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NCI Drug Dictionary

  

monoclonal antibody 4B5 anti-idiotype vaccine 
A humanized anti-idiotypic (anti-Id) monoclonal antibody (MoAb) that mimics the disialoganglioside GD2 with potential immunostimulating and antineoplastic activities. Upon administration, monoclonal antibody 4B5 anti-idiotype vaccine may elicit both cellular and humoral immune responses against GD2- expressing tumor cells. GD2 is a glycosphingolipid (ceramide and oligosaccharide) that may be highly expressed by melanomas and other neuroectodermal tumors, while only minimally expressed by normal tissues. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:4B5 monoclonal antibody anti-idiotype vaccine
MOAB 4B5 anti-idiotype vaccine
Abbreviation:MOAB 4B5