer chemotherapy at least three weeks prior to registration on the Re-treatment Study or at least six weeks if a nitrosourea
  • Biologic agent: Patient must have received their last dose of the biologic agent >= 7 days prior to study registration; for biologic agents and monoclonal antibody treatment, at least three half-lives must have elapsed prior to registration
  • Other investigational agents (not fitting into one of the above specified categories): patients must have received their last dose of any other investigational agent greater than 28 days prior to enrollment
  • Radiation: Patients must have:
  • Had their last fraction of local irradiation to the primary tumor >= 12 months prior to registration; investigators are reminded to review potentially eligible cases to avoid confusion with pseudo-progression;
  • Had their last fraction of craniospinal irradiation (> 24Gy) > 3 months prior to registration
  • Corticosteroids: Patients who are receiving dexamethasone must be on a stable or decreasing dose for at least 1 week prior to registration
  • Growth factors: Patients must be off all colony-forming growth factor(s) for at least 1 week prior to registration (filgrastim, sargramostim, erythropoietin) and at least 2 weeks for long-acting formulations

Exclusion Criteria:

  • Patients with any clinically significant unrelated systemic illness (serious infections or significant cardiac, pulmonary, hepatic or other organ dysfunction), likely interfere with the study procedures or results
  • Patients who are receiving any other anticancer or investigational agents
  • Patients with uncontrolled seizures
  • Previous mitogen-activated protein kinase kinase (MEK) inhibitor use such as PD-0325901; CI1040; AS73026; GDC 0973; ARRY43182; GSK110212
  • Prior treatment with a BRAF inhibitor such as vemurafenib or dabrafenib (previous treatment with sorafenib is allowed)
  • Patients with other factors that increase the risk of QT prolongation or arrhythmic events (e.g., heart failure, hypokalemia, family history of long QT interval syndrome) that meets New York Heart Association (NYHA) class II or above
  • Required use of a concomitant medication that can prolong the QT interval
  • History of allergic reactions attributed to compounds of similar chemical or biologic composition to AZD6244

Trial Contact Information

Trial Lead Organizations/Sponsors

National Cancer Institute

Jason FangusaroPrincipal Investigator

Trial Sites

U.S.A.
California
  Los Angeles
 Children's Hospital Los Angeles
 Girish Dhall Ph: 323-361-4629
  Email: gdhall@chla.usc.edu
 Girish DhallPrincipal Investigator
  Palo Alto
 Lucile Packard Children's Hospital at Stanford University Medical Center
 Paul G. Fisher Ph: 650-721-5889
  Email: pfisher@stanford.edu
 Paul Graham FisherPrincipal Investigator
  San Francisco
 UCSF Helen Diller Family Comprehensive Cancer Center
 Anuradha Banerjee Ph: 415-476-3831
  Email: banerjee@neurosurg.ucsf.edu
 Anuradha BanerjeePrincipal Investigator
 Anuradha Banerjee Ph: 415-476-3831
  Email: banerjee@neurosurg.ucsf.edu
 Anuradha BanerjeePrincipal Investigator
District of Columbia
  Washington
 Children's National Medical Center
 Roger J. Packer Ph: 202-884-2120
  Email: rpacker@cnmc.org
 Roger J. PackerPrincipal Investigator
Illinois
  Chicago
 Ann and Robert H. Lurie Children's Hospital of Chicago
 Jason R. Fangusaro Ph: 312-227-4846
  Email: jfangusaro@luriechildrens.org
 Jason R. FangusaroPrincipal Investigator
 Children's Memorial Outpatient Center in Lincoln Park
 Stewart Goldman Ph: 773-880-4562
  Email: sgoldman@northwestern.edu
 Stewart GoldmanPrincipal Investigator
Maryland
  Bethesda
 NIH - Warren Grant Magnuson Clinical Center
 Katherine E. Warren Ph: 301-435-4683
  Email: warrenk@mail.nih.gov
 Katherine E. WarrenPrincipal Investigator
New York
  New York
 Memorial Sloan-Kettering Cancer Center
 Ira J. Dunkel Ph: 212-639-2153
  Email: dunkeli@mskcc.org
 Ira J. DunkelPrincipal Investigator
North Carolina
  Durham
 Duke Cancer Institute
 Sridharan Gururangan Ph: 919-684-3506
  Email: gurur002@mc.duke.edu
 Sri GururanganPrincipal Investigator
Ohio
  Cincinnati
 Cincinnati Children's Hospital Medical Center
 Maryam Fouladi Ph: 513-803-0721
  Email: maryam.fouladi@cchmc.org
 Maryam FouladiPrincipal Investigator
Pennsylvania
  Pittsburgh
 Children's Hospital of Pittsburgh of UPMC
 Ian F. Pollack Ph: 412-692-5881
  Email: ian.pollack@chp.edu
 Ian F. PollackPrincipal Investigator
Tennessee
  Memphis
 St. Jude Children's Research Hospital
 Alberto Broniscer Ph: 901-595-4925
  Email: alberto.broniscer@stjude.org
 Alberto BroniscerPrincipal Investigator
Texas
  Houston
 Dan L. Duncan Cancer Center at Baylor College of Medicine
 Murali M. Chintagumpala Ph: 832-822-4266
  Email: mxchinta@txch.org
 Murali M. ChintagumpalaPrincipal Investigator

Link to the current ClinicalTrials.gov record.
NLM Identifer NCT01089101
ClinicalTrials.gov processed this data on October 15, 2014

Note: Information about this trial is from the ClinicalTrials.gov database. The versions designated for health professionals and patients contain the same text. Minor changes may be made to the ClinicalTrials.gov record to standardize the names of study sponsors, sites, and contacts. Cancer.gov only lists sites that are recruiting patients for active trials, whereas ClinicalTrials.gov lists all sites for all trials. Questions and comments regarding the presented information should be directed to ClinicalTrials.gov.

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