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Clinical Trials (PDQ®)

Pediatric Philadelphia Positive Acute Lymphoblastic Leukemia

Basic Trial Information
Trial Description
     Summary
     Eligibility Criteria
Trial Contact Information

Basic Trial Information

PhaseTypeStatusAgeSponsorProtocol IDs
Phase IITreatmentActive1 to 17Pharmaceutical / IndustryCA180-372
2011-001123-20, AALL1122, NCT01460160

Trial Description

Summary

The purpose of this study is to determine whether Dasatinib when added to standard chemotherapy is effective and safe in the treatment of pediatric philadelphia chromosome positive acute lymphoblastic leukemia

Eligibility Criteria

For more information regarding BMS clinical trial participation, please visit www.BMSStudyConnect.com.

Inclusion Criteria:

  • Newly diagnosed Philadelphia chromosome positive Acute Lymphoblastic Leukemia (ALL)
  • Age >1 year and < less than 18 years old
  • Induction chemotherapy ≤ 14 days according to institutional standard of care
  • Adequate liver, renal and cardiac function

Exclusion Criteria:

  • Prior treatment with a Oncogene fusion protein (BCR-ABL) inhibitor
  • Extramedullary involvement of the testicles
  • Active systemic bacterial, fungal or viral infection
  • Down syndrome

Trial Contact Information

Trial Lead Organizations/Sponsors

Bristol-Myers Squibb Company - New York

Children's Oncology Group

EsPhALL - European Intergroup Study on Post Induction Treatment of Philadelphia Positive Acute Lymphoblastic Leukaemia with Imatinib

Bristol-Myers SquibbStudy Director

Recruiting sites have contact information. Please contact the sites directly. If there is no contact information, please email:
  Email: Clinical.Trials@bms.com

