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NCI Dictionary of Cancer Terms


B-cell leukemia/lymphoma 2 protein  listen  (... sel loo-KEE-mee-uh/lim-FOH-muh 2 PROH-teen)

  A protein that helps control whether a cell lives or dies by blocking a type of cell death called apoptosis. The gene for the B-cell leukemia/lymphoma 2 protein is found on chromosome 18, and transfer of the B-cell leukemia/lymphoma 2 gene to a different chromosome is seen in many B-cell leukemias and lymphomas. This causes the B-cell leukemia/lymphoma 2 protein to be made in larger amounts, which may keep cancer cells from dying. Also called BCL2.