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Clinical Trials (PDQ®)

Early Surgery or Standard Palliative Therapy in Treating Patients With Stage IV Breast Cancer

Basic Trial Information
Trial Description
     Summary
     Further Trial Information
     Eligibility Criteria
Trial Contact Information

Basic Trial Information

PhaseTypeStatusAgeSponsorProtocol IDs
Phase IIIBiomarker/Laboratory analysis, TreatmentActive18 and overNCI, OtherCDR0000688097
ECOG-E2108, E2108, NCT01242800

Trial Description

Summary

RATIONALE: Early surgery may have fewer side effects and improve recovery. Palliative surgery or radiation therapy may help patients with advanced breast cancer live more comfortably. It is not yet known whether early surgery is more effective than palliative therapy for advanced breast cancer.

PURPOSE: This randomized phase III trial is studying early surgery to see how well it works compared to standard palliative therapy in treating patients with stage IV breast cancer.

Further Study Information

OBJECTIVES:

Primary

  • To evaluate whether early local therapy comprising surgery of intact primary disease compared to local palliative therapy only in patients with stage IV breast cancer, whose disease does not progress during initial optimal systemic therapy, will result in prolonged survival.

Secondary

  • To compare the time to uncontrolled chest wall disease between patients treated with these regimens.
  • To determine whether there is a difference in health-related quality-of-life (HRQOL) between patients treated with these regimens.
  • To determine whether the absolute value of circulating tumor cells (CTC) burden at 6 months following randomization (time +6) will be lower in the palliative therapy arm than in early local therapy arm, and whether this value is inversely related to survival (lower CTC, longer survival).
  • To collect tumor and blood specimens for future exploration of the biological interactions between the primary tumor and metastatic lesions and the effect of primary tumor resection.

OUTLINE: This is a multicenter study. Patients are stratified according to hormone receptor and treatment plan (ER+ or PR+, HER2-, endocrine therapy alone vs ER+ or PR+, and HER2-, chemotherapy and/or endocrine therapy vs ER- or PR-, and HER2- vs HER2+), and number of involved organ systems with distant disease (regional nodes in the axillary, supraclavicular, and internal mammary locations are not considered distant sites) (1 vs > 1). Patients are randomized to 1 of 2 treatment arms.

  • Arm I: Patients receive standard palliative therapy, if needed, to address symptoms such as tumor ulceration, pain, bulky adenopathy causing arm symptoms, and other similar situations. Therapy may consist of radiotherapy alone, surgery alone, or a combination of both.
  • Arm II: Patients undergo surgery comprising breast-conserving therapy (BCT) or total mastectomy according to patient and treating physician preference. Surgery is to occur no later than 10 weeks after completion of 32 weeks of systemic therapy. Free surgical margins must be achieved with re-excision or mastectomy for patients undergoing BCT. After completion of BCT, patients undergo radiotherapy once a day, 5 days per week. Patients who had mastectomy undergo radiotherapy at the discretion of treating physician.

Patients may undergo blood and tumor tissue sample collection for circulating tumor cells (CTC) burden and future studies.

Patients complete the Functional Assessment of Cancer Therapy - Breast Trial Outcome Index (FACT- TOI) and FACT - General (22) and the Breast Cancer Subscale (FACT-B) quality-of-life questionnaires at baseline and periodically during study.

After completion of study therapy, patients are followed up periodically for 5 years.

Eligibility Criteria

DISEASE CHARACTERISTICS:

  • Diagnosis of intact primary (not recurrent) invasive carcinoma of the breast
  • Stage IV disease
  • Confirmation of the primary tumor should be by needle biopsy (preferred)
  • Incisional surgical biopsy allowed as long as there is residual palpable or tumor image in the breast
  • Patients must be judged to be candidates for complete resection with free margins followed by radiation therapy (if radiation therapy is indicated)
  • For women not undergoing axillary dissection, sentinel node biopsy should document an axillary nodal burden of 1-2 involved lymph nodes (i.e., ACOSOG Z-11 criteria may be applied)
  • Prior non-invasive (DCIS) cancer allowed provided there has been no recurrence
  • Prior ipsilateral invasive cancer allowed if more than 5 years previous
  • No synchronous contralateral breast cancer
  • Patients should have at least one organ system involved with distant metastatic disease
  • If patient has only one metastatic lesion/focus, this must be proven by biopsy and the pathology report confirming the diagnosis of primary breast cancer, as well as the metastatic site, must be available
  • Must have available radiologic reports documenting disease status within the past 6 weeks prior to initiating systemic therapy
  • CNS metastases allowed provided projected survival > 6 months
  • Patients must have completed at least 16 weeks of optimal systemic therapy (appropriate to the tumor biological profile and the patient's age and menopausal status)
  • If systemic therapy is discontinued for toxicity, but there is no distant progression and at least 12 weeks of therapy have been delivered, then the patient remains eligible
  • Radiation therapy (if indicated) must begin within 12 weeks of final therapeutic surgical procedure (including re-excision for free margins and completion of axillary dissection)
  • Patients may register at any time from the time of diagnosis of stage IV breast cancer (if eligibility criteria met) to the time when a maximum of 30 weeks of induction systemic therapy has been completed
  • Patients must be randomized within 16-32 weeks after the start of systemic therapy
  • Patients must not have experienced disease progression since the start of systemic therapy, as evidenced by radiographic documentation of disease status before treatment and within 4 weeks +/- 2 weeks prior to randomization, including:
  • No new sites of disease
  • No enlargement of existing sites by 20% or more in longest diameter
  • No symptomatic deterioration
  • Patients who require radiotherapy to bone metastases during induction systemic therapy are eligible
  • Local disease at the primary site must be asymptomatic
  • Hormone receptor status known

PATIENT CHARACTERISTICS:

  • See Disease Characteristics
  • Menopausal status not specified
  • Patients must have adequate organ function to undergo local therapy 4 weeks +/- 2 weeks prior to randomization per investigator discretion and institutional guidelines
  • More than 5 years since other primary cancers that were curatively treated
  • Not pregnant or nursing
  • Negative pregnancy test
  • Fertile patients must use an accepted and effective contraception method

PRIOR CONCURRENT THERAPY:

