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NCI Drug Dictionary

  

anti-thymocyte globulin 
A purified gamma immunoglobulin (IgG) with immunosuppressive activity. Obtained from rabbits that have been immunized with human thymocytes, antithymocyte globulin specifically recognizes and destroys T lymphocytes. Although the exact mechanism of action is not completely understood, it appears to involve T lymphocyte clearance from the circulation and modulation of T lymphocyte activity. Administering antithymocyte globulin with chemotherapy prior to stem cell transplantation may reduce the risk of graft-versus-host disease. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:lymphocyte immune globulin
US brand names:ATGAM
Thymoglobulin
Abbreviation:ATG