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Clinical Trials (PDQ®)

Acupressure for Persistent Cancer Related Fatigue

Basic Trial Information
Trial Description
     Summary
     Eligibility Criteria
Trial Contact Information

Basic Trial Information

PhaseTypeStatusAgeSponsorProtocol IDs
Phase III, Phase IISupportive careActive18 to 75NCI, OtherCA151445
R01CA151445, NCT01281904

Trial Description

Summary

There are over 2 million breast cancer survivors today. Persistent Cancer-Related fatigue (PCRF), a state of being tired or weary, is one of the most common and distressing symptoms experienced by breast cancer (BC) survivors. Rates of significant PCRF in BC survivors range from 30% to 82% within the first 5-years of diagnosis and there are few treatment options for PCRF and these treatments require the availability of a trained practitioner, are associated with significant costs, pose a sizeable burden for the patient, or have unacceptable side-effects.

Acupressure is a technique derived from acupuncture, a component of Traditional Chinese Medicine. In acupressure, physical pressure is applied to acupuncture points by the hand, elbow, or with various devices to treat disease. Pilot studies have demonstrated that self-administered acupressure can significantly decrease PCRF by as much as 70% in cancer survivors. Acupressure can also have positive effects on sleep quality in cancer patients and other chronically ill populations. Self-administered acupressure is a non-toxic and inexpensive treatment that requires minimal instruction. It also requires little effort and time on the part of the patient to successfully complete. Thus, acupressure appears to be a promising treatment for PCRF and associated symptoms.

The investigators are conducting a single-blind, placebo controlled study to examine the specific effect of two opposing acupressure treatments compared to standard of care. The goal of this study is to determine the benefit of acupressure on treating persistent fatigue experience by many patients after completing their cancer treatment. Study patients will be randomized into one of three groups: two different types of acupressure or a standard of care arm. For those participants randomized to receive acupressure, the technique will be taught to them by a study nurse trained by an acupressure specialist. Participants will be asked to perform the acupressure daily over the next six weeks, during which time they will record their fatigue and be asked to wear an activity monitor to have their daily activity levels monitored.

Eligibility Criteria

Inclusion Criteria:

  • 18 years of age or older
  • Diagnosis of breast cancer
  • Have completed all cancer related treatments (i.e. surgery, chemotherapy, radiotherapy, immunotherapy, etc.) at least 1 year prior to enrollment except for hormone therapy which must have been initiated at least three weeks prior to enrollment
  • Apparently cancer-free
  • Able to self-administer acupressure
  • Have a complaint of persistent, moderate to severe fatigue despite standard treatment [defined as ≥ 4 on the Brief Fatigue Inventory (BFI)]
  • Able to maintain typical dietary (eating and drinking) patterns, especially the use of caffeinated beverages throughout the study
  • Willing to participate in an 11-week clinical trial that involves 5 study visits (not including the screening visit, as well as weekly phone calls

Exclusion Criteria:

  • Pregnant (per urine pregnancy test), wanting to become pregnant or Lactating
  • Diagnosis of anemia or receiving treatment for it
  • Have any comorbidities likely to cause significant fatigue (i.e., moderate to severe heart failure, hypothyroidism, chronic fatigue syndrome) either currently or before cancer diagnosis
  • Have a diagnosis of depression, receiving active treatment for depression, or have HADS score of ≥11
  • Currently taking medication for insomnia
  • Have an initiation, cessation or change of dose (up to three weeks prior to the study's start) of any chronic medications or dietary supplements or any planned change of chronic medications or dietary supplements during the study
  • Had acupuncture or acupressure within the last 6 months

Trial Contact Information

Trial Lead Organizations/Sponsors

University of Michigan Comprehensive Cancer Center

National Cancer Institute

Suzanna M Zick, ND, MPHPrincipal Investigator

Suzanna M ZickPh: 1-734-998-0016
  Email: fammed-szickstudy@med.umich.edu

Trial Sites

U.S.A.
Michigan
  Ann Arbor
 University of Michigan Comprehensive Cancer Center
 Suzanna Zick Ph: 734-998-0016
  Email: fammed-szickstudy@med.umich.edu
 Suzanna ZickPrincipal Investigator
 Richard E Harris, PhDPrincipal Investigator

Link to the current ClinicalTrials.gov record.
NLM Identifer NCT01281904
ClinicalTrials.gov processed this data on September 25, 2014

Note: Information about this trial is from the ClinicalTrials.gov database. The versions designated for health professionals and patients contain the same text. Minor changes may be made to the ClinicalTrials.gov record to standardize the names of study sponsors, sites, and contacts. Cancer.gov only lists sites that are recruiting patients for active trials, whereas ClinicalTrials.gov lists all sites for all trials. Questions and comments regarding the presented information should be directed to ClinicalTrials.gov.

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