  • See Disease Characteristics

Trial Contact Information

Trial Lead Organizations/Sponsors

Eastern Cooperative Oncology Group

National Cancer Institute

Seema A. KhanPrincipal Investigator

Trial Sites

U.S.A.
Alabama
  Mobile
 University of South Alabama Mitchell Cancer Institute
 Windy Dean-Colomb Ph: 251-445-9870
  Email: pfrancisco@usouthal.edu
Alaska
  Anchorage
 Alaska Breast Care and Surgery LLC
 Alison K Conlin Ph: 503-215-6412
 Alaska Women's Cancer Care
 Alison K Conlin Ph: 503-215-6412
 Anchorage Oncology Centre
 Alison K Conlin Ph: 503-215-6412
 Katmai Oncology Group
 Alison K Conlin Ph: 503-215-6412
 Providence Cancer Center
 Alison K Conlin Ph: 503-215-6412
Arizona
  Scottsdale
 21st Century Oncology - Scottsdale
 Steven E Finkelstein Ph: 888-823-5923
  Email: ctsucontact@westat.com
  Tucson
 Arizona Cancer Center at UMC Orange Grove
 Pavani Chalasani Ph: 520-626-9008
 Arizona Cancer Center at University Medical Center North
 Pavani Chalasani Ph: 520-626-9008
 Arizona Cancer Center at University of Arizona Health Sciences Center
 Pavani Chalasani Ph: 520-626-9008
Arkansas
  Jonesboro
 NEA Medical Clinic - East Matthews
 Carroll Dean Scroggin Ph: 888-823-5923
  Email: ctsucontact@westat.com
  Little Rock
 Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
 Rangaswamy Govindarajan Ph: 501-686-8274
California
  Berkeley
 Alta Bates Summit Comprehensive Cancer Center
 Ari D Baron Ph: 415-600-1182
  Email: SchmidtJ@cpmcri.org
  Burlingame
 Peninsula Medical Center
 Ari D Baron Ph: 415-600-1182
  Email: SchmidtJ@cpmcri.org
  Chico
 Enloe Cancer Center at Enloe Medical Center
 William E Bonis Ph: 530-332-3808
  Duarte
 City of Hope Comprehensive Cancer Center
 Laura L Kruper Ph: 800-826-4673
  Email: becomingapatient@coh.org
  El Segundo
 21st Century Oncology - El Segundo
 David Khan Ph: 888-326-9729
  Fairfield
 North Bay Cancer Center
 Brian G Vikstrom Ph: 707-646-4016
  Fresno
 California Cancer Center - Woodward Park Office
 Uma G Swamy Ph: 559-447-4050
  Greenbrae
 Marin Cancer Institute at Marin General Hospital
 Peter D. Eisenberg Ph: 415-925-5000
  Email: info@marinspecialtycare.com
  Loma Linda
 Loma Linda University Cancer Institute at Loma Linda University Medical Center
 Sharon S Lum Ph: 909-558-3375
  Long Beach
 Todd Cancer Institute at Long Beach Memorial Medical Center
 Jessica Rayhanabad Ph: 562-933-0900
  Martinez
 Contra Costa Regional Medical Center
 James H. Feusner Ph: 510-450-7600
  Monterey
 Community Hospital of the Monterey Peninsula Comprehensive Cancer Center
 John Hausdorff Ph: 831-625-4753
  Novato
 Sutter Health Western Division Cancer Research Group
 Ari D Baron Ph: 415-600-1182
  Email: SchmidtJ@cpmcri.org
  Oakland
 Alta Bates Summit Medical Center - Summit Campus
 James H. Feusner Ph: 510-450-7600
 CCOP - Bay Area Tumor Institute
 James H. Feusner Ph: 510-450-7600
  Orange
 St. Joseph Hospital Regional Cancer Center - Orange
 Michele M Carpenter Ph: 714-734-6220
  Paradise
 Feather River Hospital Cancer Center
 Sam Mazj Ph: 530-876-7995
  Email: haleew@ah.org
  San Francisco
 California Pacific Medical Center - California Campus
 Ari D Baron Ph: 415-600-1182
  Email: SchmidtJ@cpmcri.org
  Stanford
 Stanford Cancer Center
 Frederick M Dirbas Ph: 650-498-7061
  Email: ccto-office@stanford.edu
  Vallejo
 Sutter Solano Medical Center
 Ari D Baron Ph: 415-600-1182
  Email: SchmidtJ@cpmcri.org
Colorado
  Aurora
 Medical Center of Aurora - South Campus
 Keren Sturtz Ph: 888-785-6789
 Rocky Mountain Cancer Centers - Aurora
 Keren Sturtz Ph: 888-785-6789
  Boulder
 Boulder Community Hospital
 Keren Sturtz Ph: 888-785-6789
 Rocky Mountain Cancer Centers-Boulder
 Keren Sturtz Ph: 888-785-6789
  Colorado Springs
 Memorial Hospital Cancer Center - Colorado Springs
 Uchenna O Njiaju Ph: 719-365-2406
 Penrose Cancer Center at Penrose Hospital
 Keren Sturtz Ph: 888-785-6789
 Rocky Mountain Cancer Centers at the Pavilion
 Keren Sturtz Ph: 888-785-6789
  Denver
 CCOP - Colorado Cancer Research Program
 Keren Sturtz Ph: 888-785-6789
 Colorado Blood Cancer Institute
 Keren Sturtz Ph: 888-785-6789
 Porter Adventist Hospital
 Keren Sturtz Ph: 888-785-6789
 Presbyterian - St. Luke's Medical Center
 Keren Sturtz Ph: 888-785-6789
 Rocky Mountain Cancer Centers - Denver Midtown
 Keren Sturtz Ph: 888-785-6789
 Rocky Mountain Cancer Centers-Rose
 Keren Sturtz Ph: 888-785-6789
 Rose Medical Center
 Keren Sturtz Ph: 888-785-6789
 St. Joseph Hospital
 Keren Sturtz Ph: 888-785-6789
  Durango
 Mercy Medical Center
 Cynthia K. Cathcart Ph: 888-785-6789
  Englewood
 Comprehensive Cancer Care and Research Institute of Colorado LLC
 Keren Sturtz Ph: 888-785-6789
 Swedish Medical Center
 Keren Sturtz Ph: 888-785-6789
  Golden
 Mountain Blue Cancer Care Center
 Keren Sturtz Ph: 888-785-6789
  Greeley
 North Colorado Medical Center
 Keren Sturtz Ph: 888-785-6789
  Greenwood Village
 Breast Cancer Care Consultants
 Keren Sturtz Ph: 888-785-6789
  Lakewood
 Rocky Mountain Cancer Centers-Lakewood
 Keren Sturtz Ph: 888-785-6789
 St. Anthony Central Hospital
 Keren Sturtz Ph: 888-785-6789
  Littleton
 Littleton Adventist Hospital
 Keren Sturtz Ph: 888-785-6789
 Rocky Mountain Cancer Centers - Littleton
 Keren Sturtz Ph: 888-785-6789
  Lone Tree
 Rocky Mountain Cancer Centers - Lone Tree
 Keren Sturtz Ph: 888-785-6789
 Sky Ridge Medical Center
 Keren Sturtz Ph: 888-785-6789
  Longmont
 Hope Cancer Care Center at Longmont United Hospital
 Keren Sturtz Ph: 888-785-6789
 Rocky Mountain Cancer Centers - Longmont
 Keren Sturtz Ph: 888-785-6789
  Loveland
 McKee Medical Center
 Keren Sturtz Ph: 888-785-6789
  Parker
 Parker Adventist Hospital
 Keren Sturtz Ph: 888-785-6789
 Rocky Mountain Cancer Centers - Parker
 Keren Sturtz Ph: 888-785-6789
  Pueblo
 Rocky Mountain Cancer Centers - Pueblo
 Keren Sturtz Ph: 888-785-6789
 St. Mary - Corwin Regional Medical Center
 Keren Sturtz Ph: 888-785-6789
  Thornton
 Rocky Mountain Cancer Centers - Thornton
 Keren Sturtz Ph: 888-785-6789
  Wheat Ridge
 Exempla Lutheran Medical Center
 Keren Sturtz Ph: 888-785-6789
Connecticut
  Farmington
 Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center
 Christina E Stevenson Ph: 800-579-7822
  Hartford
 Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center
 Christopher M Reynolds Ph: 734-712-4673
  Norwalk
 Norwalk Hospital
 Richard C. Frank Ph: 203-852-2996
  Email: jennifer.long@norwalkhealth.org
  Norwich
 Eastern Connecticut Hematology and Oncology Associates
 Dennis E. Slater Ph: 860-886-8362
Delaware
  Lewes
 Tunnell Cancer Center at Beebe Medical Center
 Gregory A. Masters Ph: 302-733-6227
  Newark
 Christiana Gynecologic Oncology, LLC
 Gregory A. Masters Ph: 302-733-6227
 Delaware Clinical and Laboratory Physicians
 Gregory A. Masters Ph: 302-733-6227
 Helen F. Graham Cancer Center at Christiana Hospital
 Gregory A. Masters Ph: 302-733-6227