Trial Sites

U.S.A.
Alabama
  Birmingham
 UAB Comprehensive Cancer Center
 Alyssa Reddy, Site 077 Ph: 205-638-9285
Arizona
  Phoenix
 Phoenix Children's Hospital
 Jessica Boklan, Site 005 Ph: 602-546-5004
Arkansas
  Little Rock
 Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
 David L Becton, Site 098 Ph: 501-364-1691
California
  Loma Linda
 Antranik Agop Bedros
 Antranik Agop Bedros, Site 099 Ph: 909-558-4050
  Long Beach
 Jonathan Jaques Children's Cancer Center at Miller Children's Hospital
 Theodore Zwerdling, Site 046 Ph: 562-933-8626
  Los Angeles
 Children's Hospital Los Angeles
 Weili Sun, Site 014 Ph: 323-361-2643
 Kaiser Permanente Medical Center - Los Angeles
 Robert M Cooper, Site 066 Ph: 323-783-5307
  Madera
 Children's Hospital Central California
 James Ozeran, Site 013 Ph: 559-353-5463
  Orange
 Children's Hospital of Orange County
 Violet Shen, Site 019 Ph: 714-532-8646
  Palo Alto
 Lpch & Sumc
 Neyssa Marina, Site 036 Ph: 650-497-8815
  Roseville
 Kaiser Medical Center
 Steven Bergstrom, Site 101
Colorado
  Aurora
 Children's Hospital Colorado Center for Cancer and Blood Disorders
 Kelly Maloney, Site 072 Ph: 720-777-6819
Connecticut
  Hartford
 Connecticut Children's Medical Center
 Michael Isakoff, Site 025 Ph: 860-545-9614
Delaware
  Wilmington
 Alfred I. duPont Hospital for Children
 Christopher N Frantz, Site 008 Ph: 716-275-2644
District of Columbia
  Washington
 Children's National Medical Center
 Jeffrey Dome, Site 018 Ph: 202-476-2801
Florida
  Fort Myers
 Lee Cancer Care of Lee Memorial Health System
 Emad Salman, Site 034 Ph: 239-343-5333
  Gainsville
 University Of Florida
 William Slayton, Site 080 Ph: 352-265-0680 Ext.44237
  Jacksonville
 Nemours Children's Clinic
 Scott Bradfield, Site 049 Ph: 904-697-3817
  Orlando
 M.D. Anderson Cancer Center at Orlando
 Vincent Giusti, Site 037 Ph: 321-841-3837
 Nemours Childrens Hospital
 Ramamoorthy Nagasubramanian, Site 050 Ph: 407-650-7652
  Saint Petersburg
 All Children's Hospital
 Gregory Alan Hale, Site 009 Ph: 727-767-2423
  Tampa
 St. Joseph's Children's Hospital of Tampa
 Hardeo Panchoosingh, Site 059 Ph: 813-554-8586
  West Palm Beach
 St. Mary'S
 Narayana Gowda, Site 069
Georgia
  Atlanta
 AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Egleston Campus
 Todd M Cooper, Site 012 Ph: 404-785-0653
Idaho
  Boise
 Mountain States Tumor Institute at St. Luke's Regional Medical Center
 Eugenia Chang, Site 047 Ph: 208-381-2731
Illinois
  Chicago
 Ann and Robert H. Lurie Children's Hospital of Chicago
 Nobuko Hijiya, Site 022 Ph: 773-880-3443
  Maywood
 Cardinal Bernardin Cancer Center at Loyola University Medical Center
 Ricarchito Manera, Site 003 Ph: 708-216-2058
  Springfield
 Simmons Cooper Cancer Institute
 Gregory Brandt, Site 067 Ph: 217-545-7377
Indiana
  Indianapolis
 Children'S Center For Cancer And Blood Diseases
 Bassem Razzouk, Site 062 Ph: 317-338-9825
 James Whitcomb Riley Hospital For Children
 Robert J Fallon, Site 030 Ph: 317-278-1269
Kentucky
  Lexington
 Lucille P. Markey Cancer Center at University of Kentucky
 Martha Greenwood, Site 083 Ph: 859-323-3610
  Louisville
 Kosair Children's Hospital
 Kenneth Lucas, Site 033 Ph: 502-852-8457
Maryland
  Baltimore
 Alvin and Lois Lapidus Cancer Institute at Sinai Hospital
 Joseph Wiley, Site 065 Ph: 410-601-8393
 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
 Patrick Brown, Site 031 Ph: 410-955-0432
Massachusetts
  Boston
 Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute
 Lewis Silverman, Site 104 Ph: 617-632-6841
  Worcester
 UMASS Memorial Cancer Center - University Campus
 Christopher Keuker, Site 084 Ph: 508-856-3077
Michigan
  Detroit
 Children's Hospital of Michigan
 Meret Henry, Site 105 Ph: 313-966-8541
  Lansing
 Michigan State University
 Renuka Gera, Site 044 Ph: 517-364-5591
Minnesota
  Minneapolis
 Children's Hospitals and Clinics of Minnesota - Minneapolis
 Bruce Bostrom, Site 021 Ph: 612-813-5913
Mississippi
  Jackson
 Univ Of Mississippi Med Ctr
 Gail Megason, Site 085 Ph: 601-984-2065
Missouri
  Columbia
 University Of Missouri Health Care
 Thomas Loew, Site 086 Ph: 572-882-1960
  Kansas City
 Children's Mercy Hospital
 Maxine Hetherington, Site 073 Ph: 816-234-3265
  Saint Louis
 Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
 Robert Hayashi, Site 092 Ph: 314-454-4207
Nevada
  Las Vegas
 Children's Specialty Center of Nevada
 Jonathan Bernstein, Site 051 Ph: 702-384-0013
New Jersey
  Hackensack
 Hackensack University Medical Center Cancer Center
 Burton Elliot Appel, Site 029 Ph: 201-996-5619
  Morristown
 Goryeb Children'S Hospital
 Steven Halpern, Site 097 Ph: 973-971-6720
  New Brunswick
 Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School
 Richard Drachtman, Site 076 Ph: 732-235-7407
  Newark
 Newark Beth Israel Medical Center
 Peri Kamalakar, Site 108 Ph: 973-926-7161
  Paterson
 St. Joseph's Hospital and Medical Center
 Mary Ann Bonilla, Site 060 Ph: 973-754-3778
New Mexico
  Albuquerque
 University of New Mexico Cancer Center
 Koh Boayue, Site 087 Ph: 505-272-5300
New York
  New York
 Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center
