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Pediatric Philadelphia Positive Acute Lymphoblastic Leukemia

Basic Trial Information
Trial Description
     Summary
     Eligibility Criteria
Trial Contact Information

Basic Trial Information

PhaseTypeStatusAgeSponsorProtocol IDs
Phase IITreatmentActive1 to 17Pharmaceutical / IndustryCA180-372
2011-001123-20, AALL1122, NCT01460160

Trial Description

Summary

The purpose of this study is to determine whether Dasatinib when added to standard chemotherapy is effective and safe in the treatment of pediatric philadelphia chromosome positive acute lymphoblastic leukemia

Eligibility Criteria

For more information regarding BMS clinical trial participation, please visit www.BMSStudyConnect.com.

Inclusion Criteria:

  • Newly diagnosed Philadelphia chromosome positive Acute Lymphoblastic Leukemia (ALL)
  • Age >1 year and < less than 18 years old
  • Induction chemotherapy ≤ 14 days according to institutional standard of care
  • Adequate liver, renal and cardiac function

Exclusion Criteria:

  • Prior treatment with a Oncogene fusion protein (BCR-ABL) inhibitor
  • Extramedullary involvement of the testicles
  • Active systemic bacterial, fungal or viral infection
  • Down syndrome

Trial Contact Information

Trial Lead Organizations/Sponsors

Bristol-Myers Squibb Company - New York

Children's Oncology Group

EsPhALL - European Intergroup Study on Post Induction Treatment of Philadelphia Positive Acute Lymphoblastic Leukaemia with Imatinib

Bristol-Myers SquibbStudy Director

For participation information at a USA site use a phone number below. For site information outside the USA please email:
  Email: Clinical.Trials@bms.com