 Gregory A. Masters Ph: 302-733-6227
 Medical Oncology Hematology Consultants, PA at Helen F. Graham Cancer Center
 Gregory A. Masters Ph: 302-733-6227
 Regional Hematology/Oncology, PA - Newark
 Gregory A. Masters Ph: 302-733-6227
  Rehoboth Beach
 Beebe Health Campus
 Gregory A. Masters Ph: 302-733-6227
  Seaford
 Nanticoke Memorial Hospital
 Gregory A. Masters Ph: 302-733-6227
  Wilmington
 Christiana Care Health System-Wilmington Hospital
 Gregory A. Masters Ph: 302-733-6227
District of Columbia
  Washington
 Sibley Memorial Hospital
 Mehran Habibi Ph: 410-955-8804
  Email: jhcccro@jhmi.edu
 Washington Cancer Institute at Washington Hospital Center
 Bridget A Oppong Ph: 202-444-0381
Florida
  Bradenton
 21st Century Oncology - Lakewood Ranch Oncology
 Dwight L Fitch Ph: 888-823-5923
  Email: ctsucontact@westat.com
  Daytona Beach
 Florida Hospital Memorial Medical Center
 Mudussara A Khan Ph: 386-676-6025
  Fort Lauderdale
 Broward General Medical Center Cancer Center
 Barry S Berman Ph: 954-355-5346
  Gainesville
 UF Health Cancer Center
 Lisa R Spiguel Ph: 352-273-8675
  Email: trials@cancer.ufl.edu
  Jacksonville
 Baptist Cancer Institute - Jacksonville
 Troy Hancil Guthrie Ph: 904-202-7051
  Orlando
 Florida Hospital Cancer Institute at Florida Hospital Orlando
 Lee M. Zehngebot Ph: 407-303-5623
  Tampa
 H. Lee Moffitt Cancer Center and Research Institute at University of South Florida
 Roohi Ismail-Khan Ph: 800-456-7121
  Email: canceranswers@moffitt.org
  Weston
 Cleveland Clinic Florida - Weston
 Cassann N Blake Ph: 954-659-5705
Georgia
  Athens
 Northeast Georgia Cancer Care, LLC - Medical Oncology
 Sharad Anant Ghamande Ph: 706-721-1663
  Email: cancer@georgiahealth.edu
  Atlanta
 Georgia Cancer Center for Excellence at Grady Memorial Hospital
 Ruth M. O'Regan Ph: 404-778-1868
 Winship Cancer Institute of Emory University
 Ruth M. O'Regan Ph: 404-778-1868
  Augusta
 Medical College of Georgia Cancer Center
 Sharad Anant Ghamande Ph: 706-721-1663
  Email: cancer@georgiahealth.edu
  Gainesville
 Northeast Georgia Medical Center
 Richard J. LoCicero Ph: 770-219-8800
  Email: cancerpatient.navigator@nghs.com
  Savannah
 Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler
 Grant C Lewis Ph: 912-350-8568
Idaho
  Boise
 Mountain States Tumor Institute at St. Luke's Regional Medical Center
 Paul G. Montgomery Ph: 800-845-4624
 Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
 Christopher M Reynolds Ph: 734-712-4673
  Fruitland
 Saint Luke's Mountain States Tumor Institute - Fruitland
 Paul G. Montgomery Ph: 800-845-4624
  Meridian
 Mountain States Tumor Institute - Meridian
 Paul G. Montgomery Ph: 800-845-4624
  Nampa
 Saint Luke's Mountain States Tumor Institute
 Paul G. Montgomery Ph: 800-845-4624
  Post Falls
 Kootenai Cancer Center - Post Falls
 Benjamin Thomas Marchello Ph: 800-648-6274
  Twin Falls
 Mountain States Tumor Institute at St. Luke's
 Paul G. Montgomery Ph: 800-845-4624
Illinois
  Berwyn
 MacNeal Cancer Center at MacNeal Hospital
 Keith L. Shulman Ph: 773-564-5044
  Bloomington
 Illinois CancerCare - Bloomington
 Nguyet A Le-Lindqwister Ph: 800-793-2262
 St. Joseph Medical Center
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  Canton
 Illinois CancerCare - Canton
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  Carbondale
 Memorial Hospital of Carbondale
 James L. Wade Ph: 217-876-4740
  Email: kcheek@dmhhs.org
  Carthage
 Illinois CancerCare - Carthage
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  Centralia
 Centralia Oncology Clinic
 James L. Wade Ph: 217-876-4740
  Email: kcheek@dmhhs.org
  Chicago
 John H. Stroger, Jr. Hospital of Cook County
 Thomas E. Lad Ph: 312-864-6000
 Louis A. Weiss Memorial Hospital
 Keith L. Shulman Ph: 773-564-5044
 Resurrection Medical Center
 Christopher G. Rose Ph: 773-792-5116
 Robert H. Lurie Comprehensive Cancer Center at Northwestern University
 Seema A. Khan Ph: 312-695-1301
  Email: cancer@northwestern.edu
 University of Illinois Cancer Center
 Lucy F Chen Ph: 312-355-3046
  Decatur
 Cancer Care Center of Decatur
 James L. Wade Ph: 217-876-4740
  Email: kcheek@dmhhs.org
 Decatur Memorial Hospital Cancer Care Institute
 James L. Wade Ph: 217-876-4740
  Email: kcheek@dmhhs.org
  Effingham
 Crossroads Cancer Center
 James L. Wade Ph: 217-876-4740
  Email: kcheek@dmhhs.org
  Eureka
 Illinois CancerCare - Eureka
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  Galesburg
 Galesburg Clinic, PC
 Nguyet A Le-Lindqwister Ph: 800-793-2262
 InterCommunity Cancer Center of Western Illinois
 Nguyet A Le-Lindqwister Ph: 800-793-2262
 Medical and Surgical Specialists, LLC
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  Harvey
 Ingalls Cancer Care Center at Ingalls Memorial Hospital
 Mark F. Kozloff Ph: 708-915-4673
  Email: clinicaltrials@ingalls.org
  Highland Park
 Hematology Oncology Associates of Illinois-Highland Park
 Seema A. Khan Ph: 312-695-1301
  Email: cancer@northwestern.edu
  Hinsdale
 Hinsdale Hematology Oncology Associates
 Elyse Cheryl Schneiderman Ph: 630-654-1790
  Email: info@hhoaltd.com
  Kankakee
 Provena St. Mary's Regional Cancer Center - Kankakee
 Seema A. Khan Ph: 312-695-1301
  Email: cancer@northwestern.edu
  Kewanee
 Illinois CancerCare - Kewanee Clinic
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  Libertyville
 North Shore Oncology and Hematology Associates, Limited - Libertyville
 Seema A. Khan Ph: 312-695-1301
  Email: cancer@northwestern.edu
  Macomb
 Illinois CancerCare - Macomb
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  Moline
 Garneau, Stewart C MD (UIA Investigator)
 David M Spector Ph: 309-779-4200
 Spector, David MD (UIA Investigator)
 David M Spector Ph: 309-779-4200
 Trinity Cancer Center at Trinity Medical Center - 7th Street Campus
 David M Spector Ph: 309-779-4200
  Mount Vernon
 Good Samaritan Regional Health Center
 Jay W Carlson Ph: 800-821-7532
  Email: sherrijr@iora.org
  Niles
 Cancer Care and Hematology Specialists of Chicagoland - Niles
 Seema A. Khan Ph: 312-695-1301
  Email: cancer@northwestern.edu
  Oak Lawn
 Advocate Christ Medical Center
 Renee H. Jacobs Ph: 630-856-7526
  Ottawa
 Illinois CancerCare - Ottawa
 Nguyet A Le-Lindqwister Ph: 800-793-2262
 Radiation Oncology of Northern Illinois
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  Pekin
 Cancer Treatment Center at Pekin Hospital
 Nguyet A Le-Lindqwister Ph: 800-793-2262
 Illinois CancerCare - Pekin
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  Peoria
 Illinois CancerCare - Peoria
 Nguyet A Le-Lindqwister Ph: 800-793-2262
 Methodist Medical Center of Illinois
 Nguyet A Le-Lindqwister Ph: 800-793-2262
 OSF Saint Francis Medical Center Radiation Oncology Service at the Central Illinois Comprehensive CC
 Nguyet A Le-Lindqwister Ph: 800-793-2262
 OSF St. Francis Medical Center