 Alice Lee, Site 024 Ph: 212-305-2486
 New York Weill Cornell Cancer Center at Cornell University
 Alexander Aledo, Site 093 Ph: 212-746-3413
 NYU Cancer Institute at New York University Medical Center
 Linda Granowetter, Site 004 Ph: 212-263-9945
  Syracuse
 SUNY Upstate Medical University Hospital
 Karol H Kerr, Site 070 Ph: 315-464-7232
  Valhalla
 New York Medical College
 Mehmet Ozkaynak, Site 109 Ph: 914-594-4151
North Carolina
  Charlotte
 Levine Children's Hospital
 Joel Kaplan, Site 011 Ph: 704-381-9900
Ohio
  Cincinnati
 Cincinnati Children's Hospital Medical Center
 Maureen O'Brien, Site 023 Ph: 513-636-8240
  Columbus
 Nationwide Children's Hospital
 Mark Ranalli, Site 048 Ph: 614-722-3654
  Dayton
 Dayton Children's - Dayton
 Emmett Broxson, Site 017 Ph: 937-641-3432
  Toledo
 Mercy Children's Hospital
 Rama Jasty, Site 115 Ph: 419-251-8075
 The Toledo Children'S Hospital
 Dagmar Tichy Stein, Site 114 Ph: 419-291-9525
Oklahoma
  Oklahoma City
 Oklahoma University Cancer Institute
 Rene Y Mcnall-Knapp, Site 089 Ph: 405-271-4255
Oregon
  Portland
 Knight Cancer Institute at Oregon Health and Science University
 Bill Chang, Site 052 Ph: 503-418-5336
 Legacy Emanuel Hospital and Health Center and Children's Hospital
 Janice F Olson, Site 035 Ph: 503-276-9300
Pennsylvania
  Danville
 Geisinger Cancer Institute at Geisinger Health
 Jagadeesh Ramdas, Site 007 Ph: 570-271-6896
  Hershey
 Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center
 Lisa Mcgregor, Site 053
  Philadelphia
 Children's Hospital of Philadelphia
 Richard D Aplenc, Site 015 Ph: 267-426-9293
  Pittsburgh
 Children's Hospital of Pittsburgh of UPMC
 A. Kim Ritchey, Site 016 Ph: 412-692-6815
Rhode Island
  Providence
 Rhode Island Hospital Comprehensive Cancer Center
 Jennifer Welch, Site 116 Ph: 401-444-5171
Tennessee
  Knoxville
 East Tennessee Children's Hospital
 Ray Pais, Site 028 Ph: 865-541-8617
  Nashville
 Vanderbilt-Ingram Cancer Center
 Kristen Snyder, Site 111 Ph: 615-936-5557
Texas
  Austin
 Dell Children's Medical Center of Central Texas
 Sharon K Lockhart, Site 112 Ph: 512-324-0148
  Corpus Christi
 Driscoll Children's Hospital
 Cris Johnson, Site 027 Ph: 512-850-5000
  Dallas
 Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas
 Naomi Winick, Site 091 Ph: 214-456-8588
  Fort Worth
 Cook Children'S Hem/Onc Center
 Kelly Vallance, Site 026 Ph: 817-885-4073
  Houston
 Texas Children's Cancer Center and Hematology Service at Texas Children's Hospital
 Maria Gramatges, Site 010 Ph: 832-824-6835
  Temple
 Scott and White Cancer Institute
 Guy Grayson, Site 063 Ph: 254-724-5079
Utah
  Salt Lake City
 Primary Children's Medical Center
 Phillip Barnette, Site 054 Ph: 801-662-4715
Virginia
  Fairfax
 Inova Pediatric Specialty Center Ii
 Marshall Schorin, Site 113 Ph: 703-970-6587
  Norfolk
 Children'S Hosp-Kings Daughter
 Eric Lowe, Site 020 Ph: 757-668-7243
Washington
  Seattle
 Children's Hospital and Regional Medical Center - Seattle
 Rebecca Gardner, Site 064 Ph: 206-884-1591
Wisconsin
  Green Bay
 St Vincent Hospital
 John R Hill, Site 061 Ph: 920-433-8272
  Milwaukee
 Medical College of Wisconsin Cancer Center
 Richard Tower, Site 045 Ph: 414-456-4170
Australia
  Perth
 Local Institution
 Site 132
Queensland
  Herston
 Local Institution
 Site 130
Victoria
  Parkville
 Local Institution
 Site 131
Canada
Alberta
  Calgary
 Alberta Children's Hospital
 Doug Strother, Site 127 Ph: 403-955-7693
  Edmonton
 Stollery Children's Hospital at University of Alberta Hospital
 Sunil Desai, Site 121 Ph: 780-407-8790
Ontario
  London
 Children'S Hospital London Health Sciences Centre
 Paul Gibson, Site 120 Ph: 519-685-8500 Ext.55058
  Ottawa
 Children's Hospital of Eastern Ontario
 Jacqueline Halton, Site 122 Ph: 613-737-7600 Ext.2719
Quebec
  Montreal
 Chu Ste-Justine
 Yvan Samson, Site 125 Ph: 514-345-4969
 Montreal Children's Hospital at McGill University Health Center
 Sharon Abish, Site 119 Ph: 514-412-4400 Ext.22014
Puerto Rico
  San Juan
 San Jorge Children's Hospital
 Luis Clavell, Site 096 Ph: +7877281575
United Kingdom
  Birmingham
 Local Institution
 Site 148
  Cambridge
 Local Institution
 Site 156
  Cardiff
 Local Institution
 Site 165
  London
 Local Institution
 Site 151
  Manchester
 Local Institution
 Site 152
  Newcastle
 Local Institution
 Site 153
  Nottingham
 Local Institution
 Site 163
  Sheffield
 Local Institution
 Site 166

Link to the current ClinicalTrials.gov record.
NLM Identifer NCT01460160
ClinicalTrials.gov processed this data on June 12, 2014

Note: Information about this trial is from the ClinicalTrials.gov database. The versions designated for health professionals and patients contain the same text. Minor changes may be made to the ClinicalTrials.gov record to standardize the names of study sponsors, sites, and contacts. Cancer.gov only lists sites that are recruiting patients for active trials, whereas ClinicalTrials.gov lists all sites for all trials. Questions and comments regarding the presented information should be directed to ClinicalTrials.gov.

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