Trial Sites

U.S.A.
Alabama
  Birmingham
 UAB Comprehensive Cancer Center
 Alyssa Reddy, Site 077 Ph: 205-638-9559
Arizona
  Phoenix
 Phoenix Children'S Hospital/Ctr. For Cancer & Blood Ctr.
 Jessica Boklan, Site 005 Ph: 602-546-0920
Arkansas
  Little Rock
 Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
 David L Becton, Site 098 Ph: 501-364-5650
California
  Loma Linda
 Antranik Agop Bedros
 Antranik Agop Bedros, Site 099 Ph: 909-558-4050
  Long Beach
 Miller Children'S Hospital Long Branch
 Amanda Termuhlen, Site 046 Ph: 562-933-8626
  Los Angeles
 Children's Hospital Los Angeles
 Weili Sun, Site 014 Ph: 323-361-5989
 Kaiser Permanente Medical Center - Los Angeles
 Robert M Cooper, Site 066 Ph: 562-461-6941
  Madera
 Children's Hospital Central California
 James Ozeran, Site 013 Ph: 246-232-9502 Ext.2106
  Orange
 Children's Hospital of Orange County
 Violet Shen, Site 019
  Palo Alto
 Lpch & Sumc
 Neyssa Marina, Site 036 Ph: 415-497-8000
  Roseville
 Kaiser Permanente-Oakland
 Steven Bergstrom, Site 101
Colorado
  Aurora
 Children's Hospital Colorado Center for Cancer and Blood Disorders
 Kelly Maloney, Site 072 Ph: 720-777-6772
Connecticut
  Hartford
 Connecticut Children's Medical Center
 Michael Isakoff, Site 025 Ph: 860-545-9560
Delaware
  Wilmington
 Alfred I. duPont Hospital for Children
 Christopher N Frantz, Site 008 Ph: 302-651-5500
District of Columbia
  Washington
 Children's National Medical Center
 Jeffrey Dome, Site 018 Ph: 202-884-2130
Florida
  Fort Myers
 Lee Cancer Care of Lee Memorial Health System
 Emad Salman, Site 034 Ph: 239-343-5333
  Gainsville
 University Of Florida
 William Slayton, Site 080 Ph: 352-265-5503
  Jacksonville
 Nemours Children's Clinic
 Scott Bradfield, Site 049 Ph: 904-390-3792
  Orlando
 Mc Anderson Orlando/Arnold Palmer Hospital
 Vincent Giusti, Site 037 Ph: 321-841-1859
 Nemours Children'S Clinic - Orlando
 Ramamoorthy Nagasubramanian, Site 050
  St. Petersburg
 All Children's Hospital
 Gregory Alan Hale, Site 009 Ph: 813-898-7451
  Tampa
 St. Joseph's Children's Hospital of Tampa
 Hardeo Panchoosingh, Site 059
  West Palm Beach
 St. Mary'S
 Narayana Gowda, Site 069 Ph: 561-840-6125
Georgia
  Atlanta
 AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Egleston Campus
 Todd M Cooper, Site 012 Ph: 404-785-1281
Idaho
  Boise
 Mountain States Tumor Institute at St. Luke's Regional Medical Center
 Eugenia Chang, Site 047 Ph: 208-381-2731
Illinois
  Chicago
 Ann and Robert H. Lurie Children's Hospital of Chicago
 Nobuko Hijiya, Site 022
  Maywood
 Cardinal Bernardin Cancer Center at Loyola University Medical Center
 Ricarchito Manera, Site 003 Ph: 708-216-2027
  Springfield
 Simmons Cooper Cancer Institute
 Gregory Brandt, Site 067 Ph: 217-524-0326
Indiana
  Indianapolis
 Children'S Center For Cancer And Blood Diseases
 Bassem Razzouk, Site 062 Ph: 317-338-4673
 James Whitcomb Riley Hospital For Children
 Robert J Fallon, Site 030 Ph: 317-944-8784
Kentucky
  Lexington
 University Of Kentucky
 Martha Greenwood, Site 083 Ph: 859-323-2894
  Louisville
 Kosair Children's Hospital
 Kenneth Lucas, Site 033 Ph: 502-629-8808
Maryland
  Baltimore
 Alvin and Lois Lapidus Cancer Institute at Sinai Hospital
 Joseph Wiley, Site 065 Ph: 410-601-4710
 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
 Patrick Brown, Site 031 Ph: 410-955-1373
Massachusetts
  Boston
 Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute
 Lewis Silverman, Site 104 Ph: 617-632-6191
  Worcester
 UMASS Memorial Cancer Center - University Campus
 Christopher Keuker, Site 084 Ph: 508-856-8571
Michigan
  Detroit
 Children's Hospital of Michigan
 Meret Henry, Site 105 Ph: 313-745-0073
  East Lansing
 Michigan State University
 Renuka Gera, Site 044 Ph: 517-364-5591
Minnesota
  Minneapolis
 Children's Hospitals and Clinics of Minnesota - Minneapolis
 Bruce Bostrom, Site 021 Ph: 612-220-6658
Mississippi
  Jackson
 Univ Of Mississippi Med Ctr
 Gail Megason, Site 085 Ph: 601-984-2712
Missouri
  Columbia
 University Of Missouri Health Care
 Thomas Loew, Site 086 Ph: 573-882-8631
  Kansas City
 Children's Mercy Hospital
 Maxine Hetherington, Site 073 Ph: 816-234-3000
  St. Louis
 Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
 Robert Hayashi, Site 092 Ph: 314-454-4962
Nevada
  Las Vegas
 Children's Specialty Center of Nevada
 Jonathan Bernstein, Site 051
New Jersey
  Hackensack
 Hackensack University Medical Center Cancer Center
 Burton Elliot Appel, Site 029 Ph: 201-996-2255
  Morristown
 Goryeb Children'S Hospital
 Steven Halpern, Site 097 Ph: 973-971-6720
  New Brunswick
 Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School
 Richard Drachtman, Site 076 Ph: 732-235-7407
  Newark
 Newark Beth Israel Medical Center
 Peri Kamalakar, Site 108 Ph: 973-926-7161
  Paterson
 St. Joseph's Hospital and Medical Center
 Mary Ann Bonilla, Site 060 Ph: 973-754-3029
New Mexico
  Albuquerque
 Univeristy Of New Mexico
 Koh Boayue, Site 087 Ph: 505-272-5579
New York
  New York
 NYU Cancer Institute at New York University Medical Center
 Elizabeth Raetz, Site 004 Ph: 212-562-7310
 The Herbert Irving Pavilion
 Alice Lee, Site 024 Ph: 212-305-8684