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  Peru
 Illinois CancerCare - Princeton
 Nguyet A Le-Lindqwister Ph: 800-793-2262
 Valley Cancer Center
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  Princeton
 Illinois CancerCare - Princeton
 Nguyet A Le-Lindqwister Ph: 800-793-2262
  River Forest
 West Suburban Center for Cancer Care
 Isoken Koko Ph: 708-488-0882
  Rockford
 Advanced Care and Treatment Medical Group, PC
 Harvey Eric Einhorn Ph: 779-696-9400
  Email: cancercare@swedishamerican.org
  Skokie
 Hematology Oncology Associates - Skokie
 Seema A. Khan Ph: 312-695-1301
  Email: cancer@northwestern.edu
  Springfield
 Regional Cancer Center at Memorial Medical Center
 James L. Wade Ph: 217-876-4740
  Email: kcheek@dmhhs.org
Indiana
  Elkhart
 Elkhart Clinic, LLC
 Jose A. Bufill Ph: 574-237-1328
 Elkhart General Hospital
 Jose A. Bufill Ph: 574-237-1328
 Michiana Hematology-Oncology, PC - Elkhart
 Jose A. Bufill Ph: 574-237-1328
  Indianapolis
 Central Indiana Cancer Centers - East
 Hillary H Wu Ph: 317-356-2422
 St. Francis Hospital Cancer Care Services
 Subhash C Sharma Ph: 317-851-2555
  Kokomo
 Community Cancer Care at Howard Regional Health System
 Jose A. Bufill Ph: 574-237-1328
  La Porte
 Center for Cancer Therapy at LaPorte Hospital and Health Services
 Jose A. Bufill Ph: 574-237-1328
  Mishawaka
 Michiana Hematology-Oncology, PC - Mishawaka
 Jose A. Bufill Ph: 574-237-1328
 Saint Joseph's Medical Center
 Jose A. Bufill Ph: 574-237-1328
  Plymouth
 Michiana Hematology Oncology PC - Plymouth
 Jose A. Bufill Ph: 574-237-1328
  Richmond
 Reid Hospital & Health Care Services
 Howard M. Gross Ph: 765-983-3000
  South Bend
 CCOP - Northern Indiana CR Consortium
 Jose A. Bufill Ph: 574-237-1328
 Memorial Hospital of South Bend
 Thomas Joseph Reid Ph: 800-284-7370
 Michiana Hematology-Oncology, PC - South Bend
 Jose A. Bufill Ph: 574-237-1328
 South Bend Clinic
 Jose A. Bufill Ph: 574-237-1328
  Westville
 Michiana Hematology Oncology-PC Westville
 Jose A. Bufill Ph: 574-237-1328
Iowa
  Ames
 McFarland Clinic, PC
 Joseph James Merchant Ph: 515-239-2621
 William R. Bliss Cancer Center at Mary Greeley Medical Center
 Joseph James Merchant Ph: 515-239-2621
  Bettendorf
 Constantinou, Costas L MD (UIA Investigator)
 David M Spector Ph: 309-779-4200
  Boone
 McFarland Clinic PC-Boone
 Joseph James Merchant Ph: 515-239-2621
  Clive
 Mercy Cancer Center - West Lakes
 Robert J Behrens Ph: 888-244-6061
  Email: sherrijr@iora.org
  Des Moines
 Mercy Cancer Center at Mercy Medical Center - Des Moines
 Robert J Behrens Ph: 888-244-6061
  Email: sherrijr@iora.org
  Jefferson
 McFarland Clinic PC-Jefferson
 Joseph James Merchant Ph: 515-239-2621
  Marshalltown
 McFarland Clinic PC-Marshalltown
 Joseph James Merchant Ph: 515-239-2621
  Ottumwa
 South Iowa Radiation Oncology Center at Ottumwa Regional Health Center
 Robert J Behrens Ph: 888-244-6061
  Email: sherrijr@iora.org
  Sioux City
 Siouxland Hematology-Oncology Associates, LLP
 Donald Bruce Wender Ph: 712-252-0088
  West Des Moines
 Methodist West Hospital
 Robert J Behrens Ph: 888-244-6061
  Email: sherrijr@iora.org
Kansas
  Chanute
 Cancer Center of Kansas, PA - Chanute
 Shaker R. Dakhil Ph: 316-262-4467
  Dodge City
 Cancer Center of Kansas, PA - Dodge City
 Shaker R. Dakhil Ph: 316-262-4467
  El Dorado
 Cancer Center of Kansas, PA - El Dorado
 Shaker R. Dakhil Ph: 316-262-4467
  Fort Scott
 Cancer Center of Kansas - Fort Scott
 Shaker R. Dakhil Ph: 316-262-4467
  Independence
 Cancer Center of Kansas-Independence
 Shaker R. Dakhil Ph: 316-262-4467
  Kingman
 Cancer Center of Kansas, PA - Kingman
 Shaker R. Dakhil Ph: 316-262-4467
  Lawrence
 Lawrence Memorial Hospital
 Shaker R. Dakhil Ph: 316-262-4467
  Liberal
 Cancer Center of Kansas, PA - Liberal
 Shaker R. Dakhil Ph: 316-262-4467
  Newton
 Cancer Center of Kansas, PA - Newton
 Shaker R. Dakhil Ph: 316-262-4467
  Parsons
 Cancer Center of Kansas, PA - Parsons
 Shaker R. Dakhil Ph: 316-262-4467
  Pratt
 Cancer Center of Kansas, PA - Pratt
 Shaker R. Dakhil Ph: 316-262-4467
  Salina
 Cancer Center of Kansas, PA - Salina
 Shaker R. Dakhil Ph: 316-262-4467
  Wellington
 Cancer Center of Kansas, PA - Wellington
 Shaker R. Dakhil Ph: 316-262-4467
  Wichita
 Associates in Women's Health, PA - North Hillside
 Shaker R. Dakhil Ph: 316-262-4467
 Cancer Center of Kansas, PA - Medical Arts Tower
 Shaker R. Dakhil Ph: 316-262-4467
 Cancer Center of Kansas, PA - Wichita
 Shaker R. Dakhil Ph: 316-262-4467
 CCOP - Wichita
 Shaker R. Dakhil Ph: 316-262-4467
 Via Christi Cancer Center at Via Christi Regional Medical Center
 Shaker R. Dakhil Ph: 316-262-4467
  Winfield
 Cancer Center of Kansas, PA - Winfield
 Shaker R. Dakhil Ph: 316-262-4467
Kentucky
  Edgewood
 St. Elizabeth Medical Center
 Joseph Michael Guenther Ph: 859-301-5473
  Email: darla.hehman@stelizabeth.com
  Fort Thomas
 St. Luke Hospital East
 Joseph Michael Guenther Ph: 859-301-5473
  Email: darla.hehman@stelizabeth.com
  Louisville
 University of Louisville School of Medicine
 Elizabeth C Riley Ph: 866-530-5516
Louisiana
  Baton Rouge
 Ochsner Health Center - Bluebonnet
 John T Cole Ph: 888-562-4763
  New Orleans
 Medical Center of Louisiana - New Orleans
 Robert W Veith Ph: 504-568-2428
  Email: emede1@lsuhsc.edu
 New Orleans Cancer Institute at Memorial Medical Center
 John T Cole Ph: 888-562-4763
 Ochsner Cancer Institute at Ochsner Clinic Foundation
 John T Cole Ph: 888-562-4763
 Stanley S. Scott Cancer Center at Louisiana State University Medical Center - New Orleans
 Robert W Veith Ph: 504-568-2428
  Email: emede1@lsuhsc.edu
 Touro Infirmary
 Robert W Veith Ph: 504-568-2428
  Email: emede1@lsuhsc.edu
 Tulane Cancer Center at Tulane University Hospital and Clinic
 Hana F Safah Ph: 504-988-6121
Maryland
  Annapolis
 DeCesaris Cancer Institute at Anne Arundel Medical Center
 Robert R Buras Ph: 443-481-1320
  Email: kbodenhorn@aahs.org
  Baltimore
 Alvin and Lois Lapidus Cancer Institute at Sinai Hospital
 Mayer Gorbaty Ph: 410-601-6120
  Email: pridgely@lifebridgehealth.org
 Greater Baltimore Medical Center Cancer Center
 Robert B Donegan Ph: 443-849-3706
 Greenebaum Cancer Center at University of Maryland Medical Center
 Randi J Cohen Ph: 800-888-8823
 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
 Mehran Habibi Ph: 410-955-8804
  Email: jhcccro@jhmi.edu
 St. Agnes Hospital Cancer Center
 Richard S. Hudes Ph: 410-368-2910
  Columbia
 Central Maryland Oncology Center
 Randi J Cohen Ph: 800-888-8823
  Easton
 Shore Regional Cancer Center at Memorial Hospital - Easton
 Mary S. DeShields Ph: 410-820-6800ext108
  Email: srichter@shorehealth.org
  Salisbury
 Peninsula Regional Medical Center
 Paul E Zorsky Ph: 410-543-7017
  Email: sandra.heineken@peninsula.org
Massachusetts
  Boston
 Dana-Farber/Brigham and Women's Cancer Center
 Mehra Golshan Ph: 617-724-5200
 Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute
 Mehra Golshan Ph: 617-724-5200
 Eastern Cooperative Oncology Group
 Seema A. Khan Ph: 312-695-1301
  Email: cancer@northwestern.edu
  Brighton
 Caritas St. Elizabeth's Medical Center
 Dorcas D Chi Ph: 617-789-2903
  Fall River
 Hudner Oncology Center at Saint Anne's Hospital - Fall River
 John L Yang Ph: 508-674-5600
  Newton
 Newton-Wellesley Hospital
 Mehra Golshan Ph: 617-724-5200
Michigan
  Adrian
 Hickman Cancer Center at Bixby Medical Center
 Rex B Mowat Ph: 517-265-0116
 Rex B Mowat Ph: 517-265-0116
  Ann Arbor
 Saint Joseph Mercy Cancer Center
 Christopher M Reynolds Ph: 734-712-4673
  Clarkston
 21st Century Oncology-Clarkston
 Jeffrey D. Forman Ph: 248-858-6215
  Dearborn
 Oakwood Cancer Center at Oakwood Hospital and Medical Center
 Christopher M Reynolds Ph: 734-712-4673
  Detroit
 Van Elslander Cancer Center at St. John Hospital and Medical Center
 Christopher M Reynolds Ph: 734-712-4673
 Wayne State University
 Ling Ma Ph: 888-785-6789
  Escanaba
 Green Bay Oncology, Limited - Escanaba
 Brian L Burnette Ph: 800-432-6049
  Farmington Hills
 21st Century Oncology-Farmington Hills
 Jeffrey D. Forman Ph: 248-858-6215
  Flint
 Genesys Hurley Cancer Institute
 Christopher M Reynolds Ph: 734-712-4673
 Hurley Medical Center
 Christopher M Reynolds Ph: 734-712-4673
  Grand Rapids
 Butterworth Hospital at Spectrum Health
 Gilbert D Padula Ph: 616-685-5225
 Lacks Cancer Center at Saint Mary's Health Care
 Gilbert D Padula Ph: 616-685-5225
  Iron Mountain
 Green Bay Oncology - Iron Mountain
 Brian L Burnette Ph: 800-432-6049
  Jackson
 Gayle M. Jacob Cancer Center at Allegiance Health
 Christopher M Reynolds Ph: 734-712-4673
  Lansing
 Sparrow Regional Cancer Center
 Christopher M Reynolds Ph: 734-712-4673
  Livonia
 St. Mary Mercy Hospital
 Christopher M Reynolds Ph: 734-712-4673
  Midland
 MidMichigan Medical Center - Midland
 Michel R. Hurtubise Ph: 989-839-3377
  Muskegon
 Mercy General Health Partners
 Gilbert D Padula Ph: 616-685-5225
  Pontiac
 St. Joseph Mercy Oakland
 Christopher M Reynolds Ph: 734-712-4673
  Port Huron
 Mercy Regional Cancer Center at Mercy Hospital
 Christopher M Reynolds Ph: 734-712-4673
  Reed City
 Spectrum Health Reed City Hospital
 Gilbert D Padula Ph: 616-685-5225
  Royal Oak
 William Beaumont Hospital - Royal Oak Campus
 Jannifer S Stromberg Ph: 248-551-7695
  Saginaw
 Seton Cancer Institute at Saint Mary's - Saginaw
 Christopher M Reynolds Ph: 734-712-4673
  Saint Joseph
 Lakeside Cancer Specialists, PLLC
 Jose A. Bufill Ph: 574-237-1328
  St. Joseph
 Lakeland Regional Cancer Care Center - St. Joseph
 Jose A. Bufill Ph: 574-237-1328
  Traverse City
 Munson Medical Center
 Gilbert D Padula Ph: 616-685-5225
  Troy
 William Beaumont Hospital - Troy Campus
 Jannifer S Stromberg Ph: 248-551-7695
  Warren
 St. John Macomb Hospital
 Christopher M Reynolds Ph: 734-712-4673
Minnesota
  Burnsville
 Fairview Ridges Hospital
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Coon Rapids
 Mercy and Unity Cancer Center at Mercy Hospital
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Edina
 Fairview Southdale Hospital
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Fridley
 Mercy and Unity Cancer Center at Unity Hospital
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Hutchinson
 Hutchinson Area Health Care
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Maplewood
 HealthEast Cancer Care at St. John's Hospital
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
 Minnesota Oncology - Maplewood
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Minneapolis
 Hennepin County Medical Center - Minneapolis
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
 Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  New Ulm
 New Ulm Medical Center
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Robbinsdale
 Humphrey Cancer Center at North Memorial Outpatient Center
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Saint Louis Park
 CCOP - Metro-Minnesota
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
 Park Nicollet Cancer Center
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Saint Paul
 Regions Hospital Cancer Care Center
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
 United Hospital
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Shakopee
 St. Francis Cancer Center at St. Francis Medical Center
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Stillwater
 Lakeview Hospital
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Waconia
 Ridgeview Medical Center
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Willmar
 Willmar Cancer Center at Rice Memorial Hospital
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Woodbury
 Minnesota Oncology - Woodbury
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
Mississippi
  Jackson
 University of Mississippi Cancer Clinic
 Barbara S Craft Ph: 601-815-6700
  Pascagoula
 Regional Cancer Center at Singing River Hospital
 James E. Clarkson Ph: 228-809-5292
Missouri
  Bolivar
 Central Care Cancer Center at Carrie J. Babb Cancer Center
 Jay W Carlson Ph: 800-821-7532
  Email: sherrijr@iora.org
  Branson
 Skaggs Cancer Center at Skaggs Regional Medical Center
 Jay W Carlson Ph: 800-821-7532
  Email: sherrijr@iora.org
  Cape Girardeau
 Saint Francis Medical Center
 James L. Wade Ph: 217-876-4740
  Email: kcheek@dmhhs.org
  Columbia
 Ellis Fischel Cancer Center at University of Missouri - Columbia
 Donald C Doll Ph: 573-882-7440
  Joplin
 St. John's Regional Medical Center
 Jay W Carlson Ph: 800-821-7532
  Email: sherrijr@iora.org
  Kansas City
 Research Medical Center
 Rakesh Gaur Ph: 913-948-5588
  Email: aroland@kccop.org
 Saint Luke's Hospital
 Rakesh Gaur Ph: 913-948-5588
  Email: aroland@kccop.org
  Rolla
 Mercy Clinic Cancer and Hematology - Rolla
 Jay W Carlson Ph: 800-821-7532
  Email: sherrijr@iora.org
  Saint Joseph
 Heartland Regional Medical Center
 Rakesh Gaur Ph: 913-948-5588
  Email: aroland@kccop.org
  Saint Louis
 David C. Pratt Cancer Center at St. John's Mercy
 Jay W Carlson Ph: 800-821-7532
  Email: sherrijr@iora.org
 Mercy Clinic St. Louis Cancer and Breast Institute
 Jay W Carlson Ph: 800-821-7532
  Email: sherrijr@iora.org
 Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
 Julie A Margenthaler Ph: 800-600-3606
  Email: info@siteman.wustl.edu
 St. Anthony's Cancer Center
 Minxiang (Michael) Gu Ph: 888-823-5923
  Email: ctsucontact@westat.com
  Springfield
 Hulston Cancer Center at Cox Medical Center South
 Jay W Carlson Ph: 800-821-7532
  Email: sherrijr@iora.org
 St. John's Regional Health Center
 Jay W Carlson Ph: 800-821-7532
  Email: sherrijr@iora.org
Montana
  Billings
 Billings Clinic Cancer Center - 801 N 29th Street
 Benjamin Thomas Marchello Ph: 800-648-6274
 CCOP - Montana Cancer Consortium