  Syracuse
 SUNY Upstate Medical University Hospital
 Karol H Kerr, Site 070 Ph: 315-464-4210
  Valhalla
 New York Medical College
 Mehmet Ozkaynak, Site 109 Ph: 914-493-7514
North Carolina
  Charlotte
 Levine Children's Hospital
 Joel Kaplan, Site 011 Ph: 704-381-9900
Ohio
  Cincinnati
 Cincinnati Children's Hospital Medical Center
 Maureen O'Brien, Site 023 Ph: 513-636-4531
  Columbus
 Nationwide Children's Hospital
 Mark Ranalli, Site 048 Ph: 614-722-3552
  Dayton
 The Children'S Medical Center Of Dayton
 Emmett Broxson, Site 017
  Toledo
 Mercy Children's Hospital
 Rama Jasty, Site 115 Ph: 419-251-8215
 Toledo Children'S Hospital
 Dagmar Tichy Stein, Site 114 Ph: 419-291-9500
Oklahoma
  Oklahoma City
 Oklahoma University Cancer Institute
 Rene Y Mcnall-Knapp, Site 089 Ph: 405-456-3110
Oregon
  Portland
 Knight Cancer Institute at Oregon Health and Science University
 Bill Chang, Site 052 Ph: 503-494-5058
 Legacy Emanuel Hospital and Health Center and Children's Hospital
 Janice F Olson, Site 035 Ph: 503-413-2560
Pennsylvania
  Danville
 Geisinger Cancer Institute at Geisinger Health
 Jeffrey Taylor, Site 007 Ph: 570-271-5555
  Philadelphia
 Children's Hospital of Philadelphia
 Richard D Aplenc, Site 015 Ph: 215-590-1000
  Pittsburgh
 Children's Hospital of Pittsburgh of UPMC
 A. Kim Ritchey, Site 016 Ph: 412-692-5949
Rhode Island
  Providence
 Rhode Island Hospital Comprehensive Cancer Center
 Jennifer Welch, Site 116 Ph: 401-444-5853
Tennessee
  Knoxville
 East Tennessee Children's Hospital
 Ray Pais, Site 028 Ph: 615-541-8000
  Nashville
 Vanderbilt-Ingram Cancer Center
 Valerie Brown, Site 111 Ph: 615-936-1762
Texas
  Austin
 Dell Children's Medical Center of Central Texas
 Sharon K Lockhart, Site 112 Ph: 512-628-1900
  Corpus Christi
 Driscoll Children's Hospital
 Cris Johnson, Site 027 Ph: 512-850-5000
  Dallas
 Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas
 Naomi Winick, Site 091
  Fort Worth
 Cook Children'S Hem/Onc Center
 Kelly Vallance, Site 026 Ph: 682-885-7491
  Houston
 Texas Children's Cancer Center and Hematology Service at Texas Children's Hospital
 Maria Gramatges, Site 010 Ph: 713-770-1000
  Temple
 Scott and White Cancer Institute
 Guy Grayson, Site 063 Ph: 254-724-5382
Utah
  Salt Lake City
 Primary Children's Medical Center
 Phillip Barnette, Site 054 Ph: 801-588-2000
Virginia
  Fairfax
 Inova Pediatric Specialty Center Ii
 Marshall Schorin, Site 113 Ph: 571-226-5600
  Norfolk
 Children'S Hosp-Kings Daughter
 Eric Lowe, Site 020 Ph: 804-628-7000
Washington
  Seattle
 Children's Hospital and Regional Medical Center - Seattle
 Blythe G Thomson, Site 064 Ph: 206-987-4329
Wisconsin
  Green Bay
 St Vincent Hospital
 John R Hill, Site 061 Ph: 414-433-0111
  Milwaukee
 Midwest Children's Cancer Center at Children's Hospital of Wisconsin
 Richard Tower, Site 045 Ph: 414-454-5739
Australia
  Perth
 Local Institution
 Site 132
Queensland
  Herston
 Local Institution
 Site 130
Victoria
  Parkville
 Local Institution
 Site 131
Canada
Alberta
  Calgary
 Local Institution
 Site 127
Ontario
  London
 Local Institution
 Site 120
  Ottawa
 Local Institution
 Site 122
Quebec
  Montreal
 Local Institution
 Site 125
 Site 119
Saskatchewan
  Saskatoon
 Local Institution
 Site 123
Italy
  Bologna
 Local Institution
 Site 146
  Cagliari
 Local Institution
 Site 141
  Catania
 Local Institution
 Site 133
  Firenze
 Local Institution
 Site 137
  Genova
 Local Institution
 Site 136
  Monza (Mb)
 Local Institution
 Site 134
  Napoli
 Local Institution
 Site 142
  Palermo
 Local Institution
 Site 139
  Roma
 Local Institution
 Site 145
 Site 144
  Torino
 Local Institution
 Site 143
  Trieste
 Local Institution
 Site 135
Puerto Rico
  San Juan
 Local Institution
 Site 096
United Kingdom
  Aberdeen
 Local Institution
 Site 154
  Birmingham
 Local Institution
 Site 148
  Bristol
 Local Institution
 Site 155
  Cambridge
 Local Institution
 Site 156
  Cardiff
 Local Institution
 Site 165
  Edinburgh
 Local Institution
 Site 157
  Glasgow
 Local Institution
 Site 158
  Leeds
 Local Institution
 Site 159
  Liverpool
 Local Institution
 Site 150
  London
 Local Institution
 Site 151
  Manchester
 Local Institution
 Site 152
  Newcastle
 Local Institution
 Site 153
  Nottingham
 Local Institution
 Site 163
  Oxford
 Local Institution
 Site 164
  Sheffield
 Local Institution
 Site 166
  Southampton
 Local Institution
 Site 160
  Sutton
 Local Institution
 Site 147

Link to the current ClinicalTrials.gov record.
NLM Identifer NCT01460160
ClinicalTrials.gov processed this data on January 22, 2014

Note: Information about this trial is from the ClinicalTrials.gov database. The versions designated for health professionals and patients contain the same text. Minor changes may be made to the ClinicalTrials.gov record to standardize the names of study sponsors, sites, and contacts. Cancer.gov only lists sites that are recruiting patients for active trials, whereas ClinicalTrials.gov lists all sites for all trials. Questions and comments regarding the presented information should be directed to ClinicalTrials.gov.

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