 Benjamin Thomas Marchello Ph: 800-648-6274
 St. Vincent Healthcare Cancer Care Services
 Benjamin Thomas Marchello Ph: 800-648-6274
  Great Falls
 Benefis Sletten Cancer Institute
 Benjamin Thomas Marchello Ph: 800-648-6274
  Kalispell
 Kalispell Regional Medical Center
 Benjamin Thomas Marchello Ph: 800-648-6274
Nebraska
  Lincoln
 Cancer Resource Center - Lincoln
 Gamini S. Soori Ph: 402-280-4100
  Omaha
 Alegant Health Cancer Center at Bergan Mercy Medical Center
 Gamini S. Soori Ph: 402-280-4100
 CCOP - Missouri Valley Cancer Consortium
 Gamini S. Soori Ph: 402-398-6060
 Immanuel Medical Center
 Gamini S. Soori Ph: 402-280-4100
 Lakeside Hospital
 Gamini S. Soori Ph: 402-280-4100
Nevada
  Reno
 Saint Mary's Regional Medical Center
 Kathleen (Katie) B Legarza Ph: 775-770-7410
New Hampshire
  Concord
 New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care
 Douglas Jay Weckstein Ph: 603-224-2556
  Hooksett
 New Hampshire Oncology - Hematology, PA - Hooksett
 Douglas Jay Weckstein Ph: 603-224-2556
  Keene
 Kingsbury Center for Cancer Care at Cheshire Medical Center
 Gary N Schwartz Ph: 800-639-6918
  Email: cancer.research.nurse@dartmouth.edu
  Laconia
 Lakes Region General Hospital
 Douglas Jay Weckstein Ph: 603-224-2556
  Lebanon
 Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
 Gary N Schwartz Ph: 800-639-6918
  Email: cancer.research.nurse@dartmouth.edu
  Londonderry
 Dana-Farber Cancer Institute at Londonderry
 Mehra Golshan Ph: 617-724-5200
  Manchester
 Norris Cotton Cancer Center at Catholic Medical Center
 Gary N Schwartz Ph: 800-639-6918
  Email: cancer.research.nurse@dartmouth.edu
New Jersey
  Brick
 Ocean Medical Center at Meridian Health
 Kenneth D. Nahum Ph: 732-776-4240
  Camden
 Cancer Institute of New Jersey at Cooper University Hospital - Camden
 Gregory A. Masters Ph: 302-733-6227
  Mount Holly
 Virtua Fox Chase Health Cancer Program at Virtua Memorial Hospital Burlington County
 Michael S. Entmacher Ph: 888-847-8823
  Neptune
 Jersey Shore Cancer Center at Jersey Shore University Medical Center
 Kenneth D. Nahum Ph: 732-776-4240
  Newark
 Newark Beth Israel Medical Center
 Lori Schleicher Ph: 973-926-7230
  Red Bank
 Booker Cancer Center at Riverview Medical Center
 Kenneth D. Nahum Ph: 732-776-4240
  Sewell
 Radiation Oncology Center at Kennedy Health System - Sewell
 Trina A Poretta Ph: 888-847-8823
  Sparta
 Frederick R. and Betty M. Smith Cancer Treatment Center
 Rebecca J Jaslow Ph: 215-955-6084
  Voorhees
 Cancer Institute of New Jersey at Cooper - Voorhees
 Robert A Somer Ph: 856-325-6757
 Fox Chase Virtua Health Cancer Program at Virtua West Jersey
 Michael S. Entmacher Ph: 888-847-8823
New York
  Bronx
 Albert Einstein Cancer Center at Albert Einstein College of Medicine
 Lisa Wiechmann Ph: 718-904-2730
  Email: aecc@aecom.yu.edu
 Jack D. Weiler Hospital at Montefiore Medical Center - East Campus
 Lisa Wiechmann Ph: 718-904-2730
  Email: aecc@aecom.yu.edu
 Montefiore Medical Center
 Lisa Wiechmann Ph: 718-904-2730
  Email: aecc@aecom.yu.edu
  Brooklyn
 Maimonides Cancer Center at Maimonides Medical Center
 Susan Burdette-Radoux Ph: 718-765-2500
  Carmel
 Putnam Hospital Center
 Radhika Rachamalla Ph: 845-483-6483
  Cooperstown
 Bassett Healthcare Regional Cancer Program at Mary Imogene Bassett Hospital
 Eric Bravin Ph: 607-547-3073
  Email: diana.crean@bassett.org
  Fishkill
 Fishkill Radiation Oncology Center
 Radhika Rachamalla Ph: 845-483-6483
  Kingston
 Ulster Radiation Oncology Center
 Radhika Rachamalla Ph: 845-483-6483
  Mineola
 Winthrop University Hospital
 Nina D'Abreo Ph: 866-946-8476
  New York
 Beth Israel Medical Center - Petrie Division
 Paula Klein Ph: 212-367-1729
 Memorial Sloan-Kettering Cancer Center
 Tari A King Ph: 212-639-7202
 St. Luke's - Roosevelt Hospital Center - St.Luke's Division
 Paula Klein Ph: 212-367-1729
  Poughkeepsie
 Dyson Center for Cancer Care at Vassar Brothers Medical Center
 Radhika Rachamalla Ph: 845-483-6483
  Rochester
 Daisy Marquis Jones Radiation Oncology Center at Highland Hospital of Rochester
 Jonathan W Friedberg Ph: 585-275-5830
 James P. Wilmot Cancer Center at University of Rochester Medical Center
 Jonathan W Friedberg Ph: 585-275-5830
  Staten Island
 Nalitt Cancer Institute at Staten Island University Hospital
 Meekoo Dhar Ph: 718-226-8888
  Stony Brook
 Stony Brook University Cancer Center
 Christine R Rizk Ph: 800-862-2215
  White Plains
 Dickstein Cancer Treatment Center at White Plains Hospital Center
 Karen B Green Ph: 914-681-2290
North Carolina
  Greenville
 Carolina Radiation Medicine, PA
 Ron R. Allison Ph: 252-744-2161
 Leo W. Jenkins Cancer Center at ECU Medical School
 Mahvish Muzaffar Ph: 252-744-2391
  Hendersonville
 Comprehensive Cancer Center at Pardee Hospital
 James E. Radford Ph: 828-696-4716
  Statesville
 Iredell Memorial Hospital
 Ruby A. Grimm Ph: 704-873-5661
  Wilmington
 Zimmer Cancer Center at New Hanover Regional Medical Center
 Cyrus A. Kotwall Ph: 910-342-3000
  Email: cancer.research@nhrmc.org
  Winston-Salem
 Wake Forest University Comprehensive Cancer Center
 Marissa M Howard-McNatt Ph: 336-713-6771
North Dakota
  Grand Forks
 Altru Cancer Center at Altru Hospital
 Grant R Seeger Ph: 701-780-6520
  Minot
 Trinity CancerCare Center
 Patanit Watanaboonyakhet Ph: 800-862-0005
Ohio
  Akron
 McDowell Cancer Center at Akron General Medical Center
 Esther H. Rehmus Ph: 330-344-6348
  Belpre
 Strecker Cancer Center-Belpre
 J. Philip Kuebler Ph: 800-446-5532
  Canton
 Aultman Cancer Center at Aultman Hospital
 Kisa E Weeman Ph: 330-363-6891
  Chardon
 Geauga Regional Hospital
 Janice Lyons Ph: 800-641-2422
  Chillicothe
 Adena Regional Medical Center
 J. Philip Kuebler Ph: 800-446-5532
  Cincinnati
 Bethesda North Hospital
 Ching Ho Ph: 513-862-2230
 Good Samaritan Hospital Cancer Treatment Center
 Kevin J. Grannan Ph: 513-862-2230
 Oncology Hematology Care, Incorporated - Blue Ash
 Howard M. Gross Ph: 765-983-3000
  Cleveland
 Case Comprehensive Cancer Center
 Janice Lyons Ph: 800-641-2422
  Columbus
 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center
 Stephen P Povoski Ph: 866-627-7616
  Email: osu@emergingmed.com
 CCOP - Columbus
 J. Philip Kuebler Ph: 800-446-5532
 Columbus Oncology Associates, Incorporated
 J. Philip Kuebler Ph: 800-446-5532
 Doctors Hospital at Ohio Health
 J. Philip Kuebler Ph: 800-446-5532
 Grant Medical Center Cancer Care
 J. Philip Kuebler Ph: 800-446-5532
 Mount Carmel Health - West Hospital
 J. Philip Kuebler Ph: 800-446-5532
 Riverside Methodist Hospital Cancer Care
 J. Philip Kuebler Ph: 800-446-5532
 Zangmeister Center
 J. Philip Kuebler Ph: 800-446-5532
  Dayton
 David L. Rike Cancer Center at Miami Valley Hospital
 Howard M. Gross Ph: 765-983-3000
 Good Samaritan Hospital
 Howard M. Gross Ph: 765-983-3000
 Samaritan North Cancer Care Center
 Howard M. Gross Ph: 765-983-3000
  Delaware
 Delaware Health Center
 J. Philip Kuebler Ph: 800-446-5532
 Delaware Radiation Oncology
 J. Philip Kuebler Ph: 614-566-3275
 Grady Memorial Hospital
 J. Philip Kuebler Ph: 800-446-5532
  Findlay
 Blanchard Valley Regional Cancer Center
 Howard M. Gross Ph: 765-983-3000
  Franklin
 Atrium Medical Center
 Howard M. Gross Ph: 765-983-3000
  Greenville
 Wayne Hospital
 Howard M. Gross Ph: 765-983-3000
  Kettering
 Charles F. Kettering Memorial Hospital
 Howard M. Gross Ph: 765-983-3000
  Lancaster
 Fairfield Medical Center
 J. Philip Kuebler Ph: 800-446-5532
 Lancaster Radiation Oncology at Fairfield Medical Center
 J. Philip Kuebler Ph: 614-566-3275
  Marietta
 Strecker Cancer Center at Marietta Memorial Hospital
 J. Philip Kuebler Ph: 800-446-5532
  Maumee
 Northwest Ohio Oncology Center
 Rex B Mowat Ph: 517-265-0116
 Rex B Mowat Ph: 517-265-0116
  Mentor
 Lake/University Ireland Cancer Center
 Janice Lyons Ph: 800-641-2422
  Middleburg Heights
 Southwest General Health Center
 Janice Lyons Ph: 800-641-2422
  Mount Vernon
 Knox Community Hospital
 J. Philip Kuebler Ph: 800-446-5532
  Newark
 Licking Memorial Cancer Care Program at Licking Memorial Hospital
 J. Philip Kuebler Ph: 800-446-5532
 Newark Radiation Oncology
 J. Philip Kuebler Ph: 614-566-3275
  Orange Village
 UHHS Chagrin Highlands Medical Center
 Janice Lyons Ph: 800-641-2422
  Oregon
 St. Charles Mercy Hospital
 Rex B Mowat Ph: 517-265-0116
  Portsmouth
 Southern Ohio Medical Center Cancer Center
 J. Philip Kuebler Ph: 800-446-5532
  Sandusky
 University Hospitals Ireland Cancer Center at Firelands Regional Medical Center
 Janice Lyons Ph: 800-641-2422
  Springfield
 Community Hospital of Springfield and Clark County
 J. Philip Kuebler Ph: 800-446-5532
  Sylvania
 Flower Hospital Cancer Center
 Rex B Mowat Ph: 517-265-0116
  Toledo
 St. Anne Mercy Hospital
 Rex B Mowat Ph: 517-265-0116
 Toledo Clinic, Incorporated - Main Clinic
 Rex B Mowat Ph: 517-265-0116
 University of Toledo Medical Center
 Rex B Mowat Ph: 517-265-0116
  Troy
 UVMC Cancer Care Center at Upper Valley Medical Center
 Howard M. Gross Ph: 765-983-3000
  Westerville
 Mount Carmel St. Ann's Cancer Center
 J. Philip Kuebler Ph: 800-446-5532
  Westlake
 UHHS Westlake Medical Center
 Janice Lyons Ph: 800-641-2422
  Wright-Patterson Afb
 United States Air Force Medical Center - Wright-Patterson
 Brandon J Cutler Ph: 937-257-1398
  Zanesville
 Genesis - Good Samaritan Hospital
 J. Philip Kuebler Ph: 800-446-5532
Oklahoma
  Oklahoma City
 Oklahoma University Cancer Institute
 Wajeeha Razaq Ph: 405-271-4272
  Email: julie-traylor@ouhsc.edu
Oregon
  Clackamas
 Clackamas Radiation Oncology Center
 Alison K Conlin Ph: 503-215-6412
  Portland
 Providence Cancer Center at Providence Portland Medical Center
 Alison K Conlin Ph: 503-215-6412
 Providence St. Vincent Medical Center
 Alison K Conlin Ph: 503-215-6412
Pennsylvania
  Easton
 Easton Regional Cancer Center at Easton Hospital
 Sonyo Shin Ph: 610-250-4000
  Gettysburg
 Adams Cancer Center
 Amir Tabatabai Ph: 877-441-7957
  Hanover
 Cherry Tree Cancer Center
 Amir Tabatabai Ph: 877-441-7957
  Hershey
 Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center
 J. Stanley Smith Ph: 717-531-3779
  Email: CTO@hmc.psu.edu
  Lancaster
 Lancaster General Hospital
 Elizabeth Horenkamp Ph: 717-544-5511
  Langhorne
 St. Mary Regional Cancer Center
 Robert C. Reilly Ph: 215-710-4585
  Lewistown
 Lewistown Hospital
 J. Stanley Smith Ph: 717-531-3779
  Email: CTO@hmc.psu.edu
  Monroeville
 Forbes Regional Hospital
 Thomas B Julian Ph: 877-284-2000
  Philadelphia
 Albert Einstein Cancer Center
 Mark S Morginstin Ph: 215-456-3880
 Fox Chase Cancer Center - Philadelphia
 Lori J. Goldstein Ph: 215-728-4790
 Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
 Rebecca J Jaslow Ph: 215-955-6084
  Pittsburgh
 Allegheny Cancer Center at Allegheny General Hospital
 Thomas B Julian Ph: 877-284-2000
 Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital
 Thomas B Julian Ph: 877-284-2000
  State College
 Mount Nittany Medical Center
 J. Stanley Smith Ph: 717-531-3779
  Email: CTO@hmc.psu.edu
  Williamsport
 Susquehanna Cancer Center at Divine Providence Hospital
 Warren L Robinson Ph: 800-598-4282
  York
 WellSpan Health
 Amir Tabatabai Ph: 877-441-7957
PR
  San Juan
 San Juan City Hospital
 Luis Baez-Diaz Ph: 787-767-3733
South Carolina
  Charleston
 Hollings Cancer Center at Medical University of South Carolina
 Megan K Baker Ruppel Ph: 843-792-9321
 Roper St. Francis Cancer Center at Roper Hospital
 James Michael Orcutt Ph: 843-720-8386
  Email: elizabeth.strojny@roperstfrancis.com
  Greenville
 Cancer Centers of the Carolinas - Faris Road
 Jeffrey Kent Giguere Ph: 864-241-6251
 Cancer Centers of the Carolinas - Grove Commons
 Jeffrey Kent Giguere Ph: 864-241-6251
 CCOP - Greenville
 Jeffrey Kent Giguere Ph: 864-241-6251
  Greer
 Cancer Centers of the Carolinas - Greer Radiation Oncology
 Jeffrey Kent Giguere Ph: 864-241-6251
  Seneca
 Cancer Centers of the Carolinas - Seneca
 Jeffrey Kent Giguere Ph: 864-241-6251
  Spartanburg
 Cancer Centers of the Carolinas - Spartanburg
 Jeffrey Kent Giguere Ph: 864-241-6251
South Dakota
  Sioux Falls
 Sanford Cancer Center at Sanford USD Medical Center
 Miroslaw A Mazurczak Ph: 605-328-1367
 Miroslaw A Mazurczak Ph: 605-328-1367
Tennessee
  Jackson
 West Tennessee Cancer Center at Jackson-Madison County General Hospital
 Salomon Asmar Ph: 731-425-6865
  Knoxville
 U.T. Medical Center Cancer Institute
 Timothy John Panella Ph: 865-544-9773
Texas
  Dallas
 Parkland Memorial Hospital
 Asal S Rahimi Ph: 214-648-7097
 Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas
 Asal S Rahimi Ph: 214-648-7097
  Houston
 Univeristy of Texas M.D. Anderson Cancer Center
 Gildy V. Babiera Ph: 713-792-3245
  Irving
 Baylor Medical Center at Irving
 Narotham R Thudi Ph: 972-566-5588
  Laredo
 Doctor's Hospital of Laredo
 Gary W. Unzeitig Ph: 888-823-5923
  Email: ctsucontact@westat.com
  Tyler
 University of Texas Health Center at Tyler
 Edward R. Sauter Ph: 888-823-5923
  Email: ctsucontact@westat.com
Utah
  Cedar City
 Sandra L. Maxwell Cancer Center
 Vilija N Avizonis Ph: 801-507-3950
  Logan
 Logan Regional Hospital
 Vilija N Avizonis Ph: 801-507-3950
  Murray
 Jon and Karen Huntsman Cancer Center at Intermountain Medical Center
 Vilija N Avizonis Ph: 801-507-3950
  Ogden
 Val and Ann Browning Cancer Center at McKay-Dee Hospital Center
 Vilija N Avizonis Ph: 801-507-3950
  Provo
 Utah Valley Regional Medical Center - Provo
 Vilija N Avizonis Ph: 801-507-3950
  Saint George
 Dixie Regional Medical Center - East Campus
 Vilija N Avizonis Ph: 801-507-3950
  Salt Lake City
 LDS Hospital
 Vilija N Avizonis Ph: 801-507-3950
 Utah Cancer Specialists at UCS Cancer Center
 Vilija N Avizonis Ph: 801-507-3950
Washington
  Auburn
 Auburn Regional Center for Cancer Care
 Yoshio Inoue Ph: 253-403-2394
  Bellevue
 Overlake Cancer Center at Overlake Hospital Medical Center
 Yoshio Inoue Ph: 253-403-2394
  Bellingham
 St. Joseph Cancer Center
 Gary E Goodman Ph: 206-386-2323
  Email: patra.grevstad@swedish.org
  Bremerton
 Olympic Hematology and Oncology
 Gary E Goodman Ph: 206-386-2323
  Email: patra.grevstad@swedish.org
  Everett
 Providence Regional Cancer Partnership
 Yoshio Inoue Ph: 253-403-2394
  Issaquah
 Swedish Medical Center - Issaquah Campus
 Gary E Goodman Ph: 206-386-2323
  Email: patra.grevstad@swedish.org
  Longview
 Lower Columbia Regional Cancer Center at PeaceHealth-St. John Medical Center
 Alison K Conlin Ph: 503-215-6412
  Poulsbo
 Harrison Poulsbo Hematology and Onocology
 Gary E Goodman Ph: 206-386-2323
  Email: patra.grevstad@swedish.org
  Puyallup
 Good Samaritan Cancer Center
 Yoshio Inoue Ph: 253-403-2394
  Seattle
 Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
 Gary E Goodman Ph: 206-386-2323
  Email: patra.grevstad@swedish.org
 University Cancer Center at University of Washington Medical Center
 Gary E Goodman Ph: 206-386-2323
  Email: patra.grevstad@swedish.org
  Tacoma
 CCOP - Northwest
 Yoshio Inoue Ph: 253-403-2394
 Franciscan Cancer Center at St. Joseph Medical Center
 Yoshio Inoue Ph: 253-403-2394
 MultiCare Regional Cancer Center at Tacoma General Hospital
 Yoshio Inoue Ph: 253-403-2394
  Vancouver
 Southwest Washington Medical Center Cancer Center
 Alison K Conlin Ph: 503-215-6412
West Virginia
  Huntington
 Edwards Comprehensive Cancer Center at Cabell Huntington Hospital
 Maria-Rosalia B. Tria Tirona Ph: 304-399-6617
 St. Mary's Regional Cancer Center at St. Mary's Medical Center
 Arvinder S Bir Ph: 888-823-5923
  Email: ctsucontact@westat.com
  Wheeling
 Schiffler Cancer Center at Wheeling Hospital
 Lowell C Shinn Ph: 304-243-6442
Wisconsin
  Antigo
 Langlade Memorial Hospital
 Hamied R. Rezazadeh Ph: 877-405-6866
  Appleton
 Fox Valley Surgical Associates at Appleton Medical Center
 Honnie R Bermas Ph: 800-574-3872
  Chippewa Falls
 Marshfield Clinic - Chippewa Center
 Douglas J Reding Ph: 715-389-4457
  Eau Claire
 Center for Cancer Treatment & Prevention at Sacred Heart Hospital
 Douglas J Reding Ph: 715-389-4457
 Marshfield Clinic Cancer Care at Regional Cancer Center
 Douglas J Reding Ph: 715-389-4457
  Grafton
 Aurora Cancer Care-Grafton
 Rubina Qamar Ph: 888-709-2080
  Green Bay
 Green Bay Oncology, Limited at St. Mary's Hospital
 Brian L Burnette Ph: 800-432-6049
 Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center
 Brian L Burnette Ph: 800-432-6049
 St. Mary's Hospital Medical Center - Green Bay
 Brian L Burnette Ph: 800-432-6049
 St. Vincent Hospital Regional Cancer Center
 Brian L Burnette Ph: 800-432-6049
 Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center
 Rubina Qamar Ph: 888-709-2080
  Johnson Creek
 UW Cancer Center Johnson Creek
 Amye J Tevaarwerk Ph: 877-405-6866
  Kenosha
 Oncology Alliance - Kenosha South
 Rubina Qamar Ph: 888-709-2080
  La Crosse
 Gundersen Lutheran Center for Cancer and Blood
 Kurt Oettel Ph: 608-775-2385
  Email: cancerctr@gundluth.org
  Madison
 University of Wisconsin Paul P. Carbone Comprehensive Cancer Center
 Amye J Tevaarwerk Ph: 877-405-6866
  Manitowoc
 Holy Family Memorial Medical Center Cancer Care Center
 Brian L Burnette Ph: 800-432-6049
  Marinette
 Bay Area Cancer Care Center at Bay Area Medical Center
 Brian L Burnette Ph: 800-432-6049
  Marshfield
 Marshfield Clinic - Marshfield Center
 Douglas J Reding Ph: 715-389-4457
 Saint Joseph's Hospital
 Douglas J Reding Ph: 715-389-4457
  Milwaukee
 Aurora Sinai Medical Center
 Rubina Qamar Ph: 888-709-2080
 Froedtert Hospital and Medical College of Wisconsin
 Yee C Cheng Ph: 414-805-4380
  Minocqua
 Marshfield Clinic - Lakeland Center
 Douglas J Reding Ph: 715-389-4457
  New Richmond
 Cancer Center of Western Wisconsin
 Joseph W Leach Ph: 952-993-1517
  Email: MMCCOP@parknicollet.com
  Oconto Falls
 Green Bay Oncology, Limited - Oconto Falls
 Brian L Burnette Ph: 800-432-6049
  Oshkosh
 Vince Lombardi Cancer Clinic - Oshkosh
 Rubina Qamar Ph: 888-709-2080
  Rhinelander
 Ministry Medical Group at Saint Mary's Hospital
 Douglas J Reding Ph: 715-389-4457
 Douglas J Reding Ph: 715-389-4457
  Rice Lake
 Marshfield Clinic - Indianhead Center
 Douglas J Reding Ph: 715-389-4457
  Sheboygan
 Saint Nicholas Hospital
 Brian L Burnette Ph: 800-432-6049
 Vince Lombardi Cancer Clinic - Sheboygan
 Rubina Qamar Ph: 888-709-2080
  Stevens Point
 Marshfield Clinic at Saint Michael's Hospital
 Douglas J Reding Ph: 715-389-4457
 Saint Michael's Hospital Cancer Center
 Douglas J Reding Ph: 715-389-4457
  Sturgeon Bay
 Green Bay Oncology, Limited - Sturgeon Bay
 Brian L Burnette Ph: 800-432-6049
  Summit
 Aurora Medical Center
 Rubina Qamar Ph: 888-709-2080
  Wausau
 Marshfield Clinic - Wausau Center
 Douglas J Reding Ph: 715-389-4457
 University of Wisconcin Cancer Center at Aspirus Wausau Hospital
 Hamied R. Rezazadeh Ph: 877-405-6866
  West Allis
 Aurora Women's Pavilion of West Allis Memorial Hospital
 Rubina Qamar Ph: 888-709-2080
  Weston
 Diagnostic and Treatment Center
 Douglas J Reding Ph: 715-389-4457
 Marshfield Clinic - Weston Center
 Douglas J Reding Ph: 715-389-4457
  Wisconsin Rapids
 Marshfield Clinic - Wisconsin Rapids Center
 Douglas J Reding Ph: 715-389-4457
 Riverview UW Cancer Center at Riverview Hospital
 Ron James Kirschling Ph: 877-405-6866
Canada
Alberta
  Edmonton
 Cross Cancer Institute at University of Alberta
 Zsolt Gabos Ph: 780-432-8500
Manitoba
  Winnipeg
 CancerCare Manitoba
 Ethel L MacIntosh Ph: 866-561-1026
  Email: CIO_Web@cancercare.mb.ca
New Brunswick
  Saint John
 Saint John Regional Hospital
 Margot J. Burnell Ph: 506-648-6890
Quebec
  Montreal
 McGill Cancer Centre at McGill University
 Mark Basik Ph: 514-340-8222ext8248
  Email: penny.chipman@mcgill.ca
Israel
  Tel Aviv
 Tel-Aviv Sourasky Medical Center
 Tehillah S Menes Ph: 011-972-3-6974761
  Email: mop@tasmc.health.gov.il
Saudi Arabia
  Riyadh
 King Faisal Specialist Hospital and Research Center
 Kausar Suleman Ph: 011-966-1-464-7272 ext 38005

Link to the current ClinicalTrials.gov record.
NLM Identifer NCT01242800
ClinicalTrials.gov processed this data on February 11, 2014

Note: Information about this trial is from the ClinicalTrials.gov database. The versions designated for health professionals and patients contain the same text. Minor changes may be made to the ClinicalTrials.gov record to standardize the names of study sponsors, sites, and contacts. Cancer.gov only lists sites that are recruiting patients for active trials, whereas ClinicalTrials.gov lists all sites for all trials. Questions and comments regarding the presented information should be directed to ClinicalTrials.gov